Lugayan, Krisler B.

Group-23
III-Carcinogenics

Indication &
Drugs Action Contraindication Side Effects Nursing Intervention
Dosages

Generic: >Prevents reduc- >TrophoblasticTumors >contraindicated in >Nausea •Assess pt’s condition

Methotrexate tion of folic acid (choriocarcinoma, Pt.’s hypertensive to >Diarrhea before therapy and
to tetrahydro- Hydatidiform mole) Drugs or any of its >dizziness regularly thereafter to
folate by binding Adults:1-30 mgP.O or Components and in monitor the drugs effect
to dihydrolate I.M daily for 5 days. those with psoriasis Adverse Effects •Monitor fluid intake
Brand Name: reductase. May repeat course or rheumatoid arthritis and output daily.
Amethopterin, after 1 or more weeks who also have >stomatitis •Monitor uric acid level.
MTX >kill cancer cells based on response or alcoholisnm. >anemia •Regular monitor CBC
And reduces toxicity. Three to five >pruritus •Watch for increase in
Inflammation. course are used. >Pt. w/ chronic liver >hepatic fibrosis AST, Alt and alkaline
disease. >nephropathy phosphate level, w/c
Classification: are signs of hepatic
Antineoplastic, >Acute >Use cautiously & dysfunction
Antimetabolite, lymphoblastic and at modified dosage in
•Be alert for adverse
Immunosup- lymphatic Patients with impaired
reactions and drug
present, leukemia. liver or kidney function
interactions.
Adults: I.M daily 4 to 6
•Assess patient’s and
Weeks or until remis-
family’s knowledge of
sion occurs
drug therapy.
Pregnacny
Category: X