Hidrasec® [powd]

Solvay Pharma [ Zuellig ]

MIMS Class : Antidiarrheals

See related Hidrasec powd information

Contents Racecadotril
Indications Cap Treatment of acute diarrhea. Powd Adjunct to oral or parenteral
rehydration in the treatment of acute watery diarrhea in infants &
childn.
Dosage Cap Adult 100 mg. Further treatment: 8 hrly until cessation of
diarrhea. Powd Childn & infants 1.5 mg/kg/dose, w/ 1 initial dose &
3 daily divided doses.
Administration May be taken with or without food
Contraindications Powd Renal or hepatic impairment. Fructose intolerance, glucose &
galactose malabsorption syndrome or sucrase isomaltase deficiency.
Special Rehydration. Consider severe or prolonged diarrhea, maintain
Precautions feeding during diarrhea, severe vomiting, refusal of food. Childn >24
mth. Pregnancy, lactation.
Adverse Drug Drowsiness, nausea & vomiting, constipation, dizziness, headache.
Reactions Click to view ADR Monitoring Website
MIMS Class Antidiarrheals
ATC A07XA04 - Racecadotril ; Belongs to the class of other preparations
Classification used in the treatment of diarrhe

Plasil - General Information:

A dopamine D2 antagonist that is used as an antiemetic. [PubChem]

Related offers from our Drug Store:

Reglan (Metoclopramide) - for $38.42
Reglan is used for short term treatment of gastroesophageal reflux disease
(GERD) in certain patients who do not respond to other therapy.

It is used to treat symptoms of a certain digestive problem in diabetic

patients (diabetic gastroparesis). It may also be used for other conditions
as determined by your doctor.
* >> all this drugs based on Metoclopramide (usually they can be used instead of Plasil)

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Generic Reglan (Metoclopramide) - 10mg 90 pills for $52.92

Reglan (Metoclopramide) is a gastrointestinal stimulant used to treat
gastroesophageal reflux and erosions/ulcers of the esophagus. It is also used to
treat nausea, vomiting, heartburn, prolonged fullness after meals, and loss of
appetite in patients with diabetes (diabetic gastroparesis). It may also be used
to treat other conditions as determined by your doctor.

Pharmacology:

Plasil, although chemically related to procainamide, does not possess local anesthetic or
antiarrhythmic properties. Plasil is used to enhance GI motility, to treat diabetic
gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during
radiologic examination. Plasil may be used to treat chemotherapy-induced emesis and as
a radiosensitizing agents in the treatment of non-small cell lung carcinoma and
glioblastomas in the future.

Plasil for patients

Metoclopramide may impair the mental and/or physical abilities required for the
performance of hazardous tasks such as operating machinery or driving a motor
vehicle.The ambulatory patient should be cautioned accordingly.

Plasil Interactions

The effects of metoclopramide on gastrointestinal motility are antagonized by

anticholinergic drugs and narcotic analgesics. Additive sedative effects can occur when
metoclopramide is given with alcohol, sedatives, hypnotics, narcotics, or tranquilizers.

The finding that metoclopramide releases catecholamines in patients with essential

hypertension suggests that it should be used cautiously, if at all, in patients receiving
monoamine oxi-dase inhibitors.

Absorption of drugs from the stomach may be diminished (e.g., digoxin) by

metoclopramide, whereas the rate and/or extent of absorption of drugs from the small
bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol,
cyclosporine).

Gastroparesis (gastric stasis) may be responsible for poor diabetic control in some
patients. Exogenously administered insulin may begin to act before food has left the
stomach and lead to hypoglycemia. Because the action of metoclopramide will influence
the delivery of food to the intestines and thus the rate of absorption, insulin dosage or
timing of dosage may require adjustment.

Plasil Contraindications

Metoclopramide should not be used whenever stimulation of gastrointestinal motility

might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical
obstruction, or perforation.

Metoclopramide is contraindicated in patients with pheochro-mocytoma because the drug

may cause a hypertensive crisis, probably due to release of catecholamines from the
tumor. Such hypertensive crises may be controlled by phen-tolamine.

Metoclopramide is contraindicated in patients with known sensitivity or intolerance to the

drug.

Metoclopramide should not be used in epileptics or patients receiving other drugs which
are likely to cause extrapyramidal reactions, since the frequency and severity of seizures
or extrapyramidal reactions may be increased.

Additional information about Plasil

Plasil Indication: For the treatment of gastroesophageal reflux disease (GERD)

