Cardiovascular System

Antihypertensive Drugs
( A ) Diuretics
1- Loop Diuretics:
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Furosemide Lafurex 4.5 LE Nausea, Gastric discomfort, Skin Aminoglycoside: increase the ototoxic It is used if the potential
Lasix 6 LE rash, and Orthostatic hypotension. potential risk. benefit gustifies the potential
Acetylsalicylic acid: risk to the fetus.
experience salicylate toxicity.
Bumetanide Edemex 3 LE Muscle cramps, Hypotension, Lithium: not given with diuretics because There are no adequate and well
Burinex 4.3 LE dizziness, Headache, Nausea, they reduce its renal clearance lead to controlled studies in pregnant
Hyperuricemia, Hperglycemia, Gout lithium toxicity. women.Nursing should not be
Hypochloramic alkalosis, skin rash Edemex: potentiates the effect of various undertaken,it may be excreted
Hyponatreamia, Hypokalemia. antihypertensive drugs. in milk.
2- Thiazide Diuretics:
Indapamide Natrilix 13 LE Muscular cramps, Debility, The dosage of other antihypertensive It is not recommended to be
hemihydrate Hypokalaemia, Hyperuriceamia agent reduced when used with natrilix,it administered during 1st trimester
and slight reduction in glucose potentiat action of diuretics, the need for of pregnancy or during lactation
tolerance. K+supplementation should be considered. unless physician considers that
It taken in the morning. benefites outweigh possible risk.
Hydrochlorothi- Hydretic 4 LE Although there is no evidence of
azide teratogenic effect in animal study
Headache, Nausea, constipation No interaction. the safety of the product during
and mild skin reactions. pregnancy and lactation has not
been established.
3- K+_ sparing Diuretics:
Spironolactone Aldactone 18 LE Gynecomastia, breast enlargment, The concomitant administration of K +
Muscle cramps, Diarrhoea, Ataxia, supplements is not recommended, it may It may cross placenta and it
Postmenopausal bleeding, Urticaria induce hyperkalemia. It increase the half- requires that the anticipated
Mental confusion, Drowsiness, life of digoxin. benefit be weighed against
Lethargy, Headache. Carbenoxolone: cause Na+ retention and possible hazard to the foetus, it
decrease effect of spironolactone appears in breast milk.

4- Carbonic anhydrase Inhibitors:

 Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Acitazolamide Cidamex 2.5 LE It is contraindicated for patient with
liver cirrhosis, it may cause very No interaction. NO evidence
mild reaction similar to those
reported from sulfonamide.
5- Combination of diuretics:
Kcl +Furosemid Octosemide 5 LE No side effect. It isn't used with ethacrynic acid, Lithium NO evidence.
and salicylates.
Spironolactone Aldactazide 3.9LE
+ Drowsiness, Gastrointestinal No interaction. It isn't taken because it appears
Hydrochlorothi- intolerance. in milk.
azide.
Amiloride+ Yostiretic 6 LE Alcohol, barbiturates: orthostatic
Hydrochlorothi- Moduretic 7.5 LE Headace, weakness, fatigue, b.p, hypotension may occur There is no evidence of
azide. malaise, tachycardia, arrhythmia, Antidiabetic Drugs: adjustment the dose a teratogenic effect.
nausea, vomiting, diarrhea, thirst, of these drugs is required Diuretics don't prevent production
gout, dehydration, hyponatremia, Corticosteroids: intensified electrolyte of toxemia.
rash, pruritus, flushing, diaphoresis. depletion, particulary hypokalemia. Thiazides appear in breast milk.

Spironolactone Lasilactone 8.5 LE Spironolactone: reduce effect of

+ carbenoxolone.
Furosemide Hyperkalemia, irregular pulse,
drowsiness, muscular weakness in
lower limbs,increase tenderness
of the nipples, breast enlargement
mental confusion, allergic reaction
hemolytic anemia, leukopenia,
thrombocytopenia,increase serum
cholesterol level, gastrointestinal
disorders, hyponatremia, dizziness.
Salicylates: attenuate the effect of If lasilactone has to be used in
spironolactone. nursing mothers, breast-feeding
Furosemide: diminishes the potency of should be stopped .
antidiabetic Drugs. It is not recommended during
It potentiate the nephrotoxic effects of pregnancy .
aminoglycosides.
The tablet should be swallowed with a
sufficient amount of liquid, preferably with
breakfast or lunch, it is not advisable to
take the drug in the evening because of
the incresed urine excretion expected.

( B ) Medication affect renin angiotensin system

1- ACE inhibitors:
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Captopril Hypopress D 15 LE It can interacts with K sparing diuretic,
+

Capoten 20 LE Cough, Angioedema, Anorexia,Rash
Captopril 6 LE Flushing, Nausea, Vomiting, Gastric
Farcopril 9 LE irritation, Hypotension, Tachycardia.
Enalapril Ezaprile 9.5 LE Vertigoes, cephalalgy, sense of
maleate fatiguing and asthenia, hypotension
orthostatic hypotension, syncope,
nausea, diarrhea, muscular cramps
rash, cough and angioneurotic
oedema with face, tongue, severe
respiratory difficulties.
Moexipril Hcl Primox 22 LE Hypotension, orthostatism,dizziness
disturbances of vision rarly also with
loss of consciousness,disturbances
of kidney function, proteinuria,Dry
cough, Angioedema, sinusitis,
myalgia, rhinitis, glossitis,headache
alopecia, onychlolysis, tiredness.
Perindopril coversyl 4 24 LE Gastrointestinal disorders, dizziness
cramps, an unproductive cough.
Lisinopril Zestril 7 LE Dizziness, headache, diarrhea, rash
Lisopril 8 LE cough, nausea, dry mouth, fever,
Sinopril 26 LE vometing, vertigo, hypoglycaemia.
Ramipril Tritace 18 LE Dizziness, headache, drowsiness,
Corpril 8 LE cough, skin reaction, impairment of
Ramipril 4.7 LE renal function, tachycardia, edema,
Flushing, Nausea, Vomiting, Gastric
disturbances.
antineoplastic, allopurinol, indomethacin, It isn't recommended in lactation
and oral anticoagulants. and pregnancy.
tablet taken on an empty atomach one
hour before meals.
Ganglioplegics blockers: used with
caution . No proper an well cotrolled study
Beta-blocking drugs, methildopa and on pregnant women, it is not be
diuretics: enhance the antihypertensive administered in case of
effect of enalapril maleate. ascertained or supposed
The association with Ca +2 antagonists is pregnancy, it is not known that
not advisable, lithium salts may cause an this drug is detectable in milk.
of the serum concentration of lithium.
K+ sparing diuretics: can lead to an They must have been excluded
increas in the serum of potassium conc. . and the possibility of conception
Diuretics: potentiat the antihypertensive must be prevented.
effect of primox. Breast-fed infants must weaned
Lithium: increase the serum level of it owing to the lack of sufficient
Narcotics: pronounced decline in the B.p therapeutic experience, it must
Alcohol : effect of alcohol is potentiated. not be used in pregnancy.
No interactions. It is not recommended in lactation
and pregnancy.
It can interacts with diuretics, (NSAIDs), It is not recommended to be used
lithium, insulin or oral antidiabetics, other in pregnancy and lactation.
antihypertesive drugs.
(NSAIDs) and acetylsalicylic acid: It must not be taken during
attenuation of the antihypertensive effect of pregnancy, if tritace is necessary
tritace is ti be anticipated, it potentiate the during lactation, the patient must
effect of alcohol, heparin: rise in serum K+ not breast-feed, prevent infant
cocentration possible. from ingesting ramipril with milk.

2- Angiotensin ∏ Receptor antagonists:

