H2

1.

ADHD

2.

irreversible
1

H2

H2 H2

H2

9-2

H2

H2+O2

9-1

H2+O2
()
9-2

9-2

 H2+O2

H2+O2 OH

H2 OH H2O
H2

9-3


Norepinephrine, NE

Lipopolysacharide, LPS
monocytes
macrophagesM
Tumor Necrosis Factor-, TNF-
TNF- cytokinesIL-1IL-8
NF-KB NF-KB
TNF-NF-KB

NK-KB P53
NF-KB Nuclear Factor - Kappa B NF-KBP53
Protein 53 53 P53NF-KB
P53

NF-KB NF-KB

NF-KB

NF-KB
NF-KB
NF-KB

P53
P53
4

 50~60
P53
P53 NF-KB
P53 P300and CBP P300and CBP
NF-KB NF-KB P53 P53 P300
and CBP P53 NF-KB
NF-KB P300and CBP P53
NF-KB P53

TNF-
TNF-TNF- NF-KB
NF-KB P53 NF-KB P53

NF-KB IL-8 VEGF

P53

M
TNF-

NF-KB

9-4 TNF- NF-KB P53

5

 TNF-
TNF- cytokines
IL-1 Tumor-Associated-MacrophagesTAMTAM
TNF-

HRV
LFHF LF/HF /
LF/HF

1.

EB Virus B
NF- KB P53
2.
IgGIgE
NF- KB P53

3.
LF/HF

LF/HF Allostatic State

H2
1.

Cholinergic Anti-inflammatory Pathway

TNF-IL-1

Acetycholine, Ach Ach

TNF-IL-1

TNF-IL-1 NF-KB
P53

0.25g C18-3 H2+O2

HFLF

2. H2
20c.c 20c.c. H2O
H2+O2 O2 H2 O2
NK-Tcell O2
H2+O2 NK-Tcell NK-T
cell OH
H2 H2O2OH+H2
2H2O H2 H2+O2
H2+O2

2014 9 28 36
H2+O2
11 23

H2+O2 7

O2 H2 OH
2OH+H22H2O O2 NK-Tcell O2
H2

YouTube How Cells Obtain Energy ATP

a.

b.

H2

c.

H2