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Benzyl Benzoate Application is a cutaneous emulsion. It contains 25% w/v of Benzyl Benzoate in a suitable oil-inwater emulsified basis. Extemporaneous preparation The following formula and directions apply. Benzyl Benzoate 250 g Emulsifying Wax 20 g Purified Water, freshly boiled and cooled Sufficient to produce 1000 ml Melt the Emulsifying Wax, add the Benzyl Benzoate and mix. Pour the mixture into sufficient warm Purified Water to produce 1000 ml and stir thoroughly until cold.
CREAMS:
Definition Aqueous Calamine Cream contains 4% w/w of Calamine and 3% w/w of Zinc Oxide in a suitable oil-inwater emulsified basis. Extemporaneous preparation The following formula and directions apply. Calamine 40 g Zinc Oxide 30 g Liquid Paraffin 200 g Self-emulsifying Glyceryl Monostearate 50 g Cetomacrogol Emulsifying Wax 50 g Phenoxyethanol 5 g Purified Water, freshly boiled and cooled, sufficient to produce 1000 g Melt the Cetomacrogol Emulsifying Wax with the Selfemulsifying Glyceryl Monostearate, add the Liquid Paraffin and heat to about 60. Dissolve the Phenoxyethanol in about 620 g of Purified Water at about 60, add the oily phase to the phenoxyethanol solution and mix. Stir until cool, add sufficient Purified Water to produce 930 g and mix. Triturate the Calamine and the Zinc Oxide and incorporate in the cream. Uses: Has a mild astringent action on the skin and is used to relieve the discomfort of dermatitis and to allay the pain and swelling of sunburn.
LABELLING The label states that the contents of the container should be shaken before use. The label indicates the pharmaceutical form as 'cutaneous emulsion'.
Uses: Acaricide used in the treatment of scabies. Also effective in the treatment of pediculosis (infection with lice)
Dissolve the Chlorocresol in Purified Water with the aid of gentle heat. Melt the Emulsifying Ointment, add the solution of Chlorocresol while still warm, and stir gently until cold.
Packaging and storage Preserve in tight containers, at controlled room temperature, remote from fire.
Extemporaneous preparation: The following formula and directions apply. Aqueous Cream B.P. 93 500 g Benzyl Benzoate Application B.P. 93 500 g Uses: For the treatment of lice infection (pediculosis) and scabies.
mix. Stir gently until cool, add sufficient of the Purified Water to produce 1000 g and mix. Labelling The strength is stated as the percentage w/w of Cetrimide. When Cetrimide Cream is prescribed or demanded, no strength being stated, a cream containing 5% w/v shall be dispensed or supplied.
Petrolatum Rose Water Ointment USP XVI Cetyl Esters Wax (Cetyl Palmitate) . 125 g White Wax (Beeswax). 120 g Mineral Oil... 560 g Sodium Borate (Borax) .. 5 g Purified Water ..... 190 ml To make about 1000 g Reduce the cetyl esters wax and the white wax to small pieces, melt them on a steam bath with the mineral oil, and continue heating until the temperature of the mixture reaches 70O. Dissolve the sodium borate in the purified water, warmed to 70, and gradually add the warm solution to the melted mixture, stirring rapidly and continuously until it has congealed. If the ointment has been chilled, warm it slightly before attempting to incorporate other Ingredients (see USP for allowable variations). Use-Useful as an emollient, cleansing cream, and ointment base. It resembles Rose Water Ointment, differing only in that mineral oil is used in place of almond oil and omitting the fragrance. This change produces an ointment base which is not subject to rancidity like one containing a vegetable oil. This is a water-in-oil emulsion. Reference: REMINGTONS PHARMACEUTICAL SCIENCES
1000 g
Melt the emulsifying ointment with the aid of gentle heat, add the sodium phosphate, the citric acid, and the chlorocresol, previously dissolved in the water at the same temperature, and stir gently until cold.
If another antimicrobial preservative replaces Chlorocresol in this formulation, the suitability of the Cream as a diluent should be confirmed before use. Extemporaneous preparation Melt the Emulsifying Ointment with the aid of gentle heat. In a vessel that can be closed, heat about 650 g of Purified Water to about 60; add the Chlorocresol and, when it melts, vigorously shake the closed vessel to effect dissolution. Dissolve the Disodium Hydrogen Phosphate Dodecahydrate and the Citric Acid Monohydrate in the chlorocresol solution. Add the aqueous phase to the melted ointment when both are at about 60. Stir gently until cool, add sufficient Purified Water to produce 1000 g and mix. Storage If Buffered Cream is kept in aluminium tubes, their inner surfaces should be coated with a suitable lacquer.
