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Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
A J Cooper, N G Forouhi, Z Ye, B Buijsse, L Arriola, B Balkau, A Barricarte, J W J Beulens, H Boeing, F L Bchner, C C Dahm, B de Lauzon-Guillain, G Fagherazzi, P W Franks, C Gonzalez, S Grioni, R Kaaks, T J Key, G Masala, C Navarro, P Nilsson, K Overvad, S Panico, J Ramn Quirs, O Rolandsson, N Roswall, C Sacerdote, M-J Snchez, N Slimani, I Sluijs, A M W Spijkerman, B Teucher, A Tjonneland, R Tumino, S J Sharp, C Langenberg, E J M Feskens, E Riboli, N J Wareham and The InterAct Consortium
Abstract
Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated
meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case cohort study nested within eight European countries, a representative sample of 16154 participants and 12403 incident cases of T2D were identified from 340234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.801.01) for FVI; 0.89 (0.761.04) for fruit and 0.94 (0.841.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.770.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.871.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.740.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.
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European Journal of Clinical Nutrition ISSN: 0954-3007 EISSN: 1476-5640 About NPG Contact NPG Accessibility statement Help
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