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Slide 1

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Thyroid &
Parathyroid Disorders
Pamela Krupilis RN, MSN, CNS
Schuylkill Health School of Nursing

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Slide 2

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Hypothyrodism

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Schuylkill Health School of Nursing

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Slide 3

Hypothyroidism
One of the most common medical
disorders in the United States
Affects 1 in 50 women and 1 in 300 men

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Schuylkill Health School of Nursing

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Slide 4

Etiology
Results from insufficient circulating thyroid
hormone
Thyroxin T4
Thiodothyronine T3
Result of a variety of abnormalities

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Schuylkill Health School of Nursing

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Slide 5

Pathophysiology
Can be primary or secondary
Primary
Related to destruction of thyroid tissue or defective
hormone synthesis
Hashimotos Disease

Secondary
Related to pituitary disease with TSH secretion

Schuylkill Health School of Nursing

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Slide 6

Pathophysiology
May be transient, related to thyroiditis, or
result from discontinuing thyroid hormone
therapy

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Schuylkill Health School of Nursing

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Slide 7

Pathophysiology
Iodine deficiency
Most common cause worldwide and is most
prevalent in iodine-deficient areas

In places where iodine intake is adequate,


the primary cause is atrophy of the gland.

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Schuylkill Health School of Nursing

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Slide 8

Pathophysiology
May also develop because of treatment for
hyperthyroidism
Amiodarone and lithium can produce
hypothyroidism.

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Schuylkill Health School of Nursing

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Slide 9

Pathophysiology
Cretinism is caused by thyroid hormone
deficiencies during fetal or neonatal life.
All infants are screened at birth for
thyroid function.

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Schuylkill Health School of Nursing

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Slide 10

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Clinical Manifestations
Vary depending on
Severity
Duration
Age of onset

Systemic effects characterized by slowing


of body processes

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Schuylkill Health School of Nursing

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Slide 11

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Clinical Manifestations
Ranges from no symptoms to classic
symptoms and physical changes easily
detected on examination

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Schuylkill Health School of Nursing

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Slide 12

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Clinical Manifestations
Onset of symptoms may occur over
months to years.
Unless occurs after thyroidectomy, thyroid
ablation, treatment with antithyroid drugs

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Schuylkill Health School of Nursing

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Slide 13

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Clinical Manifestations
Cardiovascular system
cardiac output
cardiac contractility
Anemia
Cobalamin, iron, folate deficiencies
serum cholesterol and triglycerides

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Schuylkill Health School of Nursing

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Slide 14

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Clinical Manifestations
Respiratory system
Low exercise tolerance
Shortness of breath on exertion

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Schuylkill Health School of Nursing

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Slide 15

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Clinical Manifestations
Neurologic system
Fatigued and lethargic
Personality and mood changes
Impaired memory, slowed speech, decreased
initiative, and somnolence

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Schuylkill Health School of Nursing

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Slide 16

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Clinical Manifestations
Gastrointestinal system
motility
Achlorhydria
Constipation

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Schuylkill Health School of Nursing

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Slide 17

Clinical Manifestations
Reproductive System
Menorrhagia
Amenorrhea
Decreased Libido

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Schuylkill Health School of Nursing

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Slide 18

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Clinical Manifestations

Other changes

1.

Cold intolerance
Hair loss
Dry/coarse skin
Brittle nails
Hoarseness
Muscle weakness and swelling
Weight gain

Schuylkill Health School of Nursing

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Slide 19

Clinical Manifestations
Can lead to cholesterol level, atherosclerosis,
CAD, & poor left ventricular function.