Hydroquinone Cream
Definition Hydroquinone Cream contains 4% w/w of Hydroquinone powder finely sifted in a suitable cream basis. Reference: Remington: The Science and Practice of Pharmacy 19th Edition Hydroquinone 1,4-Benzenediol; p-Dihydroxybenzene; Hydroquinol; Quinol; Eldoquin and Eldopaque (Elder) Hydroquinone [123-31-9] C6H602 (110.11) Preparation-Various processes are employed. One involved reacting a sulfuric acid solution of aniline with manganese dioxide and reducting the resulting pbenzoquinone with sodium bisulfite. Description Fine, white needles, darken on exposure to air; melts 8 between 172 and 174O. Solubility 1 g in about 17 ml water, 4 ml alcohol, 51 ml chloroform or 16.5 ml either. Uses A hypopigmenting agent employed percutaneously to lighten localized areas of hyperpigmented skin, such as skin blemishes, lentigo, melasma, chloasma, freckles, etc. Its action is temporary, so that it is necessary to repeat the application at frequent intervals. It is a mild irritant, and erythema or rash may develop, which requires discontinuation of the drug. It should not be used near the
Melt the Cetostearyl Alcohol and heat with the Liquid Paraffin to about 60. Dissolve the Cetrimide in sufficient Purified Water to produce about 450 g. Add the aqueous solution to the oily phase when both are at about 60 and
eyes or in open cuts. It is to be used in children. Ingestion of 1 g results in tinnitus, nausea, vomiting, a sense of suffocation, shortness of breath, cyanosis, convulsions, delirium and collapse. Death has occurred with ingestion of 5 g. Irritation of the GI tract occurs with oral ingestion. Dermatitis results from skin contact. Corneal
100 g 1000 g
Salicylic Acid and Sulphur Cream B.P. 1980 Zinc and Ichthammol Cream B.P.C. 1973 Salicylic Acid, finely sifted 20 g
Precipitated Sulphur, Aqueous Cream sufficient to produce 20 g 1000 g Synonym: Zinc Oxide and Ichthammol Cream Zinc Cream Ichthammol Cetostearyl Alcohol Wool Fat 820 50 30 100 g g g g Triturate the Salicylic Acid and the Precipitated Sulphur with a part of the Aqueous Cream until smooth, and gradually add the remainder of the Aqueous Cream.
Melt together the Wool Fat and the Cetostearyl Alcohol with the aid of gentle heat, triturate the mixture with 800 g of Zinc Cream until smooth, incorporate the Ichthammol, add sufficient Zinc Cream to produce 1000 g and mix.
Melt together the wool fat and the cetostearyl alcohol with the aid of gentle heat, triturate the mixture with the zinc cream until smooth and incorporate the Ichthammol.
Triturate the salicylic acid and the sulphur with a portion of the aqueous cream until smooth and gradually add the remainder of the aqueous cream. Avoid contact with metals.
Sulphur Cream
Precipitated Sulphur, finely sifted Cold Cream USP 10 g 100 g
Extemporaneous preparation The following directions apply. Triturate the Zinc Oxide with a portion of Castor Oil until smooth and add the mixture to the remainder of the ingredients previously melted together. Stir while cooling until the temperature is about 40O.
Caution: Dilution with water renders Phenol Eardrops caustic; the preparation may be diluted with glycerol, if desired.
Extemporaneous preparation The following directions apply. Dissolve the Aluminium Sulphate in 600 ml of the Purified Water, add the Acetic Acid and then the Calcium Carbonate mixed with the remainder of the Purified Water and allow to stand for not less than 24 hours in a cool place, stirring occasionally. Filter, add the Tartaric Acid to the filtrate andmix. Storage Aluminium Acetate Ear Drops should be kept in a well-filled container and stored at a temperature not exceeding 25. When aluminium acetate solution or Burows Solution is prescibed or demanded a solution complyimg with the requirements of this monograph shall be dispensed or supplied.
Dissolve the phenol in the glycerol, with the aid of gentle heat if necessary.
Hydrogen Peroxide Solution means 6%, 20 Vol. One step preparation: Hydrogen Peroxide 30%, 100 Vol. Water ad 50 ml 1000 ml
In making this preparation the alcohol (95 percent) may be replaced by Industrial Methylated Spirit, provided that the law and the statutory regulations governing the use of industrial methylated spirit are observed.
Dissolve the Chloral Hydrate in the Water, add the Black Currant Syrup and sufficient Syrup to produce 1000 ml and mix. Labelling The label indicates the pharmaceutical form as oral solution.
100 ml
Triturate the tannic acid with the glycerol and warm gently until solution is effected. Storage: It should be stored in airtight containers.
