Synthesis of Orange II - Kel - VII

LABORATORIUM KIMIA ORGANIK
JURUSAN KIMIA
FAKULTAS MIPA
HASIL PRAKTIKUM SINTESIS SENYAWA ORGANIK

Judul : Sintesis Orange II dengan Reaksi Coupling diazo
Tanggal Percobaan : 26 November 2010
Reaksi Sintesis
O O O
CO2 -
Na2CO3 - 2 HCl -
Cl
+
HO S NH2 2 O S NH2 O S N N
O
+
Na O H2O NaNO2
O
Sulfanilic Acid
OH
Orange II
O -
Cl
- +
O S N N O N
O NaOH HO S N
O HO
Data dan Perhitungan
Hasil yang dperoleh pada pengulangan 1 = 3,31 gram dan pengulangan 2 = 3,45 gram.
Jumlah mol bahan yang digunakan pada setiap percobaan:
2,4 𝑔 0,65 𝑔
𝑛𝐴𝑠𝑎𝑚 𝑆𝑢𝑙𝑓𝑎𝑛𝑖𝑙𝑎𝑡 𝑔 =
= 0,01 𝑚𝑜𝑙 𝑛𝑁𝑎 2 𝐶𝑂3
= 𝑔 = 0,006 𝑚𝑜𝑙
173 𝑚𝑜𝑙 105,99 𝑚𝑜𝑙
0,95 𝑔 𝑛𝐻𝐶𝑙 = 12,06 𝑀 × 2,5 𝑚𝑙
𝑛𝑁𝑎 𝑁𝑂2 = 𝑔 = 0,014 𝑚𝑜𝑙
69 𝑚𝑜𝑙 = 30,15 𝑚𝑚𝑜𝑙 = 0,03 𝑚𝑜𝑙
1,8 𝑔
𝑛𝛽 −𝑛𝑎𝑓𝑡𝑜𝑙 = 𝑔 = 0,0125 𝑚𝑜𝑙
144 𝑚𝑜𝑙
Asam Sulfanilat + Na2CO3 → 2 NaC6H4NH2SO3 + CO2 + H2 O

Mula-Mula 0,01 mol 0,006 mol - - -
Reaksi 0,006 mol 0,006 mol 0,012 mol 0,006 mol 0,006 mol
Sisa 0,004 mol 0 mol 0,012 mol 0,006 mol 0,006 mol
2 NaC6H4NH2SO3 + 2 HCl + 2 NaNO2 → 2 Ion besenasulfonatdiazzoium
Mula-Mula 0,012 mol 0,03 mol 0,014 mol -
Reaksi 0,012 mol 0,012 mol 0,012 mol 0,012 mol
Sisa 0 mol 0,018 mol 0,002 mol 0,012 mol
JURUSAN KIMIA
FAKULTAS MIPA
Ion besenasulfonatdiazzoium + β-naftol → Orange II

Mula-Mula 0,012 mol 0,0125 mol -
Reaksi 0,012 mol 0,012 mol 0,012 mol
Sisa 0 mol
0,0005 mol 0,012 mol
𝑔
Jadi orange II yang dihasilkan = 0,012 𝑚𝑜𝑙 × 328 𝑚𝑜𝑙 = 3,936 𝑔
Hasil
Percobaan sistesis Orange II dilakukan dengan beberapa tahap yaitu didiazosiasi, sintesis dan
kristalisasi. Tahapan didiazosiasi dimulai dengan melarutkan 2,4 g kristal asam sulfanilat
(monohidrat) dalam 25 ml laruran 25% natrium karbonat (0,65 g Na2CO3 anhidrat dan 25 ml air)
dengan pemanasan (gambar a), reaksi yang terjadi:
O O
Na2CO3 -
HO S NH2 2 O S NH2
+
O Na O
Proses pemanasan yang dilakukan bertujuan untuk melarutkan asam sulfanilat dengan natrium
karbonat dapat berjalan dengan cepat. Setelah proses pemanasan dilakukan proses pendinginan
larutan. Setelah larutan dingin diambahkan 0,95 g natrium nitrit (gambar b) dan diaduk sampai
larut yang kemudian larutan dituangkan dalam beker yang berisi 12,5 g es aquadest dan 2,5 ml
HCl pekat untuk membentuk ion diazonium dengan cepat (gambar c), reaksi yang terjadi:
O O -
-
CO2 2 HCl Cl
- +
2 O S NH2 O S N N
Na
+
O
H2O NaNO2
O
Tahapan berikutnya adalah tahapan sintesis yang dimulai dengan melarutkan 1,8 g β-naftol
dalam 10 ml larutan NaOH 10% (gambar d) untuk membuat dalam suasana basa. Suspensi yang
didapat dari tahapan didiazosiasi dituangkan kedalam larutan β-naftol dengan pengadukan agar
terjadi percampuran yang sempurna (gambar e), reaksi yang terjadi:
OH
Orange II
O -
Cl
- +
O S N N O N
O NaOH HO S N
O HO
JURUSAN KIMIA
FAKULTAS MIPA
Tahapan yang terakhir adalah tahapan kristalisasi, dimulai dengan memanaskan campuran dari
tahap sintesis yang telah diinkubasi selama 5-10 menit sampai endapan larut. Kemudian
menambahakan 5 g NaCl dengan pemanasan dan pengadukan. Masukkan gelas beker ke dalam
cawan yang berisi air dan es dan dibiarkan sampai menjadi temperatur kamar (gambar f).
Akhirnya dengan pengadukan maka dikumpulkan hasilnya pada corong buncher (gambar g) dan
cuci dengan NaCl jenuh. Hasilnya mengering secara perlahan-lahan dan masih mengandung
NaCl. Residu yang dihasilkan ditambahkan larutan etanol dalam air ( atau etanol 70% sebanyak
50 mL) dan dikristalisasi (gambar h). Kertas saring yang sudah digunakan dicuci dengan air
yang mendidih kurang lebih 30 mL dan kemudian dikristalisasi juga karena diperkirakan masih
mengandung kristal orange II (gambar i).
Setelah didapatkan kristal orange II, kristal yang diperoleh dianalisis atau diuji titik leburnya
dengan melting point tester yang menggunakan alat bantu pipa kapiler sebagai wadah kristal.
Melting point tester diset agar panas yang diberikan melebihi titik lebur kristal orange II yaitu
170°C (titik lebur orange II = 164°C) sehingga pada suhu pertama kali kristal orange II yang
dihasilkan melebur biasanya pada bagian bawah pipa kapiler, menjadi titik lebur kristal orange
II.
Kesimpulan
Dari percobaan ini dapat disimpulkan bahwa pewarna orange II merupakan salah satu pewarna
senyawa diazonium yang disintesis dari asam sulfanilat dan β-naftol.
Nama Praktikan
 Ruri Andika SP_071810301068  Rahmad Soleh_071810301073

 Alfisa Surya Primaswara_081810301009  Citra Awwalul laili_081810301010
 Deny Susanti_081810301033  Ardian Syah Putra_081810301034
 Tety Prasiska_081810301050  Mohammad Rofik Usman _081810301051
JURUSAN KIMIA
FAKULTAS MIPA
Lampiran
Gambar a Gambar b
Gambar c Gambar d
Gambar e Gambar f
JURUSAN KIMIA
FAKULTAS MIPA
Gambar g Gambar h
Gambar i Gambar j
JURUSAN KIMIA
FAKULTAS MIPA
HASIL PRAKTIKUM SINTESIS SENYAWA ORGANIK

Judul : Sintesis Orange II dengan Reaksi Coupling diazo
Tujuan Percobaan : Studi sintesis orange II dari asam p-aminobensenasulfonat (sulfanilic

