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APPLICATIONS:

Benzyl Benzoate Application is a cutaneous emulsion. It contains 25% w/v of Benzyl Benzoate in a suitable oil-inwater emulsified basis. Extemporaneous preparation The following formula and directions apply. Benzyl Benzoate 250 g Emulsifying Wax 20 g Purified Water, freshly boiled and cooled Sufficient to produce 1000 ml Melt the Emulsifying Wax, add the Benzyl Benzoate and mix. Pour the mixture into sufficient warm Purified Water to produce 1000 ml and stir thoroughly until cold.

CREAMS:
Definition Aqueous Calamine Cream contains 4% w/w of Calamine and 3% w/w of Zinc Oxide in a suitable oil-inwater emulsified basis. Extemporaneous preparation The following formula and directions apply. Calamine 40 g Zinc Oxide 30 g Liquid Paraffin 200 g Self-emulsifying Glyceryl Monostearate 50 g Cetomacrogol Emulsifying Wax 50 g Phenoxyethanol 5 g Purified Water, freshly boiled and cooled, sufficient to produce 1000 g Melt the Cetomacrogol Emulsifying Wax with the Selfemulsifying Glyceryl Monostearate, add the Liquid Paraffin and heat to about 60. Dissolve the Phenoxyethanol in about 620 g of Purified Water at about 60, add the oily phase to the phenoxyethanol solution and mix. Stir until cool, add sufficient Purified Water to produce 930 g and mix. Triturate the Calamine and the Zinc Oxide and incorporate in the cream. Uses: Has a mild astringent action on the skin and is used to relieve the discomfort of dermatitis and to allay the pain and swelling of sunburn.

Benzyl Benzoate Application BP 2005 Aqueous Calamine Cream B.P. 1999

LABELLING The label states that the contents of the container should be shaken before use. The label indicates the pharmaceutical form as 'cutaneous emulsion'.
Uses: Acaricide used in the treatment of scabies. Also effective in the treatment of pediculosis (infection with lice)

COLLODIONS: Salactol Paints


Synonym: Lactic Acid and Salicylic Acid Paint A.P.F. Extemporaneous preparation: The following formula and directions apply. Salicylic Acid fine powder 20 g Lactic Acid 20 g Flexible Collodion ad 100 g

Aqueous Cream B.P. 1980


Aqueous Cream may be prepared in the following manner. Emulsifying Ointment Chlorocresol Purified Water, freshly boiled and cooled, 300 g 1 g 699 g

Dissolve the Chlorocresol in Purified Water with the aid of gentle heat. Melt the Emulsifying Ointment, add the solution of Chlorocresol while still warm, and stir gently until cold.

Salicylic Acid Collodion U.S.P. 1980


Salicylic Acid Collodion contains not less than 9.5 percent and not more than 11.5 percent of C7H6O3. Salicylic Acid 100 g Flexible Collodion, a sufficient quantity, to make 1000 ml Dissolve the Salicylic Acid in about 750 ml of Flexible Collodion, add sufficient of the latter to make the product measure 1000 ml, and mix.

Aqueous Cream B.P. 1999


Definition Emulsifying Ointment 300 g Phenoxyethanol 10 g Purified Water, freshly boiled and cooled, sufficient to produce 1000 g The suitability of the Cream for use as a diluent should be confirmed before use. Extemporaneous preparation Aqueous Cream may be prepared in the following manner. Dissolve the Phenoxyethanol in sufficient Purified Water at about 60 to produce a total weight of about 700 g. Melt the Emulsifying Ointment, add the phenoxyethanol solution when both are at about 60 and mix. Stir gently until cool, add sufficient of the Purified Water to produce 1000 g and mix. Uses: An emollient cream for the relief of symptoms of dry or chapped skin. Also used as a vehicle in pharmaceutical preparations.

Packaging and storage Preserve in tight containers, at controlled room temperature, remote from fire.

Salicylic Acid Collodion B.P. 1999


Definition Salicylic Acid 120 g Flexible Collodion sufficient to produce 1000 ml

Salicylic Acid Collodion B.P.C. 1973


Salicylic Acid Flexible Collodion 120 g 1000 ml

Benzyl Benzoate Cream

Extemporaneous preparation: The following formula and directions apply. Aqueous Cream B.P. 93 500 g Benzyl Benzoate Application B.P. 93 500 g Uses: For the treatment of lice infection (pediculosis) and scabies.

mix. Stir gently until cool, add sufficient of the Purified Water to produce 1000 g and mix. Labelling The strength is stated as the percentage w/w of Cetrimide. When Cetrimide Cream is prescribed or demanded, no strength being stated, a cream containing 5% w/v shall be dispensed or supplied.

Buffered Cream B.P.C. 1973


Definition Citric Acid Monohydrate Sodium Phosphate Chlorocresol Emulsifying Ointment Purified Water, freshly boiled and cooled 5 25 1 300 g g g g

Cold Cream USP

Petrolatum Rose Water Ointment USP XVI Cetyl Esters Wax (Cetyl Palmitate) . 125 g White Wax (Beeswax). 120 g Mineral Oil... 560 g Sodium Borate (Borax) .. 5 g Purified Water ..... 190 ml To make about 1000 g Reduce the cetyl esters wax and the white wax to small pieces, melt them on a steam bath with the mineral oil, and continue heating until the temperature of the mixture reaches 70O. Dissolve the sodium borate in the purified water, warmed to 70, and gradually add the warm solution to the melted mixture, stirring rapidly and continuously until it has congealed. If the ointment has been chilled, warm it slightly before attempting to incorporate other Ingredients (see USP for allowable variations). Use-Useful as an emollient, cleansing cream, and ointment base. It resembles Rose Water Ointment, differing only in that mineral oil is used in place of almond oil and omitting the fragrance. This change produces an ointment base which is not subject to rancidity like one containing a vegetable oil. This is a water-in-oil emulsion. Reference: REMINGTONS PHARMACEUTICAL SCIENCES

1000 g

Melt the emulsifying ointment with the aid of gentle heat, add the sodium phosphate, the citric acid, and the chlorocresol, previously dissolved in the water at the same temperature, and stir gently until cold.

Buffered Cream B.P. 1999


Definition Emulsifying Ointment 300 Disodium Hydrogen Phosphate Dodecahydrate 25 Citric Acid Monohydrate 5 Chlorocresol 1 Purified Water, freshly boiled and cooled, sufficient to produce 1000 g g g g g

If another antimicrobial preservative replaces Chlorocresol in this formulation, the suitability of the Cream as a diluent should be confirmed before use. Extemporaneous preparation Melt the Emulsifying Ointment with the aid of gentle heat. In a vessel that can be closed, heat about 650 g of Purified Water to about 60; add the Chlorocresol and, when it melts, vigorously shake the closed vessel to effect dissolution. Dissolve the Disodium Hydrogen Phosphate Dodecahydrate and the Citric Acid Monohydrate in the chlorocresol solution. Add the aqueous phase to the melted ointment when both are at about 60. Stir gently until cool, add sufficient Purified Water to produce 1000 g and mix. Storage If Buffered Cream is kept in aluminium tubes, their inner surfaces should be coated with a suitable lacquer.

Hydroquinone Cream
Definition Hydroquinone Cream contains 4% w/w of Hydroquinone powder finely sifted in a suitable cream basis. Reference: Remington: The Science and Practice of Pharmacy 19th Edition Hydroquinone 1,4-Benzenediol; p-Dihydroxybenzene; Hydroquinol; Quinol; Eldoquin and Eldopaque (Elder) Hydroquinone [123-31-9] C6H602 (110.11) Preparation-Various processes are employed. One involved reacting a sulfuric acid solution of aniline with manganese dioxide and reducting the resulting pbenzoquinone with sodium bisulfite. Description Fine, white needles, darken on exposure to air; melts 8 between 172 and 174O. Solubility 1 g in about 17 ml water, 4 ml alcohol, 51 ml chloroform or 16.5 ml either. Uses A hypopigmenting agent employed percutaneously to lighten localized areas of hyperpigmented skin, such as skin blemishes, lentigo, melasma, chloasma, freckles, etc. Its action is temporary, so that it is necessary to repeat the application at frequent intervals. It is a mild irritant, and erythema or rash may develop, which requires discontinuation of the drug. It should not be used near the

Cetrimide Cream B.P. 1999


Definition Cetrimide Cream contains the stated percentage w/w of Cetrimide in a suitable basis. Extemporaneous preparation The following formula and directions apply. Cetrimide 5 sufficient quantity Cetostearyl Alcohol 50 Liquid Paraffin 500 Purified Water, freshly boiled and cooled sufficient to produce 1000 g, or a g g g

Melt the Cetostearyl Alcohol and heat with the Liquid Paraffin to about 60. Dissolve the Cetrimide in sufficient Purified Water to produce about 450 g. Add the aqueous solution to the oily phase when both are at about 60 and

eyes or in open cuts. It is to be used in children. Ingestion of 1 g results in tinnitus, nausea, vomiting, a sense of suffocation, shortness of breath, cyanosis, convulsions, delirium and collapse. Death has occurred with ingestion of 5 g. Irritation of the GI tract occurs with oral ingestion. Dermatitis results from skin contact. Corneal

Wool Fat Zinc Cream sufficient to produce

100 g 1000 g

Salicylic Acid and Sulphur Cream B.P. 1980 Zinc and Ichthammol Cream B.P.C. 1973 Salicylic Acid, finely sifted 20 g
Precipitated Sulphur, Aqueous Cream sufficient to produce 20 g 1000 g Synonym: Zinc Oxide and Ichthammol Cream Zinc Cream Ichthammol Cetostearyl Alcohol Wool Fat 820 50 30 100 g g g g Triturate the Salicylic Acid and the Precipitated Sulphur with a part of the Aqueous Cream until smooth, and gradually add the remainder of the Aqueous Cream.

Melt together the Wool Fat and the Cetostearyl Alcohol with the aid of gentle heat, triturate the mixture with 800 g of Zinc Cream until smooth, incorporate the Ichthammol, add sufficient Zinc Cream to produce 1000 g and mix.

Salicylic Acid and Sulphur Cream B.P.C. 1973


Synonym: Salicylic Acid and Sulphur Application Salicylic Acid, finely sifted Precipitated Sulphur, finely sifted Aqueous Cream 20 g 20 g 960 g

Melt together the wool fat and the cetostearyl alcohol with the aid of gentle heat, triturate the mixture with the zinc cream until smooth and incorporate the Ichthammol.

