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Antioxidant, antioxidanti: Antioxidantii fantana tineretii

Terapia Anti-Aging cu antioxidanti
Fountain of Youth - Anti-Aging - Anti imbatranire
Fountain of Youth Anti-Aging

Antioxidant, antioxidanti: Antioxidantii fantana tineretii

Procesul de imbatranire cu cauzele endogene si exogene

1. Teoria radicalilor liberi in procesul de imbatrinire - Radicalii liberi considerati ca mediatori patologici. - Formarea de radicali liberi prin: Factorii exogeni ca poluarea aerului, razele-UV, radiatii ionizante, etc., factorii endogeni pot fi stres, exercitiu fizic extenuant, inflamatii, fumat, etc. - Tipuri de radicali liberi: Radicalii liberi ai oxigenului, Radicalii liberi ai azotului, Radicalul thiil,etc

Structura celulei este oxidata de actiunea agresiva a radicalilor liberi

Formarea de radicali liberi

Inalta concentratie de oxigen reactiv - radicalii liberi si cantitatea insuficienta in organism de antioxidanti, genera in organite (centrale energetice celulare) eficacitatea scazuta a repararii ADN-ului, ca rezultat: Disfunctia mitocondriala, care este o caracteristica a celulelor maligne. 2. Ginkgo Biloba extract din folium sicc. (Ginkgo extract) un inhibitor de stresul oxidativ care induce agregarea plachetara
Radicalii liberi produc stres oxidativ Distrugerile ADN-ului de radicalii liberi care produc stres oxidativ

- Mutatiile ADN-ului de radicalii liberi afecteaza energia celulara ATP Administrarea de antioxidanti ca factor anti cancer determina reversia fenotipului malign prin inhibarea celulelor de cancer - Anti cancer: EGCG Galatul de epigalocatechina
Degradarea ADN-ului prin acumularea de Reversia fenotipului malign prin inhibarea celulelor de 8-hidroxi-2-deoxiguanozina cancer

Neutralizarea de radicali liberi - Densitatea antioxidativa

Despre antioxidanti: Antioxidantii sint molecule care apara organismul de efectele oxigenului reactiv Radicalii liberi Radicalii liberi produc stres oxidativ, iar antioxidantii apara celula de radicalii liberi care sint molecule instabile, contin electroni neimperecheati, adica un electron ocupa un singur orbital. 3. Ginkgo Biloba un natural antioxidant neutralizeaza radicalii liberi si efect de protectie de dauna oxidativa a ADN 4. Ginkgo Biloba extract standardizat 24% (Egb 761) neutralizeaza radicalii liberi Disfunctia mitocondriala care este o caracteristica a celulelor maligne, datorat prin capacitatea scazuta antioxidativa.

Antioxidantii apara celula de efectele oxigenului reactiv

Antioxidantii neutralizeaza radicalii liberi Capacitate scazuta antioxidativa

Antiioxidanti se gasesc in orice celula, protejeaza organismul de distrugerile provocate la nivel celular de radicalii liberi.

4 - Antioxidantii pot neutraliza radicalii liberi limitind distrugerea provocata, daca suficienti antioxidanti sint involvati - Capacitate suficienta antioxidativa - Acid Alfa Lipoic prin proprietati si functie regenereaza alti antioxidanti ca: Vitamina C, Vitamina E, Glutation, Coenzima Q10 ofera protectie antioxidativa de efectele radicalilor liberi. Antioxidantii protejind celula de radicalii liberi - Capacitate suficienta