acid) dengan β-naftol dengan reaksi coupling diazo.
Latar Belakang
Pewarna asam yang larut air pewarna digunakan terutama dalam bentuk garam natrium atau
karboksilat asam sulfanilat. Senyawa-senyawa tersebut merupakan anionik yang menempel kuat
kepada kelompok kationik dalam serat secara langsung yang dapat berlaku untuk semua jenis
serat alami seperti kapas dan sutra serta sintetis seperti poliester dan rayon. Senyawa-senyawa itu
juga digunakan dalam cat, tinta dan kulit. Salah satu dari senyawa tersebut adalah Orange II.
Sebagai mahasiswa kimia seharusnya mengetahui bagaimana teknik yang dilakukan dan tahap-
tahap yang terjadi pada proses Orange II.
Metode sistesis yang digunakan karena lebih cepat akibat adanya asam dan sebagai katalis
sehingga dapat mengurangi adanya penyusunan ulang yang lebih stabil pada proses sintesis dan
akan mengalami tahap reaksi coupling diazo yang akan dipelajari.
Mekanisme Reaksi
Reaksi Analisis
Orange II O - O
C-N -
Cl
+
IGF
O S N N HO S NH2
O N
OH O 1. Na2CO3 O
HO S N
HO 2. NaNO2 Sulfanilic Acid
O
2-Naphthol 3. HCl
Reaksi Sintesis
O O O
CO2 -
Na2CO3 - 2 HCl -
Cl
+
HO S NH2 2 O S NH2 O S N N
O
+
Na O H2O NaNO2
O
Sulfanilic Acid
OH
Orange II
O -
Cl
- +
O S N N O N
O NaOH HO S N
O HO
JURUSAN KIMIA
FAKULTAS MIPA
Alat
Pipet volume 10 ml dan 50 ml, beaker glass 150 ml, erlenmeyer, pengaduk kaca, spatula, kertas
saring, botol wadah bahan, penangas, pompa vakum, corong buchner, melting point tester,
neraca, oven, desikator, cawan (panci panas), botol semprot, kertas saring dan ball pipet.
Bahan
Asam sulfanilat, β-naftol, Na2CO3, NaNO2, HCl pekat, NaOH 10%, NaCl, etanol 70 %,
Cara Kerja
Sulfanilic Acid
→ Didiazosiasi
→ Disintesis
→ Dikristalisasi
Hasil
1) Didiazosiasi
Larutkan 2,4 g kristal asam sulfanilat (monohidrat) dalam 25 ml laruran 25% natrium karbonat
(0,65 g Na2CO3 anhidrat dan 25 ml air) dengan cara pendidihan. Dinginkan larutan tersebut
dengan air kran. Tambahkan 0,95 g natrium nitrit dan aduk sampai larut. Tuang larutan dalam
beker yang berisi 12,5 g es dan 2,5 ml HCl pekat sampai berbentuk endapan putih yang akan
memisah dan siap dipakai. Hasil ini tidak dikumpulkan melainkan dipakai dalam bentuk
suspensi.
2) Sintesis
Larutkan 1,8 g β-naftol dalam 10 ml larutan NaOH 10% dingin dan tuanglah kedalam larutan ini,
dengan pengadukan suspensi asam sulfanilat yang sudah dibuat. Aduklah pasta kristal baik-baik
supaya terjadi percampuran yang sempurna, setelah 5-10 menit panaskan campuran itu sampai
zat padatnya melarut. Tambahakan 5 g NaCl dan larutankan semuanya dengan pemanasan dan
pengadukan. Masukkan gelas beker ke dalam cawan yang berisi air dan es dan biarkan larutan
menjadi dingin sampai temperatur kamar. Akhirnya dengan pengadukan maka dikumpulkan
hasilnya pada corong buncher dan pakai NaCl jenuh untuk mencuci endapan orange II diatas
JURUSAN KIMIA
FAKULTAS MIPA
corong Buchner dan berlangsung agak lambat. Hasilnya mengering secara perlahan-;ahan dan
masih mengandung NaCl. Namun jangan dikeringkan terlebih dahulu. Rekristalisasi dengan
larutan etanol dalam air ( atau etanol 70% sebanyak 50 mL). Pindahkan larutan ke dalam gelas
beker dan cucilah kertas saringnya dengan air mendidih dan tidak lebih dari 25 mL. Saring
melalui corong Buchner yang telah dihangatkan. Tuangkan filtratnya ke dalam elenmeyer jika
lebih dari 30 ml maka uapkan dengan mendidihkan. Dinginkan dengan air es sewaktu
mengumpulkan endapan. Bilas gelas beker induk dengan sedikit etanol. Keringkan Kristal yang
diperoleh didalam eksikator, timbang, dan tentukan titik leburnya.
Pembahasan Hasil
Setelah didapatkan kristal orange II dianalisis atau diuji titik leburnya, dan diperoleh titik lebur
165°C pada percobaan yang pertama dan 168°C pada percobaan yang kedua. Seharusnya titik
lebur orange II 164°C (www.wikipedia.com/wiki/orange_II), hasil yang diperoleh berbeda
dengan sumber referensi dikarenakan pengamatan yang kurang cermat dan teliti saat pengamatan
dan sampel yang diuji titik leburnya terlalu banyak yang dimasukkan ke dalam pipa kapiler
sehingga kesulitan mengamati suhu saat awal kristal orange II melebur. Secara stoikiometri
kristal orange II yang dihasilkan seharusnya 3,936 gram, data jumlah kristal orange II diperoleh
dengan menimbang total kristal orange II dengan berat beaker glass yang kemudian dikurangi
dengan berat beaker glass dihasilkan 3,31 gram pada percobaan 1 dan pada percobaan 2
diperoleh 3,45.gram. Data yang diperoleh dari percobaan berbeda dengan yang seharusnya
diperoleh secara stoikiometri diperkirakan sebagian kecil kristal orange II ikut tercuci pada
batang pengaduk saat pengadukan pada tahap kristalisasi.
Kesimpulan
Dari percobaan ini dapat disimpulkan bahwa pewarna orange II merupakan salah satu pewarna
senyawa diazonium yang disintesis dari asam sulfanilat dan β-naftol.
Referensi
Anonim. 2010. www.wikipedia.com/wiki/orange_II. 24 November 2010
Team Laboratorium Kimia Farmasi. 2008. Buku Petunjuk Praktikum Sintesis Bahan Obat. UNEJ
Press : Jember.
JURUSAN KIMIA
FAKULTAS MIPA
Swift. 2005. CHEM 118 Organic Lab II: Module 1: Dye Synthesis & Dyeing. Susquehanna
University : Susquehanna.
Saran
Dari percobaan yang dilakukan disarankan bagi praktikan yang akan melakukan percobaan ini
untuk lebih memperhatikan aspek-aspek dalam hal kualitatif seperti uji titik lebur dan aspek-
aspek yang mempengaruhi kuantitatif dari kristal orange II karena pasta saat kristalisasi sangat
kental.
Nama Praktikan
 Ruri Andika SP_071810301068  Rahmad Soleh_071810301073

 Alfisa Surya Primaswara_081810301009  Citra Awwalul laili_081810301010
 Deny Susanti_081810301033  Ardian Syah Putra_081810301034
 Tety Prasiska_081810301050  Mohammad Rofik Usman _081810301051
He a lt h 2
1 1
F ir e
2 0
Re a c t iv it y 0
Pe rson a l E
P r o t e c t io n
Material Safety Data Sheet

Sulfanilic acid MSDS
Section 1: Chemical Product and Company Identification
Product Name: Sulfanilic acid Contact Information:

Catalog Codes: SLS1108 Sciencelab.com, Inc.
14025 Smith Rd.
CAS#: 121-57-3 Houston, Texas 77396
RTECS: WP3895500 US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: Sulfanilic acid
Order Online: ScienceLab.com
CI#: Not available.
CHEMTREC (24HR Emergency Telephone), call:
Synonym: 4-Aminobenzenesulfonic acid 1-800-424-9300
Chemical Formula: C6H7NO3S International CHEMTREC, call: 1-703-527-3887
For non-emergency assistance, call: 1-281-441-4400
Section 2: Composition and Information on Ingredients

Composition:
Name CAS # % by Weight

Sulfanilic acid 121-57-3 100
Toxicological Data on Ingredients: Sulfanilic acid: ORAL (LD50): Acute: 12300 mg/kg [Rat].
Section 3: Hazards Identification
Potential Acute Health Effects:

Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.
Potential Chronic Health Effects:
Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.
CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to blood, the nervous system, liver. Repeated or
prolonged exposure to the substance can produce target organs damage.
Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids
open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
p. 1
Skin Contact:
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running
water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before
reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation: Not available.
Ingestion:
Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform
mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.
Section 5: Fire and Explosion Data
Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in
presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.
Section 6: Accidental Release Measures
Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on
the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the
contaminated surface and allow to evacuate through the sanitary system.
Section 7: Handling and Storage
Precautions:
Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a
fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing In
case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show the
container or the label. Avoid contact with skin and eyes
p. 2
Storage:
Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a
cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing
agents.
Section 8: Exposure Controls/Personal Protection
Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal Protection:
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits: Not available.
Section 9: Physical and Chemical Properties
Physical state and appearance: Solid. (Crystalline solid.)

Odor: Not available.
Taste: Not available.
Molecular Weight: 173.19 g/mole
Color: Colorless.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Decomposes. (288°C or 550.4°F)
Critical Temperature: Not available.
Specific Gravity: 1.485 (Water = 1)
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water.
Solubility:
Partially soluble in cold water. Insoluble in methanol, diethyl ether.
Section 10: Stability and Reactivity Data
p. 3
Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.
Section 11: Toxicological Information
Routes of Entry: Eye contact. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 12300 mg/kg [Rat].
Chronic Effects on Humans: The substance is toxic to blood, the nervous system, liver.
Other Toxic Effects on Humans:
Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.
Section 12: Ecological Information
Ecotoxicity: Not available.

BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are more toxic.
Special Remarks on the Products of Biodegradation: Not available.
Section 13: Disposal Considerations
Waste Disposal:
Section 14: Transport Information
DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.
Special Provisions for Transport: Not applicable.
Section 15: Other Regulatory Information
p. 4
Federal and State Regulations: TSCA 8(b) inventory: Sulfanilic acid
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada): CLASS D-2B: Material causing other toxic effects (TOXIC).
DSCL (EEC): R36/38- Irritating to eyes and skin.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Splash goggles.
Section 16: Other Information
References: Not available.

Other Special Considerations: Not available.
Created: 10/10/2005 08:29 PM
Last Updated: 11/06/2008 12:00 PM
The information above is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume
no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for
their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for
lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com
has been advised of the possibility of such damages.
p. 5
SIGMA-ALDRICH
Version 3.0
Revision Date 12/29/2008
Print Date 04/22/2010
1. PRODUCT AND COMPANY IDENTIFICATION
Product name : 2-Naphthol

Product Number : 130109
Brand : Aldrich
Company : Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
Telephone : +18003255832
Fax : +18003255052
Emergency Phone # : (314) 776-6555
2. COMPOSITION/INFORMATION ON INGREDIENTS
Synonyms : β-Naphthol
2-Hydroxynaphthalene
Formula : C10H8O
Molecular Weight : 144.17 g/mol
CAS-No. EC-No. Index-No. Concentration

2-Naphthol
135-19-3 205-182-7 604-007-00-5 -
3. HAZARDS IDENTIFICATION
Emergency Overview
OSHA Hazards
Target Organ Effect, Harmful by ingestion., Irritant
Target Organs
Damage to the eyes.
HMIS Classification
Health Hazard: 2
Chronic Health Hazard: *
Flammability: 1
Physical hazards: 0
NFPA Rating
Health Hazard: 2
Fire: 1
Reactivity Hazard: 0
Sigma-Aldrich Corporation
Aldrich - 130109 Page 1 of 6
www.sigma-aldrich.com
Potential Health Effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes eye irritation.
Ingestion Harmful if swallowed.
4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
5. FIRE-FIGHTING MEASURES
Flammable properties
Flash point 153 °C (307 °F) - closed cup
Ignition temperature no data available
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
Methods for cleaning up
Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.
7. HANDLING AND STORAGE
Handling
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire
protection.
Storage
Keep container tightly closed in a dry and well-ventilated place.
Light sensitive.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Contains no substances with occupational exposure limit values.

Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1
(EN 143) respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves.
Eye protection
Safety glasses
Skin and body protection
Choose body protection according to the amount and concentration of the dangerous substance at the work
place.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end
of workday.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form solid
Safety data
pH no data available
Melting point 120 - 122 °C (248 - 252 °F)
Boiling point 285 - 286 °C (545 - 547 °F)
Flash point 153 °C (307 °F) - closed cup

Ignition temperature no data available
Lower explosion limit no data available
Upper explosion limit no data available
Vapour pressure 13 hPa (10 mmHg) at 145.5 °C (293.9 °F)
Water solubility no data available
10. STABILITY AND REACTIVITY
Storage stability
Stable under recommended storage conditions.
Materials to avoid
Strong oxidizing agents, Strong bases
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
11. TOXICOLOGICAL INFORMATION
Acute toxicity
LD50 Oral - rat - 1,960 mg/kg
LD50 Dermal - rabbit - > 10,000 mg/kg
LD50 Dermal - rabbit - > 10,000 mg/kg
Irritation and corrosion
Skin - rabbit - Mild skin irritation - 24 h
Eyes - rabbit - Moderate eye irritation
Sensitisation
no data available
Chronic exposure
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as
a carcinogen or potential carcinogen by ACGIH.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as
a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is identified as
a carcinogen or potential carcinogen by OSHA.
Signs and Symptoms of Exposure

Depending on the intensity and duration of exposure, effects may vary from mild irritation to severe destruction of
tissue., Damage to the eyes., To the best of our knowledge, the chemical, physical, and toxicological properties have
not been thoroughly investigated.
Potential Health Effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes eye irritation.
Ingestion Harmful if swallowed.
Target Organs Damage to the eyes.,
Additional Information
RTECS: QL2975000
12. ECOLOGICAL INFORMATION
Elimination information (persistence and degradability)

Biodegradability Zahn-Wellens Test
Result: 92 % - Readily biodegradable.
Ecotoxicity effects
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 3.46 mg/l - 96 h
Further information on ecology
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Very toxic to aquatic organisms.
13. DISPOSAL CONSIDERATIONS
Product
Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal
service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
DOT (US)
Not dangerous goods
IMDG
UN-Number: 3077 Class: 9 Packing group: III EMS-No: F-A, S-F
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (2-Naphthol)
Marine pollutant: No
IATA
UN-Number: 3077 Class: 9 Packing group: III
Proper shipping name: Environmentally hazardous substance, solid n.o.s. (2-Naphthol)
15. REGULATORY INFORMATION
OSHA Hazards
Target Organ Effect, Harmful by ingestion., Irritant
DSL Status
All components of this product are on the Canadian DSL list.
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
CAS-No. Revision Date
2-Naphthol 135-19-3
New Jersey Right To Know Components
CAS-No. Revision Date
2-Naphthol 135-19-3
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth, or any other
reproductive defects.
16. OTHER INFORMATION
Further information
Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with
the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 02/28/2007

Date Updated: 01/30/2006
Version 1.6
Section 1 - Product and Company Information
Product Name SODIUM CARBONATE ANHYDROUS SIGMAULTRA

Product Number S7795
Brand SIAL
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313

SODIUM CARBONATE (ANHYDROUS) 497-19-8 No
Formula Na2CO3
Synonyms Bisodium carbonate * Calcined soda * Carbonic
acid, disodium salt * Crystol carbonate *
Disodium carbonate * Snowlite 1 * Soda ash *
Solvay soda
RTECS Number: VZ4050000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Irritant.
Irritating to respiratory system and skin. Risk of serious damage
to eyes.
Severe eye irritant.
HMIS RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 0
REACTIVITY: 1
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)

Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP

Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
SPECIAL REQUIREMENTS
Hygroscopic.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
SIAL - S7795 www.sigma-aldrich.com Page 2

Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a dust mask type N95 (US) or type P1 (EN 143)
respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES

Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid

Color: White
Form: Powder
Property Value At Temperature or Pressure
Molecular Weight 105.99 AMU

pH 12
BP/BP Range N/A
MP/MP Range 851 °C
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density 2.532 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:complete, colorless 1 M
in H2O, 20°C
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Hygroscopic.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS

Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Sodium/sodium oxides.

HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
SIGNS AND SYMPTOMS OF EXPOSURE

Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
TOXICITY DATA
Oral
Rat
4090 mg/kg
LD50
Inhalation
Rat
2,300 mg/m3
LC50
Remarks: Lungs, Thorax, or Respiration:Dyspnea.
Gastrointestinal:Other changes.
Oral
Mouse
6600 mg/kg
LD50
Inhalation
Mouse
1,200 mg/m3
LC50
Intraperitoneal
Mouse
117 MG/KG
LD50
Subcutaneous
Mouse
2210 MG/KG
LD50
Inhalation
Guinea pig
800 mg/m3
LC50

IRRITATION DATA
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
30S
Remarks: Rinsed
Eyes
Rabbit
50 mg
Remarks: Severe irritation effect
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 84800 NG/KG
Route of Application: Intrauterine
Exposure Time: (4D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Daphnia

Species: Daphnia magna
Time: 48 h
Value: 265 mg/l
Test Type: LC50 Fish

Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 300 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION

Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: None

Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: Xi
Indication of Danger: Irritant.
R: 36
Risk Statements: Irritating to eyes.
S: 22-26
Safety Statements: Do not breathe dust. In case of contact with
eyes, rinse immediately with plenty of water and seek medical
advice.
US CLASSIFICATION AND LABEL TEXT

Indication of Danger: Irritant.
Risk Statements: Irritating to respiratory system and skin. Risk
of serious damage to eyes.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
Do not breathe dust.
US Statements: Severe eye irritant.
UNITED STATES REGULATORY INFORMATION

SARA LISTED: No
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION

WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.

