All are similar in the context of their measurement.
But, IC50 is used generally for
chemical assays like oxidation /reduction or other colorimetric/ fluorimetric assays where one chemical concentration inhibits 50% of these processes (Even for CFU measurements for Bacterial growth inhibition). Whereas LC/LD50 will be applicable to animals (rats, mice..etc). In between LC50 and LD50, certainly LD50 will be used to represent the drugs /chemical which will kill 50% population of animals in single oral administration & where as LC50 will be used to show the concentration of a chemical in air exposed for 4hr to kill 50%of population. So, According to OECD LC50 shows the lethal conc. of a chemical in air exposed for 4hr to kill 50% of population during observation (generally 14 days) where as for single oral/dermal dose of that chemcial to kill 50% population generally referred as a lethal Dose LD50. LD50 also referred as Quantal response.