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Schuylkill Health School of Nursing

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Slide 20

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Clinical Manifestations
Those with severe long-standing
hypothyroidism may display myxedema.
Accumulation of hydrophilic
mucopolysaccharides in the dermis and other
tissues
Causes puffiness, periorbital edema, masklike
effect

Schuylkill Health School of Nursing

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Slide 21

Myxedema

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Schuylkill Health School of Nursing

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Slide 22

Myxedema

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Schuylkill Health School of Nursing

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Slide 23

Non-pitting Edema

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Schuylkill Health School of Nursing

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Slide 24

Complications
Mental sluggishness
Drowsiness
Lethargy progressing gradually or
suddenly to impairment of consciousness
or coma

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Myxedema coma

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Schuylkill Health School of Nursing

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Slide 25

Diagnostic Studies
History and physical examination
Laboratory tests
Serum TSH
Determines cause of hypothyroidism

Free T4
Serum T3
Serum T4
TPOAb (Antithyroid Peroxidase Antibodies)
Schuylkill Health School of Nursing

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Slide 26

Diagnostic Studies
Laboratory findings (contd)
Other abnormal findings are
cholesterol and triglycerides, anemia, and
creatine kinase.

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Schuylkill Health School of Nursing

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Slide 27

Diagnostic Studies
TRH stimulation test
in TSH after TRH injection suggests
hypothalamic dysfunction.
No change after TRH injection suggests
anterior pituitary dysfunction.

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Schuylkill Health School of Nursing

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Slide 28

Diagnostic Studies
Fine Needle Aspiration Biopsy
Thyroid Scan

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Schuylkill Health School of Nursing

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Slide 29

Collaborative Care
Restoration of euthyroid state as safely
and rapidly as possible
Low-calorie diet

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Schuylkill Health School of Nursing

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Slide 30

Collaborative Care
Levothyroxine (Synthroid)

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Must take regularly


Monitor for angina and cardiac dysrhythmias.

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Monitor thyroid hormone levels, and adjust


(as needed).
Liotrix (Thyrolar)

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Schuylkill Health School of Nursing

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Slide 31

Collaborative Care
Patient Education
Take medication same time daily.
Take at least 4 hours before taking
antacids.
Contact healthcare provider.
Symptoms should subside within 2 weeks.
Maintain regular visits.
Schuylkill Health School of Nursing

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Slide 32

Nursing Management
Nursing Assessment
Health history
Weight gain
Mental changes
Fatigue
Slowed/slurred speech
Cold intolerance
Skin changes

Schuylkill Health School of Nursing

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Slide 33

Nursing Management
Nursing Assessment
Health history (contd)
Constipation
Dyspnea
Recent introduction of iodine medications

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Schuylkill Health School of Nursing

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Slide 34

Nursing Management
Nursing Assessment
Physical examination
Bradycardia
Distended abdomen
Dry, thick, cold skin
Thick, brittle nails
Paresthesias
Muscular aches and pains
Schuylkill Health School of Nursing

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Slide 35

Nursing Management
Nursing Diagnosis
Imbalanced nutrition: More than body
requirements
Activity intolerance
Impaired memory

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Schuylkill Health School of Nursing

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Slide 36

Nursing Management
Planning

Experience relief of symptoms.


Maintain a euthyroid state.
Maintain a positive self-image.
Comply with lifelong thyroid replacement
therapy.

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Schuylkill Health School of Nursing

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Slide 37

Nursing Management
Nursing Implementation
Health promotion
No consensus for thyroid function screening
High-risk populations screened for subclinical
thyroid disease
Family history of thyroid disease, history of neck
radiation, women over 50, and postpartum

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Schuylkill Health School of Nursing

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Slide 38

Nursing Management
Nursing Implementation
Acute intervention
Most individuals do not require acute nursing
care.

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Managed on outpatient basis

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Schuylkill Health School of Nursing

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Slide 39

Nursing Management
Nursing Implementation
Acute intervention (contd)
Individual with myxedema coma requires
acute nursing care.

Mechanical respiratory support


Cardiac monitoring
IV thyroid hormone replacement
If hyponatremic, hypertonic saline may be
administered.
Monitor core temperature.
Schuylkill Health School of Nursing

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Slide 40

Nursing Management
Nursing Implementation
Acute intervention (contd)
Individual with myxedema coma (contd)

Vital signs
Weight
I&O
Visible edema
Cardiovascular response to hormone
Energy level
Mental alertness

Schuylkill Health School of Nursing

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Slide 41

Nursing Management
Nursing Implementation
Ambulatory and home care

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Explain nature of thyroid hormone deficiency


and self-care practices to prevent
complications.