EXTRACTS:
Definition Ipecacuanha Liquid Extract is prepared from Ipecacuanha by a method stated under the general monograph for Extracts. It contains not less than 1.90% and not more than 2.10% of total alkaloids, calculated as emetine, C 29 H 40 N 2 O 4 . Extemporaneous preparation Prepare by extracting Ipecacuanha with Ethanol (80 per cent) according to the following formula and directions. Ipecacuanha, in fine powder Ethanol (80 per cent) quantity Action and use Expectorant. 1000 g a sufficient
Extemporaneous preparation The following directions apply. Mix the Oleic Acid with the Turpentine Oil. Dilute the Dilute Ammonia Solution with 45 ml of the Purified Water, previously warmed, add to the oily solution and shake to form an emulsion. Separately dissolve the Ammonium Chloride in the remainder of the Purified Water, add to the emulsion and mix.
Definition
100 ml 1000 ml
To be diluted with an equal volume of warm water before use. Ref.: Martindale 26th Edition page 346
Emollient for the increased vitality promotes the growth of hair. Rub about 20 ml into the scalp before sleep. Shake the bottle before using. Keep out of the reach of children. Extemporaneous preparation The following directions apply. Mix all ingredients.
Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)
Phenol Lotion
Liquified Phenol Calamine Lotion to 5 g 1000 ml Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)
Uses Potassium Permanganate possesses oxidising properties which in turn confer disinfectant and deodorizing properties. It is also astringent. Though bactericidal in vitro its clinical value as a bactericide is minimized by its rapid reduction in the presence of body fluids. It is used as a 1 in 1000 solution in water as a
cleansing application to ulcers or abscesses and as a 1 in 4000 solution as a gargle or mouthwash; freshly prepared solutions should be used. Solutions of similar strengths are used as wet dressings and in baths in eczematous conditions and acute dermatitis especially where there is secondary infection. A 1% solution has been used in bromhidrosis, in mycotic infections such as athlete's foot, and in poison ivy dermatitis. A 5% solution has a powerful styptic action. A 0.02% solution in water can be employed as a stomach wash-out in the treatment of poisoning by morphine, opium, and strychnine; its use should be followed by evacuation of the stomach. It is of no value in poisoning by atropine, cocaine, or the barbiturates. Potassium permanganate has been widely used as a first-aid treatment in snake bite but it is of no value for this purpose, though a solution will destroy any venom lying free on the surface of the skin. Storage Store in airtight containers. Ref.: Martindale 28th Edition
Extemporaneous preparation The following directions apply. Dissolve the Sodium Bicarbonate in sufficient Purified Water, clarify by filtration, transfer the filtered solution into the final container, close the container so as to exclude micro-organisms and sterilise by heating in an autoclave. Storage Sodium Bicarbonate Eye Lotion should not be kept in containers that have previously been subjected to heating in an autoclave. Labelling The label states that any Eye Lotion not used within 24 hours of opening the container should be discarded. When Sodium Bicarbonate Eye Lotion is prescribed or demanded no strength being stated, a lotion containing 2% w/v of Sodium Bicarbonate shall be dispensed or supplied.
Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)
Extemporaneous preparation Dissolve the Salicylic Acid in a portion of Ethanol 96% , add the Castor Oil and sufficient Ethanol 96% to produce 1000 ml and mix.
Scalp Lotion
Resorcinol Salicylic Acid Sodium Metabisulphite Glycerin Alcohol 50% to 20 20 0.1 20 1000 g g g ml ml
1000 ml
Dissolve zinc sulfate and sulfurated potash separately, each in 450 ml purified water, and filter each solution. Add slowly the sulfurated potash solution to the zinc sulfate solution with constant stirring. Then add the required amount of purified water, and mix. Note: Prepare freshly and shake thoroughly before dispensing. Uses: An astringent, protective and mild antimicrobial preparation. The astringency is attributal to the zinc ion. The tiosulfates and polysulfides in it exert antibacterial and antifungal actions (see Sodium Thiosulfate, RPS-16, page 1176). White lotion is used in the treatment of acne vulgaris. Dose: Topical, to the skin, as required.
Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)
- Suitable for children if diluted to twice its volume water - To be freshly prepared Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)
Compound Sodium Chloride Mouthwash should be diluted with an equal volume of warm waterbefore use.
The mouthwash complies with the requirements stated under Mouthwashes and with the following requirements.
5 g 1 Liter
Melt the Simple Ointment, gradually add the Ammoniated Mercury and stir until cold. Action and uses Ammoniated mercury is a mild antiseptic and is sometimes applied to the skin surrounding the perineum to destroy threadworms and to reduce reinfection. It was formerly used in the treatment of low-grade staphylococcal infections of the skin, and in psoriasis. Precautions It should not be applied to raw surfaces because of the risk of absorption of mercury.
