Name of Drugs Generic Name: Acetylcystein e Brand Name: Fluimucil Dosage: 200mg Route: Per Orem Frequency: TID

Classification and Mechanism of Action Mucolytic Agent Exerts mucolytic action through its free sulfhydryl group which opensup the disulfide bonds in the mucoproteins thus lowering mucous viscosity. The exactmechanism of action in acetaminophen toxicity is unknown. It is thought to act by providingsubstrat e for conjugation with the toxic metabolite

Indications Treatment of respiratory affections characterized by thick and viscous hypersecretions: acute bronchitis, chronic bronchitis and its exacerbations; pulmonary emphysema, mucoviscidosis and bronchieactasis

Side Effects Hypersensitivity reactions have been reported in patients receivingacetylcyst eine, including bronchospasm, angioedema, rashes and pruritus, may occur. Other adverse effects reported include nausea and vomiting, fever, syncope, sweating, arthralgia, blurred vision.

Contraindications Known hypersensitivity to acetylcesteine. As Acetylcysteine (Fluimucil) granules and tablets contain aspartame, it is contraindicated in patients suffering from phenylketonuria.

Nursing Responsibilities Add 1 glass of H2O Monitor effectiveness of therapy and advent of adverse/allergic effects. Instruct patient in appropriate use and adverse effects to report

Monitoring Parameters Use with caution in patients > 60 years of age. Use with caution in patients with High blood pressure, ischemic heart disease, diabetes, increased intraocular press ure, GI or GU obstruction, asthma, thyroid disease, or prostatic hypertrophy. Notrecommended for use in children

Name of Drugs Generic Name: Levofloxacin Brand Name: Floxel Dosage: 500mg Route: Parenteral Frequency: OD

Classification and Mechanism of Action Fluoroquinolones It inhibits DNA topoisomerase, more commonly referred to as the DNA gyrase. DNA gyrase is necessary for bacterial DNA replication and some aspects of transcription, repair, recombination and transposition. Inhibition of DNA gyrase in susceptible microorganisms results in the inhibition of ATP-

Indications Treatment of adults 18 yr w/ mild, moderate & severe infections caused by susceptible strains of microorganisms in the following conditions: Communityacquired pneumonia, complicated & uncomplicated UTI, nosocomial pneumonia

Side Effects Diarrhea, abdominal discomfort, nausea, anorexia, abdominal pain, vomiting, stomatitis & heartburn; insomnia, headache & dizziness; rash, pruritus & eczema; muscle & joint pain; bone marrow depression. Increased liver enzymes. Pain, reddening at the inj site, phlebitis.

Contraindications Hypersensitivity to quinolones. IV Epilepsy, history of tendon disorders related to fluoroquinolone therapy. Pregnancy & lactation. Children

Nursing Responsibilities May be taken with or without food. Ensure adequate fluid intake

Monitoring Parameters Patients should be adequately hydrated. History of convulsive diseases eg epilepsy & those w/ renal insufficiency. Discontinue if CNS stimulation eg tremors, hallucinations, paranoia, depression occur.

dependent negative supercoiling of DNA, inhibition of ATP-independent relaxation of supercoiled DNA and promotion of double-stranded DNA breakage resulting in bacterial cell death.

Name of Drugs Generic Name: Trimetazidine Brand Name: Vastarel MR Dosage: 1 tab Route: Per Orem Frequency: BID

Classification and Mechanism of Action Anti-Anginal Drugs It acts by directly counteracting all the major metabolic disorders occurringwithin the ischemic cell. The actions of trimetazidine include limitation of intracellular acidosis, correction of disturbances of transmembrane ion exchanges, and prevention of excessive production of free radicals.decrease myocardial oxygen requirement bydecreasing the heart rate, ventricular volume, blood pressure and contractility. Insome cases, myocardial oxygen delivery is increased thru reversing coronaryarterial spasm.

Indications Long treatment of coronary insufficienc y, angina pectoris

Side Effects Nausea Vomiting Headache Edema

Contraindications Contraindicated who are lactated

Nursing Responsibilities Check for doctors order Monitor blood pressureand pul se rate before and after givingthe meds. Notify prescribing signsof heart failure such asswelling of hands and feet or SOB Advise patient of thesideeffects of the drug.

Monitoring Parameters Use cautiously in patients with heart failure or hypertension and in elderly patients