Generic/Brand/Classification Dose Route
Celecoxib/ The lowest effective dose Oral
Celebrex/ should be used for each
Non-sterodial Anti- patient.
inflammatory Drugs
 For the
management of
osteoarthritis, the dose
usually is 100 mg twice
daily or 200 mg as a
single dose.
 For rheumatoid
arthritis, the dose
usually is 100 or 200 mg
twice daily.
 For acute pain or
menstrual cramps, the
dose is 400 mg as a
single dose on the first
day followed by an
additional 200 mg if
needed, then 200 mg
twice daily as needed.
 For FAP, the
recommended dose is
400 mg twice daily.
Indication Contraindication
>To relieve signs and > Contraindicated in
symptoms of osteoarthritis patients with
hypersensitive to drug,
>To relieve signs and sulfonamides, aspirin, or
symptoms of ankylosing other NSAID’s
spondylitis
>Contraindicated in those
>To relieve signs and with severe hepatic
symptoms of rheumatoid impairment and in the
arthritis treatment of perioperative
pain after coronary artery
>Adjunctive treatment for bypass graft surgery.
familial adenonmatous
polyposis to reduce the >Avoid use in the third
number of adenomatous trimester of pregnancy.
colorectal polyps
>Use cautiously in patients
with history of ulcers or GI
bleeding, advanced renal
disease, dehydration,
anemia, symptomatic liver
disease, hypertension,
edema, heart failure, or
asthma and in poor
CYP2CP metabolizers.
>Use cautiously in elderly
or debilitated patients.
Nursing Responsibility
>Patients allergic to or
with a history of
anaphylactic reactions to
sulfonamides, aspirin, or
other NSAID’s may be
allergic to this drug.
>Although drug may be
used with low aspirin
dosages, the combination
may increase risk of GI
bleeding.
>Can cause fluid retention;
monitor patient with
hypertension, edema, or
heart failure.
>Drug may be hepatotoxic.
Watch out for signs and
symptoms of liver toxicity.
>Before start of therapy,
rehydrate dehydrated
patients.
>Don’t confuse Celebrex
with Cerebyx or Celexa.