PATHOPHYSIOLOGY

PREDISPOSING FACTORS PRECIPITATING FACTORS

AGE: >50 years Family History of Liver Inflammatory Bowel Disease DIET: low residue, high fat, highly
old Cancer refined, low fiber

Growth of adenomatous polyps the polyps grow slowly, and most take 5 to 10 years or MALIGNANT malignant polyps
(adenomas) longer to be malignant POLYPS the

lack of reaction by the body's defense

diminished immune response mechanisms to foreign substances malignant polyps begin to invade the
bowel wall

tumors in the right

invasion of gram negative intestine
bacteria to the bloodstream

necrosis and ulceration

sepsis
malignant bowel tumors
spread by:

lymphatic and hematogenous direct extension to nearby

circulating endotoxins channels organs
 detachment of cancer cells from the spread of cancer cells into the blood
interact with white blood cells primary tumor stream
and blood vessel walls

microorganisms is able to replicate and altered lung lung metastasis

overwhelm host defenses functions

inflammatory response
establishment of blood sup
sites (angiogen

edema of alveolar lungs were filled with exudates due to Ineffective Airway
membrane inflammation Clearance liver metastasis

gases cannot pass through air cannot enter fluid filled

edematous membrane alveoli anorexia altered protein
Risk for Ineffective Tissue metabolism
Perfusion

Impaired Gas weight loss

Exchange impaired gas
diffusion

Risk for Imbalanced Nutrition: Less than

Ineffective Breathing Body Requirement
Pattern
ATING FACTORS

Sedentary Lifestyle

malignant polyps increases in size within

the lumen

gin to invade the

wall

tumors in the left

intestine

ulceration of the blood supply

wel tumors
by:

seeding of, or implanting of cells into

the peritoneal cavity
 establishment of cancer cells to
secondary sites

lungs liver

blishment of blood supply to secondary

sites (angiogenesis)

liver metastasis

altered protein
metabolism

weakness

an
Impaired Physical
Mobility

Risk for Impaired Skin

Integrity