Sint o multime de antioxidanti in extracte de plante naturale, fitofarmaceutice, nutraceutice cu capacite de neutralizare a radicalilor liberi Antioxidanti cheie: Acid Alfa Lipoic, Coenzima Q10, Vitamine: Vitamina C, Vitamina E, Caretenoizi, (beta caroten,alfa caroten, licopen, luteina, zeaxantina) Compusi fenolici: Flavonoizi, polifenoli care confera protectie ridicata antoxidativa - Suficienti antioxidanti de recomandat: Acid Alfa Lipoic, Ceai Verde EGCG, Vitamina C, Glutation, Vitamin E, Carotenoizi, Coenzima Q10 sau enzime antioxidante ca superoxid dismutaza (SOD) care detoxifica radicalul superoxid, peroxidul de hidrogen (H 2O2) si Glutation peroxidaza (GPx) care detoxifica peroxizii celulari - Spirulina contine superoxid dismutaza (SOD) un antioxidant puternic 110000 Unitati/100g

Cel mai puternic antioxidant este

- Hidroxitirosol extr. din Ulei de Masline, cu valoarea ORAC: Capacitatea de absorbtie a radicalului liber a oxigenului de 27000 (mol TE/g), - Oleuropeina din Frunze de Maslin cu cu valoarea ORAC: 13000 (mol TE/g) - Quercitina cu valoarea ORAC de: 12000 (mol TE/g), - Extract din Samburi de Struguri, cu valoarea ORAC: 8000 (mol TE/g),

- Vitamina E este un important antioxidant solubil in grasime, reduce oxidarea lipoproteinelor cu densitate joasa LDL, previne initierea si progresia de ateroscleroza. - Vitamina C protejeaza organismul de efectele radicalilor liberi cu actiune de reparatie a ADN-ului - Cine fumeaza trebuie sa isi asigure aportul de Vitamina C, care apara organismul de efectele oxigenului reactiv-radicalii liberi, cauzat de fumat - Carotenoizi sint fito-nutrienti impiortanti solubili in grasime ca: Alfa caroten, Beta caroten, Licopene, Luteina, Zeaxantina, Astaxantina. - Carotenoizi joaca un rol important ca fotoprotectia solara, trebuie sa asiguram pielii noastre fotoprotectia necesara. - Compusi fenolici cu proprietai antiseptice, antibiotice, antifungice, antivirale. - Compusi fenolici pot fi solubil in apa sau grasime ca: Hidroxitirosol cel mai puternic antioxidant din Uleiul de Masline sau capsunii sint compusi fenolici. - Acid Alfa Lipoic este un puternic antioxidant de 40-60 ori ca Vitamina E Acid Alfa Lipoic cu actiunea de regenerare a altor antioxidanti ca: - Glutationul oxidat la glutation redus, Coenzima Q10, Vitamina C, Vitamina E, Glutationul disulfid, Cistina in Cisteina, Tioredoxina oxidata la Tioredoxina redusa - Coenzima Q10 ca antioxidant in mitocondria si celule cu protectie de peroxidarea lipidica, CoQ10 reduce oxidarea si leziunea ADN in limfocite. - Coenzima Q10 cu activitate in mitocondria: Activeaza producerea de Adenozintrifosfat (ATP) - Coenzima Q10 ca stabilizator in membrana celulara asigura permeabilitatea membranei celulare pentru ca substantele vitale sa poata intra in celula. - Scaderea concentratiei de Coenzima Q10, pe masura imbatranirii cu pina la 60% 5. Coenzima Q10 cu activitate in mitocondrii: Mitocondria uzina energetica de adenozintrifosfat (ATP) a materiei vii, activeaza producerea de adenozintrifosfat (ATP)
Coenzima Q10 cu activitate in mitocondrii: Mitocondria uzina energetica de adenozintrifosfat (ATP) a materiei vii, activeaza producerea de adenozintrifosfat (ATP)

6. Coenzima Q10 ca antioxidant in mitocondrii si celule cu protectia de peroxidare lipidica, CoQ10 reduce oxidarea si leziunea ADN in limfocite 7. Coenzima Q10 cu potential de tratament in disfunctie mitocondriala si dauna oxidativa de radicalii liberi in boala Alzheimer si Parkinson
Creier sanatos Creier cu Alzheimer