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Patient and family must understand replacement


therapy and that it is lifelong.

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Schuylkill Health School of Nursing

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Slide 42

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Teach measures to prevent skin breakdown.
Emphasize need for warm environment.
Caution patient to avoid sedatives or use
lowest dose possible.

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Schuylkill Health School of Nursing

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Slide 43

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Discuss measures to minimize constipation.
Avoid enemas because of vagal stimulation in
cardiac patient

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Schuylkill Health School of Nursing

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Slide 44

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Teach patient to notify physician immediately if
signs of overdose appear.
Orthopnea, dyspnea, rapid pulse, palpitations,
nervousness, insomnia

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Schuylkill Health School of Nursing

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Slide 45

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Patient with diabetes should test blood
glucose at least daily.
Return to euthyroid state frequently.
insulin requirements.

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Schuylkill Health School of Nursing

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Slide 46

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Thyroid preparations potentiate the effects of
some common drug groups.
Teach patient toxic signs and symptoms of these
drugs.
Anticoagulants
Digitalis compounds

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Schuylkill Health School of Nursing

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Slide 47

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Provide handouts that include verbal
instructions for patients and family members.

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Schuylkill Health School of Nursing

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Slide 48

Nursing Management
Evaluation
Expected outcomes
Have relief from symptoms.
Maintain euthyroid state as evidenced by
normal thyroid hormone and TSH levels.
Adhere to lifelong therapy.

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Schuylkill Health School of Nursing

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Slide 49

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Hyperthyroidism

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Schuylkill Health School of Nursing

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Slide 50

Hyperthyroidism
A sustained increase in synthesis and
release of thyroid hormones by thyroid
gland
Occurs more often in women
Highest frequency in 20- to 40-year-olds

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Schuylkill Health School of Nursing

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Slide 51

Etiology
Most common form
Graves disease

Other causes
Thyroiditis
Toxic nodular goiter
Exogenous iodine excess
Pituitary tumors
Thyroid cancer
Schuylkill Health School of Nursing

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Slide 52

Etiology
Thyrotoxicosis
Physiologic effects/clinical syndrome of
hypermetabolism resulting from increased
circulating levels of T3, T4

Hyperthyroidism and thyrotoxicosis occur


together as Graves disease.

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Schuylkill Health School of Nursing

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Slide 53

Pathophysiology
Graves disease
Autoimmune disease of unknown origin
Diffuse thyroid enlargement
Excessive thyroid hormone secretion

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Schuylkill Health School of Nursing

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Slide 54

Pathophysiology
Graves disease (contd)
Precipitating factors
Insufficient iodine supply
Infection
Stressful life events interacting with genetic
factors

Accounts for 75% of cases of


hyperthyroidism
Schuylkill Health School of Nursing

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Slide 55

Pathophysiology
Graves disease (contd)
Antibodies are developed to TSH receptor.
Leads to clinical manifestations of
thyrotoxicosis
May progress to destruction of thyroid tissue,
causing hypothyroidism

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Schuylkill Health School of Nursing

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Slide 56

Pathophysiology
Toxic nodular goiters
Thyroid hormonesecreting
nodules independent of
TSH
If associated with
hyperthyroidism, termed
toxic

Multiple or single nodules


Usually benign follicular
adenomas
Occur equally in men and
women

Schuylkill Health School of Nursing

Slide 57

Clinical Manifestations
Related to effect of thyroid hormone
excess
metabolism
tissue sensitivity to stimulation by
sympathetic nervous system

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Schuylkill Health School of Nursing

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Slide 58

Clinical Manifestations
Ophthalmopathy
Abnormal eye appearance or function
Exophthalmos
Protrusion of eyeballs from the orbits
Impaired drainage from orbit
Increased fat and edema in retroorbital tissues
Seen in 20% to 40% of patients

