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Biochemistry /LAST YAER FINAL QUESTIONs / 2008
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1. All of these hormones are from cholesterol except :
a. Estradiol
b. progesterone
c. Epinephrine
d. Testesterone
e. None of the above
2. Protein kinase :
a. Will inhibit glycogen phosphrylase
b. Will activate debranching enzyme
c. Will activate branching enzyme
d. Will inhibit glycogen synthase by adding phosphate group
e. None of the above
3. Muscle in resting state , which one is
a. High ATP /ADP
b. Low NADH /NAD
c. High FADH /FAD
d. LOW ATP /ADP
e. None of the above
4. Epinephrine will :
a. Inhibit adenylae cyclase
b. Increase glycogen synthesis
c. Activate adenylate cyclase
d. None of the above
5. In which reaction the biotin is a cofactor :
a. Pyruvate decarboxylase
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b. LDH
c. Alpha ketoglutarate dehydrogenase
d. Pyruvate carboxylase
e. None of the above
6. The driving for ATP synthesis in ETC is :
a. Directly from ETC
b. PH gradient between the matrix and IMS
c. PH gradient between the matrix and cytosol
d. None of the above
7. Uncoupler will :
a. Stop ATP synthesis and electron transport
b. no effect on ATP synthesis and electron transport
c. no effect on ATP synthesis but stop electron transport
d. Stop ATP synthesis with no effect electron transport
8. Which of the following enzyme in B oxidation will produce NADH :
a. Ketoacyl dehydrogenase
b. Enoyl‐CoA Hydratase.
c. Hydroxyacyl CoA dehydrogenase
d. Thiolase
e. Acyl‐CoA Dehydrogenase
9. Which of the following is purine nucleoside :
a. Guanine
b. Thymine
c. uracil
d. Adenosine
e. None of the above
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10. Which of the following reaction is irreversible in glycolysis :
a. PEP ‐‐‐‐‐‐‐‐‐Æ 2‐p‐Glycerate
b. Pyruvate ‐‐‐‐‐‐‐‐Æ PEP
c. Fructose 6 – p ‐‐‐‐‐‐‐‐‐Æ glucose ‐6‐p
d. G‐3—P ‐‐‐‐‐‐‐‐‐‐Æ DHAP
e. None of the above
11. Which of the following has less free energy :
a. ATP ‐‐‐Æ ADP
b. ADP ‐‐‐‐ÆATP
c. ATP ‐‐‐ÆAMP
d. AMP ‐‐ÆADP
12. ATP is used in which of the following :
a. Fructose 6 – p ‐‐‐‐‐‐‐‐‐Æ glucose ‐6‐p
b. PEP ‐‐‐‐‐‐‐‐‐Æ 2‐p‐Glycerate
c. Pyruvate ‐‐‐‐‐‐‐‐Æ PEP
d. Fructose ‐6‐p ‐‐‐‐‐‐‐‐‐Æ fructose 1.6 bisphosphate
e. C and d
13. Which of the following enzyme not found in glycolysis :
a. Hexokinase
b. Enolase
c. Aldolase
d. isomerase
e. Fumarase
14. What are the two enzymes that present in glyoxylate cycle :
a. Isomerase
b. fumarase
c. Malate synthase and isocitrate lyase
d. A and C
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15. How can acyl CoA inter the matrix of mitochondria :
a. By LDL
b. By carnitine
c. By ornithine
d. By CoA
e. None of the above
16. What is the control step in cholesterol synthesis :
a. HMG oxidase
b. HMG CoA oxidase
c. HMG CoA reductase
d. PFK1
e. None of the above
17. What is the common product of cholesterol and ketone body :
a. Sequalene
b. Mevalonate
c. lenosterol
d. HMG CoA
e. None of the above
18. What is the product of the rate limiting step in urea cycle :
a. HMG CoA
b. Carbomyl CoA
c. Acetyl CoA