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Losartan K+ Kanzar 12 LE hyperkelaemia, angioedema, Concomitant use of it with K + sparing
 losartan 18 LE hypotension, diarrhea, dizziness, diuretics(triamterene, amiloride) may lead
Cozaar 52 LE dry cough, myalgia, migraine, rash to increase in serum potassium It should not be used during
Losarmepha 13.5 LE urticaria, pruritus, anaemia, rarely The antihypertensive effect of losartan may pregnancy and lactation.
hepatitis, vasculitis, leg pain, cramp be blunted by the NSAID indomethacin.
insomnia, nasal congestion.
Valsartan Tareg 48 LE No clinically interaction when it is used
with amlodipine,atenolol,cimetidine,digoxin
Headache,dizziness, diarrhea,rash, Warfarin: not affect on the action of this It should not be used during
vertigo, cough, allergic reactions, drug. pregnancy and lactation.
dry mouth, myalgia,cramps,syncope Concomitant use of it with K + sparing
vomiting,dyspnea,anorexia. diuretics(triamterene, amiloride) may lead
to increase in serum potassium
Telmisartan Micardis 66 LE back pain, chest pain,cystitis, Preclinical studies don't indicate
abdominal pain, diarrhes, dyspepsia Telmisartan: increase the effect of other teratogenic effect,but have shown
Gastrointestinal disorders, myalgia antihypertensive agents. fetotoxicity, it should preferably
Arthralgia, cramps, pharyngitis, Reversible increase in serum lithium not be used during first trimester
sinusitis, skin disorders (eczema) concentrations and toxicity of pregnancy, it is contraindicated
during lactation,it appear in milk
Candesartan Atacand 40 LE Dizziness,vertigo,headache,myalgia no clinically interaction when it is used It should not be used during
Atacand plus 120 LE back pain,arthralgia,renal failure, with,digoxin,warfarin,oral contraceptives, pregnancy, if pregnancy is
Angioedema,rash,urticaria,pruritus, its antihypertensive effect may enhanced detected during treatment,
nausea,hyperkalaemia,leukopenia, by other antihypertensive agents atacand should be discontinued
hypotension, Reversible increase in serum lithium it should not be used during
concentrations and toxicity breast-feeding, it appears in milk.
( C ) Calcium channel blocker
Amlodipine alkapress 9 LE Headache,dizziness,nausea,edema Thiazide diuretics, beta blokers, NSAD safety of it on human pregnancy
besylate Amilo 28 LE fatigue, somnolence,abdominal pain long acting nitrates,oral hypoglycemic and lactation has not been
Norvasc 67.5 LE flushing, palpitations drugs:they have been safetly administered established. It could be used only
Myodura 9 LE with amlodipine if there is no safer alternative

( D ) Antiadrenergic druges
1- Beta - receptor Blocker:
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Atenolol Ateno 50 3.2 LE Ca channel blockers (diltiazem):
+2

Tenormin 50 6.6 LE Bradycardia,hypotension, fatigue, may have an additive effect when used with It used only if the benefit justifies
Atelol 50 3.5 LE lethargy,depression, nausea, rash Ateno®.Catecholamine-depleting drugs the potential risk, nursing should
 Blokium 50 5 LE cold extremeties, heart failure,
(Reserpine): have an additive effect when bediscontinued by mothers
vomiting,dyspnea,diarrhea. used with Ateno®.It alter dosage receiving Ateno®
requirement of insulin, oral antidiabetics in
previously stabilised diabetic patients.
Sotalol Hcl Betacor 4 LE Due to its beta-blocking action Ca+2 channel blockers (diltiazem),class 1 It is not recommended to be used
e.g: hypotension, bradycardia and antiarrhythmic drug ,antihypertensive agent in pregnancy and lactation
conduction disturbances in AV node leading to increase pharmacological effect.
Bisoprolol- Concor 14 LE Concor ® may potentiate the effect of
Furarate Bisocard 17 LE Dizziness,headache,nausea, other antihypertensive drugs,cocomitant It is not known that this drug pass
Bistol 6.5 LE perspiration, insomnia, diarrhea, therapy of concor ® and reserpine, into milk.Therefore, breastfeeding
muscle cramps, increase in airway a-methyldopa,clonidine or guanfacine may is not recommended during
resistance(asthmoid bronchitis) cause a considrable decrease in heart rate concor ® therapy

Propramolol Hcl Inderal 2.5 LE Caution must be exercised in( the use of it
and hypoglycaemic therapy in diabetic It should not be used during
Bradycardia,hypotension, dizziness patients, indreal prolong effect of insulin) pregnancy unless its use is
cold extremeties, heart failure, also in(prescribing a β- blocker with class1 essential,most β-blocker will pass
nightmares, insomnia, mood change antiarrhythmic drugs (disopyramide) into breast milk although to a
hypoglycaemia in neonates Digitalis glycosies may increase the variable extent.Breast-feeding is
atrioventricular cnduction time when used not recommended following the
with beta-blockers administration of this compound

Metoprolol Betaloc 10 LE Bradycardia, postural hypotension It concomitant treatment with clonidine is

cold extremeties, nausea, diarrhea, to be discontinued, β-blocker drugs should It should not be used during
dizziness, headache, dyspnea, be withdrawn several days before clonidine pregnancy and lactation unless
constipation, abdominal pain, β-blocker drugs may enhance the negative its use is essential, most
palpitations. inotropic effect when metoprolol is used β-blocke will pass into milk
with Ca+2 antagonists

2- Alpha, Beta - receptors Blockers:

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Carvediol Carvid 12.5 LE Bradycardia, postural hypotension ACE inhibitors, Alcohol: enhanced the
Cardilol 20 LE dizziness, headache, insomnia hypotensive effect.(NSAIDs): antagonise
Carvipress 9 LE Gastrointestina disturbances hypotensive effect.Antiarrhythmic: NO evidence.
Dilatrol 24 LE fatigue, cold extremeties, oedema increased risk of myocardial depression
dry mouth,impotence, eye irritation, Ca+2 channel blockers: increased risk of
 leukopenia, thrombocytopenia, bradycardia and AV block with diltiazem
3- Alpha - receptor Blocker:
Doxazosin Cardura 44 LE Although there is no evidence of
teratogenic effect in animal study,
dizziness, headache, nausea, It has no effect on protien binding of safety of it on human pregnancy
postural hypotension, diarrhea, digoxin, warfarin, phenytoin, indomethacin and lactation has not been
abdominal pain, fatigue, vomiting, It has been used without side effect with established,
edema, rash, urticaria, pruritus, thiazide diuretics,frusemide, β- blockers it should not be used during
vertigo, (NSAIDs), or anticoagulants. pregnancy and lactation unless
physician considers that benefite
outweigh possible risk.
4- Alpha 2 - receptor Blocker:
Methyldopa Aldomet 18 LE

headache, muscular weakness,
sedation, nightmares, dizziness,
bradycardia, orthostatic hypotension
edema, rash, vomiting, nausea,
diarrhea, constipation, flushing
liver disorders, breast enlargement
leukopenia, thrombocytopenia,
nasal stuffiness , myalgia.
Lithium: when it used with methyldopa, It is used under medical and
should be monitored carefully for symptom obstetric supervision for the
of lithium toxicity treatment of hypertension during
Other antihypertensive drugs:when used pregnancy.there was no clinical
with methyldopa, the hypotension effect evidence that this drug caused
is potentiated,patient should be monitored fetal abnormalities,but it can pass
carefully to detect side reactions or the placental barrier
unusual manifestation of drug idiosyncrasy Methyldopa appears in milk.
Iron: it decrease the bioavailability of therefor, caution should be is
methyldopa, this may adversely affect exercised if aldomet given to a
blood pressure control breast-feeding mother.

( E ) Combinations
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Captopril + Normaten 10 LE dizziness, headache, cough K+ retaining diuretics (spironolacton, It isn't recommended to be used
Indapamide hypersensitivity reaction,skin rashes triamterene,amilopide): not used with in pregnancy and lactation
normaten.
Captopril + Capozide 31.5 LE dizziness, headache, diarrhea, Captopril: decreases the aldosterone
hydrochlorothiazid fatigue, Malaise, rash, nausea, production,elevation of serum potassium It is execreted in milk, therefor
taste alteration, hypotension (NSAIDs): Concomitant therapy with breast-feeding should be avoided
 edema. indomethacin may require an increase in
the dose of captopril .
Lisinopril Zestoretic 23 LE dizziness, headache, diarrhea, K+ sparing diuretics: can lead to an It is contraindicated in the 2nd,
dehydrat + Lisitens 15 LE orthostatic hypotension, cough, increas in the serum of potassium level . 3rd trimesters of pregnancy
hydrochlorothiazid nausea, vomiting, rash, fatigue, Lithium: should not be given with diuretic It isn't known that this drug pass
muscle cramps, impotence, indomethacin: diminish the hypotension into milk.
asthenia, vertigo, leukopenia, efficacy of using hydrochlorothiazid.
Enalapril Ezapril-co 14 LE dizziness,angioneurotic oedema β- blockers and methyldopa: enhance
maleate + Enalazide 17 LE with face, tongue, lightheadedness, the antihypertensive effect of ezapril-co NO evidence.
hydrochlorothiazid and symptoms of K+ loss occur in Lithium: increase the serum level of it
the elderly
Valsartan + Co Dioven 57 LE dizziness, headache, diarrhea, Concomitant use of it with K+ sparing It isn't recommended to be used
hydrochlorothiazid Co-targ 56 LE insomnia, nausea, cough, myalgia, diuretics(triamterene, amiloride) may lead in pregnancy and lactation
muscle cramps, impotence. to increase in serum potassium level It isn't known that this drug pass
into milk.
Ramipril + Tritace comb 25 LE headache, taste change, cnfusion Lithium: increase the serum level of it It isn't recommended to be used
hydrochlorothiazid loss of appetite, depressed mood methyldopa: possible hemolysis in pregnancy and lactation
anxiety Allopurinol:increase likelihood of blood It isn't known that this drug pass
picture changes. into milk.
Losartan K+ + Hyzaar 52 LE dizziness, headache, nausea, rash, Lithium: increase the serum level of it It isn't recommended to be used
hydrochlorothiazid Fortzaar 45 LE sweating, angioneurotic oedema Corticosteroids: intensified electrolyte in pregnancy and lactation
fatigue, depletion, particulary hypokalemia.
Atenolol + Blokium dui 11.5 LE muscle cramps, fatigue, nausea it should not be used during
Chlorothiazide Tenedone 50 11 LE cold extremeties, sickness, No interaction. pregnancy and lactation except
leukopenia, thrombocytopenia. doctor decides necessary of it

