Professional Documents
Culture Documents
Fatty Acids
g/100g
Sources
Legumes Beans, common (dry)
g/100g
0.6
Flaxseed
Hickory nuts (dried) Peanuts Walnuts, black Walnuts, English Vegetables Beans, (cooked) Broccoli (raw) Cauliflower (raw)
22.8
1.0 0.003 3.3 6.8
Chickpeas (dry)
Cowpeas (dry) Lentils (dry) Peas, (dry) Soybeans (dry) Grains Barley, bran Corn, germ Oats, germ
0.1
0.3 0.1 0.2 1.6
Kale (raw)
Lettuce Mustard Purslane Soybeans, green (raw) Spinach (raw)
0.2
0.1 0.1 0.4 3.2 0.1
Rice, bran
Wheat, bran Wheat, germ Fruits Avocados, (raw) Raspberries (raw) Strawberries (raw)
0.2
0.2 0.7
Kris-Etherton, P.M., et al. Polyunsaturated fatty acids in the food chain in the US . AJCN. 71: 179-188, 2000. DHA/EPA Omega-3 Institute, http://dhaomega3.org
Fish Carp, cooked, dry heat Catfish, channel, farmed, cooked, dry heat Cod, Atlantic , cooked, dry heat Eel, mixed species, cooked, dry heat 0.451 0.177 0.158 0.189
0.501
0.465 0.328 2.147 0.982 0.843 0.321 0.819 0.936 0.328 0.518
The conversion of alpha-linolenic acid to EPA and DHA involves a series of chemical reactions. One of the first reactions in this series is catalyzed by the enzyme delta-6 desaturase. Further down the line is a reaction that is catalyzed by the enzyme delta-5 desaturase.
To increase the activity of your desaturase enzymes, be sure that your diet includes a sufficient amount of vitamin B6, vitamin B3, vitamin C, magnesium and zinc.
Simopoulos AP. Omega-3 fatty acids in wild plants, nuts and seeds. Asia Pacific Journal of Clinical Nutrition, 2002, Vol 11, Suppl. 6, pp S163-S173. More Info. at: www.DrMirkin.com
Arternis P Simopoulos. Omega-3 fatty acids in health and disease and in growth and development American journal of clinical nutrition
How it Functions
What are the functions of omega 3 fatty acids?
Every cell in our body is surrounded by a cell membrane composed mainly of fatty acids. The cell membrane allows the proper amounts of necessary nutrients to enter the cell, and ensures that waste products are quickly removed from the cell.
A- Promoting Healthy Cell Membranes To perform these functions optimally, however, the cell membrane must maintain its integrity and fluidity. Cells without a healthy membrane lose their ability to hold water and vital nutrients. They also lose their ability to communicate with other cells. Researchers believe that loss of cell to cell communication is one of the physiological events that leads to growth of cancerous tumors. (especially Breast cancer via several mechanisms):
1- inhibiting a pro-inflammatory enzyme called cyclooxygenase 2 (COX 2), which promotes breast cancer. 2- activating a type of receptor in cell membranes called peroxisome proliferator-activated receptor (PPAR)-, which can shut down proliferative activity. 3- increasing the expression of BRCA1 and BRCA2, tumor suppressor genes that, when functioning normally, help repair damage to DNA, thus helping to prevent cancer development.
Bernard-Gallon DJ, Vissac-Sabatier C, Antoine-Vincent D et al. Differential effects of n-3 and n-6 polyunsaturated fatty acids on BRCA1 and BRCA2 gene expression in breast cell lines. Br J Nutr 2002 Apr;87(4):281-9 2002. Source: International Journal of Cancer More Info. at: http://www.whfoods.com/genpage.php?tname=nutrient&dbid=84
B- Prostaglandin Production
Omega 3 fats play an important role in the production of powerful hormonelike substances called prostaglandins. Prostaglandins help regulate many important physiological functions including blood pressure, blood clotting, nerve transmission, the inflammatory and allergic responses, the functions of the kidneys and gastrointestinal tract, and the production of other hormones.
Weber PC, Fischer 5, von Schacky C, Lorenz R, Strasser T. Dietary omega-3 polyunsaturated fatty acids and eicosanoid formation in man. In: Simopoulos AP, Kifer RR, Martin RE, eds. Health effects of polyunsaturated fatty acids in seafoods. Orlando, FL: Academic Press, 1986:49-60.
A recently identified lipid product, that our bodies make from EPA, called resolvins, helps explain how this omega-3 fat provides antiinflammatory effects on our joints and improves blood flow. Resolvins, which have been shown to reduce inflammation in animal studies, are made from EPA by our cellular enzymes, and work by inhibiting the production and regulating the migration of inflammatory cells and chemicals to sites of inflammation. Unlike antiinflammatory drugs, such as aspirin, ibuprofen and the COX-2 inhibitors, the resolvins our bodies produce from EPA do not have negative side effects on our gastrointestinal or cardiovascular systems.
Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med. 2005 Mar 7;201(5):713-22. 2005. PMID:15753205.