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Schuylkill Health School of Nursing

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Slide 59

Exophthalmos and
Goiter of Graves Disease

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Schuylkill Health School of Nursing

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Slide 60

Clinical Manifestations
Cardiovascular system
Bruit over thyroid gland
Systolic hypertension
cardiac output
Dysrhythmias
Cardiac hypertrophy
Atrial fibrillation
Schuylkill Health School of Nursing

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Slide 61

Clinical Manifestations
GI system
appetite, thirst
Weight loss
Diarrhea
Splenomegaly
Hepatomegaly

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Schuylkill Health School of Nursing

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Slide 62

Clinical Manifestations
Integumentary system
Warm, smooth, moist skin
Thin, brittle nails
Hair loss
Clubbing of fingers
Diaphoresis
Vitiligo
Schuylkill Health School of Nursing

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Slide 63

Acropachy

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Schuylkill Health School of Nursing

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Slide 64

Clinical Manifestations
Musculoskeletal system
Fatigue
Muscle weakness
Proximal muscle wasting
Dependent edema
Osteoporosis

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Schuylkill Health School of Nursing

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Slide 65

Clinical Manifestations
Nervous system
Fine tremors
Insomnia
Ability of mood, delirium
Hyperreflexia of tendon reflexes
Inability to concentrate

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Schuylkill Health School of Nursing

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Slide 66

Clinical Manifestations
Reproductive system
Menstrual irregularities
Amenorrhea
Decreased libido
Impotence
Gynecomastia in men
Decreased fertility
Schuylkill Health School of Nursing

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Slide 67

Clinical Manifestations
Intolerance to heat
sensitivity to stimulant drugs
Elevated basal temperature

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Schuylkill Health School of Nursing

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Slide 68

Complications
Thyrotoxic crisis
Acute, rare condition, where all
manifestations are heightened
Life-threatening emergency
Death rare when treatment initiated
Presumed causes are additional stressors.
Schuylkill Health School of Nursing

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Slide 69

Complications
Thyrotoxic crisis
Manifestations include
Tachycardia
Heart failure
Shock
Hyperthermia
Restlessness
Schuylkill Health School of Nursing

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Slide 70

Complications
Thyrotoxic crisis
Manifestations (contd)
Agitation
Seizures
Abdominal pain
Nausea

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Schuylkill Health School of Nursing

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Slide 71

Complications
Thyrotoxic crisis
Manifestations (contd)
Vomiting
Diarrhea
Delirium
Coma

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Schuylkill Health School of Nursing

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Slide 72

Complications
Thyrotoxic crisis
Treatment
Thyroid hormone levels and clinical
manifestations with drug therapy

Therapy
Aimed at managing respiratory distress, fever
reduction, fluid replacement, and management
of stressors
Schuylkill Health School of Nursing

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Slide 73

Diagnostic Studies

History
Physical examination
Ophthalmologic examination
ECG
Radioactive iodine uptake (RAIU)
Indicated to differentiate Graves disease from
other forms of thyroiditis
Schuylkill Health School of Nursing

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Slide 74

Diagnostic Studies
Laboratory tests
TSH
Free thyroxine (free T4)
Total T3 and T4

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Schuylkill Health School of Nursing

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Slide 75

Collaborative Care
Goals
Block adverse effects of thyroid hormones.
Stop hormone oversecretion.

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Schuylkill Health School of Nursing

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Slide 76

Collaborative Care
Three primary treatment options
Antithyroid medications
Radioactive iodine therapy (RAI)
Subtotal thyroidectomy

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Schuylkill Health School of Nursing

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Slide 77

Collaborative Care
Drug therapy
Useful in treatment of thyrotoxic states
Not considered curative
Antithyroid drugs
Iodine
-adrenergic blockers

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Schuylkill Health School of Nursing

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Slide 78

Collaborative Care
Antithyroid drugs
Inhibit synthesis of thyroid hormone
Improvement in 1 to 2 weeks
Good results in 4 to 8 weeks
Therapy for 6 to 15 months

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Schuylkill Health School of Nursing

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Slide 79

Collaborative Care
Antithyroid drugs (contd)
Disadvantages include
Patient noncompliance
Increased rate of recurrence

First-line examples
Propylthiouracil (PTU)
Also blocks conversion of T4 to T3

Methimazole (Tapazole)
Schuylkill Health School of Nursing

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Slide 80

Collaborative Care
Iodine
Used with other antithyroid drugs in
preparation for thyroidectomy or treatment of
crisis
Large doses rapidly inhibit synthesis of T3 and
T4 and block their release into circulation.