- Coenzima Q10 este o substanta vitala, un antioxidant puternic, neutralizeaza radicalii liberi, ajuta la preintampinarea efectelor toxice exercitate de multe medicamente sintetice Ceai Verde (Camellia Sinensis) - foto Ceai Verde (Camellia Sinensis) Regnul: Plantae - Planta Increngatura: Traheofitelor - Planta vasculara Subincrengatura: Spermatofita - Planta cu saminta Clasa: Angiosperme - Dicotiledonate - Embrion

Subclasa: Dillenidae Ordinea: Theales Familia: Theaceae Genul: Camellia L. Specia: Camellia Sinensis L. - Ceai Verde 8. Ceai Verde Supreme cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are activitate antioxidanta de neutralizare a radicalilor liberi: radicalul superoxid(O2-), radicalul peroxil(RO2-), radicalul peroxinitrit(OONO -), peroxid de hidrogen(H2O2) previne oxidarea LDL - biologia si medicina radicalilor liberi 9. Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are activitate antioxidanta de neutralizare a radicalilor liberi, inhiba peroxidarea lipidelor, degradarea ADN-ului, in 8-hidroxi-2-deoxiguanozina (8-OHdG), este un biomarker a stresului oxidativ, acumulata in ADN cauzeaza disfunctia mitocondriala si criza energetica 10. Ceai Verde Supreme un produs natural fotoprotector protejaza pielea de radiatiile UV, cu activitate antioxdanta si imunomodulatoare
EGCG un produs natural fotoprotector protejaza pielea

11. Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) antioxidant puternic un inhibitor enzimei de telomeraza
EGCG cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C

12. Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) are actiune antioxidanta reduce placa aterosclerotica, meta analiza 13. Ceai Verde cu: Polifenoli, catehine si extr. Epigalocatehingalat (EGCG) in efectul de productie de citokine proinflamatorii si anti inflamator Nutraceutice - Nutraceuticele Anti Aging Systeme sint din plante naturale: Farmacia Naturala, care au efecte farmaceutice numite si fitofarmaceutice.
Quercitina cu: Flavonoizi, Polifenoli 95% din: Farmacia Naturala

Quercetin cu activitate: antioxidanta, anti-inflammatorie, antivrala, immunomodulatoare, anti cancer, gastroprotectiva, anti alergica si in prevenirea de complicatii ale diabetului. 14. Quercetina un bioflavonoid cu proprietati antioxidante
Quercetina cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C

15. Quercetina un antioxidant puternic inhiba prooxidante ca xantin oxidaza si activitatea xantin dehidrogenaza 16. Quercetina supliment nutritional cu actiune antioxidanta la estrogeni si fitoestrogeni 17. Quercetina si Rutina cu actiune de chelatizare si antioxidanta in peroxidarea lipidica 18. Quercetina si metabolitii epicatechin ca EGCG participa ca antioxidanti in plasma sanguina 19. Quercetina si Vitamina C cu efect protector de stresul oxidativ indus in neuro degenerare
Extract din Samburi de Struguri (Vitis Vinifera) OPC extr. stand. 95%

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20. Extract din Samburi de Struguri - OPC in practica, flavonoide si aplicatia lor exercita actiune anti inflamatoare, anti artritic, anti alergic, previne inbatrinirea dermei, activitate antioxidanta de neutralizare a radicalilor liberi si inhibare razelor UV
OPC 95% cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C

21. Acidul elagic reduce stresul oxidativ 22. Acid Elagic cu actiune de antioxidant si la procesul de peroxidare lipidica 23. Acid Elagic cu efect protectiv la stresul oxidativ produs de celulele PC12. 24. Capsaicina cu activitate antioxidanta
Capsaicina cu activitate antioxidanta

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25. N-Acetilcisteina efect protectiv la plamin de peroxidarea lipidica, previne sindromul de detresa respiratorie indus de dauna oxidativa a radicalilor liberi
N-Acetilcisteina efect protector la plamin