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Amiloride Hcl + Atenoretic 14 LE cold extremeties, muscle cramps, Ca+2 antagonists: potentiate effets of It should used only if possible
hydrochlorothiazid fatigue, Bradycardia, hypoglycaemia β- blockers. Diltiazem: enhance the effect benefit justifies the potential risk
Atenolol glycouria, of atenolol to the foetus, It used with caution
in nursing mothers.
Alcnolol + Tenolate SR 10 LE Gastrointestina disturbances, Combination of nifedipine and atenolol is It isn't recommended to be used
Nifedipine headache, dizziness, fatigue, usually well tolerated in pregnancy and lactation
oedema, hypotension, tachycardia,
Atenolol + Teklo 16.5 LE Bradycardia, cold extremeties,
 Amiloride postural hypotension, leg pain,
headache, dizziness, vertigo,
diarrhea,nausea, vomiting,
drowsiness.
Bisoprolol + Lodoz 27 LE headache, dizziness, tiredness
hydrochlorothiazid concor-5-plus 6 LE Gastrointestina disturbances, gout
peripheral circulatory problems
Reserpine + Brinerdine 12 LE
clopamide + hypoten 6 LE
Dihydroergocristin Gastrointestina disturbances,
orthostatic hypotension, fatigue,
thrombocytopenia,mental
depression,muscle weakness
Antiarrhythmias Drugs
Propafenone Rytmonorm 28 LE diarrhea,nausea, vomiting, vertigo,
loss of appetite,blurred vision,
convulsion, dizziness,
Amiodarone Hcl Cordarone 18 LE Corneal deposition,occasionally
aociated with colored haloes in
bright light.rarely, pigmentation or
photosensitization may occur
Thyroid dysfunction .Rarely,
respiratory disorders may occur
No interaction.
No interaction.
thiazide: lower renal lithium clearance
(NSAIDs): diminish the excretion of Na+
and water , the dosage of Brinerdine may
have to be increased when such drugs are
used concurrently.Reserpine: may cause
serious potentiation of their CNS
depressant effect .
local anaesthetics: potentiate the effect of
rytmonorm, it increases the plasma level
of metoprolol, propanolol and digoxin
Like all active products this drug may
induce more or less
NO evidence.
It isn't recommended to be used
in pregnancy and lactation
It isn't recommended to be used
in pregnancy and lactation
it should be given critical
consideration in accordance with
present views on the use of drug
in the first trimester.
It isn't recommended to be used
in pregnancy and lactation

Respiratory System
( A ) Mucolytic Drugs
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Carboxy methyl Mucosol 5 LE Gastric irritation, Skin rashes, in
cysteine hypersensitive patients. No interaction. NO evidence

Acetylcistein ACC Long 32 LE Antibiotic: should taken at intervals of at

least 2 hours
Diarrhea, vomiting, heartburn, Antitussive: cause a dangerous It should not be used during
 nausea, headaches, inflamations of congestion of secretion due to reduced pregnancy and lactation except
the mucous membrane in the mouth cough reflex. doctor decides that this drug is
Tinnitus, bronchospasms. Nitroglycerin: using ACC long enhanc absolutely necessary.
vasodilating effect of nitroglycerin.
the solution is to be drink after meals
Bromohexine Bisolvon 3.3 LE
Hcl Gastro-intestinal disturbances. No interaction. NO evidence.

Bromohexine All vent 4.5 LE Adverse metabolic effects of high dose β 2- Safety of it hasn't been studied in
Hcl + Tremor, nervousness, palpitations, agonist such as terbutaline may be pregnancy and lactation probable
Guaiphenesin + vomiting, dizziness, drowsiness, exacerbated by concomitant administration benefit should be weighed against
Terbutalline nausea, headache, muscle cramps of high doses of corticosteroids. possible risks before prescribing
Ephedrine: shouldn't taken with terbutalin All vent during pregnancy and
lactation.
Ambroxol Hcl Bronchopro 7.25 LE Gastro-intestinal disturbances, Bronchopro should not be used
Ambroxol 3.5 LE Diarrhea, Skin rashes, No interaction. during the first trimester of
pregnancy
Ambroxol Hcl + Mucosin 5 LE No disruption of gastric barriers and Not yet recommended in the first
Guaifenesin well tolerated No interaction. trimester of pregnancy

Bromhexine Hcl Solvin 3.5 LE

extract senega + It is well tolerated and no side effect Tablet should be given cautiously to patient NO evidence.
ipeca, tolu syrup+ ocures. with gastric ulceration.
anise oil
( B ) Anti- tussive Drugs
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Pipazethate Hcl Selgon 5 LE Selgon® drops should preferably be taken Pregnant women are requested to
drowsiness. on sugar or with some fluid inform their physician about the
ingestion of Selgon®
Chlorophenira- Cyrinol 6 LE
mine + used with caution in hypertension No interaction. It is not recommended to be used
Pholcodine in pregnancy and lactation

Pentoxyverine Cabella 5 LE Cutaneous allergic reactions, vertigo The use of alcohol containing medication
citrate Digestive trouble(nausea & vomiting) potentiates the sedative effect of centrally It is not recommended to be used
 constipation, dry mouth, somnolenc, acting antitussives. in pregnancy and lactation
bronchial hyposecretions
( C ) Bronchial Asthma + COPD
Salbutamol Ventolin 13 LE It should be used in the first
Salbovent 3 LE Tremor, headache, palpitations, Non selective β-blocking drugs (propanolol) trimester only if absolutely
Broncal SR 16 LE muscle cramps, slight tachycardia, shouldn't be taken with Salbutamol essential care is required in
Salbutamol 1.5 LE urticaria, angioneurotic oedema also corticosteroids, diuretics, theophylline patients with ischaemic heart
hypokalemia shouldn't be taken with Salbutamol disease, it appears in breast milk

Salbutamol + Clenil 14 LE the product is to be administered

Dipronionate +
Beclomethasone local fungal infection in mouth and
throat, light muscular tremor
complained of hoarseness.
in cases of renal necessity and
β-blocking drugs (propanolol) shouldn't be under the direct control of the
taken with Salbutamol physician; in these cases the
interrupted use more than 10 day
should be avoided

Terbutaline Aironyl 2 LE Non selective β-blocking drugs (propanolol)

Bricanyl 4 LE Tremor, headache, tachycardia, may inhibit the effect of beta stimulant the drug is only used during
palpitations, dizziness, hypokalemia corticosteroids, diuretics: may increase pregnancy if cleary needed
the risk of hypokalemia it excreted into breast milk

Ketotifen Allerban 7.7 LE drowsiness, dry mouth, slight it potentiate the effect of sedatives, alcohol NO evidence.
dizziness, hypnotics, antihistaminics

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Montelukast Clear air 35 LE
There are no adequte and well-
No side effect. No interaction. controlled studies to date using it
during pregnancy and lactation

Salmeterol + Seretide 120 LE the administration of this drug

fluticasone
paradoxical bronchospasm
Tremor, headache, palpitations,
complained of hoarseness,
tachycardia, muscle cramps,
during pregnancy and lactation
Non selective β-blocking drugs (propanolol) should only be considered if the
may inhibit the effect of beta stimulant expected benefit to the mother is
greater than any possible risk to
the foetus or child
Foramoterol Foradil 87 LE β-blocking drugs: inhibit effect of foradil The safety of foradil on pregnancy
fumarate Tremor, palpitations, headache, Quinidine, procainamide: may increase and lactation has not yet been
oedema, nausea the risk of ventricular arrhythmia. established.

Fenoterol Berotec 4.9 LE during the first trimester of

hydrobromide Restlessness, palpitations, fine β-blocking drugs: in adequate doses pregnancy, Berotec should only
tremor of the fingers, dizziness, counteract the action of Berotec be used after consultation with
fatigue, headache, sweating the doctor

Anhydrous Quibron T/SR 60 LE Adenosine:Theophylline blocks adenosine There isn't evidence of teratogenic
theophylline Minophyllin 6.15 LE Headache, nausea, vomiting, recptors. effect in pregnant woman
insomnia, cardiac arrhythmias, Aminoglutethimide: increases clearance It excreted in breast milk causes
diarrhea, tremor, tachycardia. of theophylline by induction of microsomal irritability of mild toxicity in
enzyme activity.also with carbamazepine nursing human infants

Budesonide Pulmicort 40 LE Oral ketoconazole: increased the plasma Clinical experience from pregnant
Rhinocort 27 LE Local irritation, slight haemorrhagic concentrations of oral budesonide, this women is limited .In common with
nasal secretion, epistaxis, angio- interaction is lacking for nasal budesonide other glucocorticosteroids, has
oedema, urticaria, rash,dermatitis, but greatly increased plasma levels are been shown to cause
pruritus. expected there too malformation,it shouldn't be given
during pregnancy and lactation

Central Nervous System

( A ) Anti-parkinsonism Drugs
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Biperiden Hcl Akeniton 13.5 LE Antihistamines, other anticholinergic
Gastro-intestinal disturbances, psychotropic drugs : aggravate the CNS There isn't evidence of teratogenic
dry mouth, mydriasis,photophobia, peripheral side effects. effect in pregnant woman
constipation, nausea, tachycardia Quinidine: enhance the cardiovascular It excreted in breast milk.
difficult urination, allergic reactions effects.

