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1: Cancer Lett. 1993 Aug 16;72(1-2):121-5.

Influence of ascorbic acid on MCA-induced carcinogenesis in the uterine cervix of mice. Related Articles

Chemopreventive action of selenium on

Das P, Rao AR, Srivastava PN. [Oncology.
methylcholanthrene-induced carcinogenesis in the uterine 1992]
cervix

Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. Modulation of methylcholanthrene-induced carcinogenesis in the
uterine cervix of mouse by indomethacin. [Cancer Lett.1988]
The present study evaluates the possible modulatory influence of ascorbic acid (AA) on
Modulatory influences of exogenous estrogen on MCA-induced
(methylcholanthrene) MCA-induced cervical carcinogenesis in mice. Ascorbic acid was given daily
carcinogenesis in the uterine cervix of mouse. [Cancer Lett.1988]
for different durations in drinking water at the dose level of 2 mg/ml. In animals that received
no modulator, placement of cotton threads impregnated with beeswax containing -600 Review Final report of the safety assessment of L-Ascorbic
micrograms of MCA for 16 weeks yielded 76.1% carcinomas in the uterine cervix. Administration [Int J Toxicol.2005]
Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium
of AA for the entire period of 16 weeks resulted in the reduction of MCA-induced cervical Review Strategies for phase II cancer chemoprevention trials:
carcinomas to 33.3%. AA was capable of reducing cervical cancer incidence to 33.3% even when cervix, endometrium, and ovary. [JCellBiochemSuppl.1995]
it was given for only 6 weeks following MCA-thread insertion into the uterine cervix. However,
when it was given for a period of 10 weeks after 6 weeks of MCA-thread insertion the carcinoma » See Reviews... | » See All...
incidence was as high as 66.6%. Results of the present study demonstrate that AA, especially
when given during the initiational phase, significantly inhibits MCA-induced cervical Patient Drug Information
carcinogenesis in mice.
Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...)
PMID: 8402567 [PubMed - indexed for MEDLINE] Ascorbic acid is used to prevent and treat scurvy, a disease
caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

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