ETIOLOGIC AGENT: PREDISPOSING FACTORS:

Genus Leptospirae Modifiable Non-modifiable

>Seasons >Age
>Occupation >Sex
>Geographic area

Abrasions, contact on conjunctiva,

Inhalation of aerosolized body fluid

Direct invasion in tissue

Compensatory mechanism happens

(fever, chills, headache)

Gain rapid access to the bloodstream

through the lymphatic

 Multiplication of microorganisms in

the small blood vessels

leptospiremia

Spread to all organs

In kidneys: in liver: In lungs:

Tubular nephritis tubular necrosis liver cells are being damage low levels of damage of the alveoli

Albumin in the blood and interstitial vessels

Altered the sense of altered filtration unable to excrete waste

Decreased in Oxygen products specifically the bile change in osmotic pressure altered oxygenation process

Impaired capillary

No production of RBC permeability bile in the circulation allows fluid to seep out DOB, hemoptysis

Of blood vessels

Anemia shifting of fluids and Pruritus, jaundice and azotemia

Components from ICF to ECF accumulation of fluid in the

 Peritoneum

Edema

Hematuria, Ascites

Albuminuria Abdominal discomfort,

Distention, DOB