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Schuylkill Health School of Nursing

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Slide 81

Collaborative Care
Iodine (contd)
vascularity of thyroid gland
Maximal effect seen within 1 to 2 weeks
Long-term iodine therapy is not effective.
Examples
Saturated solution of potassium iodine (SSKI)
Lugols solution

Schuylkill Health School of Nursing

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Slide 82

Collaborative Care
-adrenergic blockers
Symptomatic relief of thyrotoxicosis resulting
from -adrenergic receptor stimulation
Propranolol (Inderal) administered with other
antithyroid agents
Atenolol (Tenormin) is the preferred adrenergic blocker for patients with asthma or
heart disease.
Schuylkill Health School of Nursing

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Slide 83

Collaborative Care
Radioactive iodine therapy (RAI)
Treatment of choice in nonpregnant adults
Damages or destroys thyroid tissue

Delayed response
2 to 3 months

Treated with antithyroid drugs and Inderal


before and during first 3 months of RAI

Schuylkill Health School of Nursing

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Slide 84

Collaborative Care
RAI (contd)
High incidence of posttreatment
hypothyroidism
Need for lifelong thyroid hormone replacement

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Schuylkill Health School of Nursing

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Slide 85

Collaborative Care
Surgical therapy
Indications

Unresponsive to drug therapy


Large goiters causing tracheal compression
Possible malignancy
Individual not a good candidate for RAI

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Schuylkill Health School of Nursing

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Slide 86

Collaborative Care
Surgical therapy (contd)
Subtotal thyroidectomy
Preferred surgical procedure
Involves removal of significant portion of thyroid
90% removed to be effective

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Schuylkill Health School of Nursing

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Slide 87

Collaborative Care
Surgical therapy (contd)
Endoscopic thyroidectomy appropriate with
small nodules and no malignancy
Less scarring, pain, and recovery time

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Schuylkill Health School of Nursing

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Slide 88

Collaborative Care
Surgical therapy (contd)
Before surgery
Antithyroid drugs, iodine, and
-adrenergic blockers may be administered
To achieve euthyroid state
To control symptoms

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Schuylkill Health School of Nursing

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Slide 89

Collaborative Care
Nutritional therapy
High-calorie diet may be ordered
For hunger and prevention of tissue breakdown

Protein allowance 1 to 2 g/kg ideal body


weight
Avoid caffeine, highly seasoned foods, and
high-fiber foods

Schuylkill Health School of Nursing

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Slide 90

Thyroid Storm
Life threatening
Potential can occur during the postoperative period

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Schuylkill Health School of Nursing

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Slide 91

Thyroid Storm
Undiagnosed cases or poorly treated
hyperthyroidism
Precipitated by stress such as infection
(URI), diabetic ketoacidosis, physical or
emotional trauma, or during manipulation
of the thyroid gland.

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Schuylkill Health School of Nursing

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Slide 92

Thyroid Storm
Clinical manifestations
Very high fever
Extreme cardiovascular effects (tachycardia,
CHF, and angina)
Severs CNS effects (agitation, restlessness, &
delirium)

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Schuylkill Health School of Nursing

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Slide 93

Thyroid Storm
Treatment
Peripheral cooling
Replace fluids, glucose, and electrolytes
Beta-adrenergic blocking agents
Glucocorticoids
Antithyroid medications

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Schuylkill Health School of Nursing