SIGMA-ALDRICH sigma-aldrich.com
SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006
Version 4.0 Revision Date 13.03.2010
Print Date 20.04.2010
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA
1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product name : Sodium nitrite
Product Number : S2252
Brand : Sigma-Aldrich
Company : Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
Telephone : +18003255832
Fax : +18003255052
Emergency Phone # : (314) 776-6555
2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
According to Regulation (EC) No1272/2008
Oxidizing solids (Category 3)
Acute toxicity (Category 3)
Acute aquatic toxicity (Category 1)
According to European Directive 67/548/EEC as amended.
Contact with combustible material may cause fire. Toxic if swallowed. Very toxic to aquatic organisms.
Label elements
Pictogram
Signal word Danger

Hazard statement(s)
H400 Very toxic to aquatic life.
H272 May intensify fire; oxidiser.
H301 Toxic if swallowed.
Precautionary statement(s)
P220 Keep/Store away from clothing/ combustible materials.
P273 Avoid release to the environment.
Hazard symbol(s)
O Oxidising
T Toxic
N Dangerous for the environment
R-phrase(s)
R8 Contact with combustible material may cause fire.
R25 Toxic if swallowed.
R50 Very toxic to aquatic organisms.
S-phrase(s)
S45 In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
S61 Avoid release to the environment. Refer to special instructions/ Safety data
Sigma-Aldrich - S2252 Page 1 of 6
sheets.
Other hazards - none
3. COMPOSITION/INFORMATION ON INGREDIENTS
Formula : NNaO2
Molecular Weight : 69,00 g/mol
CAS-No. EC-No. Index-No. Classification Concentration

Sodium nitrite
7632-00-0 231-555-9 007-010-00-4 Ox. Sol. 3; Acute Tox. 3; -
Aquatic Acute 1; H400, H272,
H301
O, T, N, R 8 - R25 - R50
For the full text of the H-Statements mentioned in this Section, see Section 16.
4. FIRST AID MEASURES

General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.
6. ACCIDENTAL RELEASE MEASURES

Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
Evacuate personnel to safe areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.
7. HANDLING AND STORAGE

Precautions for safe handling
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed. Keep away from sources of ignition -
No smoking. Keep away from combustible material.

Conditions for safe storage
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
hygroscopic
8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator
type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the
respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as NIOSH (US) or CEN
(EU).
Hand protection
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.
Handle with gloves.
Eye protection
Face shield and safety glasses
Skin and body protection
Choose body protection according to the amount and concentration of the dangerous substance at the
work place.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the
product.
9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance
Form solid
Safety data
pH 9
Melting point 281 °C
Boiling point 320 °C
Flash point no data available
Ignition temperature 490 °C -
Lower explosion limit no data available
Upper explosion limit no data available
Density 2,168 g/cm3
Water solubility no data available
10. STABILITY AND REACTIVITY

Chemical stability
Stable under recommended storage conditions.
Conditions to avoid
Exposure to moisture.
Materials to avoid
Acids, Powdered metals, Ammonia, Cyanides, Amines, Activated carbon

Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - nitrogen oxides (NOx), Sodium oxides
11. TOXICOLOGICAL INFORMATION

Acute toxicity
LD50 Oral - mouse - 175 mg/kg
Remarks: Vascular:BP lowering not charactertized in autonomic section. Vascular:Regional or general
arteriolar or venous dilation.
LD50 Oral - rabbit - 186 mg/kg
LD50 Oral - Chicken - 28,944 mg/kg
LC50 Inhalation - rat - 4 h - 5,5 mg/m3
LD50 Subcutaneous - rat - 96,6 mg/kg
LD50 Intravenous - rat - 65 mg/kg
LD50 Intraperitoneal - mouse - 158 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes - rabbit - Mild eye irritation - 24 h
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: 2A - Group 2A: Probably carcinogenic to humans (Sodium nitrite)
2A - Group 2A: Probably carcinogenic to humans (Sodium nitrite)
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion Toxic if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Additional Information
RTECS: RA1225000
12. ECOLOGICAL INFORMATION

Toxicity
Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 0,092 mg/l - 96,0 h
mortality NOEC - Oncorhynchus mykiss (rainbow trout) - 0,54 mg/l - 96,0 h
Toxicity to daphnia EC50 - Daphnia magna (Water flea) - 12,5 mg/l - 48 h
and other aquatic
invertebrates.
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
Very toxic to aquatic organisms.
no data available
13. DISPOSAL CONSIDERATIONS

Product
Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the
material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental regulations.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION

ADR/RID
UN-Number: 1500 Class: 5.1 (6.1) Packing group: III
Proper shipping name: SODIUM NITRITE
IMDG
UN-Number: 1500 Class: 5.1 (6.1) Packing group: III EMS-No: F-A, S-Q
Proper shipping name: SODIUM NITRITE
Marine pollutant: No
IATA
UN-Number: 1500 Class: 5.1 (6.1) Packing group: III
Proper shipping name: Sodium nitrite
15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
16. OTHER INFORMATION

Text of H-code(s) and R-phrase(s) mentioned in Section 3
Acute Tox. Acute toxicity
Aquatic Acute Acute aquatic toxicity
H272 May intensify fire; oxidiser.
H301 Toxic if swallowed.
H400 Very toxic to aquatic life.
Ox. Sol. Oxidizing solids
N Dangerous for the environment
O Oxidising
T Toxic
R8 Contact with combustible material may cause fire.
R25 Toxic if swallowed.
R50 Very toxic to aquatic organisms.
Further information
Copyright 2010 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee
of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from
handling or from contact with the above product. See reverse side of invoice or packing slip for additional
terms and conditions of sale.

Hydrochloric acid MSDS

Product Name: Hydrochloric acid Contact Information:
Catalog Codes: SLH1462, SLH3154 Sciencelab.com, Inc.

14025 Smith Rd.
CAS#: Mixture. Houston, Texas 77396
US Sales: 1-800-901-7247
RTECS: MW4025000
TSCA: TSCA 8(b) inventory: Hydrochloric acid Order Online: ScienceLab.com
CI#: Not applicable. CHEMTREC (24HR Emergency Telephone), call:
1-800-424-9300
Synonym: Hydrochloric Acid; Muriatic Acid
International CHEMTREC, call: 1-703-527-3887
Chemical Name: Not applicable.
For non-emergency assistance, call: 1-281-441-4400
Chemical Formula: Not applicable.

Composition:
Hydrogen chloride 7647-01-0 20-38
Water 7732-18-5 62-80
Toxicological Data on Ingredients: Hydrogen chloride: GAS (LC50): Acute: 4701 ppm 0.5 hours [Rat].

Very hazardous in case of skin contact (corrosive, irritant, permeator), of eye contact (irritant, corrosive), of
ingestion, . Slightly hazardous in case of inhalation (lung sensitizer). Non-corrosive for lungs. Liquid or spray
mist may produce tissue damage particularly on mucous membranes of eyes, mouth and respiratory tract. Skin
contact may produce burns. Inhalation of the spray mist may produce severe irritation of respiratory tract,
characterized by coughing, choking, or shortness of breath. Severe over-exposure can result in death.
Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by
itching, scaling, reddening, or, occasionally, blistering.

Slightly hazardous in case of skin contact (sensitizer).
CARCINOGENIC EFFECTS: Classified 3 (Not classifiable for human.) by IARC [Hydrochloric acid].
MUTAGENIC EFFECTS: Not available.
p. 1
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
The substance may be toxic to kidneys, liver, mucous membranes, upper respiratory tract, skin, eyes, Circulatory
System, teeth.
Repeated or prolonged exposure to the substance can produce target organs damage. Repeated or prolonged
contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged
exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection.
Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in
one or many human organs.

Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention immediately.
Skin Contact:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used.Wash clothing before
reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.

Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
medical attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention immediately.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth
resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation
when the inhaled material is toxic, infectious or corrosive. Seek immediate medical attention.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
attention immediately.

Flammability of the Product: Non-flammable.
Auto-Ignition Temperature: Not applicable.
Flash Points: Not applicable.
Flammable Limits: Not applicable.
Products of Combustion: Not available.
Fire Hazards in Presence of Various Substances: of metals
Explosion Hazards in Presence of Various Substances: Non-explosive in presence of open flames and sparks, of shocks.
Fire Fighting Media and Instructions: Not applicable.
p. 2
Special Remarks on Fire Hazards:
Non combustible.
Calcium carbide reacts with hydrogen chloride gas with incandescence.
Uranium phosphide reacts with hydrochloric acid to release spontaneously flammable phosphine.
Rubidium acetylene carbides burns with slightly warm hydrochloric acid.
Lithium silicide in contact with hydrogen chloride becomes incandescent. When dilute hydrochloric acid is used,
gas spontaneously flammable in air is evolved.
Magnesium boride treated with concentrated hydrochloric acid produces spontaneously flammble gas.
Cesium acetylene carbide burns hydrogen chloride gas.
Cesium carbide ignites in contact with hydrochloric acid unless acid is dilute.
Reacts with most metals to produce flammable Hydrodgen gas.
Special Remarks on Explosion Hazards:

Hydrogen chloride in contact with the following can cause an explosion, ignition on contact, or other
violent/vigorous reaction: Acetic anhydride AgClO + CCl4 Alcohols + hydrogen cyanide, Aluminum
Aluminum-titanium alloys (with HCl vapor), 2-Amino ethanol, Ammonium hydroxide, Calcium carbide Ca3P2
Chlorine + dinitroanilines (evolves gas), Chlorosulfonic acid Cesium carbide Cesium acetylene carbide,
1,1-Difluoroethylene Ethylene diamine Ethylene imine, Fluorine, HClO4 Hexalithium disilicide H2SO4 Metal
acetylides or carbides, Magnesium boride, Mercuric sulfate, Oleum, Potassium permanganate,
beta-Propiolactone Propylene oxide Rubidium carbide, Rubidium, acetylene carbide Sodium (with aqueous HCl),
Sodium hydroxide Sodium tetraselenium, Sulfonic acid, Tetraselenium tetranitride, U3P4 , Vinyl acetate.
Silver perchlorate with carbon tetrachloride in the presence of hydrochloric acid produces trichloromethyl
perchlorate which detonates at 40 deg. C.

