C!YCOCIO!

YSIS
IronkIng down (cnfnboIIsm) of gIycogon
of fho rovorso of gIycogonosIs, buf Is n sonrnfo
nfhwny
Occurs In fho IIvor nnd muscIos
CIycogon hoshoryInso
O cnfnIyzos fho rnfo-IImIfIng sfo In fho
dogrndnfIon of gIycogon In nnImnIs by
roIonsIng gIucoso-l-hoshnfo from fho
formInnI nIhn-l,4-gIycosIdIc bond.
CIycogon hoshoryInso ncfs
on IInonr chnIns of gIycogon (ol-4
gIycosIdIc IInkngo)
O %ormInnI gIycosyI rosIduos nro
soquonfInIIy romovod by cnfnIyzIng
fho nddIfIon of n hoshnfo grou
O YIoIds gIucoso-l-hoshnfo
!nfor on formod Info gIucoso 6-hoshnfo
by hoshogIucomufnso
IhoshoryInso hnIfs nf four
rosIduos nwny from ol-6 brnnch
C!YCOCIO!YSIS
gIucnn frnnsfornso shIffs n bIock of
3 gIucosyI roIduos from fho oufor
brnnch fo fho ofhor ond
dobrnnchIng onzymo bronks fho
romnInIng (sIngIo gIucoso) ol-6
rosIduo fhnf romnIns In fho now
IInonr chnIn
Affor nII fhIs Is dono, gIycogon
hoshoryInso cnn confInuo
IIII!ICIS II%II !IVI!
A &SC!I IHOSIHO!Y!ASI
In bofh fIssuos, fho onzymo CIycogon
IhoshoryInso Is, In rosonso fo hormonnI nnd
ofhor sIgnnIs
O AcfIvnfod by hoshoryInfIon cnfnIzyod by
IHOSIHO!Y!ASI KIASI (yIoIds ncfIvo form
hoshoryInso n)
O InncfIvnfod by dohoshoryInfIon cnfnIyzod by
IHOSIHOI!O%II IHOSIHA%ASI (yIoIds
InncfIvo form hoshoryInso b)
IIII!ICIS II%II !IVI!
A &SC!I IHOSIHO!Y!ASI
AcfIvo hoshoryInso n
O AIIosforIcnIIy InhIbIfod by
A%I
CIucoso 6 hoshnfo
Iroo gIucoso; In IIvor onIy
IIII!ICIS II%II !IVI!
A &SC!I IHOSIHO!Y!ASI
InncfIvo hoshoryInso b In muscIo
O Hns bIndIng sIfo for 5`AI
5' udenosIne monopLospLute-uctIvuted pvoteIn
kInuse - onzymo fhnf Inys n roIo In coIIuInr onorgy
homoosfnsIs.
5`AI Is formod duo fo nn Incronso
of AI In muscIos
IndIcnfIon of nood for subsfrnfo mofnboIIsm
fo ormIf A%I formnfIon
AdonyInfo kInnso
cnfnIyzos roncfIon:
2 x AI <- -> A%I + 5`AI