Mock Test-2

b)

1.
between a) b) c) d)

Hemidesmosomes are structures found two adjacent plant cells two adjacent animal cells cell and extracellular matrix within a bacteria

Cholera toxin activates Gs, pertussis toxin activates Gi c) Both work by same mechanism d) Cholera toxin activates ADP ribosylation but pertussis toxin just opens the appropriate channel 6. e) f) g) h) The P53 gene is especially prone to point mutation chromosomal rearrangement loss none of the above Nitroglycerin tablets and other nitro Vasoregulators are taken to relieve angina. Which of the statements is NOT true a) It relieves the pain caused by contraction of a heart deprived of O2 because of blocked coronary arteries b) NO-induced relaxation of cardiac muscle c) Glycerin induced relaxation of cardiac muscle d) Increased cGMP synthesis diminish after the stimulus ceases Mutations in the R or C subunit of cAMPdependent protein kinase (PKA) might to

2. Some receptors for growth factors activate a protein kinase cascade, with the participation of multiple enzymes to effect a change in gene expression. Which of the following statements about a protein kinase cascade are true?

a)

Multiple steps allow the amplification of the signal.

7.

b) c)

External signals can lead to changes in gene expression. Multiple steps leading to kinase activations can result in cells having different responses, depending on the presence or absence of target proteins.

d)

Multiple steps in an activation mean that abnormal stimulation of a cell response such as growth can occur with mutations in more than one gene.

e) 3.

All of the above are true. Destruction box is a) Sequence for protein targeting b) Sequence in cyclins amino terminal c) Region of DNA required for its destruction d) Carboxy terminal sequence of suicidal enzymes. lead

8.

a)

mutation in the R subunit makes it unable to bind to the C subunit, the C subunit is never inhibited; it is constantly active.

b)

4. The specificity of the steroid-receptor interaction is exploited in the use of the drug tamoxifen. In some types of breast cancer, division of the cancerous cells depends on the continued presence of the hormone estrogen. 9. Tamoxifen competes with estrogen for including binding to the estrogen receptor, but the tamoxifen-receptor complex has little or no effect on gene expression; tamoxifen is an antagonistof estrogen. tamoxifen administered adductor a. slows or stops the growth of remaining cancerous cells b. increases the growth of cancerous cells the c. unregulated growth d. no effect on the cancerous cells but effects normal cells 5. Difference in the mechanism of cholera toxin and pertussis toxin is a) Cholera toxin activates ADP ribosylation, pertussis inhibits the same

mutation prevents the binding of cAMP to the R sub unit but still allows normal R-C interaction, the inhibition of C by R cannot be relieved by elevated cAMP so constantly inactive. c) Both a and b d) None A variety of unusual invertebrates, giant clams, mussels, and polychaete worms, live on the fringes of deep-sea hydrothermal vents, where the temperature is 60 degrees C. The muscle of a giant clam has a resting membrane potential of 95 mV. Given intracellular and extracellular ionic compositions shown below predict membrane potential?

a. b. c. d.

-90mV 90mV -190mV 190mV

10.
pathway

Two protein kinases, K1 and K2 function sequentially in regulating intracellular in response to extracellular signal. The

following observations are made: (i) Response is observed even in the absence of extracellular signal when a mutation permanently activates K1. (ii) Response is observed even in the absence of extracellular signal when K1 contains an activating mutation and K2 with inactivating mutation. (iii) No response in the cells is detected even in the presence of extracellular signal when both kinases are inactivated by mutation. Which one of the following is correct? a) K1 activates K2 b) K2 activates K1 c) K1 inhibits K2 K2 inhibits K1 11.

d)