. ________ refers to the study of the effects of drugs on the nervous system and behavior. a. Pseudopharmacology b. Neuropharmacology c.

Psychoimmunology d. Neurochemistry e. Psychopharmacology

Drugs that inactivate monoamine oxidase B would be expected to a. also block D2 receptors. b. increase the release of dopamine in response to the arrival of an action potential at the terminal buttons. c. make the dopamine transporter run in reverse. d. cause the release of serotonin into the synaptic cleft. e. increase the release of acetylcholine in response to the arrival of an action potential at the terminal buttons.

Drugs that block MAO-A are ________ agonists, whereas MAO-B blockers are ________. a. nicotinic receptor; muscarinic receptor antagonists b. glutamatinergic; glycine receptor agonists

c. dopamine; norepinephrine antagonists d. presynaptic; postsynaptic antagonists e. norepinephrine; dopamine agonists

The pharmacologic action of monoamine oxidase inhibitors is: 1. block the reuptake of monoamine neurotransmitter into the presynaptic cleft 2. blocks the metabolism of monoamine neurotransmitters 3. decreases 5HT and NE monoamines 4. enhances REM sleep 5. selective MAO-B inhibitors may be useful in psychosis

Phenelzine can result in a hypertensive crisis when coadministered with all of the following EXCEPT: 1. pickled herring (tyramine) 2. amphetamines 3. phenylpropanolamine 4. diazepam 5. ephedrine A 4

Correct pairs of pharmacologic action with CNS region of dopamine blockade include:

A. extrapyramidal effects basal ganglia B. increase prolactin secretion limbic C. antiemetic chemoreceptor trigger zone D. antipsychotic basal ganglia 1. A,B,C 2. A,C 3. B,D 4. D only 5. All of the above

A 2

Lithium carbonate is used as an alternative to the major tranquilizers in the control of manic-depressive illness. After the drug is started, how many days elapse before the antimanic effect is reached? 1. 1-5 days 2. 7-10 days 3. 11-15 days 4. 16-20 days 5. 21-25 days

Which of the following is (are) classified as a monoamine oxidase inhibitor?

I. isocarboxazid (Marplan)

II. phenylzine (Nardi!)

III. tranylcypromine (Parnate)

(A) I only

(B) III only

(C) I and II only

(D) II and III only

(E) I, II, and III only Ae

Choose the site of tyramine action: a-presynaptic storage vesicles b-reuptake channels c-alpha 1 adrenergic receptors d-beta adrenergic receptors e-alpha2 autoreceptors ans A

which of the following denature MAO and render it ineffective to react with even small amount of tyramine: a-selegline b-moclobemide c-tranylcypromine d-reboxetine e-none of the above ans C