Levodopa + Sinemet 20 LE Dyskinesias, dystonic, nausea, Antihypertensives: Postural hypotension using of levodopa in women of
Carbidopa Levocar 12 LE muscle twitching, blepharospasm , occurred.Risperidone: reduce the effect childbearing potential require that
syncope, chest pain, anorexia, of levodopa. the anticipated benefits of a drug
 palpitation, hypertension, phlebitis High protein diet: impair the absorption be weighed against possible
vomiting, diarrhea, leukopenia, of levodopa. hazards should pregnancy occur.
angioedema. it isn't known that levodopa is
excreted in human milk.
( B ) Anti-epileptic Drugs
Gabapentin Conventin 14.5 LE Somnolence, backache, dizziness, It should be administered 2hr after the It should used only if possible
fatigue, headache, nausea, vomiting intake of antacids. benefit justifies the potential risk
to the foetus.
( C ) Anti-depressant Drugs
Tianeptine Stablon 15 LE Fatigue, nausea, constipation, loss MAOIs : should leave 2 weeks after It should used only if doctor
of appetite, insomnia, drowsiness, discontinuation of treatment with MAOIs decides that this drug is
palpitation, headache, dry mouth. absolutely necessary.

Escitalopram Cipralex 86 LE Nausea, sinusitis, loss of appetite, Lithium: high fever, muscle contraction It should used only if doctor
dizziness, diarrhea, fatigue, fever, Imipramine: eliminate more slowly when decides that this drug is
sexual disturbances, constipation. it administered with Cipralex. absolutely necessary.

Sertraline Hcl Moodapex 18 LE Nausea, vomiting, dry mouth, Cimetidine: inhibits the metabolism of It should used only if possible
dizziness, diarrhea, sweating, sertraline and may result in decrease in benefit justifies the potential risk
rhinitis, weight loss, vertigo, the clearance. to the foetus.
hyperkinesia, myalgia

Gastrointestinal Tract
( A ) Anti-Spasmodic Drugs:
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Phenobarb + Spasmotal 3 LE other anticholinergics: potentiate the
Pipenzolate Br Dry mouth, constipation, sedation effect of pipenzolate Br NO evidence.
urine retention. Antihistamines: antagonizes the action
of metoclobromide.
Zingeber, Dill Aqua Ream 8.5 LE
seed oil,caraway vomiting is rare No interaction. NO evidence.
fennel, ZnSO4

Hyoscine-N- Scopinal 5 LE Dry mouth, constipation, Antacids, antidiarrheais : reduce the safety of it on pregnancy/lactation
butylbromide Buscopan 4 LE drowsiness. absorption of anticholinergics. has not yet been established.
 Hyoscine-N- Buscopan plus 3.6 LE Paracetamol : in high doses, may cause Available but limited preclinical
butylbromide Rubefaction, thrombocytopenia, liver damage when it taken with hypnotics data has shown no hazard, but
+ leukopenia, allergic reactions, and anti-epileptics The safety of it on pregnancy
Paracetamol agranulocytosis, pancytopenia, Metoclopramide : increase absorption and lactation has not yet been
bronchospasm, liver damage. rate of paracetamol established.

Propyphenazone Spasmo- 1.75 LE Hypersensitivity reactions, urticaria, Rifampicin : alter the half-life of propyph- It should used only if possible
/ Drofenine Hcl cibalgin pruritus, exanthema, angioedema, enazone.Hexahydro-adiphenin Hcl : benefit justifies the potential risk
bronchospasm, shock, nausea, increase the anticholinergic effects of to the foetus, it pass into breast
tachycardia, leucopenia, vomiting. amantadine, quinidine. milk.

Mebeverine Hcl Colospasmin 6.8 LE Gastro-intestinal disturbances,

fort dizziness, headache, insomnia, No interaction. It is better to avoid using this
allergic reactions, urticaria. drug during pregnancy.

Clidinium Br + Cloxide 4.5 LE dry mouth, constipation, urinary Cloxide : should be taken cautiously
Chlordiazepoxid hesitancy, thickness of bronchial with alcohol, cimetidine, atropine, some It isn't recommended to be used
Hcl secretion, decrease of lachrymal antiarrhythmics, anticholinergics, CNS in pregnancy and lactation
secretion, drowsiness. depressants, antitussives.

( B ) Antidiarrhoeal Drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Metronidazol Elyzol 5 LE It inhibit metabolism of warfarin and thus It crosses the placenta and not
Flagyl 6 LE Gastro-intestinal disturbances, enhance its effect. Metronidazole and be given in the 1st trimester, it
nausea, headache, insomnia, disulfiram has been reported to cause occurs in breast milk,so nursing
vertigo, drowsiness, skin rashes acute psychosis or confusional state mothers shouldn't be given it.

Tinidazole Protozol 6 LE nausea, dizziness, headache, tablets should be given during or after It is not recommended to be used
vomiting, dry mouth, metallic taste. meals. No interaction in pregnancy and lactation

Diloxamide + Furazol 4.5 LE Gastro-intestinal disturbances, It inhibit metabolism of warfarin and thus
Metronidazol vomiting, metallic taste, nausea, enhance its effect. When given with It is not recommended to be used
urticaria, headache, ataxia, dark in alcoholic beverages, Furazol may in pregnancy and lactation
urine colour, angioedema. produce abdominal cramps, vomiting.
 Dioctahedral Smecta 5 LE It is recommended not to administer any
smectite constipation in very rare other drugs at the same time as Smecta NO evidence.

Mesalazine Pentasa 9 LE Gastro-intestinal disturbances, Corticoids : increase the bleeding of GIT It should used only if possible
headache, vertigo, allergic reaction Furosemide : decrease action of diuretic benefit justifies the potential risk
to the foetus.
( C ) Laxative Drugs :
Lactulose Lactulose 10 LE It must never be taken on an empty
Flatulence, diarrhea stomach, but only after meals NO evidence.

Norethisterone Cidolut Nor 5 LE phenylbutazone, hydantions, rifampicin,

in rare case nausea may occur ampicillin, barbiturates, since they impair It is not recommended to be used
the action of steroid hormones. in pregnancy and lactation

Phenolphthalan Compound 0.5 LE It should not be given to patients

Senna, lichen laxative with symptoms of appendicitis, No interaction. It is not recommended to be used
intestinal obstruction, abdominal in pregnancy and lactation
pain of unknown cause.

( D ) Anti-peptic ulcer drugs :

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Ramitidine Rani 4 LE Antacids : decrease ranitidine absorption.
Epiran 6 LE Ketoconazol : ranitidine decrease effect
Aciloc 6 LE headache, skin rashes, dizziness, of this drug. It should be used during
Zantac 20 LE constipation, nausea, diarrhea, Ranitidine : increase the hypoglycemic pregnancy and lactation if clearly
mental confusion. effect of glipizide. indicated.
It decrease renal clearance of procainamid
and interfere with the clearance of warfarin.

Famotidine servipep 15 LE It isn't recommended to be used

Antodine 9 LE headache, dizziness, constipation, in pregnancy and lactation
diarrhea, nausea, vomiting, dry No interaction. It should used only if doctor
mouth, fatigue, decides that this drug is
absolutely necessary.

Pantoprazole Controloc 90 LE headache, constipation, diarrhea, it isn't known that pantoprazole

 abdominal pain, allergic reactions,
nausea, dizziness, muscular cramp
swelling of the lower arms and legs
fever, depression, flatulence,
visual disturbance.
It may increase or reduce the absorption
of Ketoconazole.
is excreted in human milk.
Clinical experience from pregnant
women is limited, It should used
only if possible benefit justifies
the potential risk to the foetus.

Omeprazole Gastroloc 21 LE Headache, skin rashes, dizziness,

constipation, nausea, diarrhea,
vertigo, alopecia, myalgia, arthralgia
mental confusion, agitation, dry
mouth, abdominal pain, somnolence
fatigue
It should used only if possible
No interaction. benefit justifies the potential risk
to the foetus.
it isn't known that omeprazole
is excreted in human milk.