Zinc Oxide and Olive Oil Cream


Zinc Oxide, finely sifted Olive Oil Cetostearyl Alcohol White Beeswax Arachis Oil 75 500 20 100 305 g g g g g

Triturate the salicylic acid and the sulphur with a portion of the aqueous cream until smooth and gradually add the remainder of the aqueous cream. Avoid contact with metals.

Sulphur Cream
Precipitated Sulphur, finely sifted Cold Cream USP 10 g 100 g

Zinc Oxide Cream B.P. 1999


Definition Zinc Cream contains 32% w/w of Zinc Oxide in a suitable water-in-oil emulsified basis. Extemporaneous preparation The following formula and directions apply. Zinc Oxide, finely sifted 320 g Calcium Hydroxide 0.45 g Oleic Acid 5 ml Arachis Oil 320 ml Wool Fat 80 g Purified Water, freshly boiled and cooled sufficient to produce 1000 g Mix the Zinc Oxide and the Calcium Hydroxide, triturate to a smooth paste with a mixture of the Oleic Acid and Arachis Oil, incorporate the Wool Fat and add gradually with continuous stirring sufficient Purified Water to produce 1000 g. The suitability of the Cream for use as a diluent should be confirmed before use.

UREA CREAM B.P. 1993


Urea Aqueous Cream B.P. ad 10 g 100 g

Zinc and Castor Oil Cream B.P. 1993


Synonym: Zinc and Castor Oil Ointment Zinc Oxide, finely sifted Castor Oil Cetostearyl Alcohol White Beeswax Arachis Oil 75 500 20 100 305 g g g g g

Extemporaneous preparation The following directions apply. Triturate the Zinc Oxide with a portion of Castor Oil until smooth and add the mixture to the remainder of the ingredients previously melted together. Stir while cooling until the temperature is about 40O.

EAR DROPS: Acetic Acid Ear Drops A.P.F.


Extemporaneous preparation Acetic Acid 33% Water, freshly boiled and cooled to Mix. 3 100 ml ml

Zinc and Ichthammol Cream B.P. 1999


Definition Zinc and Ichthammol Cream contains 5% w/w of Ichthammol dispersed in a suitable basis of which about 82% w/w is Zinc Cream. Extemporaneous preparation The following formula and directions apply. Ichthammol Cetostearyl Alcohol 50 30 g g

Almond Oil Ear Drops B.P. 1999


Definition Almond Oil Ear Drops are Almond Oil in a suitable container. Storage Almond Oil Ear Drops should be kept in a wellfilled, well-closed container and protected from light.

Aluminium Acetate Ear Drops B.P. 1999


Definition Aluminium Sulphate Calcium Carbonate Tartaric Acid Acetic Acid (33 per cent) Purified Water 225 100 45 250 750 g g g ml ml

Phenol Ear Drops B.P.C. 1973


Phenol Glycerin Glycerol to 40 ml 100 ml

Synonym: Aluminium Acetate Solution; Burow's Solution

Caution: Dilution with water renders Phenol Eardrops caustic; the preparation may be diluted with glycerol, if desired.

Phenol Glycerin (Reagent)


Phenol Glycerol 160 g 840 g

Extemporaneous preparation The following directions apply. Dissolve the Aluminium Sulphate in 600 ml of the Purified Water, add the Acetic Acid and then the Calcium Carbonate mixed with the remainder of the Purified Water and allow to stand for not less than 24 hours in a cool place, stirring occasionally. Filter, add the Tartaric Acid to the filtrate andmix. Storage Aluminium Acetate Ear Drops should be kept in a well-filled container and stored at a temperature not exceeding 25. When aluminium acetate solution or Burows Solution is prescibed or demanded a solution complyimg with the requirements of this monograph shall be dispensed or supplied.

Dissolve the phenol in the glycerol, with the aid of gentle heat if necessary.

Salicylic Acid Ear Drops A.P.F.


Salicylic Acid 2 g Alcohol 90% 50 ml Freshly boiled and cooled water to 100 ml Ref: Martindale 28th Edition

Sodium Bicarbonate Ear Drops B.P. 1999


Definition Sodium Bicarbonate 5 g Glycerol 30 ml Purified Water, freshly boiled and cooled sufficient to produce 100 ml Extemporaneous preparation The following directions apply. Dissolve the Sodium Bicarbonate in about 60 ml of Purified Water, add the Glycerol and sufficient Purified Water to produce 100 ml and mix. Sodium Bicarbonate Ear Drops should be recently prepared.

Boric Acid Ear Drops E.N.F.


Boric Acid Alcohol (90%) to 2 g 100 ml To be diluted with an equal volume of water when used for children.

Boric Acid Ear Drops (B.P.C. 1963, B.N.F. 1966)


Boric Acid Alcohol or Industrial Methylated Spirit Water to 18.3 g 208 ml 1000 ml

Hydrogen Peroxide Ear Drops B.P.C.


Hydrogen Peroxide Solution Water ad 25 ml 100 ml

Spirit Ear Drops B.P.C. 1973


Alcohol 95 percent Water to 50 ml 100 ml

Hydrogen Peroxide Solution means 6%, 20 Vol. One step preparation: Hydrogen Peroxide 30%, 100 Vol. Water ad 50 ml 1000 ml

In making this preparation the alcohol (95 percent) may be replaced by Industrial Methylated Spirit, provided that the law and the statutory regulations governing the use of industrial methylated spirit are observed.

Ichthammol Glycerin Ear Drops B.P.C. 1973


Synonym: Glycerin of Ammonium Ichthosulphonate Ichthammol Glycerin 100 g 900 g

ELIXIRS: Paediatric Chloral Elixir B.P. 1999


Paediatric Chloral Oral Solution Definition Paediatric Chloral Elixir is an oral solution containing 4% w/v of Chloral Hydrate in a suitable vehicle with a blackcurrant flavour. Extemporaneous preparation It is recently prepared according to the following formula and directions. Chloral Hydrate Water Black Currant Syrup Syrup sufficient to produce 40 20 200 1000 g ml ml ml

Olive Oil Ear Drops B.P. 1999


Definition Olive Oil Ear Drops are Olive Oil in a suitable container. Storage Olive Oil Ear Drops should be kept in a wellfilled, well-closed container and protected from light.

Dissolve the Chloral Hydrate in the Water, add the Black Currant Syrup and sufficient Syrup to produce 1000 ml and mix. Labelling The label indicates the pharmaceutical form as oral solution.

Glycerin ad Batch No.:

100 ml

Tannic Acid Glycerin BPC 1973


Tannic Acid Glycerol 15 g 85 g

EMULSIONS Concentrated Peppermint Emulsion B.P. 1999


Definition Concentrated Peppermint Emulsion is a 2% v/v dispersion of Peppermint Oil in a suitable vehicle containing a non-ionic surface-active agent. Extemporaneous preparation The following formula and directions apply. Peppermint Oil 20 ml Polysorbate 20 1 ml Double-strength Chloroform Water 500 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Shake the Peppermint Oil with the Polysorbate 20 and add gradually, shaking well after each addition, the Doublestrength Chloroform Water and sufficient Purified Water to produce 1000 ml

Triturate the tannic acid with the glycerol and warm gently until solution is effected. Storage: It should be stored in airtight containers.

LINIMENTS : Camphor Liniments BP, APF (BPC 1973)


Synonym : Camphorated Oil Camphor 20 g Arachis Oil 100 g It should be stored in airtight containers, in a cool place.

Methyl Salicylate Liniment B.P. 1999


Definition Methyl Salicylate is a cutaneous emulsion. It contains 25% v/v of Methyl Salicylate in Arachis Oil or other suitable fixed oil. Labelling The label indicates the pharmaceutical form as cutaneous emulsion.

EXTRACTS:
Definition Ipecacuanha Liquid Extract is prepared from Ipecacuanha by a method stated under the general monograph for Extracts. It contains not less than 1.90% and not more than 2.10% of total alkaloids, calculated as emetine, C 29 H 40 N 2 O 4 . Extemporaneous preparation Prepare by extracting Ipecacuanha with Ethanol (80 per cent) according to the following formula and directions. Ipecacuanha, in fine powder Ethanol (80 per cent) quantity Action and use Expectorant. 1000 g a sufficient

Ipecacuanha Liquid Extract B.P. 1999 White Liniment B.P. 1999


White Embrocation Definition White Liniment is a cutaneous emulsion. Oleic Acid Turpentine Oil Dilute Ammonia Solution Ammonium Chloride Purified Water 85 ml 250 ml 45 ml 12.5 g 625 ml

Extemporaneous preparation The following directions apply. Mix the Oleic Acid with the Turpentine Oil. Dilute the Dilute Ammonia Solution with 45 ml of the Purified Water, previously warmed, add to the oily solution and shake to form an emulsion. Separately dissolve the Ammonium Chloride in the remainder of the Purified Water, add to the emulsion and mix.

Liquorice Liquid Extract B.P. 1999


Definition Liquorice Liquid Extract is prepared by extracting Liquorice with Purified Water and adding sufficient Ethanol (90 per cent) to give an ethanol content of 18% v/v in the final extract. Extemporaneous preparation The following formula and directions apply. Liquorice, unpeeled, in coarse powder 1000 g Purified Water a sufficient quantity Ethanol (90 per cent) a sufficient quantity

Wintergreen Liniment A.P.F.


Synonym: Methyl Salicylate Liniment Compound A.F.P. Methyl Salicylate 25 ml Menthol 4 g Eucalyptus Oil 10 ml Arachis Oil to 100 ml

LOTIONS: Acne Lotion


Erythromycin powder Zinc Acetate Ethanol 96% ad 20 g 12 g 1000 ml

GLYCERINS : Glycerin Borax Jap. Ph.


Borax Sodium Bicarbonate 10 5 g g

Definition

Aluminium Acetate Lotion Aqueous A.P.F.


Synonym: Burow's Lotion Definition Aluminium Acetate Solution A.P.F. 5 ml Freshly boiled and cooled purified water to produce 100 ml It should be freshly prepared and used within 7 days. *To be used undiluted as a wet dressing. Note: Aluminium Acetate Solution (13%) for the preparation of Aluminium Acetate Lotion (0.65%) is available from Martindale (special order)

Phenol Liquid Calamine Lotion U.S.P. ad

100 ml 1000 ml

Compound Borax Eye Lotion B.P.C. 1954


Collyr. Borac. Co. (B.N.F. 1957) Borax Sodium Bicarbonate Distilled Water freshly boiled and cooled to 1.6 g 1.6 g 100 ml

Boric Acid Eye Lotion B.P.C. 1963 (B.N.F. 1963)


Boric Acid 3.43 g Purified water, freshly boiled and cooled to 100 ml To be diluted with an equal volume of warm water before use.