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Slide 94

Nursing Management
Nursing Assessment
Health history
Preexisting goiter
Recent infection or trauma
Immigration from iodine-deficient area
Medications
Family history of thyroid or autoimmune
disorders
Schuylkill Health School of Nursing

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Slide 95

Nursing Management
Nursing Assessment

Weight loss
Nausea
Diarrhea
Dyspnea on exertion
Muscle weakness
Insomnia
Heat intolerance
Schuylkill Health School of Nursing

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Slide 96

Nursing Management
Nursing Assessment

Decreased libido
Impotence
Amenorrhea
Irritability
Personality changes
Delirium
Schuylkill Health School of Nursing

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Slide 97

Nursing Management
Nursing Assessment
Objective Data
Agitation
Hyperthermia
Enlarged or nodular thyroid gland
Eyelid retraction
Diaphoretic skin

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Schuylkill Health School of Nursing

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Slide 98

Nursing Management
Nursing Assessment

Brittle nails
Edema
Tachypnea
Tachycardia
Hepatosplenomegaly

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Schuylkill Health School of Nursing

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Slide 99

Nursing Management
Nursing Assessment

Hyperreflexia
Fine tremors
Muscle wasting
Coma
Menstrual irregularities
Infertility
Schuylkill Health School of Nursing

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Slide 100

Nursing Management
Nursing Diagnoses
Activity intolerance
Risk for injury
Imbalanced nutrition: Less than body
requirements
Anxiety
Insomnia
Schuylkill Health School of Nursing

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Slide 101

Nursing Management
Planning
Overall goals
Experience relief of symptoms.
Have no serious complications related to
disease or treatment.
Maintain nutritional balance.
Cooperate with therapeutic plan.

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Schuylkill Health School of Nursing

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Slide 102

Nursing Management
Nursing Implementation
Acute intervention
Usually treated in outpatient setting
Those with acute thyrotoxicosis or undergoing
thyroidectomy require hospitalization and
acute care.

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Schuylkill Health School of Nursing

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Slide 103

Nursing Management
Nursing Implementation
Acute thyrotoxicosis
Requires aggressive treatment
Administer medications to block thyroid
hormone production.
Administer IV fluids.
Ensure adequate oxygenation.

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Schuylkill Health School of Nursing

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Slide 104

Nursing Management
Nursing Implementation
Acute thyrotoxicosis (contd)
Calm, quiet room
Cool room
Light bed coverings

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Schuylkill Health School of Nursing

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Slide 105

Nursing Management
Nursing Implementation
Acute thyrotoxicosis (contd)
Change linens frequently if diaphoretic.
Encourage and assist with exercise.
Establish supportive relationship.
Apply artificial tears to relieve eye discomfort.
Elevate HOB and salt restriction for edema.

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Schuylkill Health School of Nursing

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Slide 106

Nursing Management
Nursing Implementation
Acute thyrotoxicosis (contd)
Do eye exercises.
Tape eyelids shut for sleep if they cannot
close.
Wear dark glasses to reduce glare and
prevent environmental irritants.

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Schuylkill Health School of Nursing

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Slide 107

Nursing Management
Nursing Implementation
Thyroid surgery
Preoperative care

Alleviate signs/symptoms of thyrotoxicosis.


Control cardiac problems.
Assess for signs of iodine toxicity.
Oxygen, suction equipment, and tracheostomy tray
are available in room.

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Schuylkill Health School of Nursing

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Slide 108

Nursing Management
Nursing Implementation
Thyroid surgery (contd)
Preoperative teaching

Coughing, deep breathing, and leg exercises


Supporting head while turning in bed
Range-of-motion exercises of neck
Speaking difficulty for a short time after surgery
Routine postop care

Schuylkill Health School of Nursing

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Slide 109

Nursing Management
Nursing Implementation
Thyroid surgery (contd)
Postoperative care
Every 2 hours for 24 hours
Assess for signs of hemorrhage.
Assess for tracheal compression.
Irregular breathing, neck swelling, frequent
swallowing, choking

Semi-Fowlers position
Support head with pillows.
Avoid flexion of neck.
Tension on suture lines
Schuylkill Health School of Nursing

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Slide 110

Nursing Management
Nursing Implementation
Thyroid surgery (contd)
Postoperative care
Monitor vitals.
Control pain.
Check for tetany.
Trousseaus and Chvosteks signs should be monitored.
Monitor for 72 hours.