d. Arginine
e. None of the above
19. The immediate precursor for urea is :
a. glutamine
b. Arginine
c. Histidine
d. Citruline
e. None of the above
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20. If we Want to inhibit the rate limiting step in cholesterol synthesis , what will be
decreased :
a. acetylCoA
b. acetoacetyl CoA
c. melanoyl CoA
d. Mevalonate
e. None of the above
21. All are cholesterol derivatives except :
a. progesterone
b. Lecithin
c. Cortisol
d. Aldeserone
e. None of the above
22. Which of the following produce energy directly in citric cycle :
a. Citrate to Isocitrate
b. a‐Ketoglutarate to Succinyl‐CoA
c. Succinyl CoA ‐‐‐‐‐‐‐‐‐‐‐Æ succinate
d. Formation of Fumarate
e. None of the above
23. Which of the following enzyme catalyze this reaction
Isocitrate ‐‐‐‐‐‐‐‐‐‐‐Æ alpha ketoglutarate :
a. Succinyl‐CoA synthetase
b. a‐Ketoglutarate Dehydrogenase Complex
c. Aconitase
d. Isocitrate dehydrogenase
e. None of the above
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24. Degradation of glycogen in the liver will give :
a. Glucose
b. Glucose – 1 – P
c. Glucose – 6 ‐ P
d. A and B
e. None of the above
25. The source of aa lysine is :
a. Alpha ketoglutarate
b. Pyruvate
c. Ribose 5 P
d. Oxaloacetate
e. None of the above
26. Tyrosine precursor is :
a. Thriose 4 P
b. Pyruvate
c. Ribose 5 P
d. Oxaloacetate
e. Erthyrose ‐4‐P
27. What is the reducing agent in anaerobic glycolysis :
a. FADH2
b. NADPH
c. CoQH2
d. NADH
e. None of the above
28. The disaccharide the has alpha 1‐4 bond is :
a. Maltose
b. Lactose
c. Cellobiose
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d. Sucrose
e. starch
29. About Hb which one is true :
a. It is non allostetric protein and positively cooperative
b. It is an allostetric protein and negatively cooperative
c. It is non allostetric protein and negatively cooperative
d. It is an allostetric protein and positively cooperative
e. None of the above
30. About G protein , which one is false :
a. Becomes inactive when B subunit is active
b. Becomes active when alpha subunit is active
c. Becomes inactive when B subunit is active
d. Becomes active when B subunit is active
e. None of the above
31. Which reaction in glycolysis use P group from inorganic source , not from ATP :
a. G‐3‐P ‐‐‐Æ 1.3 bisphosphoglycerate
b. Fructose 6 – p ‐‐‐‐‐‐‐‐‐Æ glucose ‐6‐p
c. PEP ‐‐‐‐‐‐‐‐‐Æ 2‐p‐Glycerate
d. Pyruvate ‐‐‐‐‐‐‐‐Æ PEP
e. Fructose ‐6‐p ‐‐‐‐‐‐‐‐‐Æ fructose 1.6 bisphosphate
32. If LDL receptor is defective all are true except :
a. May lead to atherosclerosis
b. Decrease cholesterol inside the cell
c. Decrease cholesterol in blood
d. Decrease synthesis of sex hormones
e. None of the above
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33. Glutamate catabolism leads to :
a. Oxaloacetate
b. Pyruvate
c. Alpha ketoglutarate and NH4
d. Uric acid
e. None of the above
34. Acromegaly :
a. Increase growth before puberty
b. decrease growth before puberty
c. Increase growth after puberty
d. decrease growth after puberty
e. none of the above
35. Statin inhibit :
a. HMG oxidase
b. Thiolase
c. Mono oxygenase
d. HMG reductase