To be diluted with an equal volume of warm water before use. Ref.: Martindale 26th Edition page 346

Hair Lotion Oil Bath


Definition Liquid Paraffin Castor Oil Olive Oil Coconut Oil Almond Oil Lavender Oil (0.5%) q.s. Vitamin E (0.5%) 40 20 20 10 10 ml ml ml ml ml (0.5 ml) (0.5 ml)

Boric Acid Lotion 4%


Definition Boric Acid powder 40 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml

Emollient for the increased vitality promotes the growth of hair. Rub about 20 ml into the scalp before sleep. Shake the bottle before using. Keep out of the reach of children. Extemporaneous preparation The following directions apply. Mix all ingredients.

Calamine and Sulphur Lotion


Definition Sulphur prec. Calamine Lotion U.S.P. ad 20 g 1000 ml

D-Pantothenyl Alcohol Lotion (Bepanthene Lotion)


Extemporaneous preparation D-Pantothenyl Alcohol Alcohol 70% ad 5 g 100 ml

Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

Calamine Lotion B.P. 1999


Definition Calamine Lotion is a cutaneous suspension. Calamine 150 g Zinc Oxide 50 g Bentonite 30 g Sodium Citrate 5 g Liquefied Phenol 5 ml Glycerol 50 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Triturate the Calamine, the Zinc Oxide and the Bentonite with a solution of the Sodium Citrate in about 700 ml of the Purified Water and add the Liquefied Phenol, the Glycerol and sufficient Purified Water to produce 1000 ml. Labelling The label indicates the pharmaceutical form as cutaneous suspension.

Phenol Lotion
Liquified Phenol Calamine Lotion to 5 g 1000 ml Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

Potassium Permanganate (B.P., Eur. P., U.S.P.)


Soluble in 1 in 16 of water and 1 in 3.5 of boiling water giving purple solutions. An acidified solution in water is readily reduced by hydrogen peroxide, by easily oxidisable substances, and by organic matter. Store in well-closed containers avoiding contact with organic substances.

Calamine Lotion U.S.P., Phenolated

Uses Potassium Permanganate possesses oxidising properties which in turn confer disinfectant and deodorizing properties. It is also astringent. Though bactericidal in vitro its clinical value as a bactericide is minimized by its rapid reduction in the presence of body fluids. It is used as a 1 in 1000 solution in water as a

cleansing application to ulcers or abscesses and as a 1 in 4000 solution as a gargle or mouthwash; freshly prepared solutions should be used. Solutions of similar strengths are used as wet dressings and in baths in eczematous conditions and acute dermatitis especially where there is secondary infection. A 1% solution has been used in bromhidrosis, in mycotic infections such as athlete's foot, and in poison ivy dermatitis. A 5% solution has a powerful styptic action. A 0.02% solution in water can be employed as a stomach wash-out in the treatment of poisoning by morphine, opium, and strychnine; its use should be followed by evacuation of the stomach. It is of no value in poisoning by atropine, cocaine, or the barbiturates. Potassium permanganate has been widely used as a first-aid treatment in snake bite but it is of no value for this purpose, though a solution will destroy any venom lying free on the surface of the skin. Storage Store in airtight containers. Ref.: Martindale 28th Edition

Extemporaneous preparation The following directions apply. Dissolve the Sodium Bicarbonate in sufficient Purified Water, clarify by filtration, transfer the filtered solution into the final container, close the container so as to exclude micro-organisms and sterilise by heating in an autoclave. Storage Sodium Bicarbonate Eye Lotion should not be kept in containers that have previously been subjected to heating in an autoclave. Labelling The label states that any Eye Lotion not used within 24 hours of opening the container should be discarded. When Sodium Bicarbonate Eye Lotion is prescribed or demanded no strength being stated, a lotion containing 2% w/v of Sodium Bicarbonate shall be dispensed or supplied.

Salicylic Acid and Coal Tar Lotion A.P.F.


Salicylic Acid Coal Tar Solution Castor Oil Spike Lavender Oil Industrial Methylated Spirit to 2 5 1 0.1 100 g ml ml ml ml

Sodium Chloride Eye Lotion B.P. 1999


Definition Sodium Chloride Eye Lotion is a sterile aqueous solution containing 0.9% w/v of Sodium Chloride. Extemporaneous preparation The following directions apply. Dissolve the Sodium Chloride in sufficient Purified Water, clarify by filtration, transfer the filtered solution into the final container, close the container so as to exclude microorganisms and sterilize by heating in an autoclave. Labelling The label states that any Eye Lotion not used within 24 hours of opening the container should be discarded.

Salicylic Acid and Sulphur Lotion


Salicylic Acid Sulphur precip. Propylene Glycol Castor oil Ethanol 96% ad 20 20 g 200 10 1000 g ml ml ml

Sulphurated Potash and Zinc Lotion


Sulphurated Potash Zinc Sulphate Rose Water to 50 g 50 g 1000 ml

Salicylic Acid Lotion B.P. (B.P.C., B.N.F.)


Definition Salicylic Acid Castor oil Ethanol 96% to 20 g 10 ml 1000 ml

Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

White Lotion U.S.P.


Lotio Alba: Lotio Sulfurata Extemporaneous preparation Zinc Sulfate Sulfurated Potash Purified Water, a sufficient quantity To make 40 40 g g

Extemporaneous preparation Dissolve the Salicylic Acid in a portion of Ethanol 96% , add the Castor Oil and sufficient Ethanol 96% to produce 1000 ml and mix.

Scalp Lotion
Resorcinol Salicylic Acid Sodium Metabisulphite Glycerin Alcohol 50% to 20 20 0.1 20 1000 g g g ml ml

1000 ml

Dissolve zinc sulfate and sulfurated potash separately, each in 450 ml purified water, and filter each solution. Add slowly the sulfurated potash solution to the zinc sulfate solution with constant stirring. Then add the required amount of purified water, and mix. Note: Prepare freshly and shake thoroughly before dispensing. Uses: An astringent, protective and mild antimicrobial preparation. The astringency is attributal to the zinc ion. The tiosulfates and polysulfides in it exert antibacterial and antifungal actions (see Sodium Thiosulfate, RPS-16, page 1176). White lotion is used in the treatment of acne vulgaris. Dose: Topical, to the skin, as required.

Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

Sodium Bicarbonate Eye Lotion B.P. 1999


Definition Sodium Bicarbonate Eye Lotion is a sterile aqueous solution of Sodium Bicarbonate.

Zinc Sulphate Lotion B.P. 1999


Definition Zinc Sulphate Lotion is a cutaneous solution. It contains 1% w/v of Zinc Sulphate in a suitable aqueous vehicle. Labelling The label indicates the pharmaceutical form as cutaneous solution.

- Suitable for children if diluted to twice its volume water - To be freshly prepared Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

Ephedrine Nasal Drops B.P.C. 1973


Extemporaneous preparation The following formula applies. Ephedrine Hydrochloride Chorbutol; Acetone Chloroform Sodium Chloride Water sufficient to produce 0.5 g 0.5 g 0.5 g 100 ml

MOUTHWASH Compound Sodium Chloride Mouthwash B.P. 1999


Definition Compound Sodium Chloride Mouthwash contains 1% w/v of Sodium Bicarbonate and 1.5% w/v of Sodium Chloride in a suitable vehicle with a flavour of peppermint. Extemporaneous preparation The following formula applies. Sodium Bicarbonate Sodium Chloride Concentrated Peppermint Emulsion Double-strength Chloroform Water Water sufficient to produce Add: Colouring 10 15 25 500 1000 g g ml ml ml

Ephedrine Nasal Drops B.P.C. 1973


Ephedrine Hydrochloride 1.0 g Chorbutol; Acetone Chloroform 0.5 g Sodium Chloride 0.5 g Water sufficient to produce 100 ml (Suitable for children if diluted to twice its volume with normal saline) Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

Compound Sodium Chloride Mouthwash should be diluted with an equal volume of warm waterbefore use.

Glucose and Glycerol Instillation A.P.F.


Dextrose and Glycerin Nasal Drops Extemporaneous preparation Glucose Glycerol ad Date of Prep: 31.08.2004 = 1 L Customer: Ameera Pharmacy = 2 x 30 ml Glass Dropper 2 0g 100 ml

Hydrogen Peroxide Mouthwash B.P. 1999


Definition Hydrogen Peroxide Mouthwash is Hydrogen Peroxide Solution (6 per cent). Storage Hydrogen Peroxide Mouthwash should be protected from light. Labelling The label states, where applicable, that the Mouthwash contains a stabilising agent.

Menthol and Thymol Nasal Drops B.P.C. 1954


Narist. Menthol. et Thymol Menthol Thymol Cineole (Eucalyptol) Liquid Paraffin (light) to 457 mg 229 mg 0.208 ml 100 ml

PovidoneIodine Mouthwash B.P. 1999


Definition PovidoneIodine Mouthwash is either an aqueous solution of Iodinated Povidone or it is prepared by the interaction between Iodine and Povidone.

The mouthwash complies with the requirements stated under Mouthwashes and with the following requirements.

Ref.: Martindale 28th Edition = page 352

Menthol Nasal Drops


Menthol Eucalyptol Camphor Liquid Paraffin to - To be freshly prepared Ref: The National Formulary 1962 (United Arab Republic Ministry of Health) 1.0 0.2 1.0 100 g ml g ml

NASAL DROPS Argyrol Ephedrine Nasal Drops


Argotone (Rona Laboratories) Mild Silver Protein Ephedrine Hydrochloride Sodium Chloride Solution Sodium Chloride Distilled Water to 1% 0.9% 0.5% 10 9 g g

5 g 1 Liter

Sodium Chloride Nasal Drops A.P.F.


Normal Saline Nasal Drops BP Extemporaneous preparation Dissolve. Sodium Chloride Water freshly boiled and cooled ad 0.9 g 100 ml

Argyrol Ephedrine Nasal Drops


Argyrol Ephedrine Hydrochloride Distilled Water to 5 g 1 g 1 Liter

NASAL WASH Alkaline Nasal Wash A.P.F.