26. N-Acetilcisteina ca antioxidant in tratamentul de citostatica la cancer

N-Acetilcisteina cu capacitate de absorbtie a radicalului liber a oxigenului - ORAC, comparatia valorilor fata de Vitamina C

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27. N-Acetilcisteina cu actiune antioxidanta in reactia cu radicalii liberi 28. Acid Alfa Lipoic, este un puternic antioxidant de 40-60 ori ca Vitamina E, cu actiune de reciclare a altor antioxidanti, cu activitate antioxidanta de neutralizare a radicalilor liberi. - Acid Alfa Lipoic (AAL) este un di-sulfid, numit si acid tioctic sau lipoate poate regenera antioxidanti ca: Glutationul oxidat la glutation redus, Coenzima Q10, Vitamina C, Vitamina E, Glutationul disulfid, Cistina in Cisteina, Tioredoxina oxidata la Tioredoxina redusa importanta care leaga factori de transcriptie de ADN. 29. Antioxidanti reduc nivelul de F-2 isoprostan, un biomarker a stresului oxidativ, neutralizeaza radicali liberi* hidroxil (OH) , radicali oxidului nitric (NO), peroxinitrit (OONO -), peroxidul de hidrogen (H2O2), oxigenul singlet (1-O2), etc.
Actiunea acidului alfa lipoic regenereaza alti antioxidanti ca: Coenzima Q10,

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Vitamina C, Glutation, Vitamina E

30. Acid Alfa Lipoic cu activitate antioxidanta la peroxidarea lipidica 31. Acid Alfa Lipoic cu efect biologic si implicatii clinice
despre Antioxidant, antioxidanti: Antioxidantii fanatana tineretii despre Antioxidant Antioxidanti

Antioxidant Formula+Q10 Isoflavone din Pueraria cu actiune: Antioxidanta Resveratrol un polifenol din grupa fito-alexinelor. - Resveratrol combate bolile pe: Calea naturala - Medicina naturala - Resveratrol face parte din clasa de: Polifenoli, subclasa Stilbene (trans3,5,4'-trihydroxystilbene) - Resveratrol este sintetizat din p-cumaroil CoA si malonil CoA. - Recunoscut ca antioxidant care raspunde la: Stres, infectii de fungi, si radiatii ultraviolete (UV) 32. Resveratrol un antioxidant natural cu cu eficienta de actiune in oxidarea in lipozom
Resveratrol un antioxidant natural cu cu eficienta de actiune in oxidarea in lipozom

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Bibliografie-Referinte: Antioxidant, antioxidanti