Nizatidine Ulcfree 17 LE Headache, abdominal pain, Interaction may occur with high doses of
dizziness, diarrhea, constipation, asprin and other salicylates so should be It isn't recommended to be used
sneezing or skin rashes. take antacids 1 or 2 hr of taking Ulcfree. in pregnancy and lactation.

Antimicrobial Drugs
Sulfa drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
sulphamethox -- Sutaprim DS 5 LE
azol + Septazol 4 LE Nausea, vomiting, diarrhea, skin Co-administration of Septazol, warfarin, It isn't recommended to be used
Trimethoprim Sutrim 3 LE rash. phenytoin, pyrimethamine, oral, hypogly- in pregnancy and lactation.
Septrin DS 7 LE cemics are not recommended.
Chemotrim 1.7 LE

Anti-tuberculosis & Leprosy :

Rifampicin Rimactane 8 LE Reddish discoloration of body fluids Antacids, opiates, anticholinergic, It isn't recommended to be used
uriticaria, exudativecongunctivitis, ketoconozole : reduce the bioavailability in pregnancy and lactation.
pemphigoid reactions. of rifampicin. It passes into the breast milk.

Isoniazide + Rimactazid 6.6 LE Reddish discoloration of body fluids

Rifampicin uriticaria, exudativecongunctivitis, Antacids, opiates, anticholinergic, It isn't recommended to be used
pemphigoid reactions, Nausea, ketoconozole : reduce the bioavailability in pregnancy and lactation.
diarrhea, abdominal pain, hepatitis, of rifampicin. It passes into the breast milk.
 headache, dizziness, mental concomitant use of halothane & isoniazide
confusion, ataxia, leucopenia, may increase the risk of hepatotoxicity.

Anti-helminthes :
Mebendazole Antiver 2 LE Gastro-intestinal disturbances, It isn't recommended to be used
diarrhea, abdominal pain. No interaction. in pregnancy and lactation.

Flubendazole Fluvermal 12 LE It isn't known that fluvermal is

diarrhea, abdominal pain, rashes, excreted in human milk.
exanthema, urticaria, angioedema. No interaction. It isn't recommended to be used
in pregnancy and lactation.

Albendazole Bendax 5 LE diarrhea, abdominal pain, Dexamethasone, praziquantel and

Alzental 2.3 LE leucopenia, headache, dizziness, cimetidine : increase plasma concentrat- It isn't recommended to be used
Vermizole 1.5 LE thrombocytopenia. ions of albendazole sulphoxide. in pregnancy and lactation.

Antifungal Drugs ( systemic ) :

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Griseofulvin Ultragrisofulvin 3.5 LE rashes, itching, headache, fatigue It isn't recommended to be used
dizziness, leucopenia, proteinuria, Griseofulvin : it reduce the anticoagulant in pregnancy and lactation.
paraesthesia of hands & feet, effect of coumarins. Barbiturates : may the male partner must stop the
oral thrush and photosensitivity. inhibit the action of griseofulvin. drug for at least 6 months.

Terbinafine Lamisil 54 LE Plasma concentration of terbinafine may

Terbin 26 LE diarrhea, nausea, anorexia, rashes be increased by drugs that inhibit its It isn't recommended to be used
Fungisafe 7 LE headache, urticaria, arthralgia, metabolism by cytochrome P450 in pregnancy and lactation.
photosensitivity, hepatitis, jaundice, ( cimetidine ) & decreased by drugs that
induce cytochrome P450 (rifampicin ).

Itraconazol Itrapex 16 LE nausea, constipation, dyspepsia, Itrapex : may iteract with rifampicin,
headache, irregular menstruation, phenytoin, terfenadine, astemizole, It isn't recommended to be used
pruritis, urticaria, hypokalemia. cisapride, midazolam, triazolam, digoxin. in pregnancy and lactation.

Fluconazole Fungicam 10 LE Concomitant administation of rifampicin

Flucoral 14 LE diarrhea, abdominal pain, vomiting, with fluconazole reduce plasma concen- It isn't recommended to be used
Flocazole 9 LE nausea, flatulence, headache, trations of fluconazole. in pregnancy and lactation.
 dizziness, leucopenia, skin rahes Hydrochlorothiazide : increase plasma It passes into the breast milk.
thrombocytopenia. concentrations of fluconazole.

Topical Antifungal Drugs :

Bifonazole Mycospor 13 LE Slight reddening, irritation, burning,
allergic reactions may occur. No interaction. NO evidence.

Tioconazol Topzol 6 LE Local irritation, hypersensitivity

Trosyd 6.6 LE reaction appear in some patients. No interaction. NO evidence.

Nystatin + ZnO Nice--Baby 3.5 LE It is well tolerated but rare cases of

local irritation may occure No interaction. NO evidence.

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Clotrimazole + Lotriderm 4.5 LE paresthesia, edema, maculopapular
Betamethazone rash, burning, itching, irritation, It isn't recommended to be used
dryness, folliculitis, hypertrichosis, No interaction. in pregnancy and lactation.
allergic contact dermatitis, skin
atrophy.
Clotrimazole Closol 6.5 LE Synergism or antagonism between This drug should be used only if
Canesten 4 LE Erythema, stinging, bistering, clotrimazole, nystatin, amphotericin B clearly indicated during the first
Locasten 3.25 LE edema, urticaria, buning, general ,flucytosine against strains of C.albican trimester of pregnancy. Caution
Dermatin 1.3 LE irritation of the skin. has not been reported. should be exercised when it is
used by a nursing woman
Miconazole Daktarin 5.5 LE It isn't systemically absorbed,
Miconaz 4.15 LE irritation of skin, buning, allergic No interaction. can be used during pregnancy
Micoban 4.7 LE reactions. and lactation.

Miconazole + Miconaz H 5.5 LE Caution is recommended during

Hydrocortisone Daktacort 5.6 LE local irritation, burning sensation, No interaction. pregnancy and lactation period.
Mycuten D 4 LE allergic reaction, telangiectasis, treatment of large surfaces under
Monicort 5 LE hypertrichosis, atrophy. occlusive dressing should be
avoided.
Econazole nitrat Pevaryl 5 LE local irritation may occur on It's advisable to apply an antieczematous
 eczematous skin areas. drugs with pevaryl. NO evidence.

Econazole nitrat Pevisone 5.5 LE

Trimcinolone Hypersensitivity was observed in No interaction. it is recommended in the first
acetonidum very rare cases only. trimestere of pregnancy.

Ciclopirexol-- Batrafen 5.5 LE burning sensation, irritation of skin, It isn't recommended to be used
amin itching. No interaction. in pregnancy and lactation.

Chlorphenesin+ Neofungicil 2.5 LE Effect of benzoic acid is deminished by

Benzoic acid + Hypersensitivity, non immunological non ionic surfactant or due to absorption NO evidence.
ZnO contact dermatitis can occur. by kaolin, it is inactive at PH above 5

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Naftifine Hcl Exoderil 6.5 LE burning sensation, reddening The drug I unlikely to have any
dryness. No interaction. effects on fetus.

Iodochlorhydro- Vioderm 3 LE
xyquin No side effect. No interaction. NO evidence.

Tolnaftate Tineacure 3 LE No side effect. No interaction. NO evidence.

Sertaconazole Dermofix 15 LE the risk benefit ratio should be

mild local, transient erythematous No interaction. evaluated before its use during
reaction. pregnancy and lactation.

Ketoconazole Ketoderm 5 LE It should used only if doctor

Hcl Nizoral 6.3 LE burning sensation, irritation of skin, No interaction. decides that this drug is
dermatitis absolutely necessary.

Terbinafine Hcl Terbin 9 LE

Fungiban 8.5 LE
Fungisafe 7 LE itching, redness, stinging No interaction. It isn't recommended to be used
Lamisil 13 LE in pregnancy and lactation.
 Miconazole Miconaz 4.7 LE Mild GI disturbances, in rare case
Daktarin 18.5 LE allergic reactions may occure No interaction. NO evidence.

Lignocaine + Clovacaine 3.5 LE

Geranium oil + No side effect. No interaction. NO evidence.
Clove oil

Anthraquinote Salivex - L 4.9 LE

glycoside + Hypersensitivity reactions to the Food shouldn't be ingested for 60 minutes NO evidence.
Salicylic acid + drug componant are very rare. following the use.
Lidocaine Hcl

Antibiotic Drugs
( A ) Penicillin group :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Phenoxymethyl Ospen 5 LE Diarrhea, allergic reactions,
penicillin Na+ vomiting. No interaction. NO evidence.

Ampicillin Ampicillin 7 LE
trihydrate Epicocillin 4.5 LE Ampicillin may decrease the efficacy of
Hiconcil 9.6 LE Allergic reactions, skin rashes, oestrogen and affect on the absorption of When antibiotic therapy is
Ibiamox 8 LE (maculopapular eruptions), diarrhea other drugs. required during pregnancy it may
Emox 13 LE vomiting, nausea, pruritus, Increased frequency of rashes when it is be considered appropriate.
Amoxicillin 6 LE pseudomembranous colitis, used with allourinol. Trace quantities of it can be
Amoxil 7 LE hemolytic anemia, eosinophilia. Renal elimination is retarded by the detected in breast milk.
Biomox 7 LE concomitant use of probencid.

