Professional Documents
Culture Documents
Olfactory Epithelium
1.
located in the roof of the nasal cavity, contains olfactory receptor cells
The mitral cells send impulses via the olfactory tract to the
olfactory cortex (smells will be interpret and identified)
Eye
A.
B.
2)
3)
RETINAL CELLS
2. Lens : avascular, biconcave, transparent, flexible, its shape can be
changed to allow focusing of light on retina. It is enclosed in a thin, elastic
capsule and held in place just posterior to the iris by suspensory ligament.
3. Internal chambers and fluids
a) Posterior cavity filled with vitreous humor. Vitreous humor:
(1) transmit light,
(2) supports the posterior surface of the lens and holds the neural retina
firmly against the pigmented layer,
(3) contributes to intraocular pressure, helping to counteract the pulling
force of the extrinsic eye muscles.
b) Anterior cavity filled with aqueous humor, for transporting nutrients & O 2
to lens and cornea and it carries away their metabolic wastes
Sclera
Choroid
Ciliary body
the aqueous humour, and contains ciliary muscles that enable the
lens to change shape, during accommodation (focusing on near
and distant objects)
Is a pigmented muscular structure consisting of an inner ring of
circular muscle and an outer layer of radial muscle. Its function is
Iris
Pupil
Lens
Retina
along the optic nerve to the part of the brain that controls vision
Fovea
A part of the retina that is directly opposite the pupil and contains
(yellow
spot)
resolution)
Blind spot
Vitreous
a suspension for the lens so that the delicate lens is not damaged.
humour
Aqueous
humour
Accommodation
The focusing of the light rays onto the retina from objects at different
distances is known as accommodation.
light rays entering the eye from distant objects are virtually parallel and
require little refraction (bending) to bring them to a focus.
The circular ciliary muscles relax, forming a wider ring and this causes
them to pull on the suspensory ligaments, making them tight.
The ligaments in turn pull on the lens, stretching it and making it flatter.
This less rounded (less convex) lens causes less refraction.
If we now change to looking at a near object, the light rays entering the
eye from the object are spreading out (diverging) and require more
refraction to bring them to a focus
The suspensory ligaments become loose as they are not being pulled by
the muscles.
The lens is not stretched and because it is elastic it reverts to its natural
rounded shape.
This fatter (more convex) lens causes more refraction, allowing a sharp
focus to be achieved.
It means that the eye is unable to focus on distant objects, making them
seem blurred.
Light coming into the eye is focused onto the retina - an area on the rear
wall of the eyeball.
Seventy per cent of light entering the eye is focused by the cornea (a clear
dome which forms the outer covering of the pupil). The rest is focused by
the lens, which sits behind the cornea.
If the light focuses in front of the retina, the image is fuzzy. See the
illustration above.
With myopia, the cornea is too curved or the eyeball too long. This means
that images are focused in front of the retina rather than directly on it.
As an object moves towards the eye, the eye must increase its power to
keep the image on the retina.
PHOTRECEPTION
Photoreception is the process by which the eye detects light energy.
To approach this subject several areas need to be discussed
The location and packaging of the visual pigments that absorb the light
stimulus.
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PHOTORECEPTOR
-
The photoreceptor cells are found in the retina at the back of the eye.
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There are present in large very large numbers, with approximately 120
million rods and 6 millions cones per eye.
Rods and cones have three main regions. The outer segment is the light
sensitive region containing photosensitive pigments. Here light energy is
converted into a generator potential.
Vesicles are also present in cones but they consist of infoldings of the
outer membrane. The cones have a different photosensitive pigment,
iodopsin, embedded in the membranes.
The inner segment of both rods and cones contains many mitochondria to
provide the energy to resynthesise the visual pigments after they have
been broken down by light.
The synaptic zone is the equivalent of the synaptic bulb in neurons and
allows the information of synapses with bipolar cells which in turn link to
the optic nerve and then to the brain.
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Visual Transduction
The detection of light is carried out on the membrane disks in the outer
segment. These disks contain thousands of molecules of rhodopsin, the
photoreceptor molecule.
Retinal is the light-sensitive part, and it can exists in 2 forms: a cis form
and a trans form:
In the dark retinal is in the cis form, but when it absorbs a photon of light it
quickly switches to the trans form.
This changes its shape and therefore the shape of the opsin protein as
well. This process is called bleaching.
The reverse reaction (trans to cis retinal) requires an enzyme reaction and
is very slow, taking a few minutes.
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This explains why you are initially blind when you walk from sunlight to a
dark room: in the light almost all your retinal was in the trans form, and it
takes some time to form enough cis retinal to respond to the light indoors.
The final result of the bleaching of the rhodopsin in a rod cell is a nerve
impulse through a sensory neurone in the optic nerve to the brain.
However the details of the process are complicated and unexpected. Rod
cell membranes contain a special sodium channel that is controlled by
rhodopsin.
Rhodopsin with cis retinal opens it (sodium channel) and rhodopsin with
trans retinal closes it.
This means in the dark the channel is open, allowing sodium ions to flow
in and causing the rod cell to be depolarised.