To be diluted with an equal volume of warm water before use. Ref.: Martindale 26th Edition page 346
Triturate the ammoniated mercury with a portion of the yellow soft paraffin until smooth, mix with the remainder of the yellow soft paraffin, and incorporate the strong coal tar solution. Containers and Storage The directions given under Ointments (page 757) should be followed; containers should prevent evaporation.
Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)
Triturate the salicylic acid with apportion of the ammoniated mercury and coal tar ointment until smooth and gradually incorporate the remainder of the ointment. Containers and Storage The directions given under Ointments (page 757) should be followed; containers should prevent evaporation.
Triturate the Calamine with part of the White Soft Paraffin until smooth and gradually incorporate the remainder of the White Soft Paraffin.
w/w of Strong Coal Tar Solution in a suitable wateremulsifying basis. Extemporaneous preparation The following formula and directions apply. Calamine, finely sifted Zinc Oxide, finely sifted Strong Coal Tar Solution Hydrous Wool Fat White Soft Paraffin 125 g 125 g 25 g 250 g 475 g
resulting solution to the Coal Tar dispersion. Mix thoroughly and stir until cold.
Melt together the Hydrous Wool Fat and the White Soft Paraffin. Triturate the Calamine and Zinc Oxide in the melted basis and stir gently, when cooled, to about 40. Gradually incorporate the Strong Coal Tar Solution and stiruntil cold. Storage Calamine and Coal Tar Ointment should be kept in a container that minimizes evaporation losses.
Mix the Zinc Oxide with the Strong Coal Tar Solution, triturate with a portion of the Yellow Soft Paraffin until smooth, gradually incorporate the remainder of the Yellow Soft Paraffin and mix.
Extemporaneous preparation The following directions apply. Melt together and stir until cold.
Extemporaneous preparation The following directions apply. Melt together the White Soft Paraffin, Cetostearyl Alcohol and Liquid Paraffin, add the Cetrimide and stir until cold.
Triturate the Benzoic Acid and the Salicylic Acid with a portion of the Emulsifying Ointment until smooth and gradually incorporate the remainder of the Emulsifying Ointment.
Disperse the Coal Tar in the Polysorbate 80, incorporate the Salicylic Acid and mix with the previously melted Emulsifying Wax. Separately, melt the White Soft Paraffin and the Coconut Oil, incorporate the Liquid Paraffin warmed to the same temperature and add, with stirring, the
Definition Emulsifying Wax White Soft Paraffin Liquid Paraffin 300 g 500 g 200 g
Extemporaneous preparation The following directions apply. Melt together and stir until cold.
Dissolve the Phenoxyethanol and the Dried Magnesium Sulphate in sufficient warm Purified Water to produce about 500 g. Melt the Wool Alcohols Ointment and heat to about 60; gradually add the aqueous solution at about 60 with vigorous stirring until a smooth cream is obtained. Stir until cool, add sufficient Purified Water to produce 1000 g and mix. Storage Hydrous Ointment should be kept in a container made from non-absorbent material. If, on storage, some aqueous liquid separates, it is readily reincorporated by stirring.
*Japanese Pharmacopoeia has ethyl hydroxybenzoate 25 mg in place of methyl hydroxybenzoate. Melt the Stearyl Alcohol and the White Petrolatum on a steam bath, and warm to about 750. Add the other ingredients, previously dissolved in the water and warmed to 750, and stir the mixture until congeals. Packaging and Storage Preserve in tight containers.
Thoroughly incorporate the Ichthammol with the Lanolin, and combine this mixture with the Petrolatum. Packaging and Storage Preserve in collapsible tubes or in tight containers, and avoid prolonged exposure to temperature exceeding 300.
Melt the Stearyl Alcohol and the White Wax together on a steam bath, then add the Cholesterol, and stir until completely dissolved. Add the White Petrolatum, and mix. Remove from the bath, and stir until the mixture congeals.
Mix the iodine with the arachis oil, add the yellow soft paraffin, and heat gently with occasional stirring at a temperature not excedding 600 until complete combination is effected, as indicated by the disappearance of the brown colour. Standard. Content of total iodine: 4.75 to 5.25 percent w/w, calculated as I.
In preparing Hydrous Ointment the proportions of Hard Paraffin, Soft Paraffin and Liquid Paraffin used to make the Wool Alcohols Ointment may be varied to produce Hydrous Ointment having suitable properties. When Hydrous Ointment is used in a white ointment, it should be prepared from Wool Alcohols Ointment made with White Soft Paraffin; when used in a coloured ointment, it should be prepared from Wool Alcohols Ointment made with Yellow Soft Paraffin. Extemporaneous preparation The following directions apply.
Iodine Ointment with Methyl Salicylate BPC 1949, nonstain (Non-staining Ointment of Iodine with Methyl Salicylate)
Unguentum Iodi Denigrescens cum Methylis Salicylate(Ung. Iod. Denig. C. Methyl. Salicyl.) Extemporaneous preparation Methyl Salicylate Non-staining Ointment of Iodine to 50 ml 1000 g
Melt the non-staining ointment of iodine, at a low temperature, add the methyl salicylate and stir until cold. Standard.
