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creatine helps preserve Purkinje cells creatine helps sca type 1 and friedrich's ataxia Vascular endothelial growth

factor ameliorates the ataxic phenotype in a mouse m odel of spinocerebellar ataxia type 1. Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited neu rodegenerative disease caused by expansion of a glutamine repeat tract in ataxin-1 (ATXN1). Although the precise function o f ATXN1 remains elusive, it seems to be involved in transcriptional repression. We find that mutant ATXN1 represses tran scription of the neurotrophic and angiogenic factor vascular endothelial growth factor (VEGF). Genetic overexpression or phar macologic infusion of recombinant VEGF mitigates SCA1 pathogenesis, suggesting a new therapeutic strategy for this dise ase. Ducky Mouse Phenotype of Epilepsy and Ataxia Is Associated w/Decreased Calcium C hannel Current in Cerebellar Purkinje Cells Cerebellar Allografts Survive and Transiently Alleviate Ataxia in a Transgenic M odel of SCA type 1 treatable progressive ataxias: ataxia w/vit E deficiency, Wilson's disease = acc umulation of Copper -> can reverse symptoms by treatment w/Cu or Zn chelators, ataxia w/CoQ10 deficiency, cerebroten dinous xanthomatosis - can partially reverse neurological symptoms and improve cog fxn by treatment w/chenodeoxycholi c acid Dynamic task practice that challenges stability and explores stability limits an d aims to reduce upper-limb weight bearing seems an important intervention for people with cerebellar dysfunction to improv e gait and balance Strength and flexibility training may be indicated in conjunction with the above I have spinocerebellar ataxia SCA6. I used to get severe cramps and had stiffnes s and tremors when I got out of bed in the morning. I started taking 1500 mg calcium magnesium with 400iu vitamin D and all my cramps, stiffness and tremor went away. I had a calcium deficiency because my body cannot channel cal cium properly. This caused my ataxia because my cells in the cerebellum died because of lack of calcium. Conclusion: Older patients with periodic ataxia due to GLUT-1 deficiency profit from modified Atkins diet. Results seem to be similar to those seen in classical ketogenic diet BUT! can ketosis cause ataxia? causes ataxia and fatigue in pregnant deer ketogenic diet: dairy, meat, few veggies, fish -> nutritional deficiencies over time? (no fruit!) - Benefits may be higher if some form of re-feeding is employed (such as cyclical ketogenic dieting). ketogenic diet with HEALTHY fats. There has to be a way for it to still be healt hy. They wouldn't prescribe it for epileptics just to ease the epilepsy but make them unhealthy. Is carb restriction sufficient? Why 80% fat vs. 20% protein? fatigue problems? progesterone promotes brain and spinal cord healing

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