Evaluation: Pharmacology UY1/FMSB/PHCL3XX-L3S5 14march2011 : 60mins Section A: Multiple Choice Questions (Choose the ONE best answer

[e] All the above

8. What is the mechanism of ethanol induced gastritis in human?

[a] Stimulation of acid secretion [b] Expose gastric mucosal to acidity after disrupting mucin layer [c] Acidic properties of alcohol itself [d] Increase in vagus stimulus [e] Increases the proliferation of Helicobacter pylori

1. What is the drug of choice for the treatment of High-Altitude Cerebral

2.

3.

4.

5.

6.

Oedema (HACE)? [a] Chlorthalidone [b] Furosemide [c] Acetazolamide [d] Mannitol [e] Descend altitude until symptoms are reduced Which of the following anti-tuberculosis agent is nephrotoxic? [a] Isoniazid [b] Rifampicine [c] Pyrazinamide [d] Ethambutol [e] Streptomycin Which class of diuretics could exhibit cross reactivity in patients allergic to sulphonamides? [a] Thiazides [b] Loop diuretics [c] Carbonic anhydrase inhibitors [d] Osmotic diuretics [e] Anti-aldosterones Which of the following diuretics should not be combined with drugs known to be ototoxic? [a] Mannitol [b] Spironolactone [c] Furosemide [d] Hydrochlorothiazide [e] Acetazolamide Which drug family is indicated for treatment of ureter spasm? [a] Anti-muscarinic agents [b] Osmotic diuretics [c] Anti-depressants [d] Agents that acidify [e] -1 selective agonist -1 selective antagonist Tamsulosin (Flowmax) is indicated for [a] Urinary retention associated with urethritis [b] Urinary retention associated with benign prostatic hypertrophy [c] Urinary retention associated with peripheral neuropathy [d] Acute Prostatitis [e] Bladder atony

9. The mechanism of the anti-emetic effects of the neuroleptic Chlorpromazine is

[a] Acceleration of gastric emptying [b] Direct antagonising effects on gastric muscles and diaphragm [c] Blocks serotonin receptors in the Chemoreceptor trigger zone [d] Blocks histamine receptors in the vomiting centre [e] Blocks dopamine receptors in the Chemoreceptor trigger zone 10. Ondansetron [a] Is an anti-diarrhoea agent [b] Is not absorbed after oral administration [c] Is effective in ciplastin induced nausea & vomiting [d] Is effective in motion sickness [e] Is effective for hiccups (hoquets) 11. All of the following receptors are targets for potential anti-emetic drugs EXCEPT [a] Histamine H1 receptors [b] Opioid mu-receptors [c] Neurokinin (NK)1 receptors [d] Muscarinic receptors [e] 5-Hydroxytryptamine(5-HT3) receptors 12. Sulfasalazine [a] Is a prodrug [b] Is used for maintenance treatment of ulcerative colilitis [c] Is nephrotoxic [d] Should be avoided in G6PD deficiency [e] All of the Above

13. Which of the following preparations of iodine is used in public health interventions for
the control of cretinism in Cameroon? [a] iodised oil injections [b] Iodised table salt [c] Iodised drinking water [d] Lugol solution [e] Iodised milk 14. Which of the following is synthetic progesterone that is commonly used in injectable contraceptives? [a] Norethisterone [b] Estrone [c] Levonorgestrel [d] Medroxyprogesterone [e] Ethinyl estradiol 15. Pathologic hyperprolactinemia could be treated with which of the following families of drugs? Page 1 sur 3

7. Which of the following is true in the comparison between cimetidine and

ranitidine? [a] Ranitidine does bind to androgen receptors [b] Ranitidine is less likely to cause gynaecomastia [c] Ranitidine has a lower affinity for cytochrome P450 [d] Ranitidine penetrates the blood brain barrier to a lesser extend

[a] Dopamine antagonists [b] Vasopressin analogs [c] Dopamine agonists [d] Oestrogens [e] progestines 16. Which of the following testosterone preparations could ensure prolonged availability in the body? [a] Methyl testosterone tablets [b] Testosterone Propionate i.m injection [c] Fluoxymesterone tablets [d] Transdermal patches of testoterone [e] None of the above

17. Which insulin preparation is best for acute diabetic ketoacidosis?

[a] Rapid insulin [b] Intermediate acting insulin [c] Long acting insuline [d] Human insulin [e] Porcine insulin 18. Which of the following is best indicated for the treatment of diabetes insipidus [a] Oxytocine [b] Desmopressin [c] Insulin [d] Meformin [e] Furosemide 19. What is the standard concentration of all brands of commercially available insulin preparations? [a] 40iu/ml [b] 60iu/ml [c] 80iu/ml [d] 100iu/ml [e] 120iu/ml

[c] Diazepam [d] Carbamazepine [e] Magnesium sulfate 23. Which of the following anti-epileptic induces the metabolism of estrogen and can lead to unwanted pregnancies in woman using oral contraceptive? [a] Valproate acid [b] Carbamazepine [c] Diazepam [d] Lamotrigine [e] Clonazepam 24. Propofol in comparison with to sodium thiopental [a] Cannot be used for induction anesthesia [b] Has a much longer half-life [c] Produces a more rapid recovery [d] Is administered by inhalation [e] None of the above is correct

25. Which of the following drugs act by increasing the amount of synaptic monamine?
[a] Amitriptyline [b] Flouxetine [c] Paroxetine [d] All of the above [e] None of the Above

A A

20. Which of the following could be used as muscle relaxant agent in certain
neuromuscular disorders? [a] Levodopa [b] Amitryptyline [c] Ketamine [d] Atropine [e] diazepam 21. Which of the following anti-convulsant agents is indicated for febrile convulsions in children? [a] Phenytoin [b] Aspirine [c] Diazepam [d] Carbamazepine [e] Magnesium sulfate 22. Which of the following is indicated for the treatment of convulsion associated with pregnancy induced hypertension [a] Phenytoin [b] Aspirine Figure i: Dose-Effect relationship of sedative-hypnotic agents A, B, & C (For questions 26-27, refer to figure I above)

26. Curve A represents the Dose-Effect relationship of which of the following class of
sedative-hypnotic agents? [a] Ethanol [b] Barbiturates [c] Benzodiazepines [d] None of the above [e] All of the above 27. Curve B represents the Dose-Effect relationship of which of the following class of sedative-hypnotic agents? [a] Ethanol [b] Barbiturates [c] Benzodiazepines Page 2 sur 3

[d] None of the above [e] All of the above Section B: OPEN Questions 28. Describe the physiopathologic basis of symptoms associated with acute abuse of laxatives. (3pts)

29. Give a tabulated pharmacologic comparison between oral anti-diabetics Biguanides and
Sulfonylureas in terms of; (i) the prototype drugs of each group (ii) the respective
mechanism of action (iii) Therapeutic utility (iv)Adverse drug reactions (vi) Drug-drug interaction. (4pts)

30. Give a tabulated description of the pharmacologic properties of Tricyclic

Anti-depressants (TCA) and the corresponding possible clinical consequences. (3pts)

31. Give a tabulated list of various pharmacologic targets of drugs that act at
urinary bladder (vessie) and corresponding pharmacologic effects including the therapeutic uses. (3pts)

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