Pathophysiology

Predisposing factors: Precipitating factors:

Geographical area – Environmental conditions (open
tropical islands in the spaces with water pots, plants
Pacific (Philippines) etc.)
and Asia.
Immunocompromised
individuals

Aedes aegypti 8-12 days of

viral replication on

Bite from mosquito (portal of

entry in the skin.

Allowing dengue virus to be

inoculated towards the
circulation/blood (incubation
period: 3-14 days).

Virus disseminated rapidly

into the blood
and stimulates WBCs
including B
lymphocytes that produces
and secretes
Antibodies attach to the viral
antigens and then
monocytes/macrophages will
perform phagocytosis Entry to Entry to
through Fc receptor spleen the

Recognition of dengue viral

antigen on infected monocyte
by cytotoxic T cells.

Release of cytokines which

consists of vasoactive agents
such as interleukins, tumor
necrosis factor, urokinase
and platelet activating factors
  D
e

Virus targets Cellular direct

liver and destruction and
spleen infection of red
parenchymal bone marrow
cells where precursor cells as
well as

 Hepatospleen Thromboc
omegally ytopeni

Dengue
Hemorr
hagic

Increase in
number and size
of pores in the
capillaries which
leads to a

 Pleural  A
effusi sci

 R Complicati
ons:
 Intense
bleeding
 Pulmonary
edema
 Shock
 Very low BP
 Liver cirrhosis