Extemporaneous preparation Sodium Chloride Sodium Bicarbonate Borax

Melt the Simple Ointment, gradually add the Ammoniated Mercury and stir until cold. Action and uses Ammoniated mercury is a mild antiseptic and is sometimes applied to the skin surrounding the perineum to destroy threadworms and to reduce reinfection. It was formerly used in the treatment of low-grade staphylococcal infections of the skin, and in psoriasis. Precautions It should not be applied to raw surfaces because of the risk of absorption of mercury.

Mix of equal quantities.

Alkaline Nasal Wash B.P.C. 1954


Collun. Alk. (N.F. 1955) Borax Sodium Bicarbonate Liquefied Phenol Sucrose Water to 1.37 1.37 0.52 2.29 100 g g ml g ml

Ammoniated Mercury & Coal Tar Ointment B.P.C.


Extemporaneous preparation Ammoniated Mercury Strong Coal Tar Solution Yellow Soft Paraffin 25 g 25 g 950 g

Unguentum Hydrargyri Ammoniati et Picic Carbonis; Unguentum Picis Carbonis Compositum

To be diluted with an equal volume of warm water before use. Ref.: Martindale 26th Edition page 346

Alkaline Nasal Wash


Sodium Bicarbonate Sodium Chloride Borax Water to 5.0 5.0 5.0 250 g g g ml

Triturate the ammoniated mercury with a portion of the yellow soft paraffin until smooth, mix with the remainder of the yellow soft paraffin, and incorporate the strong coal tar solution. Containers and Storage The directions given under Ointments (page 757) should be followed; containers should prevent evaporation.

Ref: The National Formulary 1962 (United Arab Republic Ministry of Health)

Compound Alkaline Nasal Wash


Collun. Alk. (N.F. 1955) Borax Sodium Bicarbonate Sodium Chloride - Equal quantities For use dissolve about 1 g in 100 ml of warm water. Ref.: Martindale 26th Edition page 346

Ammoniated Mercury, Coal Tar and Salicylic Acid Ointment B.P.C.


Extemporaneous preparation Ammoniated Mercury and Coal Tar Ointment Salicylic Acid, in fine powder 980 g 20 g

Unguentum Hydrargyri Ammoniati et Picis Carbonis cum Acido Salicylico

Compound Borax Powder for Nasal Wash B.P.C. 1959


Pulv. Borac. Co. pro Collun. (N.F. 1955) Borax Sodium Bicarbonate Sodium Chloride Sucrose - Equal quantities Ref.: Martindale 26th Edition page - 346

Triturate the salicylic acid with apportion of the ammoniated mercury and coal tar ointment until smooth and gradually incorporate the remainder of the ointment. Containers and Storage The directions given under Ointments (page 757) should be followed; containers should prevent evaporation.

Calamine Ointment B.P. 1999


Definition Calamine Ointment contains 15% w/w of Calamine in a suitable hydrophobic basis. Extemporaneous preparation The following formula and directions apply. Calamine, finely sifted White Soft Paraffin 150 g 850 g

OINTMENTS Ammoniated Mercury Ointment B.P.


Definition Ammoniated Mercury Ointment contains 2.5% w/w of Ammoniated Mercury in Simple Ointment. Extemporaneous preparation The following formula and directions apply. Ammoniated Mercury, finely sifted Simple Ointment 25 g 975 g

Triturate the Calamine with part of the White Soft Paraffin until smooth and gradually incorporate the remainder of the White Soft Paraffin.

Calamine and Coal Ointment B.P. 1999


Compound Calamine Ointment Definition Calamine and Coal Tar Ointment contains 12.5% w/w each of Calamine and Zinc Oxide and 2.5%

w/w of Strong Coal Tar Solution in a suitable wateremulsifying basis. Extemporaneous preparation The following formula and directions apply. Calamine, finely sifted Zinc Oxide, finely sifted Strong Coal Tar Solution Hydrous Wool Fat White Soft Paraffin 125 g 125 g 25 g 250 g 475 g

resulting solution to the Coal Tar dispersion. Mix thoroughly and stir until cold.

Coal Tar and Zinc Ointment B.P. 1999


Definition Coal Tar and Zinc Ointment contains 30% w/w of Zinc Oxide and 10% w/w of Strong Coal Tar Solution in a suitable hydrophobic basis. Extemporaneous preparation The following formula and directions apply. Strong Coal Tar Solution Zinc Oxide, finely sifted Yellow Soft Paraffin 100 g 300 g 600 g

Melt together the Hydrous Wool Fat and the White Soft Paraffin. Triturate the Calamine and Zinc Oxide in the melted basis and stir gently, when cooled, to about 40. Gradually incorporate the Strong Coal Tar Solution and stiruntil cold. Storage Calamine and Coal Tar Ointment should be kept in a container that minimizes evaporation losses.

Cetomacrogol Emulsifying Ointment B.P. 1999


Definition White Soft Paraffin Cetomacrogol Emulsifying Wax Liquid Paraffin 500 g 300 g 200 g

Mix the Zinc Oxide with the Strong Coal Tar Solution, triturate with a portion of the Yellow Soft Paraffin until smooth, gradually incorporate the remainder of the Yellow Soft Paraffin and mix.

Compound Benzoic Acid Ointment B.P. 1999


Whitfields Ointment Definition Compound Benzoic Acid Ointment contains 6.0% w/w of Benzoic Acid and 3.0% w/w of Salicylic Acid in a suitable emulsifying basis. Extemporaneous preparation The following formula and directions apply. Benzoic Acid, in fine powder Salicylic Acid, in fine powder *Emulsifying Ointment *Emulsifying Wax (300 g) *White Soft Paraffin (500 g) *Liquid Paraffin (200 g) 60 g 30 g 910 g 273 g 455 g 182 g 1 Kg

Extemporaneous preparation The following directions apply. Melt together and stir until cold.

Cetrimide Emulsifying Ointment B.P. 1999


Definition White Soft Paraffin Cetostearyl Alcohol Liquid Paraffin Cetrimide 500 270 200 30 g g g g

Extemporaneous preparation The following directions apply. Melt together the White Soft Paraffin, Cetostearyl Alcohol and Liquid Paraffin, add the Cetrimide and stir until cold.

Triturate the Benzoic Acid and the Salicylic Acid with a portion of the Emulsifying Ointment until smooth and gradually incorporate the remainder of the Emulsifying Ointment.

Coal Tar and Salicylic Acid Ointment B.P. 1999


Definition Coal Tar and Salicylic Acid Ointment contains 2% w/v of each of Coal Tar and Salicylic Acid in a suitable emulsifying basis. Extemporaneous preparation The following formula and directions apply. Coal Tar Polysorbate 80 Salicylic Acid Emulsifying Wax White Soft Paraffin Coconut Oil Liquid Paraffin 20 40 20 114 190 540 76 g g g g g g g

Compound Mercury Ointment B.P.C. 1959


Scotts Dressing Extemporaneous preparation Strong Mercury Ointment Yellow Beeswax Arachis Oil Camphor It contains 11 to 13% of Hg Reference: Martindale 26th Edition 40 24 24 12 g g g g

Dilute Mercury Ointment B.P.C. 1959


Blue Ointment; Mercurial Ointment; Mercury Ointment Extemporaneous preparation Strong Mercury Ointment Simple Ointment It contains 9 to 11% of Hg Reference: Martindale 26th Edition 33.33 g 66.67 g

Disperse the Coal Tar in the Polysorbate 80, incorporate the Salicylic Acid and mix with the previously melted Emulsifying Wax. Separately, melt the White Soft Paraffin and the Coconut Oil, incorporate the Liquid Paraffin warmed to the same temperature and add, with stirring, the

Emulsifying Ointment B.P. 1999


10

Definition Emulsifying Wax White Soft Paraffin Liquid Paraffin 300 g 500 g 200 g

Extemporaneous preparation The following directions apply. Melt together and stir until cold.

Dissolve the Phenoxyethanol and the Dried Magnesium Sulphate in sufficient warm Purified Water to produce about 500 g. Melt the Wool Alcohols Ointment and heat to about 60; gradually add the aqueous solution at about 60 with vigorous stirring until a smooth cream is obtained. Stir until cool, add sufficient Purified Water to produce 1000 g and mix. Storage Hydrous Ointment should be kept in a container made from non-absorbent material. If, on storage, some aqueous liquid separates, it is readily reincorporated by stirring.

Hydrophilic Ointment U.S.P.


Extemporaneous preparation Prepare Hydrophilic Ointment as follows. White Petrolatum Stearyl Alcohol Propylene Glycol Sodium Lauryl Sulfate Methylparaben Propylparaben Purified Water To make about 250 250 120 10 0.25 0.15 370 1000 g g g g g g g g

Ichthammol Ointment U.S.P.


Definition Ichthammol Ointment contains an amount of Ichthammol equivalent to not less than 0.25 percent of ammonia (NH3). Extemporaneous preparation Ichthammol Lanolin Petrolatum To make 100 100 800 1000 g g g g

*Japanese Pharmacopoeia has ethyl hydroxybenzoate 25 mg in place of methyl hydroxybenzoate. Melt the Stearyl Alcohol and the White Petrolatum on a steam bath, and warm to about 750. Add the other ingredients, previously dissolved in the water and warmed to 750, and stir the mixture until congeals. Packaging and Storage Preserve in tight containers.

Thoroughly incorporate the Ichthammol with the Lanolin, and combine this mixture with the Petrolatum. Packaging and Storage Preserve in collapsible tubes or in tight containers, and avoid prolonged exposure to temperature exceeding 300.

Hydrophilic Petrolatum U.S.P. (Jap., P.)


Extemporaneous preparation Prepare Hydrophilic Petrolatum as follows: Cholesterol Stearyl Alcohol White Wax White Petrolatum To make 30 30 80 860 1000 g g g g g

Iodine Ointment BPC 1949, non-stain (Non-staining Ointment of Iodine)


Unguentum Iodi Denigrescens (Ung. Iod. Denig.) Extemporaneous preparation Iodine Arachis Oil Yellow Soft Paraffin to 50 g 150 ml 1000 g

Melt the Stearyl Alcohol and the White Wax together on a steam bath, then add the Cholesterol, and stir until completely dissolved. Add the White Petrolatum, and mix. Remove from the bath, and stir until the mixture congeals.

Mix the iodine with the arachis oil, add the yellow soft paraffin, and heat gently with occasional stirring at a temperature not excedding 600 until complete combination is effected, as indicated by the disappearance of the brown colour. Standard. Content of total iodine: 4.75 to 5.25 percent w/w, calculated as I.

