MATERIAL OF DISCUSSION The wound healing post extraction runs through some complex biologic steps, this healing

can be observed in histological by monitoring count and activity of inflammation cells especially neutrophil. Neutrophil is one of inflammation cells that involves in wound healing process, inflammation phase. Decrease of neutrophil indicates that wound healing process in inflammation phase has come to fibroblastic phase. The proof of it is shown by replacement of neutrophil to the others such as lymphocyte, macrophage, and fibroblast. Result experiment of treatment group show lower decrease of neutrophil than control group on the 1st day until 5th day. It shows, there is potential content in pressing inflammation process so that it fastens wound healing in this experiment. It is liquid extract of tuber Teki. On the contrary control group, wound healing process runs in physiological (body response) without helping of anti-inflammation agent. Anti-inflammation effect on tuber of Teki dues to flavonoid. An experiment reported that in high concentration, flavonoid can inhibit release of arachidonic by blocking cyclooxygenase path then decrease synthesis of prostaglandin. Prostaglandin can cause vascular permeability, vasodilatation and painful in inflammation process. Other mechanism anti-inflammation of flavonoid is inhibiting lipooxygenase path.
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It is able to decrease neutrophil that migrates to

inflamed tissue along with the reduce of inflammation mediator from arachidonic. Besides it, flavonoid has anti-bacteria effect because of interaction ability with DNAs bacteria. This interaction causes change of bacterial cell wall permeability, microsomes, lisosomes.
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The other anti-bacterial mechanism is releasing transduction energy to bacterial

cytoplasmic membrane and inhibiting bacterial motility. Anti-bacterial effect of falvonoid in extract tuber of Teki can press bacterial growth in second infection thats why inflammation reaction because of bacterial induction can be reduced. And migrating neutrophil to inflamed tissue decreases, too. By Nuryana 2007), other content of Teki tuber that may play in decreasing inflammation is terpen. Terpen has effects as anti-bacterial, anti-inflammation, anti-oxidant, and able to induct growth factors in wound healing. Highest content of it in Teki tuber is cyperene which has same

effect of flavonoid. Cyperene is an anti-inflammation agent for it can inhibit the formation of prostaglandin from arachidonic in cyclooxygenase path so that count of neutrophil decreases. This makes inflammation phase shortens. Thus, extract tuber of Teki is potential as a a material to reduce inflammation and fasten process of post extraction healing.