MATERIALSAFETYDATASHEET Chloroform

Section1ChemicalProductandCompanyIdentification MSDSName: Chloroform Catalog Numbers: 167730000,167730010,167730025,167735000,268320000,268320010,26832 0025,326670000,326670010,326670025,326820000,326820010,326821000, 364320000,364320010,364321000,383760000,383760010,383760025,38376 0050,383770000,383770010,383770025 AcrosOrganicsBVBA JanssenPharmaceuticalaan3a 2440Geel,Belgium AcrosOrganics OneReagentLane FairLawn,NJ07410 800ACROS01 +3214575211 +3214575299 2017967100 8004249300 7035273887

Synonyms: CompanyIdentification:

CompanyIdentification:(USA)

ForinformationintheUS,call: ForinformationinEurope,call: EmergencyNumber,Europe: EmergencyNumberUS: CHEMTRECPhoneNumber,US: CHEMTRECPhoneNumber,Europe:

Section2Composition,InformationonIngredients CAS# 67663 HazardSymbols: XN ChemicalName: Chloroform % >99% EINECS# 2006638

RiskPhrases:

22384048/20/22 Section3HazardsIdentification

EMERGENCYOVERVIEW Harmfulifswallowed.Irritatingtoskin.Limitedevidenceofacarcinogeniceffect.Harmful:dangerof seriousdamagetohealthbyprolongedexposurethroughinhalationandifswallowed.Lightsensitive. PotentialHealthEffects Eye: Skin: Vaporsmaycauseeyeirritation.Contactproducesirritation,tearing,andburningpain.May causeconjunctivitis.Causesrednessandpain. Prolongedand/orrepeatedcontactmaycauseirritationand/ordermatitis.Maycausesevere skinirritationwithpossibleburns,especiallyifskiniswetormoist.Causesrednessand pain.

Ingestion: Harmfulifswallowed.Maycausecentralnervoussystemdepression,kidneydamage,and liverdamage.Maycausegastrointestinalirritationwithnausea,vomitinganddiarrhea.May causecardiacdisturbances. Inhalation: Inhalationofhighconcentrationsmaycausecentralnervoussystemeffectscharacterizedby nausea,headache,dizziness,unconsciousnessandcoma.Causesrespiratorytractirritation. Maycauseliverandkidneydamage.Maycausecardiacsensitizationandpossiblefailure. Maycausenarcoticeffectsinhighconcentration. Chronic: Possiblecancerhazardbasedontestswithlaboratoryanimals.Prolongedorrepeatedskin contactmaycausedermatitis.Prolongedorrepeatedexposuremaycauseadverse reproductiveeffects.Maycauseliverandkidneydamage. Section4FirstAidMeasures Eyes: Immediatelyflusheyeswithplentyofwaterforatleast15minutes,occasionallylifting theupperandlowereyelids.Getmedicalaidimmediately.DoNOTallowvictimtorub eyesorkeepeyesclosed. Immediatelyflushskinwithplentyofwaterforatleast15minuteswhileremoving contaminatedclothingandshoes. Getmedicalaid.DoNOTinducevomiting.Ifconsciousandalert,rinsemouthanddrink 24cupfulsofmilkorwater.Washmouthoutwithwater. Getmedicalaidimmediately.Removefromexposureandmovetofreshairimmediately. Ifnotbreathing,giveartificialrespiration.Ifbreathingisdifficult,giveoxygen.

Skin: Ingestion: Inhalation: Notesto Physician:

Section5FireFightingMeasures GeneralInformation: ExtinguishingMedia: Substanceisnoncombustible. Usewaterspray,drychemical,carbondioxide,orchemicalfoam. Section6AccidentalReleaseMeasures General Information: Spills/Leaks: UseproperpersonalprotectiveequipmentasindicatedinSection8. Absorbspillwithinertmaterial(e.g.vermiculite,sandorearth),thenplacein suitablecontainer. Section7HandlingandStorage Handling: Donotbreathedust,vapor,mist,orgas.Donotgetineyes,onskin,oronclothing.Donot ingestorinhale.Useonlyinachemicalfumehood. Storage: Storeinacool,dryplace.Donotstoreindirectsunlight.Storeinatightlyclosedcontainer. Section8ExposureControls,PersonalProtection EngineeringControls: Facilitiesstoringorutilizingthismaterialshouldbeequippedwithaneyewashfacility andasafetyshower. Exposure Limits CAS#67663: UnitedKingdom,WELTWA:2ppmTWA9.9mg/m3TWAUnitedKingdom, WELSTEL:6ppmSTEL29.7mg/m3STEL UnitedStatesOSHA:50ppmCeiling240mg/m3Ceiling BelgiumTWA:10ppmVLE50mg/m3VLE FranceVME:2ppmVME10mg/m3VMEFranceVLE:50ppmVLE250 mg/m3VLE Germany:4ppmTWA(largetechnicalmanufactureanduse)20mg/m3TWA (largetechnicalmGermany:skinnotation

Japan:10ppmOEL49mg/m3OEL Malaysia:10ppmTWA49mg/m3TWA Netherlands:5ppmSTEL25mg/m3STELNetherlands:1ppmMAC5mg/m3 MAC Russia:5mg/m3TWA(vapour) Spain:2ppmVLAED10mg/m3VLAED PersonalProtectiveEquipment Eyes: Skin: Clothing: Wearchemicalsplashgoggles. Wearappropriateprotectiveglovestopreventskinexposure. Wearappropriateprotectiveclothingtopreventskinexposure.

