Abstract: Antibiotic widely used against bacterial infection and treatment course must be completed, but reviewing studies

by McNulty et al (2007) and Gillani Wasif Syed et al (2010) revealed that 40% - 60% of client prescribed with antibiotic show poor compliance. Over the years tax payer literally pays for medication, as in 2006 RM 56.7 million were spent on antibiotic but how much of this actually dumped to waste. Another issue related with poor compliance to treatment is resistance and this is a threat to global public health security in the 21st century (WHO 2007). In our country Assistant Medical Officer (AMO) also prescribe antibiotic, therefore this issue very much related to AMO profession. Objective: Measure the level of knowledge and usage of antibiotic among clients at Out Patient Department, Hospital Tawau. Methodology: A descriptive and quantitative study, viewed prospectively. Questionnaire comprised of three domains (demographic, knowledge, usage) used as tool. Data collection took place at Out Patient Department, Hospital Tawau from March April 2012. Data obtained translated into master score sheet and analyzed by descriptive statistic. Result: Study respondents were 30, with equal distribution among man (50%, n=15) and female (50%, n=15). From this sample of nbv30, 80% (n=24) claimed that they know what is antibiotic but 45.83% (n= 11) failed to give a correct respond about antibiotics function. Sub-analysis shows that out of this 80% (n=24) only a fraction of 33.3% (n=8) ever heard of antibiotic resistant. Intriguingly, only 43.3% (n=13) of the sample (N=30) said they complete antibiotic treatment course, despite of the finding that 80% (n=24) respondent were given explanation about antibiotic by prescriber. Conclusion: It concluded that the issue of lack of knowledge about antibiotic is a problem and some strategies which discussed in this paper brought forward to contain this issue.