Hydrous Ointment B.P. 1999


Oily Cream; Eucerin Hydrous Definition Wool Alcohols Ointment 500 Phenoxyethanol 10 Dried Magnesium Sulphate 5 Purified Water, freshly boiled and cooled, sufficient to produce 1000 g g g g

In preparing Hydrous Ointment the proportions of Hard Paraffin, Soft Paraffin and Liquid Paraffin used to make the Wool Alcohols Ointment may be varied to produce Hydrous Ointment having suitable properties. When Hydrous Ointment is used in a white ointment, it should be prepared from Wool Alcohols Ointment made with White Soft Paraffin; when used in a coloured ointment, it should be prepared from Wool Alcohols Ointment made with Yellow Soft Paraffin. Extemporaneous preparation The following directions apply.

Iodine Ointment with Methyl Salicylate BPC 1949, nonstain (Non-staining Ointment of Iodine with Methyl Salicylate)
Unguentum Iodi Denigrescens cum Methylis Salicylate(Ung. Iod. Denig. C. Methyl. Salicyl.) Extemporaneous preparation Methyl Salicylate Non-staining Ointment of Iodine to 50 ml 1000 g

Melt the non-staining ointment of iodine, at a low temperature, add the methyl salicylate and stir until cold. Standard.

11

Content of total iodine: 4.29 to 5.24 percent w/w, calculated as I.

White Beeswax

200 g

Macrogol Ointment B.P. 1999


Definition Macrogol 4000 Macrogol 300 350 g 650 g

Melt together the White Beeswax and the Wool Fat and add the Menthol previously dissolved in the Methyl Salicylate, the Cineole, and the Cajuput Oil. Incorporate the Water at the same temperature, and stir until cold. stir until cold. A standard for this ointment is given in the British Pharmaceutical Codex 1973. Storage Containers should prevent evaporation. Certain plastic containers, such as those made from polystyrene, are unsuitable for use with this ointment. Advice for patients The ointment should be massaged well into the skin. It should not be applied to broken or inflamed skin or near to the eyes or mucous membranes. The container should be kept tightly closed.

Extemporaneous preparation The following directions apply. Add the Macrogol 4000 to the Macrogol 300, warm until homogeneous and stir continuously until cold.

Menthol and Eucalyptus Ointment B.N.F. 1963


Definition Menthol Eucalyptus Oil Yellow Soft Paraffin ad 1 g 4 ml 100 g

Oleated Mercury B.P.C. 1959 (stab.)


Hydrargyrum Oleatum; Hydrarg. Oleat.; Mercury Oleate Extemporaneous preparation Yellow Mercuric Oxide Liquid Paraffin Oleic Acid 20% 5% 75%

Menthol Balsam
Definition Menthol Camphor Methyl Salicylate White Beeswax Wool Fat

Unguentum Mantholi Compositum (Dan. Disp.) 10 10 25 18 37 100 g g g g g g

Triturate the Yellow Mercuric Oxide with Liquid Paraffin, the mixed with Oleic Acid and heated at 50O until combination is effected. Foreign Pharmacopoeias: In Chin. And Ind. (as B.P.C. 1959); in Braz. And Mex. (both 25% HgO). A yellowish unctuous. Insoluble in water; slightly soluble in alcohol and ether; readily soluble in fixed oils. Protect from light. It may be employed in ointment form for uses similar to those of ammoniated mercury. Preparations:

Methyl Salicylate Ointment B.P. 1999


Strong Methyl Salicylate Ointment Definition Methyl Salicylate Ointment contains 50% w/w of Methyl Salicylate in a suitable water-emulsifying basis. Extemporaneous preparation The following formula and directions apply. Methyl Salicylate White Beeswax Hydrous Wool Fat 500 g 250 g 250 g

Oleated Mecury Ointment B.P. 1953 (Ung. Hydrarg. Oleat.)


Oleated Mercury Simple Ointment to 25% 100% It contains 5% of HgO. Store in a cool place. Protect from light. Bralium Forte (Hefa, Ger.: Grabowski) An oily lotion containing oleated mercury equivalent to 2 and 5% of mercury. For psoriasis.

Melt together the White Beeswax and the Hydrous Wool Fat, cool, add the Methyl Salicylate and stir until cold. Storage Containers should prevent evaporation. Certain plastic containers, such as those made from polystyrene, are unsuitable for use with this ointment.

Reference: Martindale 26th Edition

Paraffin Ointment B.P. 1999; BNF


Definition White Beeswax Hard Paraffin Cetostearyl Alcohol White Soft Paraffin 20 g 30 g 50 g 900 g

Methyl Salicylate Ointment, Compound B.P.C. 1973


Syn. Analgesic Balm; Unguentum Methylis Salicylatis Compositum Forte Definition Methyl Salicylate Ointment contains 50% w/w of Methyl Salicylate in a suitable water-emulsifying basis. Extemporaneous preparation The following formula and directions apply. Methyl Salicylate Cajuput Oil Cineole Water for preparations Menthol Wool Fat 500 g 25 ml 25 ml 45 ml 100 g 105 g

Extemporaneous preparation The following directions apply. Mix the ingredients, heat gently with stirring until homogeneous and stir until cold.

Salicylic Acid and Sulphur Ointment B.P.C. 1973


Extemporaneous preparation Salicylic acid, finely sifted Precipitated sulphur, finely sifted 30 g 30 g

12

Oily Cream

940 g

Triturate the salicylic acid and the precipitated sulphur with a portion of the oily cream until smooth and gradually incorporate the remainder of the cream. Advice for patients: The ointment should be applied sparingly to the affected area. It should not be applied to broken or inflamed skin; contact with the eyes should be avoided. Prolonged use should be avoided and treatment should be discontinued if excessive dryness or irritation occurs. A standard for this ointment is given in the British Pharmaceutical Codex 1973.

Extemporaneous preparation The following directions apply. Rub the starch and the benzoic acid with the purified water in a porcelain dish until a smooth mixture is produced, then add the glycerin, and mix well. Heat the mixture on a sand bath to a temperature between 140O and 144O, with constant but gentle stirring until a translucent, jelly-like mass results, and then strain through muslin. Starch Glycerite should be freshly prepared. Uses Although not an oleaginous base, this emollient preparation is sometimes used as a substitute for a fatty ointment. It has also been used as a pill excipient. Dose For external use, topically as required. Storage Store in airtight container. Ref: Rimingtons Pharmaceutical Sciences 16th Edition page-1249 Martindale: Preparation:

Salicylic Acid 6% and Urea 10% in Petrolatum


Extemporaneous preparation Salicylic Acid, fine powder Urea Water Petrolatum (Eucerin) 60 g 100 g 120 ml 720 g 1 Kg

Salicylic Acid 6% in Starch Glycerite USNF


Salicylic Acid 6% Starch (Potato) Benzoic Acid Purified Water Glycerin Eucerin To make about 96 112 2 190 700 500 1600 g g g g g g g

Salicylic Acid Ointment B.P. 1999


Definition Salicylic Acid Ointment contains 2% w/w of Salicylic Acid in a suitable water-emulsifying basis. Extemporaneous preparation The following formula and directions apply. Salicylic Acid, finely sifted Wool Alcohols Ointment 20 g 980 g

Strong Mercury Ointment B.P.C. 1959


Ung. Hydrarg. Fort.: Unguentum Hydrargyrum Cinereum Extemporaneous preparation Mercury Oleated Mercury Wool Fat White Beeswax White Soft Paraffin 30 1.5 43 7 18.5 g g g g g

Melt the Wool Alcohols Ointment, gradually add the Salicylic Acid and stir until cold. Used in acne, eczema, and ringworm

Simple Ointment B.P. 1999


Definition Wool Fat Hard Paraffin Cetostearyl Alcohol White Soft Paraffin or Yellow Soft Paraffin 50 g 50 g 50 g 850 g

A similar ointment, usually with the title Unguentum Hydrargyri, is included in many pahramacopoeias.

Dilute Mercury Ointment B.P.C. 1959


Ung. Hydrarg. Dil..; Blue Ointment; Mercurial Ointment; Mercury Ointment Extemporaneous preparation Strong Mercury Ointment Simple Ointment It contains 9 to 11% of Hg. 33.33 g 66.67 g

Unless otherwise directed in the monograph, when Simple Ointment is used in a white ointment, it should be prepared with White Soft Paraffin; when used in a coloured ointment it should be prepared with Yellow Soft Paraffin. Extemporaneous preparation The following directions apply. Mix the ingredients, heat gently with stirring until homogeneous and stir until cold.

Sulphur Ointment B.P. 1980


Extemporaneous preparation Precipitated Sulphur, finely sifted Simple Ointment prepared with White Soft Paraffin 100 g 900 g

Starch Glycerite USNF


Definition Starch (Potato) Benzoic Acid Purified Water Glycerin To make about 100 g 2 g 200 ml 700 ml 1000 g

Triturate the Precipitated Sulphur with a portion of the Simple Ointment until smooth, gradually add the remainder of the Simple Ointment, and mix thoroughly. Contents of sulphur, S 9.5 to 10.5 percent w/w. Note:

13

Uses of Sulfur precipitated An active parasiticide; a 10% sulfur paste or ointment is used as an alternative treatment for Sarcoptes scabiei (mites). Sulfur also is actively keratolytic and, in the form of full-strength ointment or in combination with other keratolytic agents such as psoriasis, seborrhea, eczema-dermatitis and lupus erythematosus. The percentage of sulfur in an ointment should be reduced in the event that a patient's skin shows intolerance. Prolonged use of sulfur may result in a characteristic dermatitis venerate. Dose - Topical, as a 10% ointment every night for 3 nights.

Zinc Oxide Ointment B.P. 1999


Definition Zinc Ointment contains 15% w/w of Zinc Oxide in a suitable water-emulsifying basis. Extemporaneous preparation The following formula and directions apply. Zinc Oxide, finely sifted Simple Ointment *Simple Ointment B.P. 1999 *Wool Fat (5%) *Hard Paraffin (5%) *Cetostearyl Alcohol (5%) *White Soft Paraffin (85%) Triturate the Zinc Oxide with a portion of the Simple Ointment until smooth, gradually add the remainder of the Simple Ointment and mix thoroughly. 150 g 850 g

Sulphur Ointment U.S.P. 1995


Definition Suffur Ointment contains not less than 9.5 percent and not more than 10.5 percent of S. Extemporaneous preparation Precipitated Sulfur Mineral Oil White Ointment To make 100 100 800 1000 g g g g

PAINTS: Castellanis Paint B.P.C. 1973


Synonyms: Fuchsine Paints; Magenta Paint Magenta Boric Acid Phenol Resorcinol Acetone Alcohol (90 per cent) Water (see page 642) to 4 g 8 g 40 g 80 g 40 ml 85 ml 1 L

Levigate the sulfur with the Mineral Oil to a smooth paste, and then incorporate with the White Ointment. Packaging and Storage Preserve in well-closed containers, and avoid prolonged exposure to excessive heat.

