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الصيدلى المحترف - الدرس الاول

الصيدلى المحترف - الدرس الاول

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منشور بواسطةmahgad

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Published by: mahgad on Feb 14, 2011
حقوق الطبع:Attribution Non-commercial

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12/21/2013

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– /

Hyperacidity – Gastric Ulcer

-

– /

duodenum

mucosa ( parietal cell )

– /

) ( ( ) Parietal cells

basolateral membrane

. mucosa mucosa .

– /

NSAIDs – mucosa . ( . ( ) . ) –

-

-

Helicobacter Pylorie

-

– /

parietal cells proton pump H/K ATPase antral G cells enterochromafin like cells vagal efferents -

( ATPase

) active transport intracellular basolateral membrane

extracelluar

. mucosa

– /

( .

)

-

.

gastric ulcer . Duodenal Ulcer ) ( ( )

-

-

gastric mucosa

-

– /

/
– – – • • • • • • • • • • • Proton pump inhibitos PPIs • • • • •

( ( /

) ) /

H2-Receptor antagonists

-

( )

– /

....

:

(-OH) HCl .

Carbonates /Bicarbonates
/ flavour

-

: ** : ** - rebound hyperacidity – – – . ( Brand Effervescent granules
/ . + Fawar fwakih

)

– *** name :

– /
flavour / / Fawar Fruit

/

. Fawar Lemon

/

. Fawar Cola / Pharofruit

/ + Pharocola

/ .

. + / Frutix

Frutamin plus

/

.

Epinos / / Xenos

– /
/ Vita care

/

. Multifruit

/

/

. ( ) ( ) Master effer k & c

Chewable tablets
/

:

Alucal

/ . + Alucal plus

/ . + + Glycodal

. Asylon

– /

(
OTC

)

(

)

Magnesium

/

oxide/Hydroxide

... ** **

: . formula *****************************

Magnesium Trisilcate

-

HCl . ******************************

– /

Aluminium Hyroxide

-

HCl : – . encephalopathy
*****************************

:

Alginic acid / Sodium alginate
( ( ) Algae )

-

*************************

Magaldrate ( Hydroxy magnesium Aluminate coplex)
HCL

– / : • • • •

Rebound acidity acid- base balance

Dimethicone /Simethicone
foam

/

-

.

:

-

< ....

<

<

-

. Acicon susp.

– /
Acicon chewable tablets

Antacid Jedco

Glycodal M Susp.

Miopan Susp.

– Riopan chewable

+ Asicon S susp.

– /
. Asicon S chewable

. Miopan Plus Susp.

+ Magsilon susp.

. Magsilon Chewable

Riopan

+ +

Sedomag susp.

.

+ Compagene Chewable +

– /

(

)

-

. + Algicap Susp.

+

Geveskone Susp.

+ +

Flux free Susp.

:

.

-

. Antacidine +

/ Maalox plus liquid sachet

– /
Alkasilon + +

Alusil

Glicosilon e

. Antacidine + +

Epicogel

+ +

Maloox Plus susp

Loburna susp

– /
. Maalox chewable tablets

. Alumage + + / Epcifam + +

+ +

Glycocain e

Mucalgine + +

Mucogel

. Moxidar + +

– /
:

(

)

.

-

. Laxomag . + + + + . + + Famo plus Laxofen

Semico

:

( OTC ... ************************

)

– / Antacid

H2- Receptor antagonist Proton Pump Inhibitos PPIs

-

– /

H2 Receptor antagonists
-

....... . ( ) tolerance . ) (

Cimetidine

-

( gynocomastia

) ** ** **

cytochrome P540

:

– /

...............
/ Aciloc 75

-

. / Aciloc 300

/ Acilight 75

/

. Aporantidin e / Histac 150

/ Histac 300

/ Epiran 75

/ /

. Rani cap

Rani 300 capsules

– /
/ Rantag 150

/ Rantag 300

/ Zantac 150

/ Zanatc 300

/ Ranitak 150 / Ranitak 300

/

. Ranitidine 150

/ . Ranitidine 300

– /
/ . Ranitidine 150

(

)

/ . Rantidol

( )
/ / / / .


/

( )

/

/

/

– /

....

– <

–( <

) < <

– < <

: : :

OTC

/ Antodine 20 / . Antodine 40 / . Antodine eff / Antodine amp

Antodine / Famotak 20 / . Famotak 40 ipci / Epicifam 20 / Epcifam 10 / Epcifam chewable / Famocid 20

– /
/ Famocid 40 . / / . Famotine 40 / . / Gasrtodomin a 20 . / Gasrtodomin a 40 Gastrofam 80 Famotin 20

/ Peptic 20 / Peptic 40 / . Servipep 20 / . Servipep 40 . / Peptofam 10

/ . Ulctect / . Ulfamid 20 / . Ulfamid 40

– /
/ . Peptifix chewable + +

( otc

)

** ** ** **

/ . Domadine 150 / . Domadine 300 / Nizatec 300 / Nizatine 150

Nizatine 300

/

. Receptoloc

/ . Ulcefree cap

– /

.....

*************************

Proton Pump inhibitors PPIs

) ( ) (

-

-

H+ /K+ ATPase . : ... ....

– /

Omeprazole
– .

-

/ Epirazole 20

/ /

/ /

/ .

/

.

/

.

/ / / /

– /
/

/ / /

/

.

/

/

/

/ / .

/ /

– /
/

/

/

.

/

/ /

/

.

/ /

– /
/ /

/ / / / .

(

)

-

OTC

-

– /


/ . Antopral 40

/ Antobral 40

Nycomide

/ Controloc 20

/ Controloc 40

/ Controloc vials

– /
/ Delpanto 20

/ /

. Pantazol 40

Nycomid

/ Pantazol vial

/ /

. Pantaloc 20

/ /

. Pantaloc 40

/

. Pantopi 20 / Pantopi 40 / Pantoprazole 40 / / . Peptoloc 40

– /
/ . Perloc 40

EPC

/ Protofix 20

/ Protofix 40

/ Protofix vial

Brand name . ) ( . – –

:

– /
/ Gastrocure 30

/

. Lansokan 15

/ Lansoprazole 15

/ Lantanon 30

/ Lanzor 15

/ Lanzor 30

T3A

/

. Lopral 30

/ Loral 30

– /
/ Peptazole / Zollipak 15 / Zollipak 30

-

/ Bepra 20

IDI

/ Idizole 20 / Pariet 20

/ Rabizole 10

/ Rabizole 20

/ Rabicid 10

– /
/ Rabicid 20

/ Ulcerostate 10

(

)
: :

-

AUG

/ AUG isoprazole 20 / / / / Isompex 40 / Isomeprazole 40 / Esogast 20 / / Klimazic 40 / Nexium 20 . Isopump 20

ICD

/ Nexium 40

– /
/ Nexium vial

TPI

/

enzyme inhibition

Cytochrome P450 . – .( ) – drug-drug interaction –

-

– /

Drug enhancing Defense mechanism
( )

mucosa NSAIDs

COX II COX1 NSAIDs .

– /

/ Misotac

/ Misoprost

/ Vagiprost

:

(

)

) .( .

– /

mucosa ... Proteas ( )

Gastric . Lymphoma carcinoma

– /

..

( ( ( – – ) –

) )

:
/

/ /

/

/ .

..

– /

OTC Applications

OTC

...... – . placebo – -

Mild hyperacidity : ) ( -

: . :

– / – –

+ +

-

Acute Hyperacidity

PPIs (

) : Chronic gastric ulcer

-

) (

.... / Copacapana ....

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