( B ) Aminoglycoside group :
Gentamycin Garamycin 8.6 LE Nephrotoxicity, neurotoxicity,
Apigen 7 LE vertigo, dizziness, skin tingling It isn't recommended to be used
Quadriderm 9 LE muscle twitching, leukopenia. No interaction. in pregnancy and lactation.
Allergic reactions, it may cause fetal harm

Tobramycin + Optidex T 14 LE It isn't recommended to be used

Dexamethasone Glaucoma, affect optic nerve No interaction. in pregnancy and lactation.
 it may cause fetal harm

Neomycin Neomycin 6 LE Use of Neomycin in pregnancy

sulfate
Gastro-intestinal disturbances,
ototpxicity and nephrotoxicity.
hasn't been established and risk
benefit should be considered
No interaction. Because of the potential serious
side effect, discontinue the drug
taking into consideration the
importance of the drug to the
mother.

( C ) Lincosamides group :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Clindamycin Hcl Clindam 15 LE An antagonism is demonstrate between
Dalacin c 35 LE clindamycin, erythromycin. Clindamycin
Gastro-intestinal disturbances, appears to have neuromascular blocking It can pass through the placenta.
vomiting, nausea, diarrhea, properties tat can enhance the effect of it should only be used during
abdominal pain, local irritation other neuromascular blockers. In patients pregnancy if necessary.
hypotension, leukopenia, pruritus, treated with such drugs, clindamycin it appears in breast milk.
eosinophilia, hypersensitivity. should, therfor,be used with caution.

Lincomycin Lincocin 18 LE Vomiting, nausea, diarrhea,

pruritus, leukopenia, enterocolitis,
neutropenia, thrombocytosis,
hypersensitivity reactions, edema,
skin rashes, urticaria, hypotension,
local reactions.
No interaction. Safety for use in pregnancy has
not been established. It is not
indicated in the newborn.

( D ) Macrolide Drugs :
erythromycin Erythrocin 12 LE Gastro-intestinal disturbances, Safety for use in pregnancy has
stearate vomiting, nausea, diarrhea, No interaction. not been established.
allergic reactions, urticaria, It can pass through the placenta.

erythromycin Eryped 9.7 LE Gastro-intestinal disturbances, Safety for use in pregnancy has
erthylsuccinate vomiting, nausea, diarrhea, not been established.
allergic reactions, urticaria, No interaction. It can pass through the placenta.
 abdominal pain, anorexia it appears in breast milk.

erythromycin Primomycin 6.5 LE It potentiates effect of carbonazepin,

stearate + Erythroprim 8 LE corticosteroid, digoxin, warfarin,
Trimethoprim theophylline. Cercurent use of these
Vomiting, nausea, diarrhea, drugs isn't recommended because It isn't recommended to be used
hypersensitivity reactions. competitive inhibitions with erythromycin in pregnancy and lactation.
may occur : Lincomycin, clindamycin, it may cause fetal harm.
clioramphenicol.

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Spiramycin Spirex 17 LE Pseudomembranous colitis, rashes
Rovamycin 24 LE urticaria, pruritus, angioedema, Levodopa : inhibition of absorption of Safety for use in pregnancy has
Rovapex 17 LE anaphylactic shocks, carbidopa with decreased levodopa not been established.
Rovac 17 LE vomiting, nausea, diarrhea, plasma levels it appears in breast milk.

Spiramycin + Spirazole 12 LE Gastro-intestinal disturbances, Alcohol : it cause Disulfiram-like reaction

Metronidazole nausea, diarrhea, unpleasant taste The effect of oral anticoagulants is It isn't recommended to be used
darkening of urine enhanced. in pregnancy and lactation.

Clorithromycin Klacid 18 LE vomiting, nausea, diarrhea, It inhibit the metabolism of these drugs
Klarimix 15 LE headache, allergic reactions, ( warfarin, trizolam, midazolam, phenytoin ) Safety for use in pregnancy and
dyspepsia, abdominal pain, CNS It potentiates theophylline toxicity. lactation hasn't been established.
side effects.

Azithromycin Xithrone 18 LE Antacids reduce the absorption of

Azrolid 18 LE azithromycin.
Mazit 17 LE Diarrhea, vomiting, nausea Azithromycin potentiate the effect of the drug shouldn't be used during
Aziwok 30 LE Gastro-intestinal disturbances, carbamazepine, digoxin, ergot alkaloid, pregnancy and lactation except
Zithrodose 13 LE dizziness, insomnia, skin rashes, valporate, cyclosporine. when necessary because safety
Zithrokan 18 LE headache, anorexia, constipation Food decreases the absorption of of it hasn't been established.
Neozolid 18 LE somnolence, pruritus, urticaria azithromycin, to be taken 1hr before or
Zithromax 54 LE 2hr after a meal.
Zisrocin 18 LE
 ( E ) Chloramphenicol
Chloramphe- Streptophe- 9 LE Diarrhea, vomiting, nausea It isn't recommended to be used
nicol + nicol gastro-intestinal disturbances, It enhance the effects and / or toxicity of in pregnancy and lactation.
Streptomycin bone marrow depression, anaemia, warfarin, oral hypoglycemic agents, oral it passes into milk and crosses
allergic reactions, conjunctivitis estrogen, It decrease absorption of vit.B12 the placenta.

Chloramphe- Cidocetin 1.5 LE Diarrhea, vomiting, nausea, mental Rifampicin, phenobarbital accelerate the It is contrainicated in lactation
nicol confusion, urticaria, hypoplastic metabolism of Chloramphenicol, it enhanc and pregnancy.
anaemia, headache. effect of warfarin, sulphonylurea.

( F ) Cephalosporin
( 1st generation ) :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Cephradine Velosef 12 LE Gastro-intestinal disturbances,
urticaria, abdominal pain, nausea This drug should be used during
Diarrhea, vomiting, leukopenia, No interaction. pregnancy only if clearly needed
pseudomembranous colitis, it is excreted into breast milk.

Cephadroxil Duricef 12.5 LE

monohydrate Ibidroxil 9.9 LE Gastro-intestinal disturbances, A false- positive glycosuria reaction when It isn't recommended to be used
Curisafe 8 LE pseudomembranous colitis, tested with Benedict's, Fehling's solution in pregnancy and lactation.
Biodroxil 7.5 LE nausea, vomiting, dyspepsia, Aminoglycoside, colistin may potentiate it passes into milk .
Longicef 7 LE allergic reactions, urticaria, the nephrotoxic effect when taken with it.
Keflex 23 LE headache, dizziness, fatigue
ceporex 15 LE eosinophilia.

( 2nd generation ) :
Cefuroxime Zinnat 25 LE Erythema multiform, anaphylaxis, drugs which reduce gastric acidity may
skin rashes, urticaria, pruritus, result in a lower bioavailability of Zinnat It should be asministered with
serum sickness, exanthematic compared with that of the fasting state, caution during the early months
necrolysis, gastro-intestinal tend to cancel the effect of enhanced post of pregnancy, it is excreted in
disturbances, nausea, vomiting. -prandial absorption. the human milk.

Cefixime Ximacef 32 LE Gastro-intestinal disturbances,

nausea, vomiting, mild diarrhea, Considration should be given to
skin rashes, pruritus, eosinophilia, No interaction. discontinuing nursing temporally
 headache, dizziness, leukopenia. during treatment with cefixime.

Cefaclor Bacticlor 12 LE skin rashes, urticaria, pruritus, AloH / MgoH in antacids diminish the
ceclor 18 LE nausea, vomiting, diarrhea, serum absorption of bacticlor. H 2 blockers don't It should be used during lactation
sickness, dizziness, insomnia, alter the rate or the extent of absorption of pregnancy only if clearly needed
pseudomembranous colitis, bacticlor, renal excretion of it inhibited by it passes into milk .
probenicid.

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Cefprozil Cefzil 34 LE skin rashes, urticaria, pruritus, Aminoglycoside : when used with cefzil
nausea, vomiting, diarrhea, serum it may cause nephrotoxicity, concomitant It should be used during lactation
sickness, dizziness, insomnia, administration of probenecid doubled the pregnancy only if clearly needed
abdominal pain, eosinophilia, area under the curve for cefprozil. it passes into milk .

Cefpodoxime Orelox 29 LE H2 blockers and antacids reduce the

abdominal pain, diarrhea, vomiting, bioavailability of Orelox and increased if NO evidence.
skin rashes. the drug taken during meals

( 3rd generation ) :
Cefotaxime Foxime 18 LE Skin eruptions and fever, diarrhea,
Ceforam 8 LE eosinophilia, leukopenia, urticaria, renal excretion of it inhibited by probenicid It should be used during lactation
Cefotax 8 LE pseudomembranous colitis, Aminoglycoside : when used with this pregnancy only if clearly needed
Claforan 15 LE nausea, pruritus. drug, it may cause nephrotoxicity.