Wool Alcohols Ointment B.P. 1999


Definition Wool Alcohols Hard Paraffin White Soft Paraffin or Yellow Soft Paraffin Liquid Paraffin 60 g 240 g 100 g 600 g

Dissolve the magenta in the alcohol and the acetone, previously mixed. Dissolve the boric acid in a portion of water; dissolve the phenol and the resorcinol in this solution, add the alcoholic magenta solution and sufficient water to produce the required volume, and mix. In making this preparation the alcohol (90 per cent) may be replaced by Industrial Methylated Spirit diluted so as to be of equivalent alcoholic strength, provided that the law and the statutory regulations governing the use of industrial methylated spirit are observed. Storage. It should be stored in airtight containers, protected from light, in a cool place.

In preparing Wool Alcohols Ointment, the proportions of Hard Paraffin, Soft Paraffin and Liquid Paraffin may be varied to produce Wool Alcohols Ointment having suitable properties. When Wool Alcohols Ointment is used in a white ointment, it should be prepared with White Soft Paraffin; when used in a coloured ointment it should be prepared with Yellow Soft Paraffin. Extemporaneous preparation The following directions apply. Melt together with the aid of gentle heat and stir until cold.

Compound Iodine Paint B.P.C. 1968


Mandl's Paint Definition Iodine 1.25 g

Zinc and Castor Oil Ointment B.P. 1999


Zinc and Castor Oil Cream Definition Zinc Oxide, finely sifted Castor Oil Cetostearyl Alcohol White Beeswax Arachis Oil 75 g 500 g 20 g 100 g 305 g

Potassium Iodide Water Peppermint Oil Alcohol 90% Glycerol ad

2.50 2.50 0.40 4.00 100

g ml ml ml ml

Extemporaneous preparation The following directions apply. Triturate the Zinc Oxide with a portion of the Castor Oil until smooth and add the mixture to the remainder of the ingredients previously melted together. Stir while cooling until the temperature is about 40.

It should be well shaken before use. Store in a cool place in airtight containers. It is used as a throat paint in the treatment of pharyngitis and follicular tonsillitis.

Compound Podophyllin Paint B.P. 1999


Definition Compound Podophyllin Paint is a cutaneous solution.

14

Podophyllum Resin Compound Benzoin Tincture sufficient to produce

150

1000 ml

In making the Compound Benzoin Tincture used to prepare Compound Podophyllin Paint, the Ethanol (90 per cent) may be replaced by Industrial Methylated Spirit 1 diluted so as to be of equivalent ethanolic strength. Labelling The label indicates the pharmaceutical form as cutaneous solution.
The law and the statutory regulations governing the use of Industrial Methylated Spirit must be observed.
1

Dental Iodine Paint Jap. Ph.


Dental Iodine Solution Extemporaneous preparation The following formula and directions apply. Iodine Potassium Iodide Zinc Sulphate Glycerol Water to 100 80 10 350 1000 g g g ml ml

Uses and administration Mercurochrome is a weak disinfectant; in the presence of organic material its effect is greatly reduced. It is non-irritant to tissues but has poor penetrating power. Aqueous solutions are of little value for skin disinfectantion but a 2% solution in a mixture of alcohol, acetone, and water has been used. Mercurochrome has also been applied as a surface disinfectant to mucous membranes and wounds but is unreliable. In genito-urinary infections mercurochrome has been used as a 1% solution for bladder and urethral irrigation. Stains on the skin caused by mercurochrome may be removed with chlorinated soda solution. Mercurochrome is a weak mercurial antiseptic that has been used for disinfection of skin and wounds.

Talbot Iodine Paint


Extemporaneous preparation The following formula and directions apply. Iodine Zinc Iodide Water Glycerin ad 25 22 10 100 g g ml ml

Gentian Violet Paint B.P.C. 1973


Crystal Violet Paint Crystal Violet Water Dissolve Crystal Violet: (Hexamethylpararosaniline hydrochloride) A 0.5% aqueous solution is applied topically in the treatment of candidal infections of the mouth, boils, chronic ulcers, and mycotic skin affections and a solution containing 0.5% of crystal violet and 0.5% of brilliant green has been used for pre-operative skin disinfectant. It has been used as cream and pessaries for vaginal infections. Crystal violet was formerly used in the treatment of strongloid and threadworm infections. A form of crystal violet is used for marking raw and unprocessed meat and citrus fruits. Containers; Labelling; Storage. The directions given under Paints (page 765) should be followed. 0.5 g 100 ml

Talbot Iodine Paint, Dilute (2%)


Extemporaneous preparation The following formula and directions apply. Talbot Iodine Paint Glycerin ad 80 ml 1000 ml

PASTES: Bismuth Subnitrate and Iodoform Paste B.P.C. 1954


Definition Bismuth Subnitrate Iodoform Liquid Paraffin, previously heated at 1500C for one hour and cooled 1g 2g 1g 1 Kg 250 g 500 g 250 g

Extemporaneous preparation The following directions apply. Triturate the Bismuth Subnitrate and the Iodoform in a sterile mortar with sufficient of the Liquid Paraffin to produce a smooth paste, using aseptic precautions; transfer the remainder of the Liquid Paraffin, and mix. Storage It should be stored in sterilized collapsible tubes, in a cool place.

Gentian Violet Paint U.S.P.


Crystal Violet Paint Extemporaneous preparation The following formula and directions apply. Gentian Violet Alcohol absolute Water to Store in airtight container. 1 g 8 ml 100 ml

Compound Aluminium Paste B.P. 1999


Baltimore Paste Definition Compound Aluminium Paste contains 20% w/w of Aluminium Powder and 40% w/w of Zinc Oxide in a suitable hydrophobic liquid basis. Extemporaneous preparation The following formula and directions apply. Aluminium Powder Zinc Oxide Liquid Paraffin 200 g 400 g 400 g

Mercurochrome Paints B.P.C.

Merbromin; Mercurodibromo-flourescein; Mercuresceine Sodique. It consists chiefly of disodium 2,7-dibromo-4hydroxymercurifluorescein Extemporaneous preparation The following formula and directions apply. Mercurochrome Water ad 2 g 100 ml

15

Mix the Aluminium Powder and the Zinc Oxide with the Liquid Paraffin until smooth.

contains not less than 85% of magnesium sulphate, calculated as MgSO 4 . Storage Magnesium Sulphate Paste should be kept in a well-closed container.

Coal Tar Paste B.P. 1999


Definition Strong Coal Tar Solution Compound Zinc Paste 75 g 925 g

Labelling The label states that the Paste should be stirred before use.

Extemporaneous preparation The following directions apply. Triturate the Strong Coal Tar Solution with a portion of the Compound Zinc Paste until smooth and gradually incorporate the remainder of the Compound Zinc Paste.

Zinc and Coal Zinc Paste B.P. 1999


Whites Tar Paste Definition Zinc and Coal Tar Paste contains 6% w/w each of Zinc Oxide and Coal Tar with 38% w/w of Starch in a suitable hydrophobic basis. Extemporaneous preparation The following formula and directions apply. Emulsifying Wax Coal Tar Zinc Oxide, finely sifted Starch Yellow Soft Paraffin 50 g 60 g 60 g 380 g 450 g

Compound Zinc Paste B.P. 1999


Definition Compound Zinc Paste contains 25% w/w each of Zinc Oxide and Starch in a suitable hydrophobic basis. Extemporaneous preparation The following formula and directions apply. Zinc Oxide, finely sifted Starch, finely sifted White Soft Paraffin 250 g 250 g 500 g

Melt the White Soft Paraffin, incorporate the Zinc Oxide and the Starch and stir until cold.

Melt the Emulsifying Wax at 70, add the Coal Tar and 225 g of the Yellow Soft Paraffin, stir at 70 until completely melted, add the remainder of the Yellow Soft Paraffin, cool to 30, add the Zinc Oxide and the Starch, stirring constantly, and stir until cold.

Dithranol Paste B.P. 1993


Definition Dithranol Paste contains Dithranol in a suitable hydrophobic basis containing 24% w/w each of Zinc Oxide and Starch and 2% w/w of Salicylic Acid. Extemporaneous preparation The following formula and directions apply. Dithranol 1 g, or a sufficient quantity Zinc and Salicylic Acid Paste sufficient to produce 100 g * * * * * Zinc and Salicylic Acid Paste (Lassar's Paste) Zinc Oxide 240 g Salicylic Acid 20 g Starch 240 g White Soft Paraffin 500 g

Zinc and Salicylic Acid Paste B.P. 1999


Lassars Paste Definition Zinc Oxide, finely sifted Salicylic Acid, finely sifted Starch, finely sifted White Soft Paraffin 240 g 20 g 240 g 500 g

Extemporaneous preparation The following directions apply. Melt the White Soft Paraffin, incorporate the Zinc Oxide, the Salicylic Acid and the Starch and stir until cold.

Mix the Dithranol with a portion of the Zinc and Salicylic Acid Paste until a smooth, even dispersion is obtained and gradually incorporate the remainder of the Zinc and Salicylic Acid Paste.

POULTICES : Kaolin Poultice B.P. 1999


Definition Heavy Kaolin 1 , finely sifted Boric Acid, finely sifted Methyl Salicylate Thymol Peppermint Oil Glycerol 527 g 45 g 2 ml 500 mg 0.5 ml 425 g

Magnesium Sulphate Paste B.P. 1999


Morisons Paste Definition Dried Magnesium Sulphate a sufficient quantity Phenol 0.5 g Glycerol, previously heated at 120 for 1 hour and cooled 55 g Extemporaneous preparation The following directions apply. Dry about 70 g of Dried Magnesium Sulphate at 150 for 1.5 hours or at 130 for 4 hours and allow to cool in a desiccator. Mix 45 g of the dried material in a warm mortar with the Phenol dissolved in the Glycerol. In preparing larger quantities of the paste the period of heating the Dried Magnesium Sulphate should be increased, if necessary, to ensure that the dried material

Extemporaneous preparation The following directions apply. Mix the Heavy Kaolin, previously dried at 100, and the Boric Acid with the Glycerol, heat at 120 for 1 hour, stirring occasionally, and allow to cool. Separately, dissolve the Thymol in the Methyl Salicylate, add to the cooled mixture, add the Peppermint Oil and mix thoroughly. The heating step may be omitted if some other satisfactory means of mixing the solid ingredients with the Glycerol is used but in this case Heavy Kaolin that has been sterilised is used.