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White Beeswax
200 g
Melt together the White Beeswax and the Wool Fat and add the Menthol previously dissolved in the Methyl Salicylate, the Cineole, and the Cajuput Oil. Incorporate the Water at the same temperature, and stir until cold. stir until cold. A standard for this ointment is given in the British Pharmaceutical Codex 1973. Storage Containers should prevent evaporation. Certain plastic containers, such as those made from polystyrene, are unsuitable for use with this ointment. Advice for patients The ointment should be massaged well into the skin. It should not be applied to broken or inflamed skin or near to the eyes or mucous membranes. The container should be kept tightly closed.
Extemporaneous preparation The following directions apply. Add the Macrogol 4000 to the Macrogol 300, warm until homogeneous and stir continuously until cold.
Menthol Balsam
Definition Menthol Camphor Methyl Salicylate White Beeswax Wool Fat
Triturate the Yellow Mercuric Oxide with Liquid Paraffin, the mixed with Oleic Acid and heated at 50O until combination is effected. Foreign Pharmacopoeias: In Chin. And Ind. (as B.P.C. 1959); in Braz. And Mex. (both 25% HgO). A yellowish unctuous. Insoluble in water; slightly soluble in alcohol and ether; readily soluble in fixed oils. Protect from light. It may be employed in ointment form for uses similar to those of ammoniated mercury. Preparations:
Melt together the White Beeswax and the Hydrous Wool Fat, cool, add the Methyl Salicylate and stir until cold. Storage Containers should prevent evaporation. Certain plastic containers, such as those made from polystyrene, are unsuitable for use with this ointment.
Extemporaneous preparation The following directions apply. Mix the ingredients, heat gently with stirring until homogeneous and stir until cold.
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Oily Cream
940 g
Triturate the salicylic acid and the precipitated sulphur with a portion of the oily cream until smooth and gradually incorporate the remainder of the cream. Advice for patients: The ointment should be applied sparingly to the affected area. It should not be applied to broken or inflamed skin; contact with the eyes should be avoided. Prolonged use should be avoided and treatment should be discontinued if excessive dryness or irritation occurs. A standard for this ointment is given in the British Pharmaceutical Codex 1973.
Extemporaneous preparation The following directions apply. Rub the starch and the benzoic acid with the purified water in a porcelain dish until a smooth mixture is produced, then add the glycerin, and mix well. Heat the mixture on a sand bath to a temperature between 140O and 144O, with constant but gentle stirring until a translucent, jelly-like mass results, and then strain through muslin. Starch Glycerite should be freshly prepared. Uses Although not an oleaginous base, this emollient preparation is sometimes used as a substitute for a fatty ointment. It has also been used as a pill excipient. Dose For external use, topically as required. Storage Store in airtight container. Ref: Rimingtons Pharmaceutical Sciences 16th Edition page-1249 Martindale: Preparation:
Melt the Wool Alcohols Ointment, gradually add the Salicylic Acid and stir until cold. Used in acne, eczema, and ringworm
A similar ointment, usually with the title Unguentum Hydrargyri, is included in many pahramacopoeias.
Unless otherwise directed in the monograph, when Simple Ointment is used in a white ointment, it should be prepared with White Soft Paraffin; when used in a coloured ointment it should be prepared with Yellow Soft Paraffin. Extemporaneous preparation The following directions apply. Mix the ingredients, heat gently with stirring until homogeneous and stir until cold.
Triturate the Precipitated Sulphur with a portion of the Simple Ointment until smooth, gradually add the remainder of the Simple Ointment, and mix thoroughly. Contents of sulphur, S 9.5 to 10.5 percent w/w. Note:
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Uses of Sulfur precipitated An active parasiticide; a 10% sulfur paste or ointment is used as an alternative treatment for Sarcoptes scabiei (mites). Sulfur also is actively keratolytic and, in the form of full-strength ointment or in combination with other keratolytic agents such as psoriasis, seborrhea, eczema-dermatitis and lupus erythematosus. The percentage of sulfur in an ointment should be reduced in the event that a patient's skin shows intolerance. Prolonged use of sulfur may result in a characteristic dermatitis venerate. Dose - Topical, as a 10% ointment every night for 3 nights.
Levigate the sulfur with the Mineral Oil to a smooth paste, and then incorporate with the White Ointment. Packaging and Storage Preserve in well-closed containers, and avoid prolonged exposure to excessive heat.
