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Abnormal RBC

Morphology
AnlsocyLosls
olkllocyLosls
EIIiptocytes Target CeIIs
PeredlLary LlllpLocyLosls
le ueflclency Anemla
Slckle Cell Anemla
CbsLrucLlve !aundlce
osL splenecLomy
Tear Drops Spherocytes
%dacryocyLe)
Myeloflbrosls/Myelodysplasla
8one Marrow MeLasLasls
1halassemla
heredlLary spherocyLosls and
lmmune hemolyLlc anemlas
%le A8C lncompaLlblllLy)
LchlnocyLe PelmeL cell
%8urr cells/CrenaLed cells)
lnLravascular coagulaLlon mlcroanglopaLhlc
hemolyLlc anemla glomerulonephrlLls and
re[ecLlon of renal LransplanLs
SickIe CeIIs Schistocytes
lnLravascular coagulaLlon mlcroanglopaLhlc
hemolyLlc anemla glomerulonephrlLls and
re[ecLlon of renal LransplanLs
SLomaLocyLes
heredlLary sLomaLocyLosls neoplasLlc
dlsorders llver dlsease and 8h null dlsease
RBC
Inclusions
oweII-JoIIy Bodies
W Round, purpIe
incIusions in
RBCs
W Composed of DNA.
W CommonIy seen in
in patients with
hypofunctioning
spIeens.
W SpIenectomy.
BasophiIic StippIing
W Numerous, smaII
purpIe incIusions
in RBCs
W Aggregates of
ribosomaI RNA.
W Most commonIy
seen in Iead
poisoning.
!appenheimer Bodies
W CIusters of dark
bIue granuIes,
irreguIar in size
and shape.
W Composed of iron
and ribosomaI
RNA.
W Seen in
siderobIastic and
hemoIytic
anemias.
CIassifications of Anemias
Microcytic, Hypochromic
ron deficiency
SiderobIastic
Chronic disease, nfIammation
Lead poisoning
ThaIassemia trait
Microcytic, ypochromic
W Many RBCs
smaIIer than
nucIeus of normaI
Iymphocytes,
increased centraI
paIIor.
W ron deficiency,
thaIassemias,
anemia of chronic
disease.
CIassifications of Anemias
ormochromic
ereditary Spherocytosis
ereditary EIIiptocytosis
!N
!D deficiency
ApIastic anemia
Acute bIood Ioss
CIassifications of Anemias
Macrocytic
'itamin B12 deficiency
FoIate deficiency
Liver disease
Macrocytic RBCs
W Most RBCs Iarger
than nucIeus of
normaI
Iymphocytes,
increased MC'.
W FoIate or 'itamin
B12 deficiencies,
aIcohoIism, and
Iiver disease.
ReticuIocytes
W mmature RBCs.
W Contain residuaI
ribosomaI RNA.
W ReticuIum stains
bIue using a
supravitaI stain
(new methyIene
bIue).
W Counted and
expressed as % of
totaI red ceIIs.
Pypochromla

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