16

Storage Kaolin Poultice should be kept in suitable containers that minimise absorption, diffusion or evaporation of the ingredients.
If an appropriate heating step, such as that described under Extemporaneous preparation, is not included in the manufacturing process, Heavy Kaolin that has been sterilised is used.
1

Aromatic Ammonia Solution B.P. 1999


Sal Volatile Solution Definition Ammonium Bicarbonate 25 g Nutmeg Oil 0.3 ml Lemon Oil 0.5 ml Ethanol (90 per cent) 37.5 ml Strong Ammonia Solution 67.5 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve the Ammonium Bicarbonate in 800 ml of the Purified Water. Separately dissolve the Lemon Oil and the Nutmeg Oil in the Ethanol (90 per cent). Add the ethanolic solution to the aqueous solution and add the Strong Ammonia Solution and sufficient Purified Water to produce 1000 ml. Add 25 g of previously sterilised Purified Talc, shake, allow to stand for a few hours, shaking occasionally, and filter. Storage Aromatic Ammonia Solution should be kept in a well-closed container and stored at a temperature not exceeding 25. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.

SOLUTIONS : Aluminium Chloride Solution BP 2005


DEFINITION Aluminium Chloride Solution is a cutaneous solution. It contains Aluminium Chloride Hexahydrate in a suitable ethanolic vehicle. PRODUCTION In making Aluminium Chloride Solution, Industrial Methylated Spirits may be used provided that the law and the statutory regulations governing the use of Industrial Methylated Spirits are observed. Content of aluminium chloride hexahydrate, AlCl3,6H2O 95.0 to 105.0% of the stated amount. STORAGE Aluminium Chloride Solution should be stored upright. LABELLING The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored; (3) that the solution is flammable.

Dilute Ammonia Solution B.P. 1999


Definition Dilute Ammonia Solution contains 10% w/w of ammonia. It is prepared by diluting Strong Ammonia Solution with freshly boiled and cooled Purified Water. Storage Dilute Ammonia Solution should be kept in a well-closed container. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored. When ammonia solution is prescribed or demanded, Dilute Ammonia Solution shall be dispensed or supplied.

Aluminium Chloride Solution


Definition Aluminium Chloride Glycerin Ethanol absolute to 6000 g 7500 g 30 LT

Aqueous Iodine Oral Solution B.P. 1999


Definition Iodine 50 g Potassium Iodide 100 g Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve the Potassium Iodide and the Iodine in 100 ml of the Purified Water and add sufficient of the Purified Water to produce 1000 ml. Storage Aqueous Iodine Oral Solution should be kept in a well-closed container, the materials of which are resistant to iodine. Labelling The label states that the solution should be well diluted before use. Aqueous Iodine Oral Solution contains in 1 ml 50 mg of Iodine and about 130 mg of total iodine, free and combined. Aqueous Iodine Oral Solution is intended to be diluted before use. When aqueous iodine solution is prescribed or demanded, Aqueous Iodine Oral Solution shall be dispensed or supplied.

Benzoic Acid Solution B.P. 1993


Definition Benzoic Acid 50 g Propylene Glycol 750 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve the Benzoic Acid in the Propylene Glycol and add sufficient Purified Water, in small quantities and with constant stirring, to produce 1000 ml. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.:

Calcium Hydroxide Solution B.P. 1999


Lime Water

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Definition Calcium Hydroxide 10 g Purified Water, freshly boiled and cooled Sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Shake together thoroughly and repeatedly; allow to stand until clear. Siphon off the clear solution as required. Storage Calcium Hydroxide Solution should be kept in a well-filled and well-closed container. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.

In making Strong Coal Tar Solution the Ethanol (96 per cent) may be replaced by Industrial Methylated Spirit 1 . Extemporaneous preparation The following directions apply. Mix the Coal Tar, warmed if necessary to render it fluid, with the Polysorbate 80, pour this mixture in a thin stream into 700 ml of Ethanol (96 per cent) in a closed vessel fitted with an agitator; continue agitation throughout the addition of the mixture and for 1 hour thereafter. Allow the mixture to stand for not less than 24 hours, decant and filter the supernatant liquid, wash the vessel and filter with Ethanol (96 per cent), combine the filtrate and washings and add sufficient Ethanol (96 per cent) to produce 1000 ml.

Cetrimide Solution B.P. 1999


Definition Cetrimide Solution is a 1% w/v cutaneous solution of cetrimide prepared by appropriately diluting Strong Cetrimide Solution with Purified Water. Cetrimide Solution is freshly prepared. Labelling The label states that the solution should not be used later than 1 week after the container is first opened. The label indicates the pharmaceutical form as cutaneous solution.

Jessners Solution
Definition Resorcinol 14 g Salicylic Acid 14 g Lactic Acid 14 ml Ethanol (95 per cent) sufficient to produce 100 ml Extemporaneous preparation The following directions apply. Dissolve the Resorcinol in a portion of water, dissolve separately the remainder items in alcohol and mix the two solutions and filter. g g

Coal Tar Solution B.P. 1999


Definition Coal Tar Polysorbate 80 Ethanol (96 per cent) sufficient to produce 200 50

Joulies Solution
Phosphate Mixture Definition Sodium Phosphate 136 g Phosphoric Acid 85% 58.8 g Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation Dissove. The solution has a pH of 4.9, contains 1725 millios- moles per litre, and provides 30.4 mg of inorganic phosphorus per ml. Dose 15 ml every 4 hours, 5 times daily.

1000 ml

In making Coal Tar Solution, the Ethanol (96 per cent) may be replaced by Industrial Methylated Spirit 1 . Extemporaneous preparation The following directions apply. Mix the Coal Tar, warmed if necessary to render it fluid, with the Polysorbate 80, pour this mixture in a thin stream into 800 ml of Ethanol (96 per cent) in a closed vessel fitted with an agitator; continue agitation throughout the addition of the mixture and for 1 hour thereafter. Allow the mixture to stand for not less than 24 hours, decant and filter the supernatant liquid, wash the vessel and filter with Ethanol (96 per cent), combine the filtrate and washings and add sufficient Ethanol (96 per cent) to produce 1000 ml. Storage Coal Tar Solution should be kept in a well-closed container. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.

Lead Subacetate Solution, Dilute B.P.C. 1973


Synonym: Liquor Plumbi Subacetatis Dilutus Definition Strong Lead Subacetate Solution Purified Water, freshly boiled and cooled to 12.5 ml 1000 ml

The law and the statutory regulations governing the use of Industrial Methylated Spirit must be observed.
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Lead Subacetate Solution, Strong B.P.C. 1973


Synonym: Liquor Plumbi Subacetatis Fortis Definition Lead Monoxide, in powder Lead Acetate Purified Water, freshly boiled and cooled to 175 250 g g

Coal Tar Solution B.P. 1999, Strong


Definition Coal Tar Polysorbate 80 Ethanol (96 per cent) sufficient to produce 400 50 g g

1000 ml

1000 ml

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Extemporaneous preparation Dissolve the lead acetate in 750 ml of the water, add the lead monoxide, and allow to stand for forty-eight hours, shaking occasionally, filter, pass through the filter sufficient of the water to produce the required volume, and mix.

Povidone Iodine Surgical Scrub Solution


Definition A detergent solution for surgical disinfection containing 7.5% percent Povidone-Iodine equivalent to 0.75% available Iodine.

and add the Ammonium Bicarbonate and the Strong Ammonia Solution to the distillate. Heat on a water bath to 60 in a sealed bottle of not less than 120-ml capacity, shaking occasionally, until solution is complete, cool, filter through absorbent cotton, mix the filtrate with the reserved distillate, add sufficient Purified Water to produce 1000 ml and mix.

Chloroform Spirit B.P. 1999


Definition Chloroform Ethanol (90 per cent) sufficient to produce 50 ml

1000 ml

Povidone Iodine Topical Solution U.S.P.


Definition Povidone Iodine 100 g (Sodium Bicarbonate- as preservative) 20 g Purified Water sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve.

Colongne Spirit
Spiritus Colonieses (Sp. Colon.) / Aqua Colonieses Definition Oil of Bergamot Oil of Lemon Oil of Neroli Oil of Rosemary Oil of Thyme Concentrated Orange-flower Water Water Alcohol (90 percent) to 5.0 2.0 1.5 0.5 3.0 41.7 1000 12.5 ml ml ml ml ml ml ml ml

Sodium Chloride Solution B.P. 1999


Definition Sodium Chloride Solution is a 0.9% w/v cutaneous solution of Sodium Chloride in Purified Water. The solution may be clarified by filtration.

Extemporaneous preparation The following directions apply. Dissolve the oils in about 900 ml of the alcohol 90 percent, add gradually the concentrated orange-flower water, previously diluted with water, and then add sufficient alcohol 90 percent to produce the required volume.

Labelling The label states, where applicable, that the contents of the container are sterile. The label indicates the pharmaceutical form as cutaneous solution. When In making this preparation the alcohol 90 percent may be normal saline is prescribed or demanded, Sodium Chloride replaced by industrial methylated spirit diluted so as to be Solution shall be dispensed or supplied. of equivalent alcoholic strength , provided that the final product contains 1 percent. v/v of ethyl phthalate and If the label states that the contents of the container are sterile, the solution complies with the following that the law and the statutory regulations governing the use of industrial methylated spirit are observed. additional requirements. Sterility Complies with the test for sterility, Appendix XVI A. Labelling The label states (1) Sterile Sodium Chloride Solution; (2) that the solution is not intended for injection; (3) the date after which the solution is not intended to be used; (4) the conditions under which it should be stored. Reference: Pharmacopoeia ___________________ Formulary page 1285

Compound Orange Spirit B.P. 1999


Definition Terpeneless Orange Oil Terpeneless Lemon Oil Anise Oil Coriander Oil Ethanol (90 per cent) sufficient to produce 2.5 1.3 ml 4.25 ml 6.25 ml 1000 ml ml

SPIRITS: Aromatic Ammonia Spirit B.P. 1999


Sal Volatile Spirit Definition Nutmeg Oil Lemon Oil Ethanol (90 per cent) Ammonium Bicarbonate Strong Ammonia Solution Purified Water sufficient to produce 3 5 750 25 67.5 1000 ml ml ml g ml ml

Lemon Spirit B.P. 1999


Definition Terpeneless Lemon Oil Ethanol (96 per cent) sufficient to produce 100 ml 1000 ml

Extemporaneous preparation The following directions apply. Distil a mixture of the Lemon Oil, the Nutmeg Oil, the Ethanol (90 per cent) and 375 ml of Purified Water. Reserve the first 875 ml of distillate. Distil a further 55 ml

Peppermint Spirit B.P. 1999 (B.P., A.P.F.)