Mechanism Of Action: Plasil inhibits gastric smooth muscle relaxation produced by
dopamine, therefore increasing cholinergic response of the gastrointestinal smooth
muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of
gastric body and increasing the phasic activity of antrum. Simultaneously, this action is
accompanied by relaxation of the upper small intestine, resulting in an improved
coordination between the body and antrum of the stomach and the upper small intestine.
Plasil also decreases reflux into the esophagus by increasing the resting pressure of the
lower esophageal sphincter and improves acid clearance from the esophagus by
increasing amplitude of esophageal peristaltic contractions. Plasil's dopamine antagonist
action raises the threshold of activity in the chemoreceptor trigger zone and decreases the
input from afferent visceral nerves. Studies have also shown that high doses of
metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral
nervous system in animals.
Drug Interactions: Atovaquone The agent decreases the effect of atovaquone
Cyclosporine Plasil increases serum levels of cyclosporine
Levodopa Levodopa decreases the effect of metoclopramide
Succinylcholine The agent increases the effect of succinylcholine
Venlafaxine Possible serotoninergic syndrome with this combination
Food Interactions: Not Available
Generic Name: Metoclopramide
Synonyms: Metaclopramide; Metaclopromide; Methochlopramide; Methoclopramide;
Metochlopramide; Metoclopramida [Inn-Spanish]; Metoclopramide Hcl; Metoclopramide
Hydrochloride; Metoclopramidum [Inn-Latin]
Drug Category: Antiemetics; Prokinetic Agents; Dopamine Antagonists
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Metoclopramide: Apo-Metoclop; Cerucal; Clopra;
Clopra-Yellow; Clopromate; DEL; Duraclamid; Elieten; Emetid; Emperal; Eucil;
Gastrese; Gastro-Timelets; Gastrobid; Gastromax; Gastronerton; Gastrosil;
Gastrotablinen; Gastrotem; Imperan; Maxeran; Maxolon; Meclopran; Metamide;
Metoclol; Metoclopramide Intensol; Metoclopramide Omega; Metocobil; Metramid;
Moriperan; Mygdalon; Neu-Sensamide; Nu-Metoclopramide; Octamide; Parmid;
Paspertin; Peraprin; Plasil; Pms-Metoclopramide; Pramiel; Pramin; Primperan;
Reclomide; Reglan; Reliveran; Terperan;
Absorption: Rapidly and well absorbed (oral bioavailability 80±15.5%).
Toxicity (Overdose): Oral, mouse LD50: 280 mg/kg. Signs of overdose include
drowsiness, disorientation, and extrapyramidal reactions.
Protein Binding: 30%
Biotransformation: Hepatic
Half Life: 5-6 hr
Dosage Forms of Plasil: Liquid Oral
Liquid Intravenous
Tablet Oral
Liquid Intramuscular
Chemical IUPAC Name: 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-
methoxybenzamide
Chemical Formula: C14H22ClN3O2
Metoclopramide on Wikipedia: http://en.wikipedia.org/wiki/Metoclopramide
Organisms Affected: Humans and other mamm

Generic Name: Metoclopramide

Brand Name: Plasil, Emex
Classification:
Therapeutic: antiemetics

Suggested Dose: PO(Adults and Children) : 1-2 mg /kg 30 min before

chemotherapy. Additional doses of 1-2mg/kg may be given q2-4 hours,
pretreatment with diphenhydramine will decrease the risk of extrapyramidal
reaction of the dosage.

Mode of Action: blocks dopamine receptors in chemoreceptor trigger zone of

the CNS. Stimulates motility of the upper GI tract and accelerates gastric
emptying.
Therapeutic Effects: decrease nausea and vomiting. Decrease symptoms of
gastric stasis.
Indication: prevention of chemotherapy-induced emesis. Treatment of
postsurgical and diabetic gastric stasis. Management of esophageal reflux.
Treatment and prevention of postoperative nausea and vomiting when
nasogastric suctioning is undesirable.
Unlabeled uses: treatment of hiccups. Adjunct management of migraine
headaches.

Contraindication:hypersensitivity, possible GI obstruction or hemorrhage; History

of seizure disorders, Pheochromocytoma. Parkinson’s disease.

Side Effects/ Adverse Effects: drowsiness, extrapyramidal reactions,

depression, irritability, restlessness, neuroleptic malignant syndrome,
arrhythmias, gynecomastia.

Drug- Interactions:

Drug-Drug: CNS depressants: may increase absorption and risk of toxicity from
cyclosporine.
Haloperidol, phenothiazines: may increase risk of extrapyramidal reactions.
Opoids and anticholinergics: may antagonize the GI effects of metoclopramide.

Nursing Responsibility:

1.) Assess patient for n/v, abdominal distention, and bowel sounds before and
after administration.
2.) Assess patient for extrapyramidal side effects.
3.) Monitor for tardive dyskinesia( uncontrolled rhythmic movement of mouth,
face, extemeties.
4.) Monitor for neuroleptic malignant syndrome( hyperthermia, muscle rigidity,
alert consciousness, irregular pulse or BP, tachycardia, and diaphoresis)
5.) Assess patient for signs of depression periodically throughout therapy.
6.) Instruct patient to take Metoclopramide as directed.
7.) May cause drowsiness. Caution patient o avoid driving or other activities
hat require alertness until response to the drug is known.
8.) Advise patient to avoid concurrent use of alcohol and other CNS
depressants while taking this medication.
9.) Advise patient to notify health care professional immediately if involuntary
movement of eyes, face or limbs occurs.

Generic Name:Racecadotril

Brand Name: Hidrasec

Classification: : Antidiarrheals

Suggested Dose:
Cap Adult 100 mg. Further treatment: 8 hrly until cessation of diarrhea. Powd Childn &
infants 1.5 mg/kg/dose, w/ 1 initial dose & 3 daily divided doses.

Mode of Action:

Indication: Cap :Treatment of acute diarrhea. Powd :Adjunct to oral or parenteral

rehydration in the treatment of acute watery diarrhea in infants & childn.

Contraindication: Powd :Renal or hepatic impairment. Fructose intolerance, glucose &

galactose malabsorption syndrome or sucrase isomaltase deficiency

Side Effects/ Adverse Effects: Drowsiness, nausea & vomiting, constipation, dizziness,
headache

Nursing Responsibility:

1. May be taken with or without food

2.