NMS NMS Labs ait nme@rmelabs.com Robert A. Mddeberg, PAD, FABFT, DABCO-T0, Laboratory Drector CONFIDENTIAL {701 Wiley Read, PO Box 432A, Wllow Grove, PA 19000.0697 Phono: (218) 857-4900 Fay: (218) 657-2072 Toxicology Report Patient Name KELLAM, TERRANCE 15-5045, Report Issued 05/06/2015 16:03, cua Nerosacal ‘Age 20 DOB 11/01/1994 praiee Gender Male University of Michigan - Wayne County Workorder 5323524 Attn: Dr. Ca J. Schmidt Paget of 4 4300 East Warren Detrot, Mi 48207 Positive Findings: ‘Compound Result Units Matrix Source Dolta.9 THE 2 ‘agit. 901 - Peripheral Blood Delta-9 Cerboxy THC 3 agin. 001 - Peripheral Blood Opiates Prosump Pos ngimt 008 - Urine Benzodiazepines Proaump Pos gil 004 - Urine ‘Cannabinoids PresumpPes ——ngimL 004 - Urine ‘See Detaled Findings section for additional information Testing Requested: Analysis Code Description ‘050U Postmortem Toncslogy Ui Seraen Addon (MAM Guartiicaton oni) 20568 ‘Spocimons Received: 1D. TuberContainer Postmortem Toxicology - Basic with Vitreous Alechel Confimation, Blood - University of Ml (CSA) Volume’ Collection Matrix Source Miscellaneous. Mass Date/Time Information OT Gay Top Tie Teil areas Peripheral Bi6ed 002 Gray Top Tube Tmi 04282018 Perioheral Blood (003 Red Top Tube 228ml —oas28/2015 Vitreous Fiat (004 Green Viat tom —oamzarzons, Urine 005 White PlssticContainer 17.65 04i2ai2018 Liver Tissue Allsemple volumes/weights ae approximations Specimens recsived on 04/28/2015, v4NMS corer ae Page 2014 Detailed Findings: Rot. Analysia and Comments Result Units Limit Specimen Source Analysis By Datta 9 THE 3 ora. 10 O01=Peripheral Blood GC-GC-GCMS. Detta9 Carbaxy THC 83 lt. 50 001 Peripheral Blood GC-GC-GOIMS Opiates Presump Pos: ait. 300 004- Urine eA This testis an unconfimed screen. Confirmation by a more defritve technique such as GC/MS is recommended, Benzodiazepines Presump Pos. af. 50 008 - Urine EIA ‘This testis an unconfirmed screen. Confirmation by @ more defiitve technique such as GCIMS is recommended ‘Connebinoids Presump Pos: ae. 20 (004 - Urine EIA ‘This tess on unconfirmed screen. Confirmation by a more defnitve technique such 48 GCIMS is recommended, Other than the above findings, examination of the specimen(s) submitted did not reveal any positive findings of toxleological significance by procedures outlined in the accompanying Analysis Summary. Reference Comments: 1. Benzodiazepines - Urine: Benzodiazepines are 9 class of drugs that are prescribed for their anxolyc, muscle relaxant, anticonvulsant ‘and hypnotic effects. The degree ofeach effect is dependent upon the specite drug, is pharmacokinetics and ‘ny relevant matabalte. ‘This resut derives ftom a presumptive test, which may be subject to cross-reactivity wth non-benzodiazeping ralated compounds, A second tests necessary to conti the presence of benzodiazepine related ‘compounds. 2. Camabinoids - Urne * Cannabinolds are chemical compounds derived fam the plant Cannabis sativa (marliuana), including active ‘omponenis, chemical congeners and metabottes. Della-&-Tetranydrocannabinel (THC) i te principal active ‘component ‘This result derives from a presumplive test, which may be subject to cross-reactivity with non-cannabinoid ‘elated compounds. A second tests necessary to conf the presence of cannabinoid related compounds. 3. Delta-9 Cerboxy THC (Inactive Metabolite) - Periherel Blood: Mariuans is a DEA Scheduie | hallucinogen. Pharmacological ithas deprossant and realty distorting effects. ‘Coteectivaly, the chemical compounds that comprise mariuana are known as Cannabincids. ‘Dalta-8-THC isthe principle paychoactve ingrediant of marjuana/hashish, Delta-9-carboxy THC (THCC) ie the inactive metabotte of THC with peak concenivations attained 32 to 240 minvies aftar smoking and may be delocied fer up to one day oF more in blood. Bath dets-9-THC and THCC may be present substantially onger inchronic users. THCC is usually not detectable after passive inhalation, 4 Dele-9 THC (Active Ingredient of Mariana) - Peripheral Bloc: ‘Marjuana is a OEA