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PY TEST SERIES-VII
Duration: 2.00 hours Max Marks: 100

1. 2. 3. 4. 5. 6. 7.

This question paper contains 40 objective type questions. Q. 1 to 40 carry 2 marks each. Q. 41and 50 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

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PY TEST SERIES-VII
1. 2. 3. 4. Which of the following antipsychotic drugs belongs to propyl aminoalkyl phenothiazine category (a) Triflupromazine (b) Perphenazine (c) Trifluperazine (d) Thioridazine Select the preffered drug to treat acute schizophrenia (a) Haloperidol (b) Clozapine (c) Penfluridol (d) Pimozide Iodine value is determined by (a) Wijs method (b) Hanus method (c) Pyridine bromide method (d) All The following statement are correct EXCEPT (a) The glycone moiety of glycoside facilitates (b) The glycone moiety of glycoside absorption of glycoside facilitates transportation of glycoside (c) Aglycone moiety of glycoside is soluble in (d) None nonpolar solvent Difference in pharmacological response produced by Resperidone from Clozapine is (a) 5HT2 blocking activity (b) & H1 - receptor blocking activity (c) Reduce prolactine level (d) Less extrapyramidal side effect The aglycones of flavonol glycoside are derived from (a) Acetate metabolism (b) Shikimic acid pathway (c) Polysaccharides nucleic acid metabolism (d) Both a and b Metabolism of obeys zero order kinetics (a) Primidone (b) Alcohol (c) Lithium salts (d) Charas Following drugs belongs to tetrahydrocannabinol except (a) Charas (b) Ganja (c) LSD (d) Bhang As per IP 1996, the disintegration test for pessaries and suppositories is carried out at (a) 36.5o 0.5o (b) 37.5o 0.5o (c) 37o 0.5o (d) 36 0.5o A base which is immisicible and not removable by water is a (a) Hydrocarbon base (b) Absorption (c) Water washable base (d) Water soluble base Mixing of semisolid is done by (a) Sigma blade mixer (b) Planetary mixer (c) Triple roller mixer (d) All First line drug for depression is (a) MAO-A inhibitors (b) SSRIs (c) TCAs (d) b & c both Local anaesthetic agent exhibit mixed anaesthetic and anti arrhythmic activity (a) Tetracaine (b) Bupivacaine (c) Cibucaine (d) Lignocaine Which of the following antidepressant block dopamine receptor, inhibit NA uptake and exhibit antidepressant & neuroleptic property (a) Amoxapine (b) Desipramine 2

5. 6. 7. 8. 9. 10. 11. 12. 13. 14.

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16. 17.

18.

19 20. 21. 22.

23.

24. 25.

26.

(c) Amitryptyline (d) Clomipramine A manic patient has been brought to the hospital with nonstop talking, singing, uncontrolled behaviour and apparent loss of contact with reality. Which of the following is the most appropriate drug for rapid control of his symptoms (a) Lithium carbonate (b) Phenobarbitone (c) Haloperidol (d) Valproic acid Which of the following is an atypical neuroleptic drug (a) Loxapine (b) Olanzapine (c) Pimozide (d) Flupenthixol Effect of alcohol on sleep has the following feature (a) It is a dependable hypnotic but is not prescribed because of abuse potential (b) It can disorganise sleep architecture (c) It consistently improves the qulity of sleep (d) It suppresses sleep apnea All of the following statement is correct about Phenothiazine except (a) Aliphatic side chain responsible for extrapyramidal effect (b) Antipsychotic activity due to substitution at 2nd position (c) Antipsychotic activity reduced due to presence of electron withdrawing gp at 2nd position (d) Piperidyl side chain reduce extrapyramidal effect Select the drug used in maintenance therapy of alcohol abstinance (a) Ondansetron (b) Naltexone (c) Acamprostate (d) All Cardiac arrhythmias and interference with male sexual function are adverse effect of (a) Haloperidol (b) Thioridazine (c) Clozapine (d) Buspirone The acid value ideal suppository is a) 200-245 (b) Below 0.2 (c) Less than 7 (d) 4 Which statement is/are correct about suppositories bases a) The absorption rate is faster from fatty bases having a lower melting range b) The absorption rate is faster with increase the hydroxyle value c) The absorption rate is faster with increase in the molecular mass of the PEG d) All The following statement is correct about LAs except (a) Ester linked LAs degraded in plasma (b) Amide linked LAs degraded in liver (c) Amide linked LAs generate potent (d) Ester linked LAs exhibit cross hypersensitive reaction resistance Tricylic antidepressant having secondary group is (a) Imipramine (b) Clomipramine (c) Desipramine (d) Doxepin Which of the following drug is an ingredient of ayurvedic prepation sudarshan powder which is used in chronic fever. (a) Quassia (b) Gentian (c) Picrorrhiza (d) Chirata T. S. of root shows triach primary xylem and thin walled cork cell. Cortex has parenchyma with oil globules and calcium oxalate. The medullary rays also present. These character shows that the drug is (a) Quassia (b) Gentian 3

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28. 29.

30. 31. 32. 33. 34.