Respirators: FollowtheOSHArespiratorregulationsfoundin29CFR1910.134orEuropeanStandardEN 149.UseaNIOSH/MSHAorEuropeanStandardEN149approvedrespiratorifexposure limitsareexceededorifirritationorothersymptomsareexperienced. Section9PhysicalandChemicalProperties PhysicalState: Clearliquid Color: APHA:10max Odor: sweetishodor pH: Notavailable VaporPressure: 213mbar@20degC Viscosity: 0.56mPas@20degC BoilingPoint: 61degC@760mmHg(141.80F) Freezing/MeltingPoint: 63degC(81.40F) AutoignitionTemperature: Notavailable FlashPoint: Notavailable ExplosionLimits:Lower: Notavailable ExplosionLimits:Upper: Notavailable DecompositionTemperature: Notavailable Solubilityinwater: 8g/l(20C) SpecificGravity/Density: 1.480 MolecularFormula: CHCl3 MolecularWeight: 119.38 Section10StabilityandReactivity ChemicalStability: Stableatroomtemperatureinclosedcontainersundernormalstorageand handlingconditions. Strongoxidizingagents,bases,aluminum,fluorine,magnesium,sodiumhydroxide, potassium,lithium,methylalcohol,sodium,caustics(e.g.ammonia,ammonium hydroxide,calciumhydroxide,potassiumhydroxide,sodiumhydroxide),acetone, dinitrogentetraoxide,triisopropylphosphine,potassiumhydroxide,perchloricacid, potassiumtertbutoxide,phosphoruspentoxide,sodiumpotassiumalloys,calcium hydroxide. Hydrogenchloride,carbonmonoxide,carbondioxide,chlorine,phosgenegas. Willnotoccur. Section11ToxicologicalInformation

ConditionstoAvoid: Hightemperatures,incompatiblematerials,light. Incompatibilities withOther Materials

Hazardous Decomposition Products Hazardous Polymerization

RTECS#: LD50/LC50:

CAS#67663:FS9100000 RTECS: CAS#67663:Draizetest,rabbit,eye:148mg Draizetest,rabbit,eye:20mg/24HModerate Draizetest,rabbit,skin:500mg/24HMild Inhalation,mouse:LC50=17200mg/m3/2H Inhalation,mouse:LC50=6000mg/m3/6H Inhalation,rat:LC50=47702mg/m3/4H Inhalation,rat:LC50=6000mg/m3/6H Oral,mouse:LD50=36mg/kg Oral,rat:LD50=695mg/kg Oral,rat:LD50=1250mg/kg Skin,rabbit:LD50=>20gm/kg . Other:Skin,rabbit:10mg/24Hopenmild

Carcinogenicity: ChloroformACGIH:A3Confirmedanimalcarcinogenwithunknownrelevanceto humansCalifornia:carcinogen,initialdate10/1/87NTP:SuspectcarcinogenIARC: Group2Bcarcinogen Other: SeeactualentryinRTECSforcompleteinformation. Section12EcologicalInformation Ecotoxicity: Fish:Rainbowtrout:LC50:2030g/l Bacteria:Pseudomonasputida:EC0:125mg/l Section13DisposalConsiderations Disposeofinamannerconsistentwithfederal,state,andlocalregulations. Section14TransportInformation IATA CHLOROFORM 6.1 1888 III IMO CHLOROFORM 6.1 1888 III RID/ADR CHLOROFORM 6.1 1888 III

ShippingName: HazardClass: UNNumber: PackingGroup:

USARQ:CAS#67663:10lbfinalRQ4.54kgfinalRQ Section15RegulatoryInformation European/InternationalRegulations EuropeanLabelinginAccordancewithECDirectives HazardSymbols:XN RiskPhrases: R22Harmfulifswallowed. R38Irritatingtoskin. R40Limitedevidenceofacarcinogeniceffect. R48/20/22Harmful:dangerofseriousdamagetohealthbyprolongedexposurethrough inhalationandifswallowed. SafetyPhrases: S36/37Wearsuitableprotectiveclothingandgloves. WGK(WaterDanger/Protection) CAS#67663:3 Canada CAS#67663islistedonCanada'sDSLList USFederal TSCA

CAS#67663islistedontheTSCAInventory. Section16OtherInformation MSDSCreationDate: 7/16/1996 Revision#2Date 11/09/2004 RevisionsweremadeinSections: Generalrevision.

Theinformationaboveisbelievedtobeaccurateandrepresentsthebestinformationcurrentlyavailableto us.However,wemakenowarrantyofmerchantibilityoranyotherwarranty,expressorimplied,with respecttosuchinformation,andweassumenoliabilityresultingfromitsuse.Usersshouldmaketheirown investigationstodeterminethesuitabilityoftheinformationfortheirparticularpurposes.Innoeventshall thecompanybeliableforanyclaims,losses,ordamagesofanythirdpartyorforlostprofitsorany special,indirect,incidental,consequential,orexemplarydamageshowsoeverarising,evenifthecompany hasbeenadvisedofthepossibilityofsuchdamages.