Evaluate difficulty in speaking/hoarseness.


Some hoarseness is expected for 3 to 4 days.
Schuylkill Health School of Nursing

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Slide 111

Nursing Management
Nursing Implementation
Ambulatory and home care
Discharge teaching
Monitor hormone balance periodically.
Decrease caloric intake to prevent weight gain.
Adequate iodine

Perform regular exercise.


Avoid environmental temperature.
Avoid goitrogens.
Schuylkill Health School of Nursing

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Slide 112

Nursing Management
Nursing Implementation
Ambulatory and home care (contd)
Discharge teaching
Regular follow-up care

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Biweekly for a month and then semiannually

After complete thyroidectomy


Lifelong thyroid replacement instruction

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Signs/symptoms thyroid failure

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Schuylkill Health School of Nursing

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Slide 113

Nursing Management
Evaluation
Relief of symptoms
No serious complications related to
disease or treatment
Cooperate with therapeutic plan.

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Schuylkill Health School of Nursing

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Slide 114

Thyroid Cancer
Affects women more than men
Low mortality rate

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Schuylkill Health School of Nursing

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Slide 115

Etiology
Radiation exposure
Radioactive fallout from nuclear weapons
tests
Exposure to radioactive iodine from
nuclear accidents
Diets high or low in iodine
X-Rays of the neck or thymus.
Schuylkill Health School of Nursing

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Slide 116

Benign Nodule

Family history
Hashimotos thyroiditis
Soft, smooth, mobile nodule
Multinodular goiter without a predominating
nodule
Gradual or sudden onset of pain or
tenderness
Schuylkill Health School of Nursing

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Slide 117

Malignant Nodule
Age
Nodule plus hoarseness, difficulty
swallowing, or shortness of breath
External neck irradiation during childhood
Firm, irregular, fixed nodule
Cervical lymphadenopathy, especially one
sided
Previous
history of thyroid cancer
Schuylkill Health School of Nursing

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Slide 118

Diagnosis

Sensitive TSH assay


T3 and T4 levels
Ultrasound
MRI
CT scan
Fine Needle Aspiration
Schuylkill Health School of Nursing

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Slide 119

Types of Thyroid Cancer

Papillary Carcinoma
Follicular Carcinoma
Medullary Carcinoma
Anaplastic Carcinoma

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Schuylkill Health School of Nursing

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Slide 120

Papillary Carcinoma
Most common
Female greater than male by 3:1
Affects individuals from 30 60 more
frequently.
Slow growing and is present for several
years before spreading to lymph nodes
Prognosis
Schuylkill Health School of Nursing

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Slide 121

Follicular Carcinma
Accounts for 10% of all thyroid cancers
Common among elderly patients and
iodine deficiency regions.
Invades blood vessels and spreads to
bone and lung
Rarely spreads to lymph nodes
Schuylkill Health School of Nursing

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Slide 122

Medullary Carcinoma
3% of all types of thyroid cancers
Presents as a mass in the neck/thyroid and
may have lymphadenopathy
Aggressive, metastasize early, and have a
poor prognosis
Total Thyroidectomy is required
Schuylkill Health School of Nursing

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Slide 123

Anaplastic Carcinoma
Accounts for 10% of thyroid cancers
Grows rapidly and spreads locally to the
neck and airway
Surgery, radiation, and chemotherapy
80% of patients die within a year of
diagnosis
Schuylkill Health School of Nursing

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Slide 124

Questions ???

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Schuylkill Health School of Nursing

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Slide 125

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Parathyroid Disorders

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Schuylkill Health School of Nursing

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Slide 126

Hyperparathyroid
Women > Men
Unknown
Benign Tumor

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Schuylkill Health School of Nursing

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Slide 127

Pathophysiology
Primary
Benign Tumor

Secondary
Vitamin D deficiency, malabsorption
Chronic Renal Failure
Hyperphosphatemia.