Dissolve the magenta in the alcohol and the acetone, previously mixed. Dissolve the boric acid in a portion of water; dissolve the phenol and the resorcinol in this solution, add the alcoholic magenta solution and sufficient water to produce the required volume, and mix. In making this preparation the alcohol (90 per cent) may be replaced by Industrial Methylated Spirit diluted so as to be of equivalent alcoholic strength, provided that the law and the statutory regulations governing the use of industrial methylated spirit are observed. Storage. It should be stored in airtight containers, protected from light, in a cool place.
In preparing Wool Alcohols Ointment, the proportions of Hard Paraffin, Soft Paraffin and Liquid Paraffin may be varied to produce Wool Alcohols Ointment having suitable properties. When Wool Alcohols Ointment is used in a white ointment, it should be prepared with White Soft Paraffin; when used in a coloured ointment it should be prepared with Yellow Soft Paraffin. Extemporaneous preparation The following directions apply. Melt together with the aid of gentle heat and stir until cold.
g ml ml ml ml
Extemporaneous preparation The following directions apply. Triturate the Zinc Oxide with a portion of the Castor Oil until smooth and add the mixture to the remainder of the ingredients previously melted together. Stir while cooling until the temperature is about 40.
It should be well shaken before use. Store in a cool place in airtight containers. It is used as a throat paint in the treatment of pharyngitis and follicular tonsillitis.
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150
1000 ml
In making the Compound Benzoin Tincture used to prepare Compound Podophyllin Paint, the Ethanol (90 per cent) may be replaced by Industrial Methylated Spirit 1 diluted so as to be of equivalent ethanolic strength. Labelling The label indicates the pharmaceutical form as cutaneous solution.
The law and the statutory regulations governing the use of Industrial Methylated Spirit must be observed.
1
Uses and administration Mercurochrome is a weak disinfectant; in the presence of organic material its effect is greatly reduced. It is non-irritant to tissues but has poor penetrating power. Aqueous solutions are of little value for skin disinfectantion but a 2% solution in a mixture of alcohol, acetone, and water has been used. Mercurochrome has also been applied as a surface disinfectant to mucous membranes and wounds but is unreliable. In genito-urinary infections mercurochrome has been used as a 1% solution for bladder and urethral irrigation. Stains on the skin caused by mercurochrome may be removed with chlorinated soda solution. Mercurochrome is a weak mercurial antiseptic that has been used for disinfection of skin and wounds.
Extemporaneous preparation The following directions apply. Triturate the Bismuth Subnitrate and the Iodoform in a sterile mortar with sufficient of the Liquid Paraffin to produce a smooth paste, using aseptic precautions; transfer the remainder of the Liquid Paraffin, and mix. Storage It should be stored in sterilized collapsible tubes, in a cool place.
Merbromin; Mercurodibromo-flourescein; Mercuresceine Sodique. It consists chiefly of disodium 2,7-dibromo-4hydroxymercurifluorescein Extemporaneous preparation The following formula and directions apply. Mercurochrome Water ad 2 g 100 ml
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Mix the Aluminium Powder and the Zinc Oxide with the Liquid Paraffin until smooth.
contains not less than 85% of magnesium sulphate, calculated as MgSO 4 . Storage Magnesium Sulphate Paste should be kept in a well-closed container.
Labelling The label states that the Paste should be stirred before use.
Extemporaneous preparation The following directions apply. Triturate the Strong Coal Tar Solution with a portion of the Compound Zinc Paste until smooth and gradually incorporate the remainder of the Compound Zinc Paste.
Melt the White Soft Paraffin, incorporate the Zinc Oxide and the Starch and stir until cold.
Melt the Emulsifying Wax at 70, add the Coal Tar and 225 g of the Yellow Soft Paraffin, stir at 70 until completely melted, add the remainder of the Yellow Soft Paraffin, cool to 30, add the Zinc Oxide and the Starch, stirring constantly, and stir until cold.
Extemporaneous preparation The following directions apply. Melt the White Soft Paraffin, incorporate the Zinc Oxide, the Salicylic Acid and the Starch and stir until cold.
Mix the Dithranol with a portion of the Zinc and Salicylic Acid Paste until a smooth, even dispersion is obtained and gradually incorporate the remainder of the Zinc and Salicylic Acid Paste.
Extemporaneous preparation The following directions apply. Mix the Heavy Kaolin, previously dried at 100, and the Boric Acid with the Glycerol, heat at 120 for 1 hour, stirring occasionally, and allow to cool. Separately, dissolve the Thymol in the Methyl Salicylate, add to the cooled mixture, add the Peppermint Oil and mix thoroughly. The heating step may be omitted if some other satisfactory means of mixing the solid ingredients with the Glycerol is used but in this case Heavy Kaolin that has been sterilised is used.
16
Storage Kaolin Poultice should be kept in suitable containers that minimise absorption, diffusion or evaporation of the ingredients.
