Professional Documents
Culture Documents
PREPARED BY
Bosede Adedire, Rachel Adejoh, Sylvia Assiamah and Tracy Brooks
CONTENT OUTLINE
Background of study
What is syphilis?
Case study
Literature review
Exhibit 1- Analysis of study violations
of
Nuremberg codes
Exhibit 2- Analysis of study violations
Warning!
Be advised this presentation
may contain explicit and
disturbing graphics.
Thank you!
BACKGROUND
Syphilis was prevalent in the early
1930s, disease and its progression
was unknown
As the disease evolved , it
prompted an urgent need to study
disease progression more
Public Health Service (PHS) carried
vigorously
out a surveillance that revealed
widespread of syphilis in Macon
Alabama
County,
Initiation of a program aimed at
controlling the disease
A two-year demonstration study in
Macon County, Alabama
Study result from demonstration
brought the study to an abrupt end
WHAT IS SYPHILIS?
THE CASE
Faces of Tuskegee team
Due to lack of funding to follow-up with
treatment, another study was initiated to
study the progression of syphilis in the
people that already got the disease.
The origination of this study started what is
now known as the Tuskegee Syphilis Study
616 participants, 399 with disease and 217
as control group
No stated ethical guidelines for research study
Order of events in study
Literature
Review..
Davis, L., Green, B., & Katz, R. V. (2012). Influence of scary beliefs
about the Tuskegee
syphilis study on willingness to participate in research. ABNF
Journal, 23, 59-62.
Literature explores the impact of past events on the willingness of African Americans to
participate in biomedical research
Sequence of events in the Tuskegee syphilis study has been
blamed for reasons why African Americans are reluctant
to participate in medical research. But scholars found out
it does not appear to be a major factor today.
Also, researchers concludes Tuskeegee
syphilis study violates moral and ethical
principles .
o VIOLATIONS
CODES VIOLATED
o Recruitment letter used vague and
unclear words to lure participants
study
o into
Researchers
exploited unsuspecting
Recruitment Letter
Nuremberg codes
o Experiment involved
unnecessary spinal taps and
blood draws
o Study continues when
treatment to disease was found
Nonmaleficence
Beneficence
Beneficence
o Scientist not ready to terminate experiment
even when they knew participants could end
up with consequences of untreated syphilis
which could cause harm, organ damage,
or death
o disability
Study continues
even when number of
participants death were reported
Nonmaleficence
Questions??
References
Beauchamp, L., & Childress, F., (2009). Principles of Biomedical
Ethics.
(5thed.).
York:
University
Press
Bozeman,
B.,New
Slade,
C., Oxford
& Hirsch,
P. (2009).
Ethics in research and
practice. American Journal of Public Health, 99, 1549-1556.
Burns, N., & Grove, S.K. (2011). Understanding nursing research. (5th ed).
Saunders Elsevier
Davis, A.J., & Aroskar, M. A. (2011). Ethical dilemmas and nursing
practice. (5th ed).
Pearson Publishers
.
Davis, L., Green, B., & Katz, R. V. (2012). Influence of scary beliefs about
the Tuskegee
syphilis study on willingness to participate in research. ABNF Journal,
23, 59-62
Gupta, U. (2013). Informed consent in clinical research: Revisiting few
concepts and areas.
in Clinical
Research,
26-32.
Retrieved
fromTuskegee
Levine,Perspectives
S., & Williams,
C., Kilbourne,
A.,1, &
Juarez,
P. D.(2012).
http://www.picronline.org/article.asp?issn=2229redux:
Evolution of legal mandates for human experimentation.
Journal of Health
3485;year=2013;volume=4;issue=1;spage=26;epage=32;aulast=Gupta
Care for the Poor and Underserved 23(4), 104-125. The Johns Hopkins
References
McCance, K., Huether, S., Brashers, V., & Rote, N. (2010).
Pathophysiology: The
Biologic Basis for Disease in Adults and Children (6th ed.).
Missouri: Mosby Inc.
Ogungbure, A. (2011). The Tuskegee syphilis study: Some ethical
reflections.
Thought and practice: A Journal of the Philosophical
Association of Kenya (PAK),
3(3), 75-92.
Porth, C. & Matfin, G. (2009). Pathophysiology: Concepts of altered
health states