Small Spill:
Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal
container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate.
Large Spill:
Corrosive liquid. Poisonous liquid.
Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside
container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Use water spray to reduce
vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal.
Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at
a concentration level above TLV. Check TLV on the MSDS and with local authorities.

Precautions:
Keep locked up.. Keep container dry. Do not ingest. Do not breathe gas/fumes/ vapor/spray. Never add water
to this product. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical
advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from
incompatibles such as oxidizing agents, organic materials, metals, alkalis, moisture.
May corrode metallic surfaces. Store in a metallic or coated fiberboard drum using a strong polyethylene inner
package.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their
respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
work-station location.
p. 3
Face shield. Full suit. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Boots.

Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits:
CEIL: 5 (ppm) from OSHA (PEL) [United States]
CEIL: 7 (mg/m3) from OSHA (PEL) [United States]
CEIL: 5 from NIOSH
CEIL: 7 (mg/m3) from NIOSH
TWA: 1 STEL: 5 (ppm) [United Kingdom (UK)]
TWA: 2 STEL: 8 (mg/m3) [United Kingdom (UK)]Consult local authorities for acceptable exposure limits.

Physical state and appearance: Liquid.
Odor: Pungent. Irritating (Strong.)
Taste: Not available.
Molecular Weight: Not applicable.
Color: Colorless to light yellow.
pH (1% soln/water): Acidic.
Boiling Point:
108.58 C @ 760 mm Hg (for 20.22% HCl in water)
83 C @ 760 mm Hg (for 31% HCl in water)
50.5 C (for 37% HCl in water)
Melting Point:
-62.25°C (-80°F) (20.69% HCl in water)
-46.2 C (31.24% HCl in water)
-25.4 C (39.17% HCl in water)
Critical Temperature: Not available.
Specific Gravity:
1.1- 1.19 (Water = 1)
1.10 (20%and 22% HCl solutions)
1.12 (24% HCl solution)
1.15 (29.57% HCl solution)
1.16 (32% HCl solution)
1.19 (37% and 38%HCl solutions)
Vapor Pressure: 16 kPa (@ 20°C) average
Vapor Density: 1.267 (Air = 1)
Odor Threshold: 0.25 to 10 ppm
Water/Oil Dist. Coeff.: Not available.
p. 4
Dispersion Properties: See solubility in water, diethyl ether.
Solubility: Soluble in cold water, hot water, diethyl ether.

Conditions of Instability: Incompatible materials, water
Incompatibility with various substances:

Highly reactive with metals.
Reactive with oxidizing agents, organic materials, alkalis, water.
Corrosivity:
Extremely corrosive in presence of aluminum, of copper, of stainless steel(304), of stainless steel(316).
Non-corrosive in presence of glass.
Special Remarks on Reactivity:

Reacts with water especially when water is added to the product.
Absorption of gaseous hydrogen chloride on mercuric sulfate becomes violent @ 125 deg. C.
Sodium reacts very violently with gaseous hydrogen chloride.
Calcium phosphide and hydrochloric acid undergo very energetic reaction.
It reacts with oxidizers releasing chlorine gas.
Incompatible with, alkali metals, carbides, borides, metal oxides, vinyl acetate, acetylides, sulphides, phosphides,
cyanides, carbonates.
Reacts with most metals to produce flammable Hydrogen gas.
Reacts violently (moderate reaction with heat of evolution) with water especially when water is added to the
product. Isolate hydrogen chloride from heat, direct sunlight, alkalies (reacts vigorously), organic materials, and
oxidizers (especially nitric acid and chlorates), amines, metals, copper and alloys (e.g. brass), hydroxides, zinc
(galvanized materials), lithium silicide (incandescence), sulfuric acid(increase in temperature and pressure)
Hydrogen chloride gas is emitted when this product is in contact with sulfuric acid.
Adsorption of Hydrochloric Acid onto silicon dioxide results in exothmeric reaction.
Hydrogen chloride causes aldehydes and epoxides to violently polymerize.
Hydrogen chloride or Hydrochloric Acid in contact with the folloiwng can cause explosion or ignition on contact or
Special Remarks on Corrosivity:

Highly corrosive. Incompatible with copper and copper alloys. It attacks nearly all metals (mercury, gold,
platinium, tantalum, silver, and certain alloys are exceptions).
It is one of the most corrosive of the nonoxidizing acids in contact with copper alloys.
No corrosivity data on zinc, steel.
Severe Corrosive effect on brass and bronze
Polymerization: Will not occur.

Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation.
Toxicity to Animals:
Acute oral toxicity (LD50): 900 mg/kg [Rabbit].
Acute toxicity of the vapor (LC50): 1108 ppm, 1 hours [Mouse].
Acute toxicity of the vapor (LC50): 3124 ppm, 1 hours [Rat].
Chronic Effects on Humans:

CARCINOGENIC EFFECTS: Classified 3 (Not classifiable for human.) by IARC [Hydrochloric acid].
May cause damage to the following organs: kidneys, liver, mucous membranes, upper respiratory tract, skin,
p. 5
eyes, Circulatory System, teeth.

Very hazardous in case of skin contact (corrosive, irritant, permeator), of ingestion, .
Hazardous in case of eye contact (corrosive), of inhalation (lung corrosive).
Special Remarks on Toxicity to Animals:

Lowest Published Lethal Doses (LDL/LCL)
LDL [Man] -Route: Oral; 2857 ug/kg
LCL [Human] - Route: Inhalation; Dose: 1300 ppm/30M
LCL [Rabbit] - Route: Inhalation; Dose: 4413 ppm/30M
Special Remarks on Chronic Effects on Humans:

May cause adverse reproductive effects (fetoxicity).
May affect genetic material.
Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:
Skin: Corrosive. Causes severe skin irritation and burns.
Eyes: Corrosive. Causes severe eye irritation/conjuntivitis, burns, corneal necrosis.
Inhalation: May be fatal if inhaled. Material is extremely destructive to tissue of the mucous membranes and
upper respiratory tract. Inhalation of hydrochloric acid fumes produces nose, throat, and larryngeal burning, and
irritation, pain and inflammation, coughing, sneezing, choking sensation, hoarseness, laryngeal spasms, upper
respiratory tract edema, chest pains, as well has headache, and palpitations. Inhalation of high concentrations
can result in corrosive burns, necrosis of bronchial epithelium, constriction of the larynx and bronchi, nasospetal
perforation, glottal closure,
occur, particularly if exposure is prolonged. May affect the liver.
Ingestion: May be fatal if swallowed. Causes irritation and burning, ulceration, or perforation of the
gastrointestinal tract and resultant peritonitis, gastric hemorrhage and infection. Can also cause nausea, vomitting
(with "coffee ground" emesis), diarrhea, thirst, difficulty swallowing, salivation, chills, fever, uneasiness, shock,
strictures and stenosis (esophogeal, gastric, pyloric). May affect behavior (excitement), the cardiovascular
system (weak rapid pulse, tachycardia), respiration (shallow respiration), and urinary system (kidneys- renal
failure, nephritis).
Acute exposure via inhalation or ingestion can also cause erosion of tooth enamel.
Chronic Potential Health Effects:
dyspnea, bronchitis. Chemical pneumonitis and pulmonary edema can also

Ecotoxicity: Not available.
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products of Biodegradation: The products of degradation are less toxic than the product itself.

Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
p. 6
DOT Classification: Class 8: Corrosive material
Identification: : Hydrochloric acid, solution UNNA: 1789 PG: II
Special Provisions for Transport: Not available.

