amoxicillin and clavulanate potassium Apo-Amoxi-Clav (CA), Augmentin, Augmentin-Duo (UK), Augmentin ES-600, Augmentin XR, Clavulin (CA),

Novo-Clavamoxin (CA) Pharmacologic class: Aminopenicillin Therapeutic class: Anti-infective Pregnancy risk category B Action Amoxicillin inhibits transpeptidase, preventing cross-linking of bacterial cell wall and leading to cell death. Addition of clavulanate (a beta-lactam) increases drug's resistance to beta-lactamase (an enzyme produced by bacteria that may inactivate amoxicillin). Availability Oral suspension: 125 mg amoxicillin with 31.25 mg clavulanic acid/5 ml, 200 mg amoxicillin with 28.5 mg clavulanic acid/5 ml, 250 mg amoxicillin with 62.5 mg clavulanic acid/5 ml, 400 mg amoxicillin with 57 mg clavulanic acid/5 ml, 600 mg amoxicillin with 42.9 mg clavulanic acid/5 ml Tablets (chewable): 125 mg amoxicillin with 31.25 mg clavulanate, 200 mg amoxicillin with 28.5 mg clavulanate, 250 mg amoxicillin with 62.5 mg clavulanate, 400 mg amoxicillin with 57 mg clavulanate Tablets (extended-release): 1,000 mg amoxicillin with 62.5 mg clavulanate Tablets (film-coated): 250 mg amoxicillin with 125 mg clavulanate, 500 mg amoxicillin with 125 mg clavulanate, 875 mg amoxicillin with 125 mg clavulanate Indications and dosages Lower respiratory tract infections, otitis media, sinusitis, skin and skin-structure infections, and urinary tract infections (UTIs) caused by susceptible strains of gram-negative and gram-positive organisms Adults and children weighing more than 40 kg (88 lb): 500 mg q 12 hours or 250 mg P.O. q 8 hours (based on amoxicillin component). For severe infections, 875 mg P.O. q 12 hours or 500 mg P.O. q 8 hours. Serious infections and community-acquired pneumonia Adults and children weighing more than 40 kg (88 lb): 875 mg P.O. q 12 hours or 500 mg P.O. q 8 hours Infants and children ages 3 months and older weighing less than 40 kg (88 lb): 20 to 45 mg/kg/day P.O. in divided doses q 12 hours or 20 to 40 mg/kg/day in divided doses q 8 hours, based on severity of infection and amoxicillin component (125 mg/5 ml or 250 mg/5 ml suspension) Infants younger than 3 months: 30 mg/kg/day P.O. (based on amoxicillin component) divided q 12 hours. (125 mg/5 ml oral suspension is recommended.) Recurrent or persistent acute otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis in children ages 2 and younger and in children who have received antibiotic therapy within last 3 months Children ages 3 months to 12 years: 90 mg/kg/day of Augmentin ES-600 P.O. q 12 hours for 10 days Dosage adjustment Renal impairment Hemodialysis Infants ages 3 months and younger Contraindications Hypersensitivity to drug or any penicillin Phenylketonuria (some products) History of cholestatic jaundice or hepatic dysfunction associated with this drug

Precautions Use cautiously in: severe renal insufficiency, infectious mononucleosis pregnant patients. Administration Ask about history of penicillin allergy before giving. Give with or without food. Know that maximum dosage for infants ages 3 months and younger is 30 mg/kg/day divided q 12 hours. Be aware that 12-hour dosing is recommended to reduce diarrhea. Refrigerate oral suspension when possible, or store at room temperature for up to 7 days. Route P.O. Onset Peak Duration Unknown Unknown 1-2.5 hr 6-8 hr