If an appropriate heating step, such as that described under Extemporaneous preparation, is not included in the manufacturing process, Heavy Kaolin that has been sterilised is used.
1
17
Definition Calcium Hydroxide 10 g Purified Water, freshly boiled and cooled Sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Shake together thoroughly and repeatedly; allow to stand until clear. Siphon off the clear solution as required. Storage Calcium Hydroxide Solution should be kept in a well-filled and well-closed container. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.
In making Strong Coal Tar Solution the Ethanol (96 per cent) may be replaced by Industrial Methylated Spirit 1 . Extemporaneous preparation The following directions apply. Mix the Coal Tar, warmed if necessary to render it fluid, with the Polysorbate 80, pour this mixture in a thin stream into 700 ml of Ethanol (96 per cent) in a closed vessel fitted with an agitator; continue agitation throughout the addition of the mixture and for 1 hour thereafter. Allow the mixture to stand for not less than 24 hours, decant and filter the supernatant liquid, wash the vessel and filter with Ethanol (96 per cent), combine the filtrate and washings and add sufficient Ethanol (96 per cent) to produce 1000 ml.
Jessners Solution
Definition Resorcinol 14 g Salicylic Acid 14 g Lactic Acid 14 ml Ethanol (95 per cent) sufficient to produce 100 ml Extemporaneous preparation The following directions apply. Dissolve the Resorcinol in a portion of water, dissolve separately the remainder items in alcohol and mix the two solutions and filter. g g
Joulies Solution
Phosphate Mixture Definition Sodium Phosphate 136 g Phosphoric Acid 85% 58.8 g Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation Dissove. The solution has a pH of 4.9, contains 1725 millios- moles per litre, and provides 30.4 mg of inorganic phosphorus per ml. Dose 15 ml every 4 hours, 5 times daily.
1000 ml
In making Coal Tar Solution, the Ethanol (96 per cent) may be replaced by Industrial Methylated Spirit 1 . Extemporaneous preparation The following directions apply. Mix the Coal Tar, warmed if necessary to render it fluid, with the Polysorbate 80, pour this mixture in a thin stream into 800 ml of Ethanol (96 per cent) in a closed vessel fitted with an agitator; continue agitation throughout the addition of the mixture and for 1 hour thereafter. Allow the mixture to stand for not less than 24 hours, decant and filter the supernatant liquid, wash the vessel and filter with Ethanol (96 per cent), combine the filtrate and washings and add sufficient Ethanol (96 per cent) to produce 1000 ml. Storage Coal Tar Solution should be kept in a well-closed container. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.
The law and the statutory regulations governing the use of Industrial Methylated Spirit must be observed.
1
1000 ml
1000 ml
18
Extemporaneous preparation Dissolve the lead acetate in 750 ml of the water, add the lead monoxide, and allow to stand for forty-eight hours, shaking occasionally, filter, pass through the filter sufficient of the water to produce the required volume, and mix.
and add the Ammonium Bicarbonate and the Strong Ammonia Solution to the distillate. Heat on a water bath to 60 in a sealed bottle of not less than 120-ml capacity, shaking occasionally, until solution is complete, cool, filter through absorbent cotton, mix the filtrate with the reserved distillate, add sufficient Purified Water to produce 1000 ml and mix.
1000 ml
Colongne Spirit
Spiritus Colonieses (Sp. Colon.) / Aqua Colonieses Definition Oil of Bergamot Oil of Lemon Oil of Neroli Oil of Rosemary Oil of Thyme Concentrated Orange-flower Water Water Alcohol (90 percent) to 5.0 2.0 1.5 0.5 3.0 41.7 1000 12.5 ml ml ml ml ml ml ml ml
Extemporaneous preparation The following directions apply. Dissolve the oils in about 900 ml of the alcohol 90 percent, add gradually the concentrated orange-flower water, previously diluted with water, and then add sufficient alcohol 90 percent to produce the required volume.
Labelling The label states, where applicable, that the contents of the container are sterile. The label indicates the pharmaceutical form as cutaneous solution. When In making this preparation the alcohol 90 percent may be normal saline is prescribed or demanded, Sodium Chloride replaced by industrial methylated spirit diluted so as to be Solution shall be dispensed or supplied. of equivalent alcoholic strength , provided that the final product contains 1 percent. v/v of ethyl phthalate and If the label states that the contents of the container are sterile, the solution complies with the following that the law and the statutory regulations governing the use of industrial methylated spirit are observed. additional requirements. Sterility Complies with the test for sterility, Appendix XVI A. Labelling The label states (1) Sterile Sodium Chloride Solution; (2) that the solution is not intended for injection; (3) the date after which the solution is not intended to be used; (4) the conditions under which it should be stored. Reference: Pharmacopoeia ___________________ Formulary page 1285
Extemporaneous preparation The following directions apply. Distil a mixture of the Lemon Oil, the Nutmeg Oil, the Ethanol (90 per cent) and 375 ml of Purified Water. Reserve the first 875 ml of distillate. Distil a further 55 ml
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Ethanol (90 per cent) sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve the Peppermint Oil in Ethanol (90 per cent) and add sufficient Ethanol (90 per cent) to produce 1000 ml. If the solution is not clear, shake with previously sterilised Purified Talc and filter.