e. None of the above
36. Insulin , which one is true :
a. decrease glycogen synthesis
b. Increase glucose degradation
c. Increase glycogen synthesis
d. A and B
e. B and C
37. Which of the following is reversible :
a. Acetyl CoA ‐‐‐‐‐‐‐‐‐‐Æ acetoacetyl CoA
b. Cholesterol ‐‐‐‐‐‐‐‐‐Æ sequalene
c. Fructose 6 ‐‐‐‐‐‐‐‐Æ fructose 1.6
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d. None of the above
38. Non equilibrium in citric acid cycle is :
a. Step 1
b. Step 2
c. Step 3
d. Step 4
e. None of the above
39. 16:1∆11 which one is false :
a. Monounsaturated
b. The double bond is between C11 and C12
c. Needs 8 cycles in B oxidation
d. A and C
e. B and C
40. The first step in pentose hexose phosphate pathway :
a. 6. Phosphogluconate ‐‐‐‐‐‐‐‐‐‐‐Æ ribulose ‐5‐P
b. Ribulose 5‐p ‐‐‐‐‐‐‐Æ ribose 5‐P
c. Glu6‐p ‐‐‐‐‐‐‐‐‐Æ 6. Phosphogluconate
d. Ribulose 5‐p ‐‐‐‐‐‐‐Æ xylulose 5‐P
e. None of the above
41. The allostetric inhibitor leads to :
a. Covalent modification of enzyme
b. Adding phosphate group
c. Conformational change in the enzyme
d. A and B
e. A and C
42. The second step in pentose hexose pathway is :
a. 6. Phosphogluconate ‐‐‐‐‐‐‐‐‐‐‐Æ ribulose ‐5‐P
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b. Ribulose 5‐p ‐‐‐‐‐‐‐Æ ribose 5‐P
c. Glu6‐p ‐‐‐‐‐‐‐‐‐Æ 6. Phosphogluconate
d. Ribulose 5‐p ‐‐‐‐‐‐‐Æ xylulose 5‐P
e. None of the above
43 If the substrate concentration is much lower than Km :
a. The rate is constant
b. The order is zero order
c. Rate of reaction depends on substrate concentration
d. A and B
e. None of the above
44 Not part of nitrogenase complex :
a. Ferredoxine
b. Dinitrogenase reductase
c. Dinitrogenase
d. Pectin
e. None of the above
45 All of the following are nitrogen containing compound except :
a. Amino acid
b. Hb
c. Purine
d. Maltose
e. Cytochrome
46 All are cofactor for pyruvate dehydrogenase complex except :
a. Mg
b. Lipioc acid
c. FAD
d. NAD
e. Acetyl CoA
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47 All in cytosol except :
a. Glycolysis
b. Anabolism of FA
c. Citric cycle
d. Catabolism of FA
e. C and D
48 The enzyme that convert phospholipid to FA is :
a. Lipase
b. Reductase
c. Bile salt
d. Phospholipase
e. None of the above
49 All are reduced except:
a. FADH2
b. NADH
c. CoQH
d. Fe+3
e. None of the above
50 Glucogenic amino acid produce :
a. Pyruvate and oxaloaceate
b. Acetyl CoA
c. Ketone body
d. A and B
e. B and C
51 Hexokinase used for :
a. glu‐6‐p ‐‐‐‐‐‐‐‐‐‐‐Æ Glu
b. Glu ‐‐‐‐‐‐‐‐‐‐‐Æ glu‐6‐p
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c. Glu 6 – p ‐‐‐‐‐‐‐‐‐Æ fructose ‐6‐P
d. Fructose 6‐P ‐‐‐‐‐‐‐‐‐‐Æ fructose 1.6 bisphosphate
e. None of the above
52 Glucose ‐6‐p phsphatase used for :
a. glu‐6‐p ‐‐‐‐‐‐‐‐‐‐‐Æ Glu
b. Glu ‐‐‐‐‐‐‐‐‐‐‐Æ glu‐6‐p
c. Glu 6 – p ‐‐‐‐‐‐‐‐‐Æ fructose ‐6‐P
d. Glucose ‐6‐‐‐‐‐‐‐‐‐‐‐‐‐Æglucose
e. None of the above
53 Which amino acid disturb the alpha helix :
a. Glycine
b. Alanine
c. cysteine
d. Proline
e. None of the above
54 Which of amino acid has positive charge side chain :
a. Alanine
b. Glutamine
c. Proline
d. serine
e. Histidine
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