Cefoperazone Cefazone 7.5 LE renal excretion of it inhibited by probenicid

Cefobid 16 LE skin rashes, urticaria, pruritus, Aminoglycoside : when used with this It should be used during lactation
mild diarrhea, leukopenia. drug, it may cause nephrotoxicity. pregnancy only if clearly needed

Ceftriaxone Rocephin 26 LE diarrhea, nausea, vomiting,

Ceftriaxone 18 LE eosinophilia, leukopenia, hemolytic There aren't any interactions and the It should be used during lactation
anemia, skin rashes, urticaria, elimination of Rocephin isn't altered by pregnancy only if clearly needed
pruritus, dizziness, headache, probencid. it passes into milk .

( 4th generation ) :
Cefepime Hcl Maxipime 22.5 LE skin rashes, urticaria, pruritus,
diarrhea, nausea, vomiting, colitis,
 headache, fever, eosinophilia,
leukopenia, erythema multiform,
Stevens-Jonhnson syndrome,
hemolytic anemia, exanthematic
necrolysis.
There aren't any interactions It should be used during lactation
pregnancy only if clearly needed
it passes into milk .

( G ) Quinolone Drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Ciprofloxacin Ciproquin 25 LE Theophylline : its serum level increased
Hcl Ciprobay 46 LE skin rashes, urticaria, pruritus, by ciprofloxacin. Ciprofloxacin crosses placenta
Ciprofloxacin 16 LE diarrhea, nausea, vomiting, colitis, AloH / MgoH in antacids diminish the its use isn't recommended in
Ciprocin 20 LE dizziness, abdominal pain, absorption of ciprofloxacin. pregnancy. It secreted in breast
Ciprofar 15 LE Stevens-Jonhnson syndrome, Probencid : inhibit the renal excretion of milk. Breast feeding should be
Serviflox 15 LE hemolytic anemia, exanthematic ciprofloxacin. discontinued.
Bactiflox 16.5 LE necrolysis. (NSAIDs): it increase the CNS effect of
Cipromax 33 LE quinolones.

Ofloxacin Kiroll 34.5 LE dizziness, abdominal pain, AloH / MgoH in antacids diminish the Safety for use in pregnancy and
Ofloxin 18 LE diarrhea, nausea, vomiting, colitis, absorption of ofloxacin. lactation hasn't been established.
Ocuflox 15 LE hemolytic anemia, exanthematic It increase the effect of cuomarin drugs its use isn't recommended in
Tarivid 47 LE necrolysis, skin rashes, urticaria, Glibenclamide : its serum level pregnancy and lactation because
pruritus, restlessness. increased by ofloxacin. it secreted in breast milk.

Sparfloxacin Parox 32 LE diarrhea, nausea, dyspepsia, AloH / MgoH in antacids diminish the
Sparatec 36 LE dizzines, abdominal pain, flatulence absorption of sparfloxacin by chelation. It isn't recommended to be used
QT interval prolongation. also in Zinc / Iron salts in pregnancy and lactation.

Levofloxacin Levoxin 25 LE AloH / MgoH in antacids diminish the

Unibiotic 25 LE diarrhea, nausea, sleep disorders absorption of levofloxacin by chelation.
Leo-flox 20 LE increasein liver enzymes ALT/ AST also in Zinc / Iron salts It isn't recommended to be used
Tavanic 85 LE hemolytic anemia, vomiting (NSAIDs): it increase the CNS effect of in pregnancy and lactation.
Tavacin 27 LE Stevens-Jonhnson syndrome, quinolones.
Larivex 30 LE hemolytic anemia, exanthematic Probencid : inhibit the renal excretion of
necrolysis. levofloxacin.
 Lomefloxacin Lomex or 25 LE Probencid : inhibit the renal excretion of
Lomax diarrhea, nausea, vomiting, Lomefloxacin. It isn't recommended to be used
dizziness, AloH / MgoH in antacids diminish the in pregnancy and lactation.
absorption of Lomefloxacin.

( H ) Tetracycline Drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Tetracycline Hcl Tetracid 3.5 LE Tetracid with antacids,milk may result in
diarrhea, nausea, vomiting, subtherapeutic serum concentration of it. It isn't recommended to be used
flatulence, pruritus, glossitis. Diuretics, Methoxyflurane may be in pregnancy and lactation.
exacerbated the nephrotoxic effect of it.

Oxytetracycline Tetra 2.5 LE It should be used during lactation

Oxypol 5 LE Hypersensitivity, allergic reactions, There aren't any interactions. pregnancy only if clearly needed
Terramycine 3 LE dermatitis. it passes into milk .

Doxycycline Doxy 7 LE It advisable to avoid administration of

diarrhea, nausea, vomiting, urticaria doxycycline with penicillin AloH / MgoH It isn't recommended to be used
anorexia, oesophagitis, oedema, in antacids diminish the absorption of in pregnancy and lactation.
2nd infection. doxycycline.

Doxycycline Hcl Tolexine 11 LE Dental dyschromia or enamel Retinoids :Intracranial high blood pressure Doxycycline crosses placenta
Vibramycin 16 LE hypoplasia, nausea, epigastric pain It potentiate the activity of antivitamin K It should be used during lactation
Farcodoxin 9 LE diarrhea, anorexia, glossitis, rash, compounds.AloH / MgoH in antacids pregnancy only if clearly needed
Doxymycin 4 LE pruritis,urticaria, hemolytic anaemia diminish the absorption of doxycycline. it passes into milk .

( I ) Antibiotic combination :
Amoxicillin + Klavox 32 LE
Clavulanic A Curam 21 LE diarrhea, nausea, vomiting, urticaria It reduce the effect of oral contraceptives It should be used during lactation
Augmentin 28 LE pseudomembranous colitis, Probencid : inhibit the renal excretion of pregnancy only if clearly needed
Magna biotic 12 LE Stevens-Jonhnson syndrome, this drug. it passes into milk .
E moxdar 18 LE hemolytic anemia, exanthematic
Hibiotic 22 LE necrolysis.
 Ampicillin Na Ampiclox 6.6 LE
trihydrate + diarrhea, indigestion, urticaria, Probencid : inhibit the renal excretion of It isn't recommended to be used
Cloxacillin hypersensitivity, erythematous rash this drug. in pregnancy and lactation.

Analgesic and Antipyretic Drugs

( A ) Acetysalicylate Drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Acetysalicylate EZ Acard 7.5 LE With anticoagulants increase risk of the
Aggrex 1 LE Bronchospasm, gastro-intestinal bleeding.With antacids increase excretion It isn't recommended to be used
Aspocard 1.25 LE haemorrhage, nausea, vomiting, so decrease its effect.With corticosteroid in pregnancy and lactation
Aspocid 2 LE allergic reactions,implicated in increase risk of gastro-intestinal bleeding, It should used only if doctor
Alexoprine 1 LE some cases of Reye's syndrome With Metoclopramide + Dompridone decides that this drug is
Rivo micro 1 LE in children. enhance asprin effect. absolutely necessary.

( B ) Paracetamol Drugs :
Paracetamol Panadol 18 LE Although there is epidemiological
Adol 4 LE urticaria, skin rashes, blood With anticoagulants increase risk of the evidence of the safety of
Cetal 2 LE disorders have been reported. bleeding. Paracetamol in pregnancy and
Paramol 4 LE allergic reactions, impair hepatic or Cholestyramine: diminish the absorption lactation, medical advice should
renal function. of Paracetamol. be sought befor using this product

Paracetamol + Pronto plus 5 LE Although there is epidemiological

Caffeine Panadol extra 12 LE hypersensitivity reactions, skin With anticoagulants increase risk of the evidence of the safety of
Abimol extra 5 LE reddening, allergic reactions with bleeding. Paracetamol in pregnancy and
exanthems & disorder in blood cell Cholestyramine: diminish the absorption lactation, medical advice should
of Paracetamol. be sought befor using this product

Paracetamol + Panadol cold 30 LE allergic reactions,skin reactions,

Pseudoephedrin & flue restlessness, insomnia, anxiety, With anticoagulants increase risk of the It isn't recommended to be used
Hcl + Ascorbic Europack 20 LE tachycardia, urinary retention bleeding. in pregnancy and lactation.
acid Ezamole-C 3.5 LE disorder in blood cells, vomiting, Cholestyramine: diminish the absorption
Efferalgan 9 LE nausea. of Paracetamol.
 ( C ) Non steroidal analgesic
Ketoprofen Bi alcofan 2.5 LE gastro-intestinal haemorrhage, It isn't recommended to use asprin with It should used only if possible
Ketoprek 5 LE diarrhea, anorexia, flatulence, ketoprofen also probenecid not taken with benefit justifies the potential risk
Ketofan 5 LE abdominal pain, dizziness, ketoprofen. to the foetus.
Fastum 3.6 LE

Anti-inflammatory Drugs :
Systemic and Topicaly
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Tenoxicam Epicotil 11.8 LE It should used only if possible
Gastralgia, heartburn, nausea, It shouldn't be administered with K + benefit justifies the potential risk
dizziness, headache, itching, rash sparing diuretics. to the foetus.it passes into milk.
(NSAIDs): it increase the clearance and The use of epicotil during late
volume of distribution of tenoxicam. pregnancy should be avoided

Piroxicam Inflacam 4 LE Stomatitis, anorexia, nausea,
Brexin 12 LE constipation, abdominal pain,
flatulence, indigestion, ulceration,
dizziness, headache, insomnia,
depression, nervousness,
hypersensitivity reactions.
Aspirin : decrease the plasma levels of
piroxicam.
Warfarin : cause serious GIT bleeding It isn't recommended to be used
higher than using the drug alone. in pregnancy and lactation.
Piroxicam : diminish the antihypertensive
effect of ACE inhibitors.