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Schuylkill Health School of Nursing

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Slide 128

Pathophysiology
Tertiary
Hyperplasia
Loss of negative feedback system

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Schuylkill Health School of Nursing

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Slide 129

Clinical Manifestations
Bone effects
Decrease bone density

Kidney effects
Nephrolithiasis

Gastrointestinal

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Schuylkill Health School of Nursing

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Slide 130

Clinical Manifestations
Asymptomatic
Major
Muscle weakness, loss of appetite,
constipation, fatigue, emotional disorders,
shortened attention span
Osteoporosis
Nephrolithiasis
Schuylkill Health School of Nursing

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Slide 131

Complications

Renal Failure
Pancreatitis
Cardiac
Long bone fractures

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Schuylkill Health School of Nursing

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Slide 132

Diagnosis

PTH, Ca+ and PUrine Ca+


Creatinine
Amylase/Lipase
Alkaline Phosphatase

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Schuylkill Health School of Nursing

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Slide 133

Diagnosis

Bone Density
DEXA Scan
MRI/CT sound
Ultrasound

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Schuylkill Health School of Nursing

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Slide 134

Surgery
Parathyroidectomy
Partial
Total

Autotransplantation of normal parathyroid


gland

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Schuylkill Health School of Nursing

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Slide 135

Nonsurgical Treatment
Annual examination
Serum PTH, Calcium, Phosphorous,
Alkaline Phosphatase, Creatinine, & BUN
X-Rays
Urinary calcium excretion
Reinforce mobility
Dietary
Schuylkill Health School of Nursing

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Slide 136

Nonsurgical Treatment
Medications
Biphosphonates (alendronate[Fosamax])
Inhibits osteoclastic bone
resorption and normalizes
Calcium levels.

Schuylkill Health School of Nursing

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Slide 137

Nonsurgical Treatment
Phosphates
Oral administration
Inhibits calcium-absorbing effects of Vitamin D
in the GI tract
Contraindicated with poor renal function

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Schuylkill Health School of Nursing

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Slide 138

Nonsurgical Treatment
Calcimimetic agents ( cinacalet [Senispar])
FDA approved for Secondary Hyperparathyroidism and
Parathyroid carcinoma
Increases sensitivity of the calcium receptor on the
parathyroid gland.

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Schuylkill Health School of Nursing

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Slide 139

Nursing Management
Nursing Implementation
Parathyroidectomy
Hemorrhage
Fluid and electrolyte disturbance
Tetany
Monitor intake and output
Encourage mobility

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Schuylkill Health School of Nursing

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Slide 140

Nursing Management
Nursing Implementation
Non-surgical Candidate
Meal plan
Consult Dietitian
Exercise program
Encourage to maintain regular appointments
Educate patient on the s/s hyper/hypocalcemia

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Schuylkill Health School of Nursing

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Slide 141

Hypoparathyroid
Etiology

Uncommon
Iatrogenic
Idiopathic
Parathyroidectomy
Autoimmune
Pseudohypoparathyrodism
Chronic Renal Failure
Schuylkill Health School of Nursing
Alcoholics

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Slide 142

Pathophysiology
Inadequate PTH
Decrease Ca+
Increase P-

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Schuylkill Health School of Nursing

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Slide 143

Clinical Manifestations
Tetany
Painful tonic spasms of smooth and
skeletal muscles
Dysrhythmias
Decrease PTH and Ca+ levels
Increase P- levels
Schuylkill Health School of Nursing

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Slide 144

Nursing Management
Treat hypocalcemia
Ca+ gluconate, Ca+ chloride, or Ca+
gluceptate IV slowly

Rebreathing
Nutrition
Medication
Ca+ supplements
Hytakerol, calcitrol, Calciferol
Schuylkill Health School of Nursing

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Slide 145

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Questions???

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Schuylkill Health School of Nursing

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