concentrated juice of commerce and Water, and adding to this solution sufficient Benzoic Acid to give a final concentration of not more than 800 ppm, or suffi-cient Sodium Metabisulphite or other suitable sulphite to give a final concentration of not more than 350 ppm of sulphur dioxide. Storage Black Currant Syrup should be kept in a wellfilled, well-closed container, protected from light and stored at a temperature not exceeding 25. Black Currant Syrup contains, in 10 ml, about 7.5 mg of ascorbic acid.
The requirement for Content of ascorbic acid does not apply when Black Currant Syrup is used as a flavouring agent for pharmaceutical purposes.
1
1000 ml
Labelling The label states that the preparation is flammable and should be kept away from a naked flame.
One or more suitable antimicrobial preservatives may be added. Extemporaneous preparation The following directions apply. Heat together until dissolved and add sufficient boiling Purified Water to produce 1000 g. Labelling The label states the names and proportions of any added antimicrobial preservatives. When antimicrobial preservatives are added the suitability of the Syrup as a vehicle or diluent should be confirmed before use. The pH of Syrup may affect the solubility of basic or acidic materials.
Extemporaneous preparation The following directions apply. Dissolve the Citric Acid Monohydrate in some of the Syrup, add the Invert Syrup, the Lemon Spirit and sufficient Syrup to produce 1000 ml and mix. Storage Lemon Syrup should be stored at a temperature not exceeding 25.
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Extemporaneous preparation The following directions apply. Dissolve the Potassium Iodide and the Iodine in the Purified Water and add sufficient Ethanol (90 per cent) to produce 1000 ml. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored. The label indicates the pharmaceutical form as cutaneous solution. When iodine tinture is prescribed or demanded Alcoholic Iodine Solution shall be dispensed or supplied.
1000 ml
Extemporaneous preparation The following directions apply. Macerate the Barbados Aloes or Cape Aloes, the prepared storax and the Sumatra Benzoin with 800 ml of Ethanol (90 per cent) in a closed vessel for not less than 2 days, shaking occasionally, filter and pass sufficient Ethanol (90 per cent) through the filter to produce 1000 ml.
Mix the Ethanol (90 per cent) and the Acetic Acid (6 per Extemporaneous preparation The following directions cent) with the Glycerol and 450 ml of Purified Water and add the Ipecacuanha Liquid Extract and sufficient Purified apply. Water to produce 1000 ml. Allow to stand for not less than Dissolve the Chloroform in the Purified Water by shaking. 24 hours; filter.
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Dissolve the Anise Oil in the Ethanol (90 per cent) and add Cetomacrogol Emulsifying Wax B.P. gradually, with vigorous shaking after each addition, sufficient Water to produce 1000 ml. Add 50 g of 1999 previously sterilised Purified Talc, or other suitable Non-ionic Emulsifying Wax filtering aid, allow to stand for a few hours, shaking Definition occasionally, and filter. Cetostearyl Alcohol 800 g Concentrated Camphor Water B.P. Macrogol Cetostearyl Ether (22) 200 g
1999
Definition Racemic Camphor Ethanol (90 per cent) Water sufficient to produce 40 g 600 ml 1000 ml
Extemporaneous preparation The following directions apply. Melt together and stir until cold. Characteristics A white or almost white, waxy solid or flakes melting when heated to a clear almost colourless liquid; odour faint and characteristic of cetostearyl alcohol. Practically insoluble in water, producing an emulsion; moderately soluble in ethanol (96%); partly soluble in ether.
Extemporaneous preparation The following directions apply. Dissolve the Racemic Camphor in the Ethanol (90 per cent) and add, gradually, with vigorous shaking after each addition, sufficient Water to produce 1000 ml.
Dissolve the oil of rose in the alcohol (90 per cent.) and add sufficient water in successive small portions to produce the required volume, shaking vigorously after each addition. Add (1/2 oz.) of purified talc, and shake; allow to stand for a few hours, occasionally shaking, and filter. Rose water may be prepared by diluting concentrated rose water with 39 times its volume of water; the product contains about 1.25 per cent. v/v of alcohol (90 per cent.). Triple rose water may be prepared by diluting concentrated rose water with 12 times its volume of water; the product contains about 4 per cent. v/v of alcohol (90 per cent)
WAX:
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