V.

PATHOPHYSIOLOGY

PREDISPOSING FACTORS
Non-Modifiable Modifiable

• Family History • DM / Hemolytic disease / liver disorders

• Race (Native American, Caucasian, • Obesity / high-caloric diet /
Mexican-American) high cholesterol diet
• Age (Forty) (hyperalimentation)
• Gender (Female) • Pregnancy / multiparity
• Eliminated estrogen (Fertile)
Abnormal bile constituent secretions
• Familial
Biliary stasis
• Decrease gallbladder emptying
• Decrease absorptive ability of Decrease bile solubility
gallbladder
•
•
•
Increase bile concentration
Decrease concentration of bile salts }
Liver secretes bile high in cholesterol
Precipitation

Formation of stone in the

gallbladder

Bile may obstruct & remain Heavy fat meal

in the gallbladder

Bile initiates chemical Secretion of

reaction A B cholecystokinia

Antolysis & edema Gallbladder contracts

A B and tries to empty

Blood Vessels
Gallstone may move
Compressed
and dislodge
Pain (Guarding
Gangrene Behavior)
Increase SGPT Stone in the ductal
Decrease
Fever fat soluble
Increase
Decrease
Ischemia ofAlkaline
intestinal
tissue System 18
Phosphatase vitamin
Chills
Vomitingabsorption
Perforation
Pain (Guarding
possible
Behavior)
Steatorrhea
Possible
absorption
surrounding of stone
of fatty
the Backflow
Jaundice
of bile Bleeding
Inflammation
Couldtendencies
lead to
Weight Loss Serum
Fat Bilirubin
intolerance Irritation
Lukocytosis
Increase
Weakness PTT
acids Cachexia Clay-colored stool infection