This in turn means that rod cells release neurotransmitter in the dark.
In the light everything is reversed, and the bipolar cell is depolarised and
forms a nerve impulse, which is passed to the ganglion cell and to the
brain.
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Cones
Outer segment is cone shaped
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Visual Acuity
Visual acuity the amount of detail that can be seen. The cones are responsible
for high visual acuity (high resolution). Although there are far more rods than
cones, we use cones most of the time because they have fine discrimination and
can resolve colours. To do this we constantly move our eyes so that images are
focused on the small area of the retina called the fovea. You can only read one
word of a book at a time, but your eyes move so quickly that it appears that you
can see much more. Spatially, much more clarity is perceived in cones than for
the rods. This is because one cone cell synapses to one bipolar cell which in
turn synapses onto one ganglion cell as the information is relayed to the visual
cortex. The more densely-packed the cone cells, the better the visual acuity. In
the fovea of human eyes there are 160 000 cones per mm 2, while hawks have 1
million cones per mm2, so they really do have far better acuity.
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Ear
A. Outer (external) ear
1. auricle (pinna) - composed of elastic cartilage covered with thin skin and
an occasional hair
helix (the rim) - thicker
lobule (earlobe) fleshy, lacks supporting cartilage
f(x): auricle to direct sound waves into external auditory canal.
2. external auditory canal (meatus)
short curved tube that extends from the auricle to the eardrum
the entire canal lined with hairy skin, sebaceous gland and
ceruminous glands.
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2. three ossicles transfer vibration from eardrum to oval window, which sets
the fluids of inner ear into motion, and stimulates hearing receptors
oval window - An oval opening located on the medial wall of the tympanic
cavity, leading into the vestibule, to which the base of the stapes is
connected and through which the ossicles of the ear transmit the sound
vibrations to the cochlea.
3. communicates with nasopharynx through pharyngotympanic auditory
tube (Eustachian tube) for balancing air pressure
Eustachian tube - a tube that connects the middle ear to the back of the
nose; it equalizes the pressure between the middle ear and the air outside.
When you "pop" your ears as you change altitude (going up a mountain or
in an airplane), you are equalizing the air pressure in your middle ear.
4. round window - An opening on the medial wall of the middle ear that
leads into the cochlea and is covered by the secondary tympanic
membrane
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cochlear nerves - these carry electro-chemical signals from the inner ear (the
cochlea) to the brain.
SOUND
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Sound is the compression and rarefaction of air, or, in other words, alternating air
pressure. The distance between the pressure peaks is called the wavelength.
The frequency of the sound is {wavelength -1 x speed of sound} . The frequency
determines the pitch of the sound. Humans can detect sound in the frequency
range 20 to 20,000Hz (Hz = cycles, or waves, per second).
Sound - Vibrations transmitted through an elastic material or a solid, liquid, or
gas, with frequencies in the range of 20 to 20,000 hertz, capable of being
detected by human organs of hearing.
TRANSDUCTION of SOUND into ELECTRICAL EVENTS
The numbers in the diagram below indicate the sequence of events in the
detection and transduction of sound waves.
THE EAR
1. Sound waves enter the external ear and are directed towards the
tympanic membrane.
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window end where the basilar membrane is narrow and thick, and low
frequencies vibrate the apical end where the membrane is wide and thin}.
7. The cilia of the hair cells, which contact the overlying tectorial membrane,
bend as the basilar membrane vibrates, this opens ion channels and
causes the entry of ions into the hair cell and a generator potential
develops. If large enough, the generator potential causes transmitter
release from the hair cells which excites the afferent nerve. Displacement
of the stereocilia in the direction of the tallest stereocilia (called the
kinocilium in hair cells of the vestibular system and immature auditory
system) is excitatory and in the opposite direction is inhibitory. One theory
suggests a mechanical link to ion channels which opens a "trap door" as it
is pulled taut. This is a little fanciful and it is thought that the ion channels
are located at the base of the stereocilia but are indeed
mechanoreceptors, in that they respond to mechanical pressure. The
endolymph surrounding a hair cell is K+ rich and so K+ (and calcium)
enter the hair cell, causing a depolarisation.
8. The action potentials are transmitted along the cochlear branch of the
vestibulocochlear nerve, activating auditory pathways in the central
nervous system, eventually terminating in the auditory area of the
temporal lobe of the cerebral cortex.
9. Finally, the vibrations in the scala tympani are dissipated out of the round
window, into the middle ear.
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AUDITORY PATHWAY
Afferent nerves from the cochlear (spiral) ganglion terminate in the cochlear
nucleus in the brainstem.
Axons from neurons in the cochlear nucleus project to the superior olive, inferior
colliculus, medial geniculate nucleus (of the thalamus) and the auditory cortex
(Brodman areas 41 and 42).
Note that auditory input projects to both sides of the cortex. The superior olive
and the inferior colliculus send efferent fibres back to the stapedius and tensor
tympani muscles respectively. These muscles are concerned with protecting the
middle ear bones from overload.
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