Peppermint Essence Definition Peppermint Oil 100 ml

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Ethanol (90 per cent) sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve the Peppermint Oil in Ethanol (90 per cent) and add sufficient Ethanol (90 per cent) to produce 1000 ml. If the solution is not clear, shake with previously sterilised Purified Talc and filter.

concentrated juice of commerce and Water, and adding to this solution sufficient Benzoic Acid to give a final concentration of not more than 800 ppm, or suffi-cient Sodium Metabisulphite or other suitable sulphite to give a final concentration of not more than 350 ppm of sulphur dioxide. Storage Black Currant Syrup should be kept in a wellfilled, well-closed container, protected from light and stored at a temperature not exceeding 25. Black Currant Syrup contains, in 10 ml, about 7.5 mg of ascorbic acid.
The requirement for Content of ascorbic acid does not apply when Black Currant Syrup is used as a flavouring agent for pharmaceutical purposes.
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Surgical Spirit B.P. 1999


Definition Methyl Salicylate Diethyl Phthalate Castor Oil Industrial Methylated Spirit sufficient to produce 5 20 25 ml ml ml

Invert Syrup B.P. 1999


Definition Invert Syrup is a mixture of glucose and fructose prepared by hydrolysing a 66.7% w/w solution of Sucrose with a suitable mineral acid, such as hydrochloric acid, and neutralising the resulting solution using, for example, calcium carbonate or sodium carbonate. The degree of inversion is at least 95%. Storage Invert Syrup should be stored at a temperature of 35 to 45.

1000 ml

Labelling The label states that the preparation is flammable and should be kept away from a naked flame.

SYRUPS: Syrup B.P. 1999


Definition Sucrose Purified Water sufficient to produce 667 g 1000 g

Ipecacuanha Syrup (Emetic) A.P.F.


Definition Ipecacuanha liquid extract Dilute acetic acid Glycerol Syrups to Dose children under 2 years 15 ml 2 to 3 years 20 ml 3 to 4 years 25 ml *Contains 0.12% w/v total alkaloids calculated as emetine. The dose should be followed by a tumblerful of water and if there is no response after 20 minutes, a further dose and a tumblerful of water should be given. To be administered only under medical supervision. Reference: Martindale Extra Pharmacopoeia 29th Edition 6 ml 2.5 ml 10 ml 100 ml

One or more suitable antimicrobial preservatives may be added. Extemporaneous preparation The following directions apply. Heat together until dissolved and add sufficient boiling Purified Water to produce 1000 g. Labelling The label states the names and proportions of any added antimicrobial preservatives. When antimicrobial preservatives are added the suitability of the Syrup as a vehicle or diluent should be confirmed before use. The pH of Syrup may affect the solubility of basic or acidic materials.

Aromatic Castor Oil U.S.P.


Definition Cinnamon Oil USNF Clove Oil Saccharin Vanillin Alcohol Castor Oil ad 0.3 0.1 50 100 3 100 ml ml mg mg ml ml

Lemon Syrup B.P. 1999


Definition Lemon Spirit Citric Acid Monohydrate Invert Syrup Syrup sufficient to produce 5 ml 25 gm 100 ml 1000 ml

Extemporaneous preparation The following directions apply.

Black Currant Syrup B.P. 1999


Definition Black Currant Syrup is prepared either from the clarified juice of Black Currant or from concentrated black currant juice of commerce. It contains a suitable antioxidant. Permittedfood grade colours may be added. Production It is prepared by dissolving 700 g of Sucrose either in 560 ml of clarified juice, previously diluted with Water to a weight per ml of 1.045 g, or in 560 ml of a solution of the same weight per ml prepared from the

Extemporaneous preparation The following directions apply. Dissolve the Citric Acid Monohydrate in some of the Syrup, add the Invert Syrup, the Lemon Spirit and sufficient Syrup to produce 1000 ml and mix. Storage Lemon Syrup should be stored at a temperature not exceeding 25.

Orange Syrup B.P. 1999


Definition Orange Tincture Syrup sufficient to produce 60 ml 1000 ml

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Potassium Syrups (1)


Potassium Chloride Potassium Gluconate Sodium Benzoate Glycerin Black Currant Syrup Simple Syrup Distilled Water ad 4.00 10.86 0.10 10.00 10.00 25.00 100.00 g g g ml ml ml ml

Extemporaneous preparation The following directions apply. Dissolve the Potassium Iodide and the Iodine in the Purified Water and add sufficient Ethanol (90 per cent) to produce 1000 ml. Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored. The label indicates the pharmaceutical form as cutaneous solution. When iodine tinture is prescribed or demanded Alcoholic Iodine Solution shall be dispensed or supplied.

Potassium Syrups (2)


Potassium Chloride Potassium Gluconate Sodium Benzoate Water Glycerin Black Currant Syrup Simple Syrup ad 4.00 g 10.86 g 0.10 g 10.00 ml 10.00 ml 10.00 ml 100.00 ml

Iodine Tincture B.P., 2.5%


Definition Iodine B.P. Potassium Iodide Propylene Gycol Distilled Water Ethanol 90% 25 25 g g 250 ml 25 ml 1000 ml

TINCTURES: Compound Benzoin Tincture B.P. 1999


Friars Balsam Definition Barbados Aloes or Cape Aloes Prepared storax, of commerce Sumatra Benzoin, crushed Ethanol (90 per cent) sufficient to produce 20 100 100 g g g

Orange Tincture B.P. 1999


Definition Dried Bitter-Orange Peel, in moderately fine powder 110 g Ethanol (70 per cent) a sufficient quantity Extemporaneous preparation The following directions apply. Prepare 1000 ml of tincture by percolation, Appendix XI F.

1000 ml

Extemporaneous preparation The following directions apply. Macerate the Barbados Aloes or Cape Aloes, the prepared storax and the Sumatra Benzoin with 800 ml of Ethanol (90 per cent) in a closed vessel for not less than 2 days, shaking occasionally, filter and pass sufficient Ethanol (90 per cent) through the filter to produce 1000 ml.

WATERS: Chloroform Water B.P.


Definition Chloroform 2.5 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml Extemporaneous preparation The following directions apply. Dissolve the Chloroform in the Purified Water by shaking.

Ipecacuanha Tincture B.P. 1999


Definition Ipecacuanha Liquid Extract Acetic Acid (6 per cent) Ethanol (90 per cent) Glycerol Purified Water sufficient to produce 100 ml 16.5 ml 210 ml 200 ml 1000 ml

Double-strength Chloroform Water B.P. 1999


Definition Chloroform 5 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml

Extemporaneous preparation The following directions apply.

Mix the Ethanol (90 per cent) and the Acetic Acid (6 per Extemporaneous preparation The following directions cent) with the Glycerol and 450 ml of Purified Water and add the Ipecacuanha Liquid Extract and sufficient Purified apply. Water to produce 1000 ml. Allow to stand for not less than Dissolve the Chloroform in the Purified Water by shaking. 24 hours; filter.

Alcoholic Iodine Solution B.P. 1999


Definition Alcoholic Iodine Solution is a cutaneous solution. Iodine Potassium Iodide Purified Water Ethanol (90 per cent) sufficient to produce 25 25 25 1000 g g ml ml

Concentrated Anise Water B.P. 1999


Definition Anise Oil Ethanol (90 per cent) Water sufficient to produce 20 ml 700 ml 1000 ml

Extemporaneous preparation The following directions apply.

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Dissolve the Anise Oil in the Ethanol (90 per cent) and add Cetomacrogol Emulsifying Wax B.P. gradually, with vigorous shaking after each addition, sufficient Water to produce 1000 ml. Add 50 g of 1999 previously sterilised Purified Talc, or other suitable Non-ionic Emulsifying Wax filtering aid, allow to stand for a few hours, shaking Definition occasionally, and filter. Cetostearyl Alcohol 800 g Concentrated Camphor Water B.P. Macrogol Cetostearyl Ether (22) 200 g

1999

Definition Racemic Camphor Ethanol (90 per cent) Water sufficient to produce 40 g 600 ml 1000 ml

Extemporaneous preparation The following directions apply. Melt together and stir until cold. Characteristics A white or almost white, waxy solid or flakes melting when heated to a clear almost colourless liquid; odour faint and characteristic of cetostearyl alcohol. Practically insoluble in water, producing an emulsion; moderately soluble in ethanol (96%); partly soluble in ether.

Extemporaneous preparation The following directions apply. Dissolve the Racemic Camphor in the Ethanol (90 per cent) and add, gradually, with vigorous shaking after each addition, sufficient Water to produce 1000 ml.

Concentrated Peppermint Water B.P. 1973


Definition Peppermint Oil Ethanol (90 per cent) Water sufficient to produce 2 ml 60 ml 1000 ml

Shaken with talc and filtered.. It is 40 times as strong as peppermint water.

Peppermint Water B.P. 1973


Definition Concentrated Peppermint Water Water sufficient to produce 2.5 1000 ml ml

Shaken with talc and filtered.. It is 40 times as strong as peppermint water.

Concentrated Rose Water B.P.C.


Aqua Rose Concentrata Definition Oil of Rose Alcohol (90 per cent) Water 10 ml 500 ml to 1000 ml 48 m. 5 fl. oz. to 10 fl. oz.

Dissolve the oil of rose in the alcohol (90 per cent.) and add sufficient water in successive small portions to produce the required volume, shaking vigorously after each addition. Add (1/2 oz.) of purified talc, and shake; allow to stand for a few hours, occasionally shaking, and filter. Rose water may be prepared by diluting concentrated rose water with 39 times its volume of water; the product contains about 1.25 per cent. v/v of alcohol (90 per cent.). Triple rose water may be prepared by diluting concentrated rose water with 12 times its volume of water; the product contains about 4 per cent. v/v of alcohol (90 per cent)

WAX:

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