STREPTOCCOCAL INFECTION

ANTIBODY FORMATION

ANTIGEN-ANTIBODY COMPLEX DEPOSIT IN GLOMERULUS

ACUTE INFLAMMATION AND DAMAGE

PERMEABILITY OF CAPILLARY GLOMERULUS SWELLING CELL PROLIFERATION

NON MODIFIABLE RISK FACTOR CONGESTION MODIFIABLE RISK FACTORS

• Age ACUTE GLOMERULONEPHRITIS LEADING TO CHORNIC GLOMERULONEPHRITIS • Diet

• Heredity • Nephrotoxins
• Gender REPEATED INFLAMMATION • Sedentary
lifestyle
STAGE 1 GFR (>90 mL/min/1.73 m2).ISCHEMIA, NEPHRON LOSS, SHRINKAGE OF KIDNEY

DEC. RENAL BLOOD FLOW

DEC. RENAL RESERVE

DAMAGE TO NEPHRONS

STAGE 2 GFR (60-89 mL/min/1.73 m2). 50% DAMAGE

STAGE 3 GFR (30-59 mL/min/1.73 m2). >75% DAMAGE

RENAL INSUFFICIENCY

REMAINING NEPHRONS UNDERGO CHANGES

REMAINING NEPHRONS FILTER MORE SOLUTES

STAGE 4 GFR (15-29mL/min/1.73 m2). HYPERTROPHY OF REMAINING NEPHRONS

FURTHER LOSS OF NEPHRON FUNCTIONS

LOSS OF NON EXCRETORY RENAL FUNCTION STAGE 5 ESRD LOSS OF EXCRETORY RENAL FUNCTION

DISTURBANCE in REPRODUCTION CALCIUM ABSORPTION HYPERPHOSPHATEMIA PHOSPHATE EXCRETION

IMMUNE DISTURBANCES HYPOCALCEMIA HYPERKALEMIA POTASSIUM EXCRETION

LIPID PRODUCTION HYPERPARATHYROIDISM METABOLIC ACIDOSIS HYDYOGEN EXCRETION

IMPAIRED INSULIN ACTION EDEMA WATER RETENTION SODIUM REABSORTION

HEART FAILURE IN TUBULE
ACTIVATION OF VIT D HYPERTENSION

FAILURE TO PRODUCE
ERYTHROPOIETIN EXCRETION OF NITROGENOUS WASTE

RBC PRODUCTION
BUN URIC ACID PERIPHERAL CNS CHANGES BLEEDING
NERVE TENDENCIES
HEMOGLOBIN CHANGES
CREATININE
PRURITUS ALTERED
ANEMIA PERICARDITIS TASTE

PALLOR PROTEINURIA
FATIGUE