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Mechanical Digestion:
• Chewing by teeth and churning by stomach
• Increases surface are of food
Chemical Digestion:
• Hydrolysis using water to break chemical bonds
• Uses enzymes specific to particular substrates
• Enzyme may be released in its active form, inactive form, or be attached
to membranes
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A2 Biology Module 2805: Mammalian Physiology and Behaviour
(i) state the site of production and action, and explain the functions of:
pepsin, trypsin, chymotrypsin, exopeptidases, amylases, maltase, lipase
and bile salts.
(e) describe the structure of the stomach and its functions in digestion
and absorption.
Cardiac Sphincter: Allows food to enter the stomach from the oesophagus
Pyloric Sphincter: Contracts to keep food in stomach for a few hours, then
relaxes and lets the partly digested chyme to pass into the duodenum
Layers of Stomach:
A Mucosa: With gastric pits
B Sub-mucosa: Connective tissue E
F
C Muscularis Externa: Smooth F
muscle (circular and longitudinal)
D Serosa: Connective tissue
Function of Stomach:
• Gastrin secreted by gastric glands
(pits) stimulates secretion of
gastric juice (pepsinogen/HCl)
• E: Oxynic Cell: Secretes HCl
(pH1)
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A2 Biology Module 2805: Mammalian Physiology and Behaviour
(h) describe the gross structure and histology of the pancreas and
explain its functions as an exocrine gland.
Pancreatic juice:
• Trypsin: Protease (endopeptidase)
hydrolyzes protein in middle of chain to
separate polypeptides
• Chymotrypsin: Protease (endopeptidase)
hydrolyzes protein in middle of chain to separate polypeptides
• Carboxypeptidase: Protease (exopeptidase) Hydrolyzes end peptide bond
to release terminal amino acid
• Lipase: lipds → glycerol + fatty acids
• Amylase: Starch → maltose
• HCO3- (hydrogen carbonate) ions: Neutralizes chyme (food and acids)
from stomach. Makes pH suitable for digestive enzymes
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A2 Biology Module 2805: Mammalian Physiology and Behaviour
(f) describe the structure of the ileum and its functions in digestion and
absorption.
D
Absorbtion via epithelial lining of ileum:
• Villi present (villus diagram on left, 1mm)
• Columnar epithelium (A) with microvilli (B)
(brush border) to give large surface area
for absorption
• Glucose absorbed by sodium cotransport:
Many mitochondria produce ATP for
active transport of Na+ out of bottom of cell into
tissue fluid. This creates a concentration gradient
for Na+. Na+ and glucose in lumen allowed to
diffuse in together (facilitated diffusion) through
protein channel for polar molecules
• Amino acids also absorbed via Na+ cotransport with different proteins for
each amino acid
• Facilitated diffusion of glucose and amino acids at the base end
of the cell near the capillary (D) for transport to blood
• Fatty acids and glycerol being non-polar, can diffuse through the
(phospholipid) membrane and are converted to triglycerides on
the smooth endoplasmic reticulum then surrounded by protein in
golgi to form chylomicrons. They then enter the lacteal (C) then
lymph system
The colon (part of the large intestine) absorbs water and ions:
• Folded large surface area for absorption
• Large numbers of goblet cells to secrete mucus
• Water absorbed by osmosis
• Ions absorbed by active transport
(k) outline the role of the nervous system and hormones in the control of
digestion.
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A2 Biology Module 2805: Mammalian Physiology and Behaviour
Secretin hormone:
• Release of secretin by epithelial cells of the duodenum stimulated by
acidic food arriving in the duodenum
• Stimulates release of juice containing HCO3- ions from the pancreas
• Also acts on the liver to stimulate the synthesis of bile
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A2 Biology Module 2805: Mammalian Physiology and Behaviour