Mayaud, L., Lai, P. S., Clifford, G. D., Tarassenko, L., Celi, L. A., & Annane, D. (2013).

Dynamic Data During Hypotensive Episode Improves Mortality Predictions Among Patients With Sepsis and Hypotension. Critical care medicine, 41(4), 954-962.
Page Number Pg.1 - Abstract Notes The given paper uses a genetic algorithm to extract the most important 30 variables from 189 extracted variables to develop a mortality prediction model. Data collection was carried out before, during and after hypotensive episodes, for patients who had sepsis and hypotension. Comments Most recent 2013 study. Can be a very good stepping stone for carrying out pattern mining research towards mortality prediction.

Introduction (Pg 1 - 2)

Demerits of present scoring models Scoring and mortality probability models have been largely used to superficially inform prognosis and allocate resources. Group level predictions are possible but are lacking at individual levels. Clinicians identification of worst values is biased can be a cause for low prediction performance. Future emphasis on early goaldirected therapy from septic shock. Development of early warning systems. Nothing has been done to look at variability patterns in an individuals physiological signals at the onset of hypotension. Details of MIMIC-II database and data collection methods. Extracted data split into training and test sets. Genetic algorithm used to obtain most important variables. Model built using logistic regression and prediction performance obtained on test set. Compared using older severity shock models.

Look into the development of hypotension in sepsis. Use dimensionality reduction algorithms to select variables from MIMIC Potential comparison against this paper and severity scoring models Good references Excellent outline of deficiencies in the current system

Materials and Methods (Pg 2 - 4)

Important for data extraction Procedure has been properly explained

Results (4 - 6)

AUC curve used to demonstrate performance. P-values have been reported.

AUC curve is the standard performance measure and gives a good basis for comparison Looking for association relationships between predictors First clinical study that is using this approach Very logical and unbiased

Discussion (6-8)

Promising: Predictive modelling in sepsis using dynamic information in conjunction with GA (heuristic search). Significant predictors not known before Personalized treatment: Monitor blood pressure rise in response to certain volume of cryustalloids

Shameek Ghosh commenced his doctoral research in AAI on 19th July, 2013 under the supervision of Associate Professor Jinyan Li. He received his Bachelors in Engineering, from the Visvesvaraya Technological University (VTU) in India, followed by a two year stint as a software engineer in Wipro Technologies, Bangalore and then a Masters at the Defence Institute of Advanced Technology in Pune, India. Before coming to AAI, he had been working as a junior research fellow at the Centre for Development of Advanced Computing (C-DAC) in Pune, India. His current research interests are related to big data mining for healthcare analytics research.