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Table 1.

Glucocorticoid Comparison,7,8
Agent
Equivalent Dose
(approximate mg)

Route of
Administration

Relative AntiRelative
inflammatory
Mineralocorticoid
Potency
Potency
Betamethasone
0.6 0.75
IM, PO
20 30
0
Dexamethasonea
0.75
IM, IV, PO
25 30
0
Hydrocortisoneb
20
IM, IV, PO
1
2
Methylprednisolone
4
IM, IV, PO
5
0
Prednisolone
5
PO
4
1
Prednisone
5
PO
4
1
a
Dexamethasone sodium phosphate is in short supply from one or more manufacturers.1-4
b
Some patients may not be able to tolerate the higher mineralocorticoid activity of hydrocortisone.

Biologic
Half-Life
(hours)
36 54
36 54
8 12
18-36
18-36
18-36

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