P.O. (extended) Unknown 1-4 hr

Adverse reactions CNS: lethargy, hallucinations, anxiety, confusion, agitation, depression, dizziness, fatigue, hyperactivity, insomnia, behavioral changes, seizures (with high doses) GI: nausea, vomiting, diarrhea, abdominal pain, stomatitis, glossitis, gastritis, black "hairy" tongue, furry tongue, enterocolitis, pseudomembranous colitis GU: vaginitis, nephropathy, interstitial nephritis Hematologic: anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, hemolytic anemia, agranulocytosis, bone narrow depression, eosinophilia Hepatic: cholestatic hepatitis Respiratory: wheezing Skin: rash Other: superinfections (oral and rectal candidiasis), fever, anaphylaxis Interactions Drug-drug. Any food: enhanced clavulanate absorption Chloramphenicol, macrolides, sulfonamides, tetracycline: decreased amoxicillin efficacy Hormonal contraceptives: decreased contraceptive efficacy Probenecid: decreased renal excretion and increased blood level of amoxicillin Drug-food. Any food: enhanced clavulanate absorption Drug-herbs. Khat: decreased antimicrobial effect Patient monitoring Monitor patient carefully for signs and symptoms of hypersensitivity reaction. Monitor for seizures when giving high doses. Check patient's temperature and watch for other signs and symptoms of superinfection, especially oral or rectal candidiasis. Patient teaching Instruct patient to immediately report signs or symptoms of hypersensitivity reaction, such as rash, fever, or chills. Tell patient he may take drug with or without food. Inform patient that drug lowers resistance to some types of infections. Instruct him to report new signs or symptoms of infection (especially of mouth or rectum). Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids. Tell patient taking hormonal contraceptives that drug may reduce contraceptive efficacy. Suggest she use alternative birth control method.

 Inform parents that they may give liquid form of drug directly to child or may mix it with foods or beverages. As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, foods, and herbs mentioned above. What is the most important information I should know about Amoxicillin and clavulanate? If you have ever had an allergic reaction to penicillin or to a cephalosporin, you may also be allergic to Amoxicillin and clavulanate. Tell your doctor about any past drug allergies. If you switch from one tablet form to another (regular, chewable, or extended-release tablet), take only the new tablet form and strength prescribed for you. The strength of clavulanate potassium is not the same among the different tablet forms, even though the amount of amoxicillin may be the same as in the tablet you were using before. This medicine may not be as effective or could be harmful if you do not use the exact tablet form your doctor has prescribed. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin and clavulanate will not treat a viral infection such as the common cold or flu. Amoxicillin and clavulanate can pass into breast milk and may cause a yeast infection, diarrhea, or allergic reaction in a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Amoxicillin and clavulanate can make birth control pills less effective. Use a second nonhormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Amoxicillin and clavulanate. What is Amoxicillin and clavulanate? Amoxicillin and clavulanate is an antibiotic in a group of drugs called penicillins. Amoxicillin and clavulanate fights bacteria in the body. Amoxicillin and clavulanate is used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. Amoxicillin and clavulanate may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking Amoxicillin and clavulanate? If you have ever had an allergic reaction to penicillin or to a cephalosporin, you may also be allergic to Amoxicillin and clavulanate. Tell your doctor about any past drug allergies. Before taking Amoxicillin and clavulanate, tell your doctor if you have: liver disease (or a history of hepatitis or jaundice); kidney disease; or mononucleosis. If you have any of these conditions, you may not be able to use Amoxicillin and clavulanate, or you may need a dosage adjustment or special tests during treatment. Some forms of this medication contain as much as 7 mg of phenylalanine per dose. Tell your doctor if you have phenylketonuria (PKU) or otherwise need to restrict your intake of phenylalanine. FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Amoxicillin and clavulanate can pass into breast milk and may cause a yeast infection, diarrhea, or allergic reaction in a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ads by Google

