Oocyte freezing Circular from IVF unit of Jordan Hospital

Dr. Muin Fedah

Dr. Muin Fedah Direcor of I.V.F & Genetics Center

Obstetrician & Gynecologist Infertility Specialist I.V.F

Oocyte freezing Circular from IVF unit of Jordan Hospital

Most of the cancer in young age in females is curable but chemotherapy and radiology are markedly effecting the female fertility, advance science now found the way to preserve their fertility one is the most powerful tool now is oocyte freezing

Who would benefit from egg freezing?

Several groups may potentially benefit from egg freezing:

Preservation of fertility before a young single cancer patient receives radiotherapy or chemotherapy. Women who need to have their ovaries removed such as women who are carriers of BRC1 and II mutation genes in order to reduce the risk of developing breast cancer. Other reasons like women want to get pregnant at late age.

Egg freezing entails not a costly and minimal invasive IVF treatment. After the eggs are collected they are frozen. The human egg is the largest cell in the human body. It contains huge amounts of water and its outer layer is fairly water-resistant. Problems occur during freezing as this water will turn to ice crystals, which disrupt the eggs DNA and membrane structure. Therefore cryoprotectants (antifreeze solutions) are used to replace this water to reduce ice formation. Freezing eggs should be performed within 2 hours of egg collection. There are two techniques for freezing eggs: Vitrification ultrarapid freezing. This is a new method where the vial or straw is plunged directly into liquid nitrogen; the cooling rates are so rapid that ice crystals does not have a chance to form, and the mixture of cryoprotectant and egg forms a glass-like solidification of cells. Vitrifaction method appears to be associated with a significantly higher survival rates compared to slow freezing. Results appear promising approximately 10 babies are born per 100 eggs and it is much simpler technique (Petracco et al ESHRE 2007).

The usual period for storing eggs is 10 years at least; however it is possible to store the eggs for longer. Egg freezing is new based on current data, egg freezing appears to be safe. Fortunately, to date, no abnormalities have been reported from the 200 babies born worldwide so far. There are very high rates of egg survival (99%), fertilization rates (92%), pregnancy rates (32%) and healthy babies using virtification technique. Conclusions Viable fertility preservation method offering excellent outcomes in infertile women treated using this technology

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