Curriculum Vita Andrew Guerin Volk Email: avolk@lumc.edu Cell: (708) 404-4737 Work: (708) 297-3194 Education Ph.D.

Loyola University Chicago Molecular Biology Advisor: Dr. Jiwang Zhang, M.D., Ph.D. Baylor University Waco, TX Biology July 2009 December 2014

B.Sc.

August 2004 - May 2009

Research Positions July 2010 December 2015 Dissertation Research Loyola University Chicago January 2009 May 2009 Undergraduate Research Associate Baylor University Waco, TX

Fellowships and Awards April 2013 Dec. 2015 Ruth L. Kirschstein National Research Service Award (NRSA) F31 Pre-doctoral Fellowship National Cancer Institute, the National Institutes of Health (NIH-NCI) Langerbeck Award for Excellence in Undergraduate Research Mentoring Nomination: Loyola University Chicago Ruth L. Kirschstein National Research Service Award (NRSA) T32 Training Award for Experimental Immunology Institutional Research Training Award, Loyola University Chicago Graduate Research Mentoring Program Fellowship Loyola University Chicago

April 2013 Aug. 2012 April 2013

June 2012 Aug. 2012

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Peer-Reviewed Publications (Chronological Order) Andrew Volk, Jin Li, Junping Xin, Dewen You, Xingli Liu, Yechen Xiao, Peter Breslin, Zejuan Li, Wei Wei, Rachel Schmidt, Xinyu Li, Jun Zhang, Zhou Zhang, Sucha Nand, Jianke Zhang, Jianjun Chen, Jiwang Zhang. Sensitizing Acute Myeloid Leukemia Cells to NF-B Inhibitor Treatment by Blocking TNF-JNK-AP1 Signaling. (Submitted: Nature Medicine) Dewen You, Junping Xin, Andrew Volk, Jin Li, Wei Wei, Rachel Schmidt, Jun Zhang, Sucha Nand, Eun-Kyoung Breuer, Paul Kuo, Peter Breslin, Ameet Kini, Jiwang Zhang. Fak Stimulates a PI3k-AktmTor-Independent Survival Signal in T Lymphocytic Leukemia Cells. (Submitted: Nature) Jun Zhang, Christopher Seet, Clare Sun, Jing Li, Dewen You, Yechen Xiao, Andrew Volk, Peter Breslin,Wei Wei, Zhijian Qian, Nancy J. Zeleznik-Le, Manuel Diaz, Zhou Zhang, Jiwang Zhang. p27kip1 Maintains a Subset of Leukemic Stem Cells the Quiescent State in Murine MLL-Leukemia. (Under Review: Blood). Peter Breslin, Andrew Volk*, Jiwang Zhang. The Stem Cell Niche and Its Role in Self-Renewal, Aging, and Malignancy. The Encyclopedia of Molecular Cell Biology and Molecular Medicine Third Edition. January 2012. (*Co-First Author) Yechen Xiao, Hongling Li, Jun Zhang, Andrew Volk, Shubin Zhang, Wei Wei, Peter Breslin, Jiwang Zhang. TNF- /FAS-RIP1-Induced Cell Death Signaling Separates Hematopoietic Stem Cells/Progenitors into Two Distinct Populations. Blood. Dec 2011. 118: 6057-6066 Public Presentations and Seminars International Society of Stem Cell Research 2013 Annual Meeting Poster Presentation. Co-inhibition of TNF-JNK-AP1 and NF-kB Synergize in Acute Myeloid Leukemia Stem and Progenitor Cells. Andrew Volk, Junping Xin, Dewen You, Rachel Schmidt, Wei Wei, Peter Breslin, Sucha Nand, Jiwang Zhang. Boston MA, June 2013 LUC Interdisciplinary Research Symposium, Oral Presentation, Panel Session Award. Developing Novel Anti-Leukemia Therapies by Targeting Inflammation. Andrew Volk, Junping Xin, Dewen You, Rachel Schmidt, Wei Wei, Peter Breslin, Sucha Nand, Jiwang Zhang. Chicago IL, April 2013 American Society of Hematology 2012 Annual Meeting Poster Presentation. Sensitizing Leukemic Cells to NF-B Inhibitor Treatment by Repressing TNF-mediated, NF-B-Independent Survival Signaling. Andrew Volk, Yechen Xiao, Junping Xin, Dewen You, Rachel Schmidt, Shubin Zhang, Wei Wei, Peter Breslin, Sucha Nand Jiwang Zhang. Atlanta GA, December 2012 LUC Molecular Biology Program Retreat Poster Presentation, First Place Award. Sensitizing Leukemic Cells to NF-B Inhibitor Treatment by Repressing TNF-mediated, NF-B-Independent Survival Signaling. Andrew Volk, Jiwang Zhang. Chicago IL, September 2012 International Society of Stem Cell Research 2012 Annual Meeting Poster Presentation. p27kip1 Maintains a Subset of Leukemic Stem Cells the Quiescent State in Murine MLL-Leukemia. Jun Zhang, Christopher Seet, Clare Sun, Jing Li, Dewen You, Andrew Volk, Peter Breslin,Wei Wei, Zhijian Qian, Nancy J. Zeleznik-Le, Manuel Diaz, Zhou Zhang, Jiwang Zhang. Tokyo Japan, June 2012 Volk, Andrew Guerin 2

