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Datasheet of Epibrassinolide

Description:
Epibrassinolide (EBR; B1105; 24-Epibrassinolide) is a biologically active compound of the brassinosteroids, steroid-derived
plant growth regulator family; was shown as a potential apoptotic inducer in various cancer cells without affecting the non-tumor
cell growth. in vitro: Induction of apoptotic cell death was observed in prostate cancer cell lines after EBR treatment. In addition,
EBR induced the decrease of intracellular polyamine levels, accompanied by a significant ornithine decarboxylase (ODC)
down-regulation in each prostate cancer cell and also modulated ODC antizyme and antizyme inhibitor expression levels only in
LNCaP cells. transcriptional expression of eight genes involved in astaxanthin biosynthesis exposed to EBR (25 and 50 mg/L)
was analyzed using qRT-PCR. The results demonstrated that both 25 and 50 mg/L EBR could increase astaxanthin productivity
and the eight carotenogenic genes were up-regulated by EBR with different expression profiles. Moreover, EBR25 induction had
a greater influence on the transcriptional expression of ipi-1, ipi-2, crtR-B, lyc and crtO (> 5- fold up-regulation) than on psy, pds,
bkt; EBR50 treatment had a greater effect on the transcriptional expression of ipi-2, pds, lyc, crtR-B, bkt and crtO than on ipi-1
and psy. Furthermore, astaxanthin biosynthesis under EBR was up-regulated mainly by ipi1? and psy at the post-transcriptional
level, pds, lyc, crtR-B, bkt and crtO at the transcriptional level and ipi-2 at both levels. Arabidopsis seedlings treated with BR
24-epibrassinolide (BL) show increased lateral roots (LR) density, inhibition of primary root (PR) elongation and NO
accumulation. Similar effects were observed adding the NO donor GSNO to BR-receptor mutant bri1-1.

Chemical Information
Catalog

DC9363

Purity of current batch:

>98%

Molecular Weight (MW)

480.68

Molecular Formula

C28H48O6

CAS No.

78821-43-9

Solubility (25C)

DMSO

Storage

Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room

temperature for at least 1 hour.