Schedule | hallucinogen, Prarmacologcaly, thes depressant and realy distorting effects. CColeetvely, the chemical compounds that comprise marjuana are known as Cannaninoids. Deita.0-THC Is the principle psychoactive ingredient of marjvanashashish It rapidly leaves the blood. even ‘dunng emoking, fallng to below datactabe lvels within several hours. THC conoentrabons in blood are usualy ‘bout one-half that of serumyplaema concertralions, The active metabolite, 11-hydtoxy-THC, may als fll below detectable levelashorly afer inhalation. Data S-carbaxy-THC (THCC) i the inactive metabolite of THC ‘wih peak concentrations attained 32 to 240 minutes ater smoking and may be detected for up to one day of ‘more in blood. Both delta-9-THC and THCC may be present substantially longer in chronic users, viaNMS ae eee Patient ID 15-5045 Page 3 of 4 Reference Comment Reported usual peak THC concentrations in serum after smoking 1.75% or 3.55% THC marluana cigaretias are 50-270 ng/mL atter beginning of smoking, decreasing to less tan 5 ng/mL by 2 hrs. Corresponding deka S.carboxy-THC concentrations range from 10~ 101 ng/mi about 32 to 240 minutes aftr the begining of smoking and devine slowly. Passive inhalation of marjuana smoke hat been reported to produce blood THC concertrations up to 2 ngimL. Deta-0-carboxy THC concentrations in blood may not be present following passive inhalation of manjuana smoke 5. Opiates - Urine: Opiates are a cass of crugs that have efflocts similar fo morphine. These diugs are most commonly prescribed a8 anaigesies forthe rele! of paln, bul ave also uiized fer sedation, preanesthetc medication and anesthesia inthe hospital setting, anc as anttussives and entictarheals in ambulatory mesicine. This result derives fom a presumptive test, which may be subject to cross-reactuity wth non-opiate relate ‘compounds. A second tests nacessary 10 confm the presence of opiate elated compounds. Uniess altemate arrangements are made by you, the remainder ofthe submited specimens willbe discarded two (2) ‘years from the date ofthis report; and generated data willbe dscarced five (5) years fom the date the analyses were Performed, Workorder 15123924 was electronically signed on 05/08/2015 14:43 by: phew M po—— Derive M, Teer, CCorttvng Stentst Analysis Summary and Reporting Limits: ‘Aol he loving tess were pesomed fri cate, Fr each es, compounds ite wae inclu ine spe. The Reporting int itd foreach compocré represents ihe bwest concastan of ne compoue hat mlb epee basa ontve Mite compound sted a0 Wono beet, lis tt present ave ne Reporag Lit, Pees ert he Poatog Facing secon ore report for hate compeuncs hat were ened as beng preset cae 500138 -Cenabnois Contmaton, Boo (Foren) ParpheraSoed Analysis by Mutt-cimensional Gas ChromatographyMass, Spectrometry (GC-GC-GCIMS} for ‘Compound Bab Limit Someaund ‘Rot Limit ‘1-Hydroxy Deli THC 5.0 ngimt Detta-6 THE Ong Della Carboxy THC 5.9 agit ‘Acode 80500 - Postmortem Toxicology - Urine Screen Add-on (6-MAM Quantification only) Analysis by Enzyme Immunoassay (EIA) for ‘Compound ‘Rat Limit Somanund Bet_Limt Amphetamines 500 ngiL Methadone 300 ng/mL, Bariturates 030 mogimL plates 300 ngimt. Benzodiazepines 50 nail Oxycodone 400 agit. ‘Cannabinoice 20ngImL Phencyesdine 25 ngimt, Cocaine / Metaboltes 160 pginL. Propoxyphene 300 ngint, ‘code 80568 - Postmortem Tox\cology - Basic wth Vitreous Alcohol Confirmation, Bloed - Unversity of Ml (CSA) - Peripheral Analysis by Enzyme-Linked Immunosorbent Assay (ELISA) for v4CONFIDENTIAL, Workorder 18129924 Chain 15123824 Patient 10 15-5045 196 4 of Analysis Summary and Reporting Limits: ‘Compound Rot. Limit Bat Lieat Amphetamines 20.ngImL 0.80 ngimt arcturates (0.040 mogtmi 25 ngime Benzodiazepines 100 agit 20.ngimL Buprenompnine / Metabolite 0.80 agit 20 ng. ‘Connabinoids| 10 ngimi. 10 mgmt. Cocaine /tetabottes 209m. 10 ngimt. Analysis by Headspace Gas Chromatography (GC) for ‘Sameound Bot Limit ‘Comaound Ret Limit Acetone 5.0 mala tsopropenol 5.0 mold Ethanct romgiet. Methanol 5.0 mgial. va