American Society of Hematology 2011 Annual Meeting Oral Presentation, Abstract Achievement Award. TNF-/Fas-RIP-1-Induced Cell Death Signaling Separates Murine Hematopoietic Stem Cells/Progenitors into Two Distinct Populations. Yechen Xiao, Andrew Volk, Jiwang Zhang. San Diego CA, December 2011 Manuscripts in Preparation 1) Andrew Volk, Jiwang Zhang. Review: The Role of Inflammation in Leukemogenesis. (In Preparation) 2) Andrew Volk, Andrew Dingwall, Jiwang Zhang. Review: Mutations in chromatin remodeling complexes drive B-Cell lymphoma development. (In Preparation) Scientific Projects April 2013 Present July 2011 April 2013 July 2010 August 2011 JNK-c-JUN-dependent differentiation block in AML TNF signaling in hematopoiesis and leukemogenesis Role of MLL in early embryonic development

Professional Associations and Service April 2013 April 2013 Present February 2011 Present January 2012 2013 Poster Session Judge: Chicago Area Undergraduate Symposium (CAURS) Member: International Society for Stem Cell Research (ISSCR) Member: American Association for the Advancement of Science (AAAS) Member: American Heart Association (AHA)

Dissertation Title and Description The Role of Inflammation in Leukemogenesis: Identifying Targets for Novel Therapeutic Strategies Many studies have shown that inflammation leads to cell death in normal tissues. There is mounting evidence in most mammalian tissues that suggests inflammation promotes cancer formation. Our studies focus on differences between normal blood stem cells and leukemia stem cells. We have shown that a critical difference between leukemia stem cells and normal blood stem cells is in their response to inflammation. Characterizing this difference has led us to the discovery of novel anti-leukemia therapeutic strategies that are able to specifically target leukemia stem cells while simultaneously protecting normal blood stem cells.

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Professional References Dr. Jiwang Zhang, M.D., Ph.D. Loyola University Chicago, Health Sciences Division Stem Cell Research Institute jzhang@lumc.edu Dr. Manuel Diaz, M.D. Loyola University Chicago, Health Sciences Division Stritch School of Medicine mdiaz@lumc.edu Dr. Andrew Dingwall, Ph.D. Loyola University Chicago, Health Sciences Division Department of Pathology adingwall@lumc.edu Dr. Mitchell Denning, Ph.D. Loyola University Chicago, Health Sciences Division Molecular Biology Program Director mdennin@lumc.edu

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