Diclofenac Na Olfen 9 LE nausea, vomiting, diarrhea, GIT Glucocorticoids : increase risk of GIT It must not be taken in the last 3
Voltaren 11.2 LE bleeding, headache, dizzness, bleeding. monthes of pregnancy. The use
Rheumarene 4.8 LE drowsiness, bronchospasm, Acetylsalicylic acid : decrease serum of diclofenac in first 6 monthes
Clofen 23.5 LE hypersensitivity reactions, level of diclofensac. of pregnancy and lactation should
Divido 23.5 LE Stevens-Jonhnson syndrome, Diclofenac : increase the serum levels of only be considered after a
exanthematic necrolysis. digoxin, phenytoin, lithium drugs. medical appraisal of benefit risk.

Diclofenac K Rapidus 11.5 LE nausea, vomiting, diarrhea, GIT Diclofenac : increase the serum levels of Safety for use in pregnancy and
Cataflam 18 LE bleeding, headache, dizzness, digoxin, phenytoin, lithium drugs. lactation hasn't been established.
Catafast 18 LE drowsiness, bronchospasm, Warfarin : cause serious GIT bleeding It should not be given especially
hypersensitivity reactions, higher than using the drug alone. in 3rd trimester of pregnancy.

Aceclofenac Bristaflam 10 LE dyspepsia, abdominal pain, nausea (NSAIDs): enhance effect of Li, digoxin.
 diarrhea, constipation, vomiting, Aceclofenac : diminish antihypertensive It isn't recommended to be used
flatulence, dizziness, insomnia. effect of ACE inhibitors and diuretics. in pregnancy and lactation.

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Ibuprofen Brufen 3.3 LE Dyspepsia, GIT bleeding, skin rash Ibuprofen : increase the serum levels of It should be used during lactation
thrombocytopenia, toxic amblyopia lithium drugs. pregnancy only if clearly needed

Ibuprofen + Cetafen 5.5 LE Gastro-intestinal disturbances,

Paracetamol Contafever 10 LE nausea, vomiting, mild diarrhea, It isn't recommended to be used
dyspepsia, gastritis, hypersensitivity There aren't any interactions. in pregnancy and lactation.
reactions, thrombocytopenia.

Meloxicam Anticox ∏ 10 LE nausea, abdominal pain, stomatitis Cholestyramine: increase elimination of It isn't recommended to be used
Melocam 12 LE dizziness, headache, itching, rash meloxicam. in pregnancy and lactation.

Sulindac Rudac 13 LE dyspepsia, nausea, diarrhea, rash Warfarin : cause serious GIT bleeding
constipation, dizziness, headache higher than using the drug alone. It isn't recommended to be used
GIT bleeding, Aspirin : may decrease its effectiveness. in pregnancy and lactation.

Rofecoxib Arthidol 9.5 LE nausea, heartburn, dyspepsia, It isn't recommended to be used

diarrhea, headache, hypertension, There aren't any interactions. in pregnancy and lactation.
dizziness, GIT bleeding. it should be avoided in late stage

Celecoxib Celoxib 16 LE (NSAIDs): diminish antihypertensive It should used only if possible

Celebrex 24 LE GI manifestation such as dyspepsia effect of ACE inhibitors and diuretics. benefit justifies the potential risk
abdominal pain. It should not taken with fluconazole to the foetus.

Lornoxicam Xefo 15.5 LE stomach pain, diarrhea, indigestion it may interacte with Li, anticoagulants, It isn't recommended to be used
dizziness, nausea, vomiting antidiabetic, ACE inhibitors, diuretic drugs in pregnancy and lactation.

Glucosamine Dorofen 31.5 LE

sulfate + Ginko heartburn, diarrhea, nausea, it may interacte with anticoagulants, It isn't recommended to be used
Flavonoid dyspepsia, headache, constipation, in pregnancy and lactation.

Unsaponifiables Piascledine 30 LE
of Avocado and No side effect if taken during meal There aren't any interactions. Usage during pregnancy and
Soya. lactation is not yet investigated

Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Glucosamine Glucosamine 14 LE Gastro-intestinal disturbances,
sulfate + vit C drowsiness, headache, kin rashes There aren't any interactions. NO evidence.

Glucosamine Cartilgin 13 LE
sulfate + vit C Gastro-intestinal disturbances, It isn't recommended to be used
Chondrotin nausea, vomiting, abdominal pain, There aren't any interactions. in pregnancy and lactation.
sulfate constipation, diarrhea,

Herpago phytum Herpago 13 LE

procumbens No side effect. Herpago : may affect action of warfarin, Avoid during first trimesters of
extract patients should be monitored regularly pregnancy.

Leflunomide Apetoid 15 LE Diarrhea, elevation of liver enzymes Aspirin, NSAIDs and corticosteroids may
( ALT/ AST ), alopecia, rash, be continued during treatment with It isn't recommended to be used
pancytopenia. Leflunomide. in pregnancy and lactation.

Indomethacine Indotopic 3.25 LE Redness, itching, it should be

avoided to contact with eye, ulcers, There aren't any interactions. It isn't recommended to be used
traumatic wounds, mucous tissues in pregnancy and lactation.

Prednisolone Predsol 10 LE Sodium retention and potassium Glucocorticoids : is recommended upon

Na phosphate loss occur only very rarely.
Symptoms of hypercorticoidism
only occur after prolonged therapy
with high doses. Milder phenomena
of autonomic unbalance which
occurs occasionally does not as a
rule require special measures.
administration of anticonvulsants, rifampin
bronchodilators. Its dose should be Pregnant women should take
reduced upon administration of estrogens, this drug under strict medical
ketoconazole, erythromycin. supervision.
(NSAIDs): increase risk of GI ulceration Breast feeding should be avoided
It may interacte with anticoagulants like during therapy by the product.
Warfarin or Heparin.

Fever few + Welevon 12 LE Hyperensitivity reactions to its The doses of anticoagulants must be
White willow + component like acetyl salicylate adjusted with concomitant treatment with NO evidence.
Estere C , Vit B6 drugs Welevon

Anti-Allergic Drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Dexamethasone Phenadone 7 LE it is contraindicated in active and
Chlorphenir- questionably healed tuberculosis, There aren't any interactions. NO evidence.
amine maleate peptic ulcer, diabetes, osteoporosis
marked emotional instability

Desloratadine Aerius 5 LE fatigue, headache, dry mouth, It should used only if possible
hypersensitivity reactions, There aren't any interactions. benefit justifies the potential risk
tachycardia, palpitations, to the foetus.

Loratadine Claritine 23 LE Safety for use in pregnancy and

fatigue, headache, sedation, alcohol, loratadine has no potentiating lactation hasn't been established.
nervousness, alopecia. effects. It should used only if possible
benefit justifies the potential risk
to the foetus.

Chlorphenox- Allergex 2.5 LE

amin Hcl dryness mouth. There aren't any interactions. NO evidence.

Pseudoephedrin Clarinase 12.5 LE insomnia, dry mouth, headache, alcohol, loratadine has no potentiating
Hcl + somnolence, dizziness, fatigue, effects, ketoconazole, erythromycin Safety for use in pregnancy and
Loratadine nausea, abdominal pain, anorexia. increase plasma level of Loratadine. lactation hasn't been established.

Cyproheptadine Triactin 4 LE drowsiness, dryness of mouth, To be used only when clearly

Hcl throat, thickening of the broncial There aren't any interactions. indicated in the 1st trimester &
secretion, dizziness, skin rash. should be avoided in last stage

Fexofenadine Telfast 30 LE drowsiness, dizziness, headache, ketoconazole, erythromycin increase It isn't recommended to be used
Hcl nausea, fatigue, urticaria, pruritus. plasma level of Fexofenadine Hcl. in pregnancy and lactation.
Cetirizine Di Hcl Cetrak 6 LE Gastro-intestinal disturbances, Safety for use in pregnancy and
Clearet 10 LE headache, tachycardia, dizziness. There aren't any interactions. lactation hasn't been established.