Informatii din bibliografia electronica la tema: Nutritie si sanatate

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- Beal MF. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA. fbeal@med.cornell.edu Ann N Y Acad Sci. 2003 Jun;991:120-31. 8. Mazur WM, Wahala K, Rasku S, Salakka A, Hase T, Adlercreutz H. Lignan and isoflavonoid concentrations in tea. Department of Clinical Chemistry, University of Helsinki, Finland. Br J Nutr. 1998 Jan;79(1):37-45. - Imai K, Nakachi K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. British Medical Journal, 1995; 310: 693-696. 9. Shigenaga MK, Ames BN. Assays for 8-hydroxy-2'-deoxyguanosine, a biomarker of in vivo oxidative DNA damage. Free Radic. Biol. Med., 1991; 10: 211-6. - H. Kasai, P.F. Crain, Y. Kuchino, S. Nishimura, A.Ootsuyama and H. Tanooka. Carcinogenesis 7:1849-51, 1986. 10. Katiyar SK. Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Curr Drug Targets Immune Endocr Metabol Disord. 2003 Sep;3(3):234-42. - H. Ochi. Rouka seigyo syokuhin no kaihatsu (Development of foods for control of aging) Korin Press, p. 294, 1995. 11. Chyu KY, Babbidge SM, Zhao X, Dandillaya R, Rietveld AG, Yano J, Dimayuga P, Cercek B, Shah PK. Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. Atherosclerosis Research Center, Division of Cardiology, and Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine at the University of California, Los Angeles, CA 90048, USA.Circulation. 2004 May 25;109(20):2448-53. Epub 2004 May 10 - Peters U, Poole C, Arab L. Does tea affect cardiovascular disease A meta-analysis. Am J Epidemiol. 2001;154(6):495-503. 12. Crouvezier, S., Powell, B., Keir, D., and Yaqoob, P. (2001) The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. Cytokine 13, 280-286. 13. Khalfoun B, et al., Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6. Adv Exp Med Biol 1997;400B:58997 - Terano T, et al. Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis. Biochem Pharmacol 1986 Mar 1;35(5):779-85 -R aederstorff D, et al. Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. Int Arch Allergy Immunol 1996 Nov;111(3):284-90 - Mayatepek E, et al. Influence of dietary (n-3)-polyunsaturated fatty acids on leukotriene B4 and prostaglandin E2 synthesis and course of experimental tuberculosis in guinea pigs. Infection 1994 Mar-Apr;22(2):106-12 - Khalfoun B, et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. Transplantation 1996 Dec 15;62(11):1649-57 14. Morand C, Crespy V, Manach C, Besson C, Demigne C, Remesy C. Plasma metabolites of quercetin and their antioxidant properties. Laboratoire des Maladies Metaboliques et des Micronutriments, Institut National de la Recherche Agronomique de Clermont-Ferrand/Theix, 63122 Saint-Genes-Champanelle, France. - Hollman PC, van Trijp JM, Mengelers MJ, de Vries JH, Katan MB. Bioavailability of the dietary antioxidant flavonol quercetin in man. DLO State Institute for Quality

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Control of Agricultural Products (RIKLIT-DLO), Wageningen, The Netherlands. p.c.h.hollman@rikilt.dlo.nl Cancer Lett. 1997 Mar 19;114(1-2):139-40. 15. Bindoli A, Valente M, Cavallini L. Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun. 1985 Sep;17(9):831-9. 16. Wiseman H, O'Reilly J. Influence of the dietary flavonoid quercetin on the cardioprotective antioxidant action of oestrogen and phytoestrogens. Biochem Soc Trans. 1997 Feb;25(1):108S. 17. Afanas'ev IB, Dorozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. All-Union Vitamin Research Institute, Moscow, U.S.S.R. Biochem Pharmacol. 1989 Jun 1;38(11):1763-9. 18. Terao J. Dietary flavonoids as antioxidants in vivo: conjugated metabolites of (-)epicatechin and quercetin participate in antioxidative defense in blood plasma. J Med Invest. 1999 Aug;46(3-4):159-68. 19. Heo HJ, Lee CY. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. Department of Food Science and Technology, Cornell University, Geneva, NY 14456, USA. J Agric Food Chem. 2004 Dec 15;52(25):7514-7. 20. Schwitters B, et al. OPC in practice. Bioflavanols and their applications. Rome, Italy: Alfa Omega, 1993. - Masquelier J. Procyanidolic oligomers. J Parums Cosm Arom 95: 8997, 1990. 21. Yu YM, Chang WC, Wu CH, Chiang SY. Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid. Department of Nutrition, China Medical University, Taichung, Taiwan. yuyamei@hotmail.com J Nutr Biochem. 2005 Nov;16(11):675-81. Epub 2005 Aug 2. 22. Majid S, Khanduja KL, Gandhi RK, Kapur S, Sharma RR. Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice. Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Biochem Pharmacol. 1991 Sep 12;42(7):1441-5. - Osawa, T., Ide, A., Su, J. D., and Namiki, M., Inhibition of lipid peroxidation by ellagic acid. J. Agric. Food Chem., 35, 808812 - Ashoori F, Suzuki S, Zhou JH, Isshiki N, Miyachi Y. Involvement of lipid peroxidation in necrosis of skin flaps and its suppression by ellagic acid. Department of Plastic and Reconstructive Surgery, Kyoto University Hospital, Japan. Plast Reconstr Surg. 1994 Dec;94(7):1027-37. 23. Pavlica S, Gebhardt R. Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells. Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstr. 16, Leipzig, 04103, Germany. Free Radic Res. 2005 Dec;39(12):1377-90. 24. Ochi T, Takaishi Y, Kogure K, Yamauti I.Antioxidant activity of a new capsaicin derivative from Capsicum annuum. J Nat Prod. 2003 Aug;66(8):1094-6. 25. Ortolani O, Conti A, De Gaudio AR, et al. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock. 2000; 13:14-18. - Sala R, Moriggi E, Corvasce G, Morelli D. Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant damage. Eur Respir J. 1993; 6:440-446. 26. Bongers V, de Jong J, Steen I, et al. Antioxidant-related parameters in patients treated for cancer chemoprevention with N-acetylcysteine. Europ J Cancer. 1995;