Function of Omega 3
Reduce inflammation throughout your body Keep your blood from clotting excessively Maintain the fluidity of your cell membranes lower the amount of lipids (fats such as cholesterol, vLDL, and triglycerides) circulating in the bloodstream
Function of Omega 3
(cont.)
increase the activity of another chemical derived from endothelial cells (endotheliumderived nitric oxide), which causes arteries to relax and dilate reduce the production of messenger chemicals called cytokines, which are involved in the inflammatory response associated with atherosclerosis reduce the risk of becoming obese and improve the body's ability to respond to insulin by stimulating the secretion of leptin, a hormone that helps regulate food intake, body weight and metabolism, and is expressed primarily by adipocytes (fat cells) help prevent cancer cell growth
1- Osmundsen H, Clouet P. Metabolic effects of omega-3 fatty acids. Biofactors 2000;13(1-4):5-8 2000. PMID:15800. 2- Heller A, Koch T. [Immunonutrition with omega-3-fatty acids. Are new anti-inflammatory strategies in sight?]. Zentralbl Chir 2000;125(2):123-36 2000. PMID:15830. 3- Popp-Snijders C, Schouten JA, Heine RJ, et al. Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes. Diabetes Res 1987 Mar;4(3):141-7 1987. PMID:8990. 4- Severus WE, Littman AB, Stoll AL. Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder. Harv Rev Psychiatry 2001 Nov-2001 Dec 31;9(6):280-93 2001. PMID:15780. Source: The George Mateljan Foundation More Info. at: http://www.whfoods.com/genpage.php?tname=nutrient&dbid=84
Health Conditions
Omega 3 fatty acids may play a role in the prevention and/or treatment of the following health conditions:
Alzheimer's disease Asthma Attention deficit hyperactivity disorder (ADHD) Bipolar disorder Cancer Cardiovascular disease Depression Diabetes Eczema High blood pressure Migraine headaches Multiple sclerosis Obesity Osteoarthritis Osteoporosis Psoriasis Rheumatoid arthritis
1- Osmundsen H, Clouet P. Metabolic effects of omega-3 fatty acids. Biofactors 2000;13(1-4):5-8 2000. PMID:15800. 2- Heller A, Koch T. [Immunonutrition with omega-3-fatty acids. Are new anti-inflammatory strategies in sight?]. Zentralbl Chir 2000;125(2):123-36 2000. PMID:15830. Source: The George Mateljan Foundation More Info. at: http://www.whfoods.com/genpage.php?tname=nutrient&dbid=84
Deficiency Symptoms
What are deficiency symptoms for omega 3 fatty acids? Recent statistics indicate that nearly 99% of people in the United States do not eat enough omega 3 fatty acids. However, the symptoms of omega 3 fatty acid deficiency are very vague, and can often be attributed to some other health conditions or nutrient deficiencies. Consequently, few people (or their physicians, for that matter) realize that they are not consuming enough omega 3 fatty acids. The symptoms of omega 3 fatty acid deficiency include fatigue, dry and/or itchy skin, brittle hair and nails, constipation, frequent colds, depression, poor concentration, lack of physical endurance, and/or joint pain.
Drug-Nutrient Interactions
Fish oil supplements containing high amounts of omega 3 fatty acids have been shown to reduce high blood pressure in people taking cyclosporine, an immunosuppressive drug used to prevent rejection of transplanted organs. In addition, a high dietary intake of omega 3 fats, especially from fish, may decrease blood pressure and thin the blood. People taking prescription blood pressure medications and/or anticoagulants should consult with their physician before taking fish oil supplements.
Nutrient Interactions
Vitamin E, the primary fat-soluble antioxidant, protects omega 3 fats from oxidation. Oxidation is a chemical process that produces free radicals.
1- Possible side effects such as belching, nausea, diarrhea, bloating, and intestinal gas. 2- Very high doses may cause a fishy body odor and/or "fish breath". 3- In some people, fish oil supplementation has been reported to increase cholesterol LDL levels. However, others have reported that taking garlic supplements can counteract this effect.
4- Diabetes: taking large amounts of fish oil may make it more difficult to control blood sugar levels.
5- Fish oil may have a blood-thinning effect, it is recommended that anyone taking anticoagulant medications (blood thinning medications) such as Coumadin or taking any over-the-counter blood thinners such as aspirin, consult with a physician before taking any supplements.
Cod liver oil contains both vitamin A and D, and consuming excessive amounts of these two vitamins can cause toxicity and dangerous side effects. Flaxseed oil appears to be safe with very few omega 3 side effects. Flaxseed oil may cause mild gastrointestinal symptoms as diarrhea.
Age
Children
Men
Women
Pregnancy
Lactation
Birth to 12 months
1-13 years
14+ years
Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1997.
4-8
9-13
14-18
19+
Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, 2001.
Guidelines issued by the Workshop on the Essentiality of Recommended Dietary Intakes (RDI) for Omega-3 Fatty Acids in 1999 sponsored by the National Institutes of Health (NIH):
People must consume at least: 2% of their total daily calories as omega-3 fats.
e.g: person consuming 2000 calories per day should eat sufficient omega-3-rich foods to provide at least 4 grams of omega-3 fatty acids.
(100g) of shrimp, mixed species, containing approximately 152mg of cholesterol. 2 Mullet contains, 90 mg fish cholesterol per 100 gram.
CHOLESTEROL INTAKE The safe range of cholesterol intake is: 200-400 mg/day.
1
Salmon
Spiny lobster
Oyster
Mullet