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Matching
A)
tertiary structure
B)
keratin
C)
molecular chaperone
D)
hydropathy value
E)
cis
F)
trans
G)
forbidden conformation
H)
I)
collagen
J)
peptide group
K)
ribonuclease A
L)
alpha
1. The helix and the pleated sheet, with their repeating and values, are examples of
______.
Ans: H
Level of Difficulty: Easy
Section 8-1. Secondary Structure
2. ______ is found in bone, teeth, cartilage, and tendons.
Ans: I
Level of Difficulty: Easy
Section 8-1. Secondary Structure
3. The arrangement of the regular structural elements and the positions of atoms in the protein
are considered part of ______.
Ans: A
Level of Difficulty: Easy
Section 8-3. Globular Proteins
4. A historical denaturation/renaturation experiment was carried out using the protein ______.
Ans: K
Level of Difficulty: Easy
Section 8-4. Protein Stability
5. A rigid, planar structure consisting of about 40% double bond character is characteristic of a
______.
Ans: J
Level of Difficulty: Easy
Section 8-1. Secondary Structure
6. A good way to predict whether an amino acid side chain is on the outside or inside of a
protein is to use its ______.
Ans: D
Level of Difficulty: Easy
Section 8-4. Protein Stability
8. In most peptide groups (with the exception of proline) the ______ conformation is not
commonly observed
Ans: E
Level of Difficulty: Easy
Multiple Choice
10. In a Ramachandran diagram, ______ of the area represents allowed conformations of a
polypeptide chain.
A) more than 90%
B) more than 50%
C) about 50%
D) less than 25%
E) none of the above
Ans: D
Level of Difficulty: Medium
Section 8-1. Secondary Structure
11. In a protein, the most conformationally restricted amino acid is ______; the least
conformationally restricted is ______.
A) Trp, Gly
B) Met, Cys
C) Pro, Gly
D) Ile, Ala
E) Ala, Pro
Ans: C
Level of Difficulty: Easy
12. Conformation(s) that has (have) both a favorable hydrogen bonding pattern and and
values that fall within the allowed Ramachandran conformational regions is (are) _.
A) helix
B) collagen helix
C) sheet
D) All of the above
E) None of the above
Ans: D
Level of Difficulty: Easy
Section 8-1. Secondary Structure
13. Which one of these characteristics is not true for the helix?
A) There are 3.6 amino acids per turn.
B) There is a requirement for glycine every third amino acid residue.
C) A hydrogen bond forms between the carbonyl oxygen of the nth amino acid residue and the
-NH group of the (n + 4)th amino acid residue.
D) Proline is typically not found in the helix.
E) It is right-handed.
Ans: B
Level of Difficulty: Easy
Section 8-1. Secondary Structure
19. Crystalline proteins assume nearly the same structures as the proteins in solution. Several
lines of evidence support this statement; which is the most compelling?
A) A crystalline protein is essentially in solution, because of the waters of hydration that
crystallize along with the protein.
B) Electron density maps can be obtained at high resolution.
C) Different crystal forms of the same protein have virtually identical conformations.
20. In the absence of ascorbic acid, prolyl oxidase is unable to oxidize proline residues in
collagen to hydroxyproline, resulting in:
A) sickle-cell anemia
B) prion diseases
C) amyloid formation
D) the disease scurvy
E) brittle hair and nails
Ans: D
Level of Difficulty: Easy
Section 8-2. Fibrous Proteins
21. Of the following, which amino acid is least likely to be found on the surface of a singlesubunit protein?
A) Gly
B) Asp
C) Lys
D) Trp
E) Ser
Ans: D
Level of Difficulty: Easy
Section 8-3. Globular Proteins
22. Lysine can form a salt bridge by associating with a nearby _____ residue.
A) Gly
B) Ser
C) Glu
D) Gln
E) Pro
Ans: C
Level of Difficulty: Easy
Section 8-4. Protein Stability
23. The low pH found in the gut can enhance the digestibility of dietary protein by causing
_____.
A) Amide hydrolysis
B) Protein denaturation
C) Disulfide reduction
D) Prion formation
E) Cysteine oxidation
Ans: B
Level of Difficulty: Easy
Section 8-4. Protein Stability
24. The most conformationally-restricted amino acid is _________.
A) proline
B) alanine
C) tryptophan
D) glycine
E) tyrosine
Ans: A
Level of Difficulty: Easy
Section 8-1. Secondary Structure
25. For -sheets, the terms parallel and anti-parallel refer to ___________.
A) the direction of the associated peptide strands
B) the orientation of the amide crosslinks
C) the quaternary structure of the protein
D) the orientation of the hydrogen bonding
D) the topology of the reverse turns
Ans: A
Level of Difficulty: Easy
Section 8-1. Secondary Structure
E) rolls
Ans: A
Level of Difficulty: Easy
Section 8-3. Globular Proteins
29. Which of the following is not an example of a supersecondary structural element?
A) -helix
B) -barrel
C) immunoglobin fold
D) -hairpin
E) Greek key motif
Ans: A
Level of Difficulty: Medium
Section 8-3. Globular Proteins
30. The Protein Data Bank (PDB) is a database that primarily contains information about
_____.
A) gene sequences
B) biohazards
C) enzyme specificity
D) protein structure
E) protein function
Ans. D
Level of Difficulty: Easy
Section 8-3. Globular Proteins
31. Non-covalent forces that stabilize protein structure include all of the following except
__________.
A) the hydrophobic effect
B) salt bridges
C) metal-ion coordination
D) hydrogen bonding
E) disulfide bridges
Ans: E
Level of Difficulty: Easy
Section 8-4. Protein Stability
32. The classic experiment demonstrating that reduced and denatured RNase A could refold into
the native form demonstrates that _______.
A) 1 structure can determine 3 structure
B)
C)
D)
E)
Ans: A
Level of Difficulty: Easy
Section 8-4. Protein Stability