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31A:921-923. - Oikawa S, Yamada K, Yamashita N, et al. N-acetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA. Carcinogenesis. 1999; 20:1485-1490. 27. Aruoma OI, Halliwell B, Hoey BM, Butler B: The antioxidant action of Nacetylcysteine; its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. J Free Radic Biol Med 1989, 6:593-597. 28. Packer L, Witt EH, Tritschler, HJ. Alpha-lipoic as a biological antioxidant. Free Rad Biol Med. 1995; 19:227-250. - Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic and concentration, recycling and biosynthesis in rat hepatocytes-reversal with (R)alpha-lipoic acid supplementation. FASEB J. 1998; 12:1183-1189. 29. Dietrich, M., G. Block, M. Hudes, J. D. Morrow, E. P. Norkus, M. G. Traber, C. E. Cross and L. Packer (2002). "Antioxidant supplementation decreases lipid peroxidation biomarker F(2)- isoprostanes in plasma of smokers." Cancer Epidemiol Biomarkers Prev 11(1): 7-13. - Calabrese V, Ravagna A, Colombrita C, Scapagnini G, Guagliano E, Calvani M, Butterfield DA, Giuffrida Stella AM. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2. Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. J Neurosci Res. 2005 Jan 7. - Marangon K, Devaraj S, Tirosh O, et al. Comparison of the effect of alpha-lipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Free Rad Biol Med. 1999; 27:1114-1121. - Kagan V, Khan S, Swanson C, et al. Antioxidant action of thioctic acid and dihydrolipoic acid. Free Radic Biol Med 1990;9S:15. - Martin E, Rosenthal RE, Fiskum G. Pyruvate dehydrogenase complex: Metabolic link to ischemic brain injury and target of oxidative stress. Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland. J Neurosci Res. 2005 Jan 1;79(1-2):240-7. 31. Scholich H, Murphy ME, Sies H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. Biochem Biophys Acta 1989;1001:25661. - Kagan V, Serbinova E, Packer L. Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun 1990;169:8517. - Busse E, Zimmer G, Schorpohl B, et al. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arzneimittelforschung1992;42:82931. 30. Nichols TW Jr. Alpha-lipoic acid: biological effects and clinical implications. Altern Med Rev 1997;2:17783 32. Stojanovic S, Sprinz H, Brede O. Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation. Research Unit Time-Resolved Spectroscopy, University of Leipzig, Permoserstrasse 15, D-04318 Leipzig, Germany. Arch Biochem Biophys. 2001 Jul 1;391(1):79-89. Literatura - Chemistry and Applications of Green Tea by Takehiko Yamamoto, Lekh Raj Juneja, Djoing-Chi Chu, Mujo Kim, L.R. Juneja, D.C. Chu, M. Kim

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