Promo Sale Optik Melawai Kunjungi Outlet Kami Dan Dapatkan Discount Besar Sampai Dengan 50% www.optikmelawai.com Potassium sulfite Purity:44%-46% Packing:250Kg drum www.jinychem.com Great Hair, Zero Risk Undetectable Custom Hairpieces. No Contracts, 100% Guaranteed. www.HairDirect.com How should I take Amoxicillin and clavulanate? Take this medication exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. If you switch from one tablet form to another (regular, chewable, or extended-release tablet), take only the new tablet form and strength prescribed for you. The strength of clavulanate potassium is not the same among the different tablet forms, even though the amount of amoxicillin may be the same as in the tablet you were using before. This medicine may not be as effective or could be harmful if you do not use the exact tablet form your doctor has prescribed. Take each dose with a full glass of water. Take the medicine at the start of a meal to reduce stomach upset. The Augmentin tablet should be swallowed whole. The Augmentin Chewable tablet must be chewed before swallowing. Do not swallow a chewable tablet whole. Do not crush or chew the Augmentin XR (extended-release) tablet. Swallow the pill whole, or break the pill in half and take both halves one at a time. If you have trouble swallowing a whole or half pill, talk with your doctor about using another form of Amoxicillin and clavulanate. Shake the liquid form of this medicine well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Amoxicillin and clavulanate should be taken at evenly spaced intervals as prescribed. It is important to take Amoxicillin and clavulanate regularly to get the most benefit. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin and clavulanate will not treat a viral infection such as the common cold or flu. This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Amoxicillin and clavulanate. Store the tablets at room temperature away from moisture and heat. Store the liquid form of this medicine in the refrigerator. Throw away any unused liquid after 10 days. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Amoxicillin and clavulanate overdose may include nausea, vomiting, stomach pain, skin rash, drowsiness, or hyperactivity. What should I avoid while taking Amoxicillin and clavulanate? Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Ads by Google Siegfried Pharmaceutical and Chemical Development and Production www.siegfried.ch Dojo Software Committed to medication safety. Medication Management Software dojo-software.com BeaconHospital Cyberknife Non-invasive brain cancer treatment Meet with specialists. Book now. www.beaconhospital.com.my What are the possible side effects of Amoxicillin and clavulanate? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have diarrhea that is severe or lasts longer than 3 days, or if you have nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Keep taking the medication and talk with your doctor if you have any of these less serious side effects: mild diarrhea, gas, stomach pain; nausea or vomiting; headache; skin rash or itching; white patches in your mouth or throat; or vaginal yeast infection (itching or discharge). Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. See also: Amoxicillin and Clavulanate side effects (in more detail) What other drugs will affect Amoxicillin and clavulanate? Before taking Amoxicillin and clavulanate, tell your doctor if you are using any of the following drugs: allopurinol (Zyloprim); probenecid (Benemid); or another antibiotic (for the same or for a different infection). If you are using any of these drugs, you may not be able to use Amoxicillin and clavulanate, or you may need dosage adjustments or special tests during treatment. Amoxicillin and clavulanate can make birth control pills less effective. Use a second nonhormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Amoxicillin and clavulanate. There may be other drugs not listed that can affect Amoxicillin and clavulanate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Next Page Side Effects More Amoxicillin and Clavulanate resources Side Effects Pregnancy Warnings Drug Images Drug Interactions Support Group 94 Reviews - Add your own review/rating

Compare Amoxicillin and Clavulanate with other medications Aspiration Pneumonia Bacterial Infection Bronchiectasis Bronchitis Febrile Neutropenia Kidney Infections Melioidosis Otitis Media Pneumonia Sinusitis Skin and Structure Infection Skin Infection Small Bowel Bacterial Overgrowth Strep Throat Upper Respiratory Tract Infection Urinary Tract Infection Where can I get more information? Your pharmacist has additional information about Amoxicillin and clavulanate written for health professionals that you may read. What does my medication look like? Amoxicillin and clavulanate is available with a prescription under the brand name Augmentin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you. Augmentin chewable 125 mg- round, yellow, lemon-limeflavored tablets Augmentin chewable 200 mg - round, pink, cherry-bananaflavored tablets Augmentin chewable 250 mg - round, mottled-yellow, lemon-limeflavored tablets Augmentin chewable 400 mg - round, mottled-pink, cherry-bananaflavored tablets Augmentin 250 mg - oval, white, film-coated tablets Augmentin 500 mg - oval, white, film-coated tablets Augmentin 875 mg - capsule-shaped, white, scored tablets Augmentin suspension 125 mg per 5 mL (1 teaspoon)banana-flavored liquid Augmentin suspension 200 mg per 5 mL (1 teaspoon) orange-raspberryflavored liquid Augmentin suspension 250 mg per 5 mL (1 tsp)orange-flavored liquid Augmentin suspension 400 mg per 5 mL (1 teaspoon) orange-raspberryflavored liquid Augmentin ES-600 suspension 600 mg per 5 mL (1 teaspoon)orange-raspberryflavored suspension Augmentin XR 1000mg - oval, white, film-coated tablets