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(_..t~~ 18 9{)

Study of the Expression of Proto-oncogenes c-fosc-myc after PTA

Sui Guangchao

Lin Zuojun

Hu Meihao

CCollege of Life Sciences. P~king University , B~ijing)

Huang Y onglin

Wang Lanfen

Zhao Jinjun

(The First Hospital of Harbin Medical ColI~g~. Harbin)

c - fos and c - mye are two proto - oncogenes that are related to the proliferation of cells. Blood vessel restenosis after percutaneous trans luminal angioplasty (PTA) is due to the proliferation of smooth muscle cells on blood vessel wall. Since an animal model has been established with white rabbit, total cell RNA was harvested from arterial walls in different durations after PTA, and the expressions of the two proto-oncogenes were tested using dot - bol tting hybridization assny. It was found that the transcriptions of e - fos and c - mye were enhanced in 15 minutes after PTA and reached their climaxes at 30 minutes and 2 hours, respectively.

Key Words: PTA; Restenosis; Proto-oncogenes

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