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Antigen g
y Foreignsubstancesthatelicitanimmuneresponse
(immunogens)
y Thesmallestunitofanantigencapableofbinding
broughttothesurfaceofacell
Innateimmunity y
External Internal
Dendritic cells
y Foundinskin,mucus
b t i bacteria
Dendritic cells
y Present P antigens i of f
cells(APCs)
Macrophages p g
y Firstcellsinthebloodto
encounteranantigen
y Attackanythingnot
recognisedasself
y Activitymediatedby
interferonandNO
y Digestanddisplayantigen
ontheirsurface
Naturalkillercells
y Targetabnormalcells y Activitymediated d dby b
perforins
Adaptive p immunity y
Cells
Lymphocytes
y Bcells y Tcells
Molecules
Immunoglobulinsuperfamily
y Antibodies y Tcellreceptors(TcR) y Majorhistocompatibility
complexes(MHC)
Adaptiveimmunitycharacterisedbyspecificityandmemory
Cellsofadaptive p immunity y
Tcells
y KillerTcellsattachtotarget
Bcells
cells(cf.NKcellsofinnate immunity)
y SomeTcellsremainas
memorycells
y HelperTcellsassistin
lymphnodes
Differentiationofcellsofadaptive y immunity
Moleculesofadaptive p immunity y
Immunoglobulinsuperfamily
y Solubleimmunoglobulins g y ReceptorsonthesurfaceofT
cells(TcR)
y Major M j histocompatibility hi ibili
complexes(MHC)
Alternatesplicing p g
Hybridomas y
Achecklistofthecomponentsof y immunity
Innate
y Barriers(skin,mucous
Adaptive
Respondtospecificantigens
Lymphatic y p system y
Lymphatic y p system y
Dendritic cells
y Foundinskin,mucus
b t i bacteria
Antigen g presentation p
Dendritic cells
y Present P antigens i of f
cells(APCs)
TheTcellreceptor p (TcR) ( )
MHCandTcR interaction