Federal and State Regulations:
Connecticut hazardous material survey.: Hydrochloric acid
Illinois toxic substances disclosure to employee act: Hydrochloric acid
Illinois chemical safety act: Hydrochloric acid
New York release reporting list: Hydrochloric acid
Rhode Island RTK hazardous substances: Hydrochloric acid
Pennsylvania RTK: Hydrochloric acid
Minnesota: Hydrochloric acid
Massachusetts RTK: Hydrochloric acid
Massachusetts spill list: Hydrochloric acid
New Jersey: Hydrochloric acid
New Jersey spill list: Hydrochloric acid
Louisiana RTK reporting list: Hydrochloric acid
Louisiana spill reporting: Hydrochloric acid
California Director's List of Hazardous Substances: Hydrochloric acid
TSCA 8(b) inventory: Hydrochloric acid
TSCA 4(a) proposed test rules: Hydrochloric acid
SARA 302/304/311/312 extremely hazardous substances: Hydrochloric acid
SARA 313 toxic chemical notification and release reporting: Hydrochloric acid
CERCLA: Hazardous substances.: Hydrochloric acid: 5000 lbs. (2268 kg)
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada):
CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
CLASS E: Corrosive liquid.
DSCL (EEC):
R34- Causes burns.
R37- Irritating to respiratory system.
S26- In case of contact with eyes, rinse
immediately with plenty of water and seek
medical advice.
S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the
label where possible).
HMIS (U.S.A.):
Health Hazard: 3
Fire Hazard: 0
Reactivity: 1
p. 7
Health: 3
Flammability: 0
Reactivity: 1
Specific hazard:
Gloves.
Full suit.
Vapor respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
Face shield.

References:
-Hawley, G.G.. The Condensed Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987.
-SAX, N.I. Dangerous Properties of Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984.
-The Sigma-Aldrich Library of Chemical Safety Data, Edition II.
-Guide de la loi et du règlement sur le transport des marchandises dangeureuses au canada. Centre de conformité
internatinal Ltée. 1986.
Created: 10/09/2005 05:45 PM
Last Updated: 09/14/2009 10:34 AM
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even
if ScienceLab.com has been advised of the possibility of such damages.
p. 8
SIGMA-ALDRICH

Version 1.10
Product Name SODIUM HYDROXIDE, 50% SOLUTION IN WATER

Product Number 415413
Brand SIAL
Fax: 800-325-5052

SODIUM HYDROXIDE SOLUTIONS (>5%) 1310-73-2 No
Ingredient Name CAS # Percent SARA 313

WATER 7732-18-5 <= 95 No
SODIUM HYDROXIDE 1310-73-2 >= 5 No
Formula NaOH
EMERGENCY OVERVIEW
Corrosive.
Causes burns.
Exothermic in contact with water
HMIS RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 2
NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 2
ORAL EXPOSURE
conscious. Call a physician. Do not induce vomiting.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Dry chemical powder.
Unsuitable: Do not use water.
FIREFIGHTING
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL

Evacuate area.

Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.

Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on
skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
Incompatible Materials: Do not allow contact with water
Safety shower and eye bath. Use only in a chemical fume hood.

SIAL - 415413 www.sigma-aldrich.com Page 2

(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Other: Faceshield (8-inch minimum).

Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
USA OSHA. PEL 2 mg/m3
USA ACGIH TLV 2 mg/m3
Appearance Physical State: Liquid
Molecular Weight 40 AMU

pH N/A 14
BP/BP Range 105.0 - 140.0 °C
MP/MP Range - 12.0 - 10. °C
Freezing Point N/A
Vapor Pressure < 18 mmHg 20 °C
Vapor Density > 1 g/l
SG/Density 1.327 g/cm3 25 °C
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Viscosity N/A
Surface Tension N/A
Flash Point N/A
Flammability N/A
Solubility Solubility in Water:Miscible. Soluble.
N/A = not available
STABILITY
Stable: Stable.
Conditions of Instability: Absorbs carbon dioxide from air. Heat
of solution is very high, and with limited amounts of water,
violent boiling may occur

Conditions to Avoid: Air sensitive.
Materials to Avoid: Water, Acids, Organic materials, Chlorinated
solvents, Aluminum, Phosphorus, Tin/tin oxides, Zinc.

Hazardous Decomposition Products: Sodium/sodium oxides.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Eye Contact: Causes burns.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. May be harmful
if inhaled.

Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
IRRITATION DATA
Skin
Rabbit
500 mg
24 HR
Eyes
Rabbit
0.5 mg
24 HR
No data available.

Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
DOT
Proper Shipping Name: Sodium hydroxide solution
UN#: 1824
Class: 8
Packing Group: Packing Group II

Hazard Label: Corrosive
PIH: Not PIH
IATA
Proper Shipping Name: Sodium hydroxide solution
IATA UN Number: 1824
Hazard Class: 8
Packing Group: II
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: C
Indication of Danger: Corrosive.
R: 35
Risk Statements: Causes severe burns.
S: 26-37/39-45
suitable gloves and eye/face protection. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
US CLASSIFICATION AND LABEL TEXT

Indication of Danger: Corrosive.
Risk Statements: Causes burns.
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
US Statements: Exothermic in contact with water

SARA LISTED: No

DSL: No
NDSL: No
DISCLAIMER
WARRANTY

SIGMA-ALDRICH

Version 1.12
Product Name SODIUM CHLORIDE ACS REAGENT

Product Number S9888
Brand SIAL
Fax: 800-325-5052

SODIUM CHLORIDE 7647-14-5 No
Formula NaCl
Synonyms Common salt * Dendritis * Extra Fine 200 Salt *
Extra Fine 325 Salt * Halite * H.G. blending *
Natriumchlorid (German) * Purex * Rock salt *
Saline * Salt * Sea salt * Table salt * Top flake
* USP sodium chloride * White crystal
RTECS Number: VZ4725000
HMIS RATING
HEALTH: 0
FLAMMABILITY: 0
REACTIVITY: 0
NFPA RATING
HEALTH: 0
FLAMMABILITY: 0
REACTIVITY: 0
ORAL EXPOSURE
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Noncombustible. Use extinguishing media appropriate to
surrounding fire conditions.
FIREFIGHTING
For fires involving this material, do not enter any enclosed or
confined fire space without proper protective equipment. This
may include self-contained breathing apparatus to protect
against the hazardous effects of the normal products of
combustion or oxygen deficiency

Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.

Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
HANDLING
User Exposure: Avoid inhalation. Avoid contact with eyes, skin,
and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Safety shower and eye bath. Mechanical exhaust required.

(EU). Respiratory protection is not required. Where protection
from nuisance levels of dusts are desired, use type N95 (US) or

type P1 (EN 143) dust masks.
Hand: Protective gloves.

Wash thoroughly after handling.
Appearance Physical State: Solid
Molecular Weight 58.44 AMU

pH 7
BP/BP Range 1,413 °C
MP/MP Range 801 °C
Freezing Point N/A
Vapor Pressure 1 mmHg 865 °C
Vapor Density N/A
SG/Density 2.165 g/cm3
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Viscosity N/A
Surface Tension N/A
Flash Point N/A
Flammability N/A
Solubility Solubility in Water:Soluble.
Other Solvents: 36G/100ML @ 20 °C
N/A = not available
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.

Hazardous Decomposition Products: Sodium/sodium oxides, Hydrogen
chloride gas.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.

Eye Contact: Sodium chloride (NaCl) in contact with eyes can
cause irritation or redness due to abrasion.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.

Ingestion of large amounts causes vomiting and diarrhea.
Dehydration and congestion may occur in internal organs.
Hypertonic salt solutions can produce inflammatory reactions in
the gastrointestinal tract.
TOXICITY DATA
Oral
Rat
3000 mg/kg
LD50
Inhalation
Rat
> 42,000 mg/m3
LC50
Oral
Mouse
4000 mg/kg
LD50
Intraperitoneal
Mouse
2602 MG/KG
LD50
Subcutaneous
Mouse
3 GM/KG
LD50
Intravenous
Mouse
645 MG/KG
LD50
Intracervical
Mouse
131 MG/KG
LD50
Skin
Rabbit
> 10000 mg/kg
LD50
IRRITATION DATA
Skin
Rabbit
50 mg
24H

Skin
Rabbit
500 mg
24H
Eyes
Rabbit
100 mg
Eyes
Rabbit
100 mg
24H
Eyes
Rabbit
10 mg
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 1710 MG/KG
Route of Application: Intraperitoneal
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Embryo or Fetus: Fetal death. Effects on
Embryo or Fetus: Fetotoxicity (except death, e.g., stunted
fetus).
Species: Mouse
Dose: 1900 MG/KG
Route of Application: Subcutaneous
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 1900 MG/KG
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 2500 MG/KG
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 125 MMOL/L
Cell Type: fibroblast
Mutation test: DNA inhibition
Species: Rat

Route: Oral
Dose: 16800 MG/KG
Exposure Time: 4W
Mutation test: Unscheduled DNA synthesis
Species: Rat
Route: Oral
Dose: 400 MG/KG
Mutation test: Other mutation test systems
Species: Rat
Route: Intraperitoneal
Dose: 2338 MG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Dose: 101 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
Species: Mouse
Dose: 57200 UMOL/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 4 GM/L
Cell Type: lung
Mutation test: Micronucleus test
Species: Hamster
Dose: 275 MMOL/L
Cell Type: ovary
Mutation test: DNA damage
Species: Hamster
Dose: 160 MMOL/L
Cell Type: ovary
Species: Hamster
Dose: 7500 MG/L
Cell Type: lung
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 27 MG/KG
Route of Application: Intraplacental
Exposure Time: (15W PREG)
Result: Effects on Fertility: Abortion.
Species: Rat
Dose: 145 GM/KG
Route of Application: Oral
Exposure Time: (7D PRE/1-22D PREG)
Result: Effects on Newborn: Delayed effects.
Species: Rat
Dose: 56400 MG/KG
Route of Application: Oral

Exposure Time: (5D PRE-21D POST)
Result: Effects on Newborn: Biochemical and metabolic. Maternal
Effects: Postpartum.
Species: Rat
Dose: 10 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (17-20D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 10 MG/KG
Route of Application: Parenteral
Exposure Time: (1D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rat
Dose: 500 MG/KG
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 50 MG/KG
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 13440 MG/KG
Exposure Time: (2-6D PREG)
Species: Monkey
Dose: 6 GM/KG
Exposure Time: (18W PREG)
Species: Horse, donkey

Dose: 480 MG/KG
Route of Application: Intraplacental
Result: Effects on Embryo or Fetus: Fetal death. Maternal
Effects: Other effects. Endocrine:Estrogenic.
No data available.

