Chemistry 418 Winter 2009 Nuclear Chemistry and Radiochemistry Professor Kenneth Krohn

Class location/hour: Bagley 108, MF 9:30 - 10:50 Office: NW055, Health Sciences; office hours by appointment E-mail: kkrohn@u.washington.edu; Phone: 206-598-6245 Course website: http://depts.washington.edu/chem/courses/ Course goals: This course is designed to build a basic familiarity with natural radioactivity, nuclear systematics and reactions, radioactive decay processes, stellar nucleosynthesis, applications of radioactivity. It will emphasize nuclear and radiochemical methods applied to chemical analyses in the physical and biological sciences. January 5, Mon: January 9, Fri: January 12, Mon: January 16, Fri: January 19, Mon: January 23, Fri: January 26, Mon: January 30, Fri: February 2, Mon: February 6, Fri: Course Introduction. Radioactivity, Radiation and Isotopes in Chemistry. Historical perspective on nuclear chemistry and radiochemistry. Radioactive Decay: Nuclear structure, mass-energy relationships and decay mechanisms. Rates of Radioactive Decay. Sequential decay equilibria. Martin Luther King Holiday Nuclear Reactions. Particles, energetics and radionuclide production. Chemical Effects on Isotopic Decay: Rates, modes and perturbed angular correlations. Interaction of Radiation with Matter: Radiation detectors and health effects of radiation. Chemical Effects of Nuclear Reactions: Theory and experiment for (n,) and IT chemistry. Chemical Applications of Radioactivity for Analysis: Rutherford backscattering and Mossbauer spectroscopy. MID-Term Exam as a take-home problem set. February 9, Mon: February 13, Fri: February 20, Fri: Stellar Nucleosynthesis: Fusion and the origin of the elements. Nuclear Dating: Theory, production of 14C, sample preparation and analysis. Nuclear Medicine: Imaging and positron emission tomography. Positron Tomography Imaging of Neurotransmission. Imaging pre- and post-synaptic function. (Prof. J. Link) Nuclear Particle Accelerators. Sources of bombarding particles. Chemical effects of Nucleogenesis: Hot atom chemistry. Tracer Studies with 13N (10 min) and 15N (stable): Air pollution & denitrification. Student Presentations. MID-Term Exam as a take-home problem set. Student Presentations. Student Presentations. Final exam time, 8:30 to 10:20 am: Student Presentations.

February 16, Mon: Presidents Holiday

February 23, Mon: Reactors and Chain Reactions: Neutron activation analysis and nuclear energy. February 27, Fri: March 2, Mon: March 6, Fri: March 9, Mon: March 13, Fri: March 16, Mon: March 18, Wed:

Grading: Based on two take-home examinations (50 points each) due in class on Monday following distribution, course participation (25 points), and a written report (50 points) with an oral presentation and questioning on the same topic (25 points). The research report should be about ten double-spaced pages in length, based on ~5 literature references, and may either 1. present a review of one of the classic experiments in the development of our understanding of atomic or nuclear structure, or 2. propose an experiment that uses radiation or radioisotopes to answer a research question of your interest. In the historical case, it should describe the experiment in the context of the time when it was done and describe its impact on future research. In the research case, it should describe methods, anticipated results, and how they would be interpreted. Graduate students are encouraged to follow option 2. Aspects of tracers, radiation or nuclear methods should be emphasized in the report. The subject area for your paper should be discussed well in advance with the instructor and must be turned in by Monday, February 23.

Course Bibliography TJC Welch, EJ Potchen, MJ Welch. Fundamentals of the Tracer Method. WB Saunders, Philadelphia, 1972. EJ Hall. Radiation and Life. Pergamon Press, New York, 1976. G Friedlander, GW Kennedy, ES Macias and JM Miller. Nuclear and Radiochemistry. 3rd ed., John Wiley & Sons, New York, 1981. Recommended textbook for Chem 418. JW Root & KA Krohn. Short-lived Radionuclides in Chemistry and Biology. Advances in Chemistry vol 197, American Chemical Society, Washington, DC, 1981. BEIR V. Health Effects of Exposure to Low Levels of Ionizing Radiation. National Academy Press, Washington, 1990. WD Ehman & DE Vance. Radiochemistry and Nuclear Methods of Analysis. Wiley-Interscience, New York, 1991. JP Adloff & R Guillaumont. Fundamentals of Radiochemistry. CRC Press, Boca Raton, 1993. N Tsoulfanidis. Measurement and Detection of Radiation. 2nd ed. Taylor & Francis, London, 1995. C Schwarz, A Tour of the Subatomic Zoo. A Guide to Particle Physics. American Institute of Physics Press, New York, 1997. KH Lieser, Nuclear and Radiochemistry, 2nd revised ed., Wiley-VCH, Berlin, 2001. G Choppin, JO Liljenzin and J Rydberg. Radiochemistry and Nuclear Chemistry. 3rd ed. ButterworthHeinemann, Oxford, 2002. MF L'Annunziata, ed. Handbook of Radioactivity Analysis, 2nd ed., Academic Press, Amsterdam, 2003. MJ Welch & CS Redvanly, eds. Handbook of Radiopharmaceuticals, Radiochemistry and Applications, Wiley, London, 2003.