You are on page 1of 3

1.- Houtmeyers E, Gosselink R, Bayanm-Ramirez G, et al. Effects of drugs on mucous clearance. Eur Respir J 1999; 14: 452-67 2.

- Ziment I. Acetylcysteine: a drug with an interesting past and a fascinating future. Respiration 1986; 50 Suppl. 1: 26-30 3.- Van As A. Pulmonary airway defence mechanisms: an appreciation of integrated mucociliary activity. Eur J Respir Dis 1980; 61 Suppl. 111: 21-4 4- Ventresca GP, Cicchetti V, Ferrari V. Acetylcysteine. In: Braga PC, Allegra L, editors. Drugs in Bronchial Mucology. New York: Raven Press, 1989: 77-102 5.- De Caro L, Ghizzi A, Costa R, et al. Pharmacokinetics and bioavailability of oral acetylcysteine in healthy volunteers. Arzneim Forsch 1989;39:382- 385. 6.- Borgstrom L, Kagedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 1986;31:217-222. 7.- Bonanomi L, Gazzaniga A. Toxicological, pharmacokinetic and metabolic studies on acetylcysteine. Eur J Respir Dis 1980;61:45-51. 8.- Olsson B, Johansson M, Gabrielsson J, Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 1988;34:77-82. 9.- Sjodin K, Nilsson E, Hallberg A, Tunek A. Metabolism of N-acetyl-l-cysteine. Biochem Pharm 1989;38:39813985. 10.- Cotgreave IA, Berggren M, Jones TW, et al. Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems. Biopharm Drug Dispos 1987;8:377-386. 11. Fluimucil: summary of product characteristics. 2002 12. Tomasi A. New acquisitions and therapeutic role of N-acetylcysteine in airways diseases caused by cigarette smoke and pollution. Eur Rev Med Pharmacol Sci 2004; 8 (3 Suppl. 1): 4-28 13.- Dekhuijzen PNR. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J 2004; 23: 629-36 14.- Cotgreave IA, Moldus P. Lung protection by thiol-containing antioxidants. Bull Eur Physiopathol Respir 1987; 23: 275-7 15.- Rahman I, MacNee W. Oxidative stress and adaptive response of glutathione in bronchial epithelial cells. Clin Exp Allergy 2002; 32 (4): 486-8 16.-Ventresca GP, Cicchetti V, Ferrari V. Acetylcysteine. In: Braga PC, Allegra L, editors. Drugs in Bronchial Mucology. New York: Raven Press, 1989: 77-102 17.- Simon LM, Suttorp N. Lung cell oxidant injury: decrease in oxidant mediated cytotoxicity by N-acetylcysteine. Eur J Respir Dis 1985; 66 Suppl. 139: 132-5 18.- Linden M, Wieslander E, Eklund A, et al. Effects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokers. Eur Respir J 1988; 1 (7): 645-50 19.- Corcoran GB, Wong BK. Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by Nacetyl-L-cysteine in vivo: Studies with N-acetyl-D-cysteine in mice. J Pharm Exp Ther 1986;238:54-61. 20.- Pratt S, Ioannides C. Mechanism of the protective action of N-acetylcysteine and methionine against paracetamol toxicity in the hamster. Arch Toxicol 1985;57:173-177.

21. Bernard GR, Wheeler AP, Arons MM, et al. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest 1997;112:164-172. 22. Pastor A, Collado PS, Almar M, Gonzalez- Gallego J. Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J Hepatol 1997;27:363-370. 23. Burgunder JM, Varriale A, Lauterburg BH. Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration. Eur J Clin Pharmacol 1989;36:127-131. 24. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-597. 25.- Tegner H, Torelmalm NG. Interaction between N-acetylcysteine and cigarette smoke extract. Eur J Respir Dis 1985; 66 Suppl. 139: 130-1 26.- Olivieri D, Marsico SA, Del Donno M. Improvement of mucociliary transport in smokers by mucolytics. Eur J Respir Dis 1985; 66 Suppl. 139: 142-5 27.- Rogers DF, Godfrey RW, Majumdar S, et al. Oral N-acetylcysteine speeds reversal of cigarette smoke-induced mucous cell hyperplasia in the rat. Exp Lung Res 1988; 14 (1): 19-35 28.- Rogers DF, Turner NC, Marriott C, et al. Oral N-acetylcysteine or Scarboxymethylcysteine inhibit cigarette smoke-induced hypersecretion of mucus in rat larynx and trachea in situ. Eur Respir J 1989; 2 (10): 955-60 29.- Lightowler JE, Lightowler NM. Comparative mucolytic studies on dithiothreitol, N-acetylcysteine and Lcysteine on human respiratory mucus in vitro and their effects on the rate of flow of mucus in the exposed trachea of the rat on topical application. Arch Int Pharmacodyn Ther 1971; 189 (1): 53-8 30.- Sheffner AL, Medler EM, Jacobs LW, et al. The in vitro reduction in viscosity of human tracheobronchial secretions by acetylcysteine. Am Rev Respir Dis 1964; 90: 721-9

31.- Morandini GC, Perduca , Finiguerra M, et al. Recent advances of knowledge on the mechanism of action of drugs modifying the bronchial secretions. Int J Clin Pharm Res 1986; 6 (5): 415-23 32.- Rochat T, Lacroix J-S, Jornot L. N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells. J Cell Physiol 2004; 201: 106-16 33.- Iravani J, Melville GN, Horstmann G. N-Acetylcysteine and mucociliary activity in mammalian airways. Arzneimittelforschung 1978; 28 (2): 250-4 34.- Kogi K, Saito T, Kase Y et al. Pharmacological effects of N-acetyl-Lcysteine on the respiratory tract. (1). Quantitative and qualitative changes in respiratory tract fluid and sputum [In Japanese]. Nippon Yakurigaku Zasshi 1981; 77 (6): 569-78 35.- Richardson PS. The physical and chemical properties of airway mucus and their relation to airway function. Eur J Respir Dis 1980; 61 Suppl. 111: 13-15 36.- Hirsch SR, Kory RC. An evaluation of the effect of nebulized Nacetylcysteine on sputum consistency. J Allergy 1967; 39 (5): 265-73 37.- Streightoff F, Redman CE., Delong DC. In vivo antiviral chemotherapy. II. Anti-influenza action of compounds affecting mucous secretions. Antimicrob Ag Chemother 1966; 6: 503-8 38.- Ungheri D, Pisani C, Sanson G, et al. Protective effect of N-acetylcysteine in a model of influenza infection in mice. Int J Immunopathol Pharmacol 2000; 13 (3): 123-8 39.- Stagnaro R, Pierri I, Piovano P, et al. Thiol containing antioxidant drugs and the human immune system. Bull Eur Physiopathol Respir 1987; 23: 303-7

40.- Victor VM, De La Fuente M. N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress. Free Radic Res 2002; 36 (1): 33-45 41.- De la Fuente M, Victor VM. Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress. Free Radic Res 2001; 35 (1): 73-84 42.- Ghezzi P, Ungheri D. Synergistic combination of N-acetylcysteine and ribavirin to protect from lethal influenza viral infection in a mouse model. Int J Immunopathol Pharmacol 2004; 17 (1): 99-102 43.- Venketaraman V, Dayaram YK, Amin AG, et al. Role of glutathione in macrophage control of mycobacteria. Infect Immun 2003; 71(4): 1864-71

You might also like