Small amounts may be washed down the drain with excess water.
Observe all federal, state, and local environmental regulations.

DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.

SARA LISTED: No
TSCA INVENTORY ITEM: Yes

DSL: Yes
NDSL: No
DISCLAIMER
WARRANTY

He a lt h 2
3 3
F ir e
2 0
Re a c t iv it y 0
Pe rson a l E
P r o t e c t io n

Ethyl alcohol 200 Proof MSDS
Product Name: Ethyl alcohol 200 Proof Contact Information:

Catalog Codes: SLE2248, SLE1357 Sciencelab.com, Inc.
14025 Smith Rd.
CAS#: 64-17-5 Houston, Texas 77396
RTECS: KQ6300000 US Sales: 1-800-901-7247
TSCA: TSCA 8(b) inventory: Ethyl alcohol 200 Proof
Order Online: ScienceLab.com
CI#: Not applicable.
CHEMTREC (24HR Emergency Telephone), call:
Synonym: Ethanol; Absolute Ethanol; Alcohol; Ethanol 1-800-424-9300
200 proof; Ethyl Alcohol, Anhydrous; Ethanol, undenatured;
Dehydrated Alcohol; Alcohol International CHEMTREC, call: 1-703-527-3887
Chemical Name: Ethyl Alcohol For non-emergency assistance, call: 1-281-441-4400
Chemical Formula: CH3CH2OH

Composition:

Ethyl alcohol 200 Proof 64-17-5 100
Toxicological Data on Ingredients: Ethyl alcohol 200 Proof: ORAL (LD50): Acute: 7060 mg/kg [Rat]. 3450 mg/kg [Mouse].
VAPOR (LC50): Acute: 20000 ppm 8 hours [Rat]. 39000 mg/m 4 hours [Mouse].

Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Slightly hazardous in case of skin contact
(permeator), of ingestion.
Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: A4 (Not classifiable for human or
animal.) by ACGIH. MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Classified PROVEN for human. DEVELOPMENTAL TOXICITY: Classified Development toxin
[PROVEN]. Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE]. The substance is toxic
to blood, the reproductive system, liver, upper respiratory tract, skin, central nervous system (CNS). Repeated or prolonged
exposure to the substance can produce target organs damage.
p. 1
Eye Contact:
Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids
open. Cold water may be used. Get medical attention.
Skin Contact:
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated
clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical
attention.
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
attention if symptoms appear.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical
attention.
Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.
Flammability of the Product: Flammable.

Auto-Ignition Temperature: 363°C (685.4°F)
Flash Points: CLOSED CUP: 12.78°C (55°F). OPEN CUP: 17.78°C (64°F) (Cleveland).
Flammable Limits: LOWER: 3.3% UPPER: 19%
Products of Combustion: These products are carbon oxides (CO, CO2).
Fire Hazards in Presence of Various Substances:
Highly flammable in presence of open flames and sparks, of heat. Slightly flammable to flammable in presence of oxidizing
materials.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of open
flames and sparks, of heat, of oxidizing materials, of acids.
Fire Fighting Media and Instructions:
Flammable liquid, soluble or dispersed in water. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use alcohol foam,
water spray or fog.
Special Remarks on Fire Hazards:
Containers should be grounded. CAUTION: MAY BURN WITH NEAR INVISIBLE FLAME Vapor may travel considerable
distance to source of ignition and flash back. May form explosive mixtures with air. Contact with Bromine pentafluoride is likely
to cause fire or explosion. Ethanol ignites on contact with chromyl chloride. Ethanol ignites on contact with iodine heptafluoride
gas. It ignites than explodes upon contact with nitrosyl perchlorate. Additon of platinum black catalyst caused ignition.
Special Remarks on Explosion Hazards:
Ethanol has an explosive reaction with the oxidized coating around potassium metal. Ethanol ignites and then explodes on
contact with acetic anhydride + sodium hydrosulfate (ignites and may explode), disulfuric acid + nitric acid, phosphorous(III)
oxide platinum, potassium-tert-butoxide+ acids. Ethanol forms explosive products in reaction with the following compound :
p. 2
ammonia + silver nitrate (forms silver nitride and silver fulminate), iodine + phosphorus (forms ethane iodide), magnesium
perchlorate (forms ethyl perchlorate), mercuric nitrate, nitric acid + silver (forms silver fulminate) silver nitrate (forms ethyl
nitrate) silver(I) oxide + ammonia or hydrazine (forms silver nitride and silver fulminate), sodium (evolves hydrogen gas).
Sodium Hydrazide + alcohol can produce an explosion. Alcohols should not be mixed with mercuric nitrate, as explosive
mercuric fulminate may be formed. May form explosive mixture with manganese perchlorate + 2,2-dimethoxypropane. Addition
of alcohols to highly concentrate hydrogen peroxide forms powerful explosives. Explodes on contact with calcium hypochlorite
Small Spill:
Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container.
Large Spill:
Flammable liquid. Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth,
sand or other non-combustible material. Do not touch spilled material. Prevent entry into sewers, basements or confined
areas; dike if needed. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS
and with local authorities.
Precautions:
Keep locked up.. Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do
not ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. In case of insufficient ventilation, wear
suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid
contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids, alkalis, moisture.
Storage:
Store in a segregated and approved area. Keep container in a cool, well-ventilated area. Keep container tightly closed and
sealed until ready for use. Avoid all possible sources of ignition (spark or flame). Do not store above 23°C (73.4°F).
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective
threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location.
Splash goggles. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Use a
respirator if the exposure limit is exceeded.
Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits:
TWA: 1900 (mg/m3) from OSHA (PEL) [United States] TWA: 1000 (ppm) from OSHA (PEL) [United States] TWA: 1900 (mg/
m3) from NIOSH [United States] TWA: 1000 (ppm) from NIOSH [United States] TWA: 1000 (ppm) [United Kingdom (UK)]
TWA: 1920 (mg/m3) [United Kingdom (UK)] TWA: 1000 STEL: 1250 (ppm) [Canada]Consult local authorities for acceptable
exposure limits.
Physical state and appearance: Liquid. (Liquid.)

Odor:
p. 3
Mild to strong, rather pleasant; like wine or whiskey. Alcohol-like; Ethereal, vinous.
Taste: Pungent. Burning.
Molecular Weight: 46.07 g/mole
Color: Colorless. Clear
pH (1% soln/water): Not available.
Boiling Point: 78.5°C (173.3°F)
Melting Point: -114.1°C (-173.4°F)
Critical Temperature: 243°C (469.4°F)
Specific Gravity: 0.789 (Water = 1)
Vapor Pressure: 5.7 kPa (@ 20°C)
Vapor Density: 1.59 (Air = 1)
Odor Threshold: 100 ppm
Water/Oil Dist. Coeff.: The product is more soluble in water; log(oil/water) = -0.3
Dispersion Properties: See solubility in water, methanol, diethyl ether, acetone.
Solubility:
Easily soluble in cold water, hot water. Soluble in methanol, diethyl ether, acetone.

