Anxiolytic drugs 1. Which of these anxiolytic agents relieves anxiety without causing marked sedative effects ?

a) Diazepam b) Chlordiazepoxide c) Buspirone d) Clorazepate 2. Which of the following has minimal abuse liability? a) Oxazepam b) Buspirone c) Flumazenil d) Alprazolam 3. In a) b) c) d) contrast to benzodiazepines, buspirone: Interact directly with GABA-ergic system Has more marked hypnotic, anticonvulsant, or muscle relaxant properties Causes less psychomotor impairment and does not affect driving skills Has maximal abuse liability

CNS Pharmacology

4. Which of the following sedative-hypnotic drugs does not potentiate the CNS depressant effects of ethanol, phenothiazines, or tricyclic antidepressants? a) Buspirone b) Phenobarbital c) Diazepam d) Chloralhydrate 5. Limitation of buspirone is: a) A low therapeutic index b) An extremely slow onset of action c) A high potential of development of physical dependence d) Impairment of motor functions during working hours 6. Restlessness, anxiety, orthostatic hypotension, generalized seizures, severe tremor, hallucination & psychosis are symptoms of: a) Tolerance b) Withdrawal c) Drug interactions between barbiturate and diazepam d) None of the above 7. Flumazenil is used to: a) Reverse the CNS depressant effects of hypnotic benzodiazepines overdose b) Hasten recovery following use of hypnotic benzodiazepines in anesthetic and diagnostic procedure c) Reverse benzodiazepine-induced respiratory depression d) All of the above 8. Flumazenil given intravenously: a) Has intermediate onset and duration of action about 2 hours b) Acts rapidly but has a short half-life c) Has an effect lasting 3-5 hours d) Has duration of action longer than 6 hours 9. Anxiolytics are also useful for:

a) b) c) d) 10. a) b) c) d) 11. a) b) c) d) 12. a) b) c) d) 13. a) b) c) d) 14. a) b) c) d)

Anxiolytic drugs Treatment of epilepsy and seizures Insomnia Muscle relaxation in specific neuromuscular disorders All of the above

CNS Pharmacology

The agents of choice in the treatment of most anxiety states is : Barbiturates Benzodiazepines Lithium salts Phenothiazines Which of the following anxiolytics is a benzodiazepine derivative: Buspirone Clordiazepoxide Meprobamate Chloral hydrate The benzodiazepine, which has the shortest elimination half-life is : Quazepam Triazolam Diazepam Clorazepate Anxiolytic dosage reduction is recommended in : Patients taking cimetidine Patients with hepatic dysfunction Elderly patients All of the above

Which of the following benzodiazepines is preferred for elderly patients? Answer Clorazepate s: Clordiazepoxide 1.d Triazolam Prazepam 2.b 3.b 15. Which of the following anxiolytics is a partial agonist of brain 5-HT1A 4.b receptors? 5.d a) Buspirone 6.c b) Alprozolam 7.a c) Chlorazepat 8.a d) Phenelzine 9.c 10.b 16.The competitive antagonist of BZ receptors is : 11.c a) Flumazenil b) Buspirone 12.a c) Picrotoxin 13.b d) Diazepam 14.b 15.d 16.b