35

36.

37.

38. 39.

(c) Picrorrhiza (d) Chirata Which of the following statement is correct about Imbibition (a) It is a process in which taking up of certain amount of liquid without a measearable increase in volume (b) It is similar to swelling (c) It is opposite to syneresis (d) None of the above Antianxiety drug Buspirone differ from BZD because buspirone has (a) No muscle relaxant or anticonvulsnt activity (b) No toletance or physical dependnce (c) No interaction with BZD receptor (d) All Which of the following statement is incorrect about Clozapine (a) Exhibit 5HT2 & - receptor blocking activity (b) Potent D2 blocking activity result in few extra pyramidal symptoms (c) Reserve drug for resistant schizophrenia (d) Agranulocytosis is major side effect The biological source of arbutin is (a) Unripe fruits of vanilla planifolia (b) Dried fruits of solanum khasianum (c) Dried leaves of aritostaphylos uvaursi (d) Dried ripe fruits of ammi visnaga Vanishing cream bases are come in the category of (a) Water removal bases (b) Emulsified bases (c) Emulsifiable bases (d) Both a and b Scopoletin is the derivative of benzo--pyrone and the additional groupings is (a) OH at 6, OH at 7 (b) OCH3 at 7, OH at 6 (c) OCH3 at 6, OH at 7 (b) O-glucose at 8 To Manic patient, which of the following drug shouldnt be prescribed (a) Verapamil (b) Lisinopril (c) Losartan (d) Acetazolamide Cheese reaction in a MAO inhibited patient manifests (a) Precipitous fall on blood pressure and shock (b) Acute manic episode (c) Convulsions (d) Hypertensive crisis Ester linked LAs , which is weakly absorbed and produce long lasting anaesthesia without systemic toxicity is (a) Procaine (b) Cocaine (c) Lignocaine (d) Benzocine A drug, which is used in treatment of post phlebitis syndrome, raynauds disease and the chemical constituents of it is specified platelet activating factor antagonists. The drug is (a) Buck wheat (b) Khella (c) Maiden hair tree (d) Bavchi D value is defined as (a) The time (in min.) required to reduce the (b) The time (in hrs) required to reduce microbial population by 90% the microbial population by 90% (c) The time (in min.) required to reduce the (d) The time (in hrs) required to reduce microbial population by 99% the microbial population by 99% The mechanism of hepatoprotective activity of silymerin is/are (a) Trapping superoxide anions (b) Stimulation of RNA sunthesis (c) Blocking the receptor sites (d) All Acute muscular dystoniasis developed as side effect during antipsychotic therapy treated by (a) Amentadine (b) Diazepam (c) Promethazine (d) Trihexyphenidyl 4

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41.

42.

43. 44.

Normally the rectal temperature is (a) 25oC (b) 30oC (c) 36oC (d) 40oC LINKED QUESTION Cocoa butter (suppository base) is thout to be capable of existing in four crystalline states. When the cool cocoa butter (20oc) is poured into a container, which is cooled at deep freeze temperature. The cocoa butter so formed is (a) form (b) form (c) form (d) form The melting point of above cocoa butter is (a) 18oC (b) 34oC o (c) 24 C (d) 30oC DATA FOR 43-44 A small quantity of chemical constituent is dissolved in alcohol to which 3 times propylene glycol, 5 times acetic acid and 40 times water is added. A blue fluorescence is observed under ultra violet light. The chemical constituent is (a) Xanthotocin (b) Gentiopicrin (c) Picrasmin (d) Soralen The category of glycosidal plant in which above chemical constituents is present is (a) Bitter glycoside (b) Steroidal glycoside (c) Coumarin and furanocoumarin glycoside (d) Phenol glycoside

DATA FOR 45-46

45. 46. There are many types pf antidepressants drugs and many of them are long acting while some are short acting An example of short acting antidepressants drug is (a) Fluxetine (b) Valproate (c) Etorphine (d) Moclobemide the drugs selected above acts by (a) Inhibiting the MOA-A (b) Inhibiting the 5HT (c) Inhibiting the MOA-B (d) Inhibiting the NA LINKED QUESTION 47-48 Which of the following antipsychotic drug is used as a reserve drug in resistant schizophrenia (a) Olanzapine (b) Clonazepine (c) Flupenthixol (d) Trifluperazine The action of above drug is (a) Potent dopamine D2 receptor blocking action (b) weak dopamine D2 receptor blocking action (c) Potent dopamine D2 and 5-HT2 receptor blocking (d) Potent dopamine D2 and 1 action receptor blocking action DATA FOR 49-50 Many non ionic surface active material are used for formulating both water soluble and oil soluble drugs. The water dispersible bases have the advantages of handling at elevated temp Surfactant most commonly used in suppooitories bases are all EXCEPT (a) Tween (b) Poly ethylene glycol (c) Myrj (d) Span Aerosol OT is used with water dispersible bases claimed to have following action (a) Rapid disintegration of suppository (b) Rapid dissolution of suppository (c) High lipophilicity (d) Its melting points lies between 36-38oC 5

47. 48.

49. 50.

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