Similarity factor f2

Difference factor f1 4
2

Number of time points, n = Time 10 15 20 30 45 60 75 120 Rt 89 103 107 107 107 {Rt-Tt} 6.23 5.41 1.22 1.43 1.98 0 0 0 sum (Rt-Tt) 2 sum (Rt-Tt) sum Rt Similarity factor f2 Difference factor f1 Tt 83 97 106 106 105

Insert nubmer of points where both productcs 85%

(Rt-Tt) 38.8129 29.2681 1.4884 2.0449 3.9204 0 0 0 16.27 75.5347 513.47 68 3

Number of points in Rt and Tt must be the same and must be similar to n (number of time points)

Rt = Cumulative percentage dissolved of Reference product at time t Tt = Cumulative percentage dissolved of Test product at time t