SRI VENKATESWARA COLLEGE OF PHARMACY/RVS

Hospital
Department of Pharmacy Practice

Name and year of student: Shareen.Shaik

Date:

Trade Name and category of drug: Atorvastatin (Anti cholesteremic agents)

Brand name, Manufacturer &Price: Aztor, Sun Pharmaceutical Industries
Ltd,Rs.198.00/40mg.

Available formulations with strength: Capsule, Tablet 5mg,10mg,20mg,40mg.

Mechanism of action of drug: Atorvastatin selectively and competitively inhibits
the hepatic enzyme HMG-CoA reductase which is responsible for converting HMGCoA to mevalonate in the cholesterol biosynthesis which results in decrease of
hapatic cholesterol levels.

Pharmacokinetics Parameters:
ADME: Low systemic bioavailability is due to pre-systemic clearance by
gastrointestinal mucosa and first-pass metabolism in the liver, distribution is 381 L,
metabolized to ortho - and para hydroxylated derivatives and various beta-oxidation
products. Eliminated primarily in bile after hepatic and / or extra hepatic metabolism.
Protein binding: >98% bound to plasma proteins.
t1/2: 14 hours
Peak plasma levels:

Pharmacodynamics Parameters:
Uses with dose: Given against heart disease and dosage of not more than once
every 2 to 4 weeks.
ADR: Myalgia, constipation, asthenia, abdominal pain, nausea and hepatotoxicity.
Drug interactions: Increased risk of rhadbomyolysis

Special conditions:
Pregnancy/Breast feeding: Contraindicated in pregnant women, and during breast
feeding.
Geriatric: --Paediatric: --Liver impairment: Should be prevented in case of liver disease
Kidney impairment: ---

SRI VENKATESWARA COLLEGE OF PHARMACY/RVS

Hospital
Department of Pharmacy Practice
Other specific details: Alcohol can increase the risk of serious side effects,when
atorvastatin is administered.

Sign of student

Credit out of 10:

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