Conditions of Instability: Incompatible materials, heat, sources of ignition.
Incompatibility with various substances: Reactive with oxidizing agents, acids, alkalis.
Corrosivity: Non-corrosive in presence of glass.
Special Remarks on Reactivity:
Ethanol rapidly absorbs moisture from the air. Can react vigorously with oxiders. The following oxidants have been
demonstrated to undergo vigorous/explosive reaction with ethanol: barium perchlorate, bromine pentafluoride, calcium
hypochlorite, chloryl perchlorate, chromium trioxide, chromyl chloride, dioxygen difluoride, disulfuryl difluoride, fluorine nitrate,
hydrogen peroxide, iodine heptafluoride, nitric acid nitrosyl perchlorate, perchloric acid permanganic acid, peroxodisulfuric
acid, potassium dioxide, potassium perchlorate, potassium permanganate, ruthenium(VIII) oxide, silver perchlorate, silver
peroxide, uranium hexafluoride, uranyl perchlorate. Ethanol reacts violently/expodes with the following compounds: acetyl
bromide (evolves hydrogen bromide) acetyl chloride, aluminum, sesquibromide ethylate, ammonium hydroxide & silver
oxide, chlorate, chromic anhydride, cyanuric acid + water, dichloromethane + sulfuric acid + nitrate (or) nitrite, hydrogen
peroxide + sulfuric acid, iodine + methanol + mercuric oxide, manganese perchlorate + 2,2-dimethoxy propane, perchlorates,
permanganates + sulfuric acid, potassium superoxide, potassium tert-butoxide, silver & nitric acid, silver perchlorate, sodium
hydrazide, sulfuric acid + sodium dichromate, tetrachlorisilane + water. Ethanol is also incompatible with platinium, and
sodium. No really safe conditions exist under which ethyl alcohol and chlorine oxides can be handled. Reacts vigorously with
acetyl chloride
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.
p. 4
Routes of Entry: Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals:
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral
toxicity (LD50): 3450 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 39000 mg/m3 4 hours [Mouse].
Chronic Effects on Humans:
CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) by ACGIH. MUTAGENIC EFFECTS: Mutagenic for
mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC EFFECTS: Classified PROVEN for human.
DEVELOPMENTAL TOXICITY: Classified Development toxin [PROVEN]. Classified Reproductive system/toxin/female,
Reproductive system/toxin/male [POSSIBLE]. Causes damage to the following organs: blood, the reproductive system, liver,
upper respiratory tract, skin, central nervous system (CNS).
Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of skin contact (permeator), of ingestion.
Special Remarks on Toxicity to Animals:
Lowest Published Dose/Conc: LDL[Human] - Route: Oral; Dose: 1400 mg/kg LDL[Human child] - Route: Oral; Dose: 2000 mg/
kg LDL[Rabbit] - Route: Skin; Dose: 20000 mg/kg
Special Remarks on Chronic Effects on Humans:
May affect genetic material (mutagenic) Causes adverse reproductive effects and birth defects (teratogenic) , based on
moderate to heavy consumption. May cause cancer based on animal data. Human: passes through the placenta, excreted in
maternal milk.
Special Remarks on other Toxic Effects on Humans:
Acute potential health effects: Skin: causes skin irritation Eyes: causes eye irritation Ingestion: May cause gastrointestinal tract
irritation with nausea, vomiting, diarrhea, and alterations in gastric secretions. May affect behavior/central nervous system
(central nervous system depression - amnesia, headache, muscular incoordination, excitation, mild euphoria, slurred speech,
drowsiness, staggaring gait, fatigue, changes in mood/personality, excessive talking, dizziness, ataxia, somnolence, coma/
narcosis, hallucinations, distorted perceptions, general anesthetic), peripherial nervous system (spastic paralysis)vision
(diplopia). Moderately toxic and narcotic in high concentrations. May also affect metabolism, blood, liver, respiration (dyspnea),
and endocrine system. May affect respiratory tract, cardiovascular(cardiac arrhythmias, hypotension), and urinary systems.
Inhalation: May cause irritation of the respiratory tract and affect behavior/central nervous system with symptoms similar
to ingestion. Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may casue dermatitis, an allergic
reaction. Ingestion: Prolonged or repeated ingestion will have similiar effects as acute ingestion. It may also affect the brain.
Ecotoxicity: Ecotoxicity in water (LC50): 14000 mg/l 96 hours [Rainbow trout]. 11200 mg/l 24 hours [fingerling trout].
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.
Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental control regulations.
DOT Classification: CLASS 3: Flammable liquid.
p. 5
Identification: : Ethanol UNNA: 1170 PG: II
Special Provisions for Transport: Not available.
Federal and State Regulations:

California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,
birth defects or other reproductive harm, which would require a warning under the statute: Ethyl alcohol 200 Proof (in alcoholic
beverages) California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: Ethyl alcohol 200 Proof (in alcoholic beverages)
Connecticut hazardous material survey.: Ethyl alcohol 200 Proof Illinois toxic substances disclosure to employee act: Ethyl
alcohol 200 Proof Rhode Island RTK hazardous substances: Ethyl alcohol 200 Proof Pennsylvania RTK: Ethyl alcohol 200
Proof Florida: Ethyl alcohol 200 Proof Minnesota: Ethyl alcohol 200 Proof Massachusetts RTK: Ethyl alcohol 200 Proof
Massachusetts spill list: Ethyl alcohol 200 Proof New Jersey: Ethyl alcohol 200 Proof Tennessee: Ethyl alcohol 200 Proof
California - Directors List of Hazardous Substances (8 CCR 339): Ethyl alcohol 200 Proof TSCA 8(b) inventory: Ethyl alcohol
200 Proof
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the
European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada):
CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F). CLASS D-2A: Material causing other toxic effects
(VERY TOXIC).
DSCL (EEC):
R11- Highly flammable. S7- Keep container tightly closed. S16- Keep away from sources of ignition - No smoking.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 3
Reactivity: 0
Personal Protection: E
Health: 2
Flammability: 3
Reactivity: 0
Specific hazard:
Gloves. Lab coat. Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Splash goggles.
References:
-SAX, N.I. Dangerous Properties of Indutrial Materials. Toronto, Van Nostrand Reinold, 6e ed. 1984. -Material safety data
sheet emitted by: la Commission de la Santé et de la Sécurité du Travail du Québec. -Hawley, G.G.. The Condensed
Chemical Dictionary, 11e ed., New York N.Y., Van Nostrand Reinold, 1987. -The Sigma-Aldrich Library of Chemical Safety
Data, Edition II. HSDB, RTECS, and LOLI databases.
p. 6
Created: 10/09/2005 05:28 PM
Last Updated: 11/01/2010 12:00 PM
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume
no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for
their particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for
lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.com
has been advised of the possibility of such damages.
p. 7

Synthesis of Orange II - Kel - VII

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Synthesis of Orange II - Kel - VII

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LABORATORIUM KIMIA ORGANIK

HASIL PRAKTIKUM SINTESIS SENYAWA ORGANIK

Tanggal Percobaan : 26 November 2010

Data dan Perhitungan

Jumlah mol bahan yang digunakan pada setiap percobaan:

Asam Sulfanilat + Na2CO3 → 2 NaC6H4NH2SO3 + CO2 + H2 O

Ion besenasulfonatdiazzoium + β-naftol → Orange II

 Ruri Andika SP_071810301068  Rahmad Soleh_071810301073

HASIL PRAKTIKUM SINTESIS SENYAWA ORGANIK

Tujuan Percobaan : Studi sintesis orange II dari asam p-aminobensenasulfonat (sulfanilic

Anonim. 2010. www.wikipedia.com/wiki/orange_II. 24 November 2010

 Ruri Andika SP_071810301068  Rahmad Soleh_071810301073

Material Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Name: Sulfanilic acid Contact Information:

Section 2: Composition and Information on Ingredients

Name CAS # % by Weight

Section 3: Hazards Identification

Potential Acute Health Effects:

Section 4: First Aid Measures

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Section 6: Accidental Release Measures

Section 7: Handling and Storage

Section 8: Exposure Controls/Personal Protection

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Crystalline solid.)

Section 10: Stability and Reactivity Data

Section 11: Toxicological Information

Routes of Entry: Eye contact. Inhalation. Ingestion.

Section 12: Ecological Information

Ecotoxicity: Not available.

Section 13: Disposal Considerations

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Section 15: Other Regulatory Information

Section 16: Other Information

References: Not available.

1. PRODUCT AND COMPANY IDENTIFICATION

Product name : 2-Naphthol

CAS-No. EC-No. Index-No. Concentration

4. FIRST AID MEASURES

6. ACCIDENTAL RELEASE MEASURES

7. HANDLING AND STORAGE

Contains no substances with occupational exposure limit values.

9. PHYSICAL AND CHEMICAL PROPERTIES

Flash point 153 °C (307 °F) - closed cup

10. STABILITY AND REACTIVITY

11. TOXICOLOGICAL INFORMATION

Signs and Symptoms of Exposure

12. ECOLOGICAL INFORMATION

Elimination information (persistence and degradability)

14. TRANSPORT INFORMATION

15. REGULATORY INFORMATION

16. OTHER INFORMATION

MATERIAL SAFETY DATA SHEET

Date Printed: 02/28/2007

Section 1 - Product and Company Information

Product Name SODIUM CARBONATE ANHYDROUS SIGMAULTRA

Section 2 - Composition/Information on Ingredient

Substance Name CAS # SARA 313

Section 3 - Hazards Identification

For additional information on toxicity, please refer to Section 11.