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  • Abstract Ashraf CCC

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    A series of fused steroidal derivatives containing pyranone moiety were prepared via Michael addition reaction of a, b-unsaturated steroidal ketones with ethyl chloroacetate in basic medium. The compounds were screened in vitro for anticancer activity against some particular human cancer cell lines using the MTT assay. Our results demonstrate that the synthesized compounds exhibited good to moderate anticancer properties.

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    A series of fused steroidal derivatives containing pyranone moiety were prepared via Michael addition reaction of a, b-unsaturated steroidal ketones with ethyl chloroacetate in basic medium. The compounds were screened in vitro for anticancer activity against some particular human cancer cell lines using the MTT assay. Our results demonstrate that the synthesized compounds exhibited good to moderate anticancer properties.

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    17 views1 page

    Abstract Ashraf CCC

    Uploaded by

    aburayhan411
    A series of fused steroidal derivatives containing pyranone moiety were prepared via Michael addition reaction of a, b-unsaturated steroidal ketones with ethyl chloroacetate in basic medium. The compounds were screened in vitro for anticancer activity against some particular human cancer cell lines using the MTT assay. Our results demonstrate that the synthesized compounds exhibited good to moderate anticancer properties.

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    SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRANONE STEROID AS ANTI-CANCER AGENTS

    Shamsuzzamana*, Ashraf Mashraia, HenaKhanama, AyazMahmoodDaraand Himanshu Guptab a Department of Chemistry, Aligarh Muslim University, Aligarh- 202002, India b Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee- 247667, India *Email: shamsuzzaman9@gmail.com

    ABSTRACT In an attempt to find a new class of anticancer agents, a series of fused steroidal derivatives containing pyranone moiety were prepared via Michael addition reaction of , -unsaturated steroidal ketones with ethyl chloroacetate in basic medium. The characterization of novel compounds was accomplished by spectroscopic techniques such as IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis.The compounds were screened in vitro for anticancer activity against some particular human cancer cell lines using the MTT assay.Our results demonstrate that the synthesized compounds exhibited good to moderate anticancer properties.

    Theme - Chemistry for SustainableDevelopment and